TGF-beta receptor type-2

Basic Information

Uniprot ID: P37173
Secondary ID: B4DTV5
Symbol: TGFBR2
Other Name: TGFR-2,TGF-beta type II receptor,Transforming growth factor-beta receptor type II,TGF-beta receptor type II,TbetaR-II
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Kinase,Receptor,Serine/threonine-protein kinase,Transferase

Target Classification

Category I Category II Category III
Extracellular Growth factor and receptor TGF-beta superfamily

Related Compound

Target ID Name Interaction
D0445 GW788388 inhibitor
D0534 LY2109761 inhibitor
D1129 NP-40208 antagonist

Fibrosis Related Property

Reference Record 1

PubMed ID 25108224 Compound ID
CAS Name
Model mice Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGF-β

Reference Record 2

PubMed ID 24282226 Compound ID
CAS Name
Model vitro Fibrosis Disease Corneal fibrosis
Process I
Process II fibroblasts migration
Process III
Mechanism

Reference Record 3

PubMed ID 18075500 Compound ID D0445
CAS 452342-67-5 Name GW788388
Model vitro Fibrosis Disease Renal fibrosis
Process I
Process II EMT,cells proliferation,cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 18034274 Compound ID D1129
CAS Name NP-40208
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 28458155 Compound ID D0534
CAS 700874-71-1 Name LY2109761
Model vitro,human Fibrosis Disease Keloid
Process I
Process II fibroblasts proliferation,fibroblasts apoptosis
Process III prevenet collagen deposition
Mechanism Targeting TGF-β1/Smad signaling pathway

Reference Record 6

PubMed ID 28122173 Compound ID
CAS Name
Model vitro Fibrosis Disease Scar
Process I
Process II fibroblasts activation
Process III
Mechanism