GW788388

Basic Information

CAS ID: 452342-67-5
Molecular Formula: C25H23N5O2
Molecular Weight: 425.5 g/mol
Monoisotopic Mass: 425.1852 g/mol
Class: Small Molecule
Natural Product: No
Other Names: GW-788388
Analysis: Drug repositioning mechanism analysis

O NH O N NH N N

Compound Structure and Identifier

InChI: InChI=1S/C25H23N5O2/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31) See All
InChI Key: SAGZIBJAQGBRQA-UHFFFAOYSA-N
Smiles: O=C(NC1CCOCC1)c2ccc(cc2)c3cc(ccn3)c4c[nH]nc4c5ccccn5 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0007 TGF-beta receptor type-1 inhibitor
T0008 TGF-beta receptor type-2 inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 18075500 Target ID T0008
Uniprot ID TGF-beta receptor type-2 Name TGF-beta receptor type-2
Model vitro Fibrosis Disease Renal fibrosis
Process I
Process II EMT,cells proliferation,cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 18075500 Target ID T0007
Uniprot ID TGF-beta receptor type-1 Name TGF-beta receptor type-1
Model vitro Fibrosis Disease Renal fibrosis
Process I
Process II EMT,cells proliferation,cells apoptosis
Process III prevenet collagen deposition
Mechanism

Related Link

PubChem: 10202642
ChEMBL: CHEMBL202887