UO126

Basic Information

CAS ID: 109511-58-2
Molecular Formula: C18H16N6S2
Molecular Weight: 380.5 g/mol
Monoisotopic Mass: 380.0878 g/mol
Class: Small Molecule
Natural Product: No
Other Names: U-0126
Analysis: Drug repositioning mechanism analysis

NH2 N NH2 S NH2 N S NH2

Compound Structure and Identifier

InChI: InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+ See All
InChI Key: DVEXZJFMOKTQEZ-JYFOCSDGSA-N
Smiles: N\C(=C(\C#N)/C(=C(\N)/Sc1ccccc1N)/C#N)\Sc2ccccc2N See All
Molfile: Download

Related Target

Target ID Name Interaction
T0967 Mitogen-activated protein kinase inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 16871530 Target ID T0383
Uniprot ID Dual specificity mitogen-activated protein kinase kinase 1 Name Dual specificity mitogen-activated protein kinase kinase 1
Model vitro,mice Fibrosis Disease Dermal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 19434726 Target ID T0967
Uniprot ID Mitogen-activated protein kinase Name Mitogen-activated protein kinase
Model vitro,human Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation,HSCs proliferation
Process III prevenet collagen deposition
Mechanism Targeting ERK 1/2 and PI3K-Akt pathways

Related Link

PubChem: 3006531
ChEMBL: CHEMBL34704