Oxysterols receptor LXR-alpha

Basic Information

Uniprot ID: Q13133
Secondary ID: A8K3J9
Symbol: NR1H3
Other Name: LXRA,Liver X receptor alpha,Nuclear receptor subfamily 1 group H member 3
Class: Single Protein
Type: anti-fibrotic
Molecular Function: Activator,DNA-binding,Receptor

Target Classification

Category I Category II Category III
Intracellular Nuclear receptor NR1 family

Related Compound

Target ID Name Interaction
D0224 AZ876 agonist
D0266 T0901317 agonist
D0556 GW3965 agonist

Fibrosis Related Property

Reference Record 1

PubMed ID 26667495 Compound ID D0556
CAS 405911-17-3 Name GW3965
Model mice Fibrosis Disease Arteriolar fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 25684370 Compound ID D0224
CAS 898800-26-5 Name AZ876
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 25102981 Compound ID
CAS Name
Model human Fibrosis Disease Liver fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 4

PubMed ID 24618263 Compound ID D0266
CAS 293754-55-9 Name T0901317
Model vitro,mice Fibrosis Disease Skin fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting IL-6