Platelet-derived growth factor receptor alpha

Basic Information

Uniprot ID: P16234
Secondary ID: B2RE69
Symbol: PDGFRA
Other Name: PDGFR2,PDGF-R-alpha,PDGFR-alpha,Alpha platelet-derived growth factor receptor,Alpha-type platelet-derived growth factor receptor,CD140 antigen-like family member A,CD140a antigen,Platelet-derived growth factor alpha receptor,Platelet-derived growth factor receptor 2,PDGFR-2,
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Developmental protein,Kinase,Receptor,Transferase,Tyrosine-protein kinase

Target Classification

Category I Category II Category III
Extracellular Growth factor and receptor PDGF famliy

Related Compound

Target ID Name Interaction
D0102 Imatinib antagonist
D0107 Crenolanib inhibitor
D0468 SU9518 inhibitor
D0924 Olaratumab inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 28734947 Compound ID D0924
CAS Name Olaratumab
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II HSCs proliferation,HSCs migration
Process III
Mechanism

Reference Record 2

PubMed ID 28228756 Compound ID
CAS Name
Model vitro,human Fibrosis Disease Systemic sclerosis
Process I
Process II cells proliferation,cells migration
Process III
Mechanism

Reference Record 3

PubMed ID 27569721 Compound ID D0107
CAS 670220-88-9 Name Crenolanib
Model vitro,mice Fibrosis Disease Muscle fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 22730381 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 21716259 Compound ID D0102
CAS 152459-95-5 Name Imatinib
Model mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 16556328 Compound ID D0468
CAS 251356-32-8 Name SU9518
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II fibroblasts activation,cells proliferation,cells apoptosis
Process III
Mechanism

Reference Record 7

PubMed ID 29170419 Compound ID D0102
CAS 152459-95-5 Name Imatinib
Model vitro,human Fibrosis Disease Fibrosis
Process I
Process II cells proliferation
Process III
Mechanism