Dactolisib

Basic Information

CAS ID: 915019-65-7
Molecular Formula: C30H23N5O
Molecular Weight: 469.6 g/mol
Monoisotopic Mass: 469.1903 g/mol
Class: Small Molecule
Natural Product: No
Other Names: NVP-BEZ235-ANA | NVP-BEZ235 | DACTOLISIB TOSYLATE | DACTOLISIB | NVP-BEZ235-NX | BEZ-235
Analysis: Drug repositioning mechanism analysis

N O N N N N

Compound Structure and Identifier

InChI: InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3 See All
InChI Key: JOGKUKXHTYWRGZ-UHFFFAOYSA-N
Smiles: CN1C(=O)N(c2ccc(cc2)C(C)(C)C#N)c3c1cnc4ccc(cc34)c5cnc6ccccc6c5 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0363 Serine/threonine-protein kinase mTOR inhibitor
T0954 Phosphoinositide 3-kinase inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 26663013 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Pancreatic fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 2

PubMed ID 25258031 Target ID T0954
Uniprot ID Phosphoinositide 3-kinase Name Phosphoinositide 3-kinase
Model vitro,mice Fibrosis Disease Systemic sclerosis
Process I
Process II fibroblasts activation
Process III prevenet collagen deposition
Mechanism Targeting PI3K/Akt/mTOR

Reference Record 3

PubMed ID 25258031 Target ID T0363
Uniprot ID Serine/threonine-protein kinase mTOR Name Serine/threonine-protein kinase mTOR
Model vitro,mice Fibrosis Disease Systemic sclerosis
Process I
Process II fibroblasts activation
Process III prevenet collagen deposition
Mechanism Targeting PI3K/Akt/mTOR

Related Link

PubChem: 11977753
ChEMBL: CHEMBL1879463