Sulfasalazine

Basic Information

CAS ID: 599-79-1
Molecular Formula: C18H14N4O5S
Molecular Weight: 398.4 g/mol
Monoisotopic Mass: 398.0685 g/mol
Class: Small Molecule
Natural Product: No
Other Names: UCINE | SULPHASALAZINE | SALAZOPYRIN E.C. | S.A.S. | AZULFIDINE | SALICYLAZOSULFAPYRIDINE | AZULFIDINE EN-TABS | SAS-500 | Azulfidine EN | COLIZINE | Polymer of Sulfasalazine | Salazosulfapyridine | S.A.S.-500 | SULFASALAZINE | SALAZOPYRIN-EN | SALAZOPYRIN
Analysis: Drug repositioning mechanism analysis

OH O OH N N S O O NH N

Compound Structure and Identifier

InChI: InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+ See All
InChI Key: NCEXYHBECQHGNR-QZQOTICOSA-N
Smiles: OC(=O)c1cc(ccc1O)N=Nc2ccc(cc2)S(=O)(=O)Nc3ccccn3 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0389 Inhibitor of nuclear factor kappa-B kinase subunit alpha inhibitor
T0390 Inhibitor of nuclear factor kappa-B kinase subunit beta inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 15633128 Target ID T0390
Uniprot ID Inhibitor of nuclear factor kappa-B kinase subunit beta Name Inhibitor of nuclear factor kappa-B kinase subunit beta
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II HSCs apoptosis
Process III
Mechanism

Reference Record 2

PubMed ID 15633128 Target ID T0389
Uniprot ID Inhibitor of nuclear factor kappa-B kinase subunit alpha Name Inhibitor of nuclear factor kappa-B kinase subunit alpha
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II HSCs apoptosis
Process III
Mechanism

Related Link

PubChem: 5339
ChEMBL: CHEMBL421