Peroxisome proliferator-activated receptor delta

Basic Information

Uniprot ID: Q03181
Secondary ID: A8K6J6
Symbol: PPARD
Other Name: NR1C2,PPAR-delta,NUCI,Nuclear hormone receptor 1,NUC1,Nuclear receptor subfamily 1 group C member 2,Peroxisome proliferator-activated receptor beta,PPAR-beta
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Activator,DNA-binding,Receptor

Target Classification

Category I Category II Category III
Intracellular Nuclear receptor NR1 family

Related Compound

Target ID Name Interaction
D0234 Endurobol agonist
D0259 GW0742 agonist

Fibrosis Related Property

Reference Record 1

PubMed ID 25752881 Compound ID
CAS Name
Model vitro,human Fibrosis Disease Scar
Process I
Process II fibroblasts proliferation,fibroblasts migration
Process III
Mechanism

Reference Record 2

PubMed ID 25477952 Compound ID D0234
CAS 317318-70-0 Name Endurobol
Model rat Fibrosis Disease Corneal fibrosis
Process I
Process II cells activation,cells proliferation,myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 25006409 Compound ID D0259
CAS 317318-84-6 Name GW0742
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 23046570 Compound ID
CAS Name
Model mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II HSCs activation,HSCs proliferation
Process III prevenet collagen deposition
Mechanism Targeting p38 and JNK MAPK pathways

Reference Record 5

PubMed ID 21244753 Compound ID D0259
CAS 317318-84-6 Name GW0742
Model mice Fibrosis Disease Pulmonary fibrosis
Process I attenue inflammation
Process II cells apoptosis
Process III
Mechanism

Reference Record 6

PubMed ID 17543901 Compound ID D0234
CAS 317318-70-0 Name Endurobol
Model vitro Fibrosis Disease Cardiac fibrosis
Process I
Process II fibroblasts proliferation,myofibroblasts differentiation
Process III
Mechanism

Reference Record 7

PubMed ID 17346664 Compound ID D0234
CAS 317318-70-0 Name Endurobol
Model vitro Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism