PD98059

Basic Information

CAS ID:	167869-21-8
Molecular Formula:	C16H13NO3
Molecular Weight:	267.284 g/mol
Monoisotopic Mass:	267.09 g/mol
Class:	Small Molecule
Natural Product:	No
Other Names:	4H-1-Benzopyran-4-one, 2-(2-amino-3-methoxyphenyl)-\|2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one\|2-(2'-amino-3'-methoxyphenyl)oxanaphthalen-4-one\|NSC 679828\|PD 098059
Analysis:	Drug repositioning mechanism analysis

Compound Structure and Identifier

InChI:	InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3	See All
InChI Key:	QFWCYNPOPKQOKV-UHFFFAOYSA-N
Smiles:	COc1cccc(C2=CC(=O)c3ccccc3O2)c1N	See All
Molfile:	Download

Related Target

Target ID	Name	Interaction
T0342	Mitogen-activated protein kinase 1	inhibitor
T0343	Mitogen-activated protein kinase 3	inhibitor
T0383	Dual specificity mitogen-activated protein kinase kinase 1	inhibitor
T0384	Dual specificity mitogen-activated protein kinase kinase 2	inhibitor
T0971	Extracellular signal-regulated kinases	inhibitor
T0984	Mitogen-activated protein kinase kinase	inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID	28616713	Target ID	T0342
Uniprot ID	Mitogen-activated protein kinase 1	Name	Mitogen-activated protein kinase 1
Model	vitro	Fibrosis Disease	Fibrosis
Process I
Process II	EMT
Process III
Mechanism

Reference Record 2

PubMed ID	25873302	Target ID	T0343
Uniprot ID	Mitogen-activated protein kinase 3	Name	Mitogen-activated protein kinase 3
Model	vitro	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II	EMT
Process III
Mechanism	Targeting MAPK signaling

Reference Record 3

PubMed ID	25406076	Target ID	T0384
Uniprot ID	Dual specificity mitogen-activated protein kinase kinase 2	Name	Dual specificity mitogen-activated protein kinase kinase 2
Model	vitro,rat	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 4

PubMed ID	25406076	Target ID	T0383
Uniprot ID	Dual specificity mitogen-activated protein kinase kinase 1	Name	Dual specificity mitogen-activated protein kinase kinase 1
Model	vitro,rat	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 5

PubMed ID	24303948	Target ID	T0342
Uniprot ID	Mitogen-activated protein kinase 1	Name	Mitogen-activated protein kinase 1
Model	vitro,rat	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs proliferation,cells apoptosis
Process III
Mechanism

Reference Record 6

PubMed ID	22976296	Target ID	T0984
Uniprot ID	Mitogen-activated protein kinase kinase	Name	Mitogen-activated protein kinase kinase
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID	17039283	Target ID	T0342
Uniprot ID	Mitogen-activated protein kinase 1	Name	Mitogen-activated protein kinase 1
Model	vitro	Fibrosis Disease	Joint fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 8

PubMed ID	16871530	Target ID	T0342
Uniprot ID	Mitogen-activated protein kinase 1	Name	Mitogen-activated protein kinase 1
Model	vitro,mice	Fibrosis Disease	Dermal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID	16289155	Target ID	T0343
Uniprot ID	Mitogen-activated protein kinase 3	Name	Mitogen-activated protein kinase 3
Model	vitro	Fibrosis Disease	Keloid
Process I
Process II
Process III
Mechanism

Reference Record 10

PubMed ID	16289155	Target ID	T0342
Uniprot ID	Mitogen-activated protein kinase 1	Name	Mitogen-activated protein kinase 1
Model	vitro	Fibrosis Disease	Keloid
Process I
Process II
Process III
Mechanism

Reference Record 11

PubMed ID	27025157	Target ID	T0971
Uniprot ID	Extracellular signal-regulated kinases	Name	Extracellular signal-regulated kinases
Model	vitro,rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II	fibroblasts proliferation
Process III	prevenet collagen deposition
Mechanism	Targeting ERK1/2

Reference Record 12

PubMed ID	26054450	Target ID
Uniprot ID		Name
Model	vitro	Fibrosis Disease	Keloid
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Related Link

PubChem:	4713
ChEMBL: