Imatinib

Basic Information

CAS ID: 152459-95-5
Molecular Formula: C29H31N7O
Molecular Weight: 493.6 g/mol
Monoisotopic Mass: 493.259 g/mol
Class: Small Molecule
Natural Product: No
Other Names: GLIVEC | IMATINIB MESYLATE | IMATINIB MESILATE | STI-571 | STI 571 | Gleevec | GLEEVEC | IMATINIB
Analysis: Drug repositioning mechanism analysis

N N O NH NH N N N

Compound Structure and Identifier

InChI: InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) See All
InChI Key: KTUFNOKKBVMGRW-UHFFFAOYSA-N
Smiles: CN1CCN(Cc2ccc(cc2)C(=O)Nc3ccc(C)c(Nc4nccc(n4)c5cccnc5)c3)CC1 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0024 Platelet-derived growth factor receptor alpha antagonist
T0028 Platelet-derived growth factor receptor beta antagonist
T0986 Protein tyrosine kinase inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 27918111 Target ID
Uniprot ID Name
Model mice Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 24140598 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II HSCs proliferation
Process III
Mechanism

Reference Record 3

PubMed ID 24013728 Target ID
Uniprot ID Name
Model human,mice Fibrosis Disease Systemic sclerosis
Process I
Process II fibroblasts accumulation
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 22691216 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Systemic sclerosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 21716259 Target ID T0024
Uniprot ID Platelet-derived growth factor receptor alpha Name Platelet-derived growth factor receptor alpha
Model mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 21716259 Target ID T0028
Uniprot ID Platelet-derived growth factor receptor beta Name Platelet-derived growth factor receptor beta
Model mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 21518801 Target ID T0986
Uniprot ID Protein tyrosine kinase Name Protein tyrosine kinase
Model vitro,human,mice Fibrosis Disease Systemic sclerosis
Process I
Process II myofibroblasts differentiation,myofibroblasts accumulation
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 20201077 Target ID T0986
Uniprot ID Protein tyrosine kinase Name Protein tyrosine kinase
Model vitro,human,mice Fibrosis Disease Systemic sclerosis
Process I
Process II
Process III
Mechanism

Reference Record 9

PubMed ID 19846571 Target ID
Uniprot ID Name
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II fibroblasts proliferation,myofibroblasts acccumulation
Process III prevenet collagen deposition
Mechanism Targeting Abl mTORC1

Reference Record 10

PubMed ID 19151753 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Systemic sclerosis
Process I
Process II
Process III
Mechanism Targeting c-Abl and Egr-1

Reference Record 11

PubMed ID 17849262 Target ID T0986
Uniprot ID Protein tyrosine kinase Name Protein tyrosine kinase
Model vitro,mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II fibroblasts migration
Process III prevenet collagen deposition
Mechanism

Reference Record 12

PubMed ID 16835260 Target ID
Uniprot ID Name
Model mice Fibrosis Disease Fibrosis
Process I
Process II fibroblasts proliferation,fibroblasts migration
Process III
Mechanism

Reference Record 13

PubMed ID 14504092 Target ID
Uniprot ID Name
Model human Fibrosis Disease Bone marrow fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 14

PubMed ID 29170419 Target ID T0024
Uniprot ID Platelet-derived growth factor receptor alpha Name Platelet-derived growth factor receptor alpha
Model vitro,human Fibrosis Disease Fibrosis
Process I
Process II cells proliferation
Process III
Mechanism

Reference Record 15

PubMed ID 29170419 Target ID T0028
Uniprot ID Platelet-derived growth factor receptor beta Name Platelet-derived growth factor receptor beta
Model vitro,human Fibrosis Disease Fibrosis
Process I
Process II cells proliferation
Process III
Mechanism

Reference Record 16

PubMed ID 28965860 Target ID T0986
Uniprot ID Protein tyrosine kinase Name Protein tyrosine kinase
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Related Link

PubChem: 5291
ChEMBL: CHEMBL941