Protein tyrosine kinase

Basic Information

Uniprot ID:	PF07714
Secondary ID:
Symbol:
Other Name:
Class:	Protein Famliy
Type:	pro-fibrotic
Molecular Function:

Target Classification

Category I	Category II	Category III
Other

Related Compound

Target ID	Name	Interaction
D0015	Dasatinib	inhibitor
D0102	Imatinib	inhibitor
D0487	Genistein	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	21518801	Compound ID	D0102
CAS	152459-95-5	Name	Imatinib
Model	vitro,human,mice	Fibrosis Disease	Systemic sclerosis
Process I
Process II	myofibroblasts differentiation,myofibroblasts accumulation
Process III	prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID	20201077	Compound ID	D0102
CAS	152459-95-5	Name	Imatinib
Model	vitro,human,mice	Fibrosis Disease	Systemic sclerosis
Process I
Process II
Process III
Mechanism

Reference Record 3

PubMed ID	17849262	Compound ID	D0102
CAS	152459-95-5	Name	Imatinib
Model	vitro,mice	Fibrosis Disease	Idiopathic pulmonary fibrosis
Process I
Process II	fibroblasts migration
Process III	prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID	12174389	Compound ID	D0487
CAS	446-72-0	Name	Genistein
Model	vitro,rat	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs proliferation
Process III
Mechanism

Reference Record 5

PubMed ID	29121645	Compound ID	D0015
CAS	302962-49-8	Name	Dasatinib
Model	human	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 6

PubMed ID	29121645	Compound ID	D0015
CAS	302962-49-8	Name	Dasatinib
Model	human	Fibrosis Disease	Systemic sclerosis
Process I
Process II
Process III
Mechanism

Reference Record 7

PubMed ID	28965860	Compound ID	D0102
CAS	152459-95-5	Name	Imatinib
Model	vitro,rat	Fibrosis Disease	Liver fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism