LY2109761

Basic Information

CAS ID: 700874-71-1
Molecular Formula: C26H27N5O2
Molecular Weight: 441.5 g/mol
Monoisotopic Mass: 441.2165 g/mol
Class: Small Molecule
Natural Product: No
Other Names:
Analysis: Drug repositioning mechanism analysis

N O O N N N N

Compound Structure and Identifier

InChI: InChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2 See All
InChI Key: IHLVSLOZUHKNMQ-UHFFFAOYSA-N
Smiles: C(CN1CCOCC1)Oc2ccc3c(ccnc3c2)c4c5CCCn5nc4c6ccccn6 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0007 TGF-beta receptor type-1 inhibitor
T0008 TGF-beta receptor type-2 inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 28458155 Target ID T0008
Uniprot ID TGF-beta receptor type-2 Name TGF-beta receptor type-2
Model vitro,human Fibrosis Disease Keloid
Process I
Process II fibroblasts proliferation,fibroblasts apoptosis
Process III prevenet collagen deposition
Mechanism Targeting TGF-β1/Smad signaling pathway

Reference Record 2

PubMed ID 28458155 Target ID T0007
Uniprot ID TGF-beta receptor type-1 Name TGF-beta receptor type-1
Model vitro,human Fibrosis Disease Keloid
Process I
Process II fibroblasts proliferation,fibroblasts apoptosis
Process III prevenet collagen deposition
Mechanism Targeting TGF-β1/Smad signaling pathway

Related Link

PubChem: 11655119
ChEMBL: CHEMBL260015