GVAP (Genome Variation Analysis Platform) is a high-performance genomic variant analysis tool specifically designed for bacterial and viral genome studies. Users can input target genome sequences (bacteria or viruses) along with their corresponding reference genome sequences, and the system employs high-precision alignment algorithms to detect various types of genomic variations, including SNPs (Single Nucleotide Polymorphisms), InDels (Insertions/Deletions), and Structural Variants (SVs), while generating comprehensive variant annotation reports. This tool is widely applicable in molecular epidemiological investigations, pathogen surveillance, and vaccine/drug target research, providing a robust and comprehensive solution for microbial genomic variant analysis.