Proteasome

Basic Information

Uniprot ID:
Secondary ID:
Symbol:
Other Name:
Class:	Protein Famliy
Type:	pro-fibrotic
Molecular Function:

Target Classification

Category I	Category II	Category III
Other

Related Compound

Target ID	Name	Interaction
D0327	Bortezomib	inhibitor
D0387	Lactacystin	inhibitor
D0965	MG132	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	22609986	Compound ID	D0327
CAS	179324-69-7	Name	Bortezomib
Model	mice	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting ARAF

Reference Record 2

PubMed ID	21175982	Compound ID	D0965
CAS	133407-82-6	Name	MG132
Model	vitro,rat	Fibrosis Disease	Renal fibrosis
Process I
Process II	myofibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism	Targeting Smad

Reference Record 3

PubMed ID	21175982	Compound ID	D0387
CAS	133343-34-7	Name	Lactacystin
Model	vitro,rat	Fibrosis Disease	Renal fibrosis
Process I
Process II	myofibroblasts differentiation
Process III
Mechanism	Targeting Smad

Reference Record 4

PubMed ID	16959829	Compound ID	D0965
CAS	133407-82-6	Name	MG132
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 5

PubMed ID	16440346	Compound ID	D0327
CAS	179324-69-7	Name	Bortezomib
Model	vitro	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs apoptosis,HSCs accumulation
Process III
Mechanism

Reference Record 6

PubMed ID	16440346	Compound ID	D0965
CAS	133407-82-6	Name	MG132
Model	vitro	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs apoptosis
Process III
Mechanism