| CM000714.1_70 |
78.463 |
0.0 |
clpC |
VF0072 |
ClpC |
Stress survival |
VFC0282 |
27-kDa stress protein belongs to the Hsp100/Clp family; Regulation of Clp protease expression is mediated by CtsR, the product of the first gene in the ClpC operon |
(clpC) endopeptidase Clp ATP-binding chain C [ClpC (VF0072) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CM000714.1_96 |
74.177 |
0.0 |
tufA |
VF0460 |
EF-Tu |
Adherence |
VFC0001 |
|
(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| CM000714.1_159 |
67.234 |
0.0 |
gndA |
VF0560 |
Capsule |
Immune modulation |
VFC0258 |
The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. |
(gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| CM000714.1_242 |
73.333 |
0.0 |
groEL |
VF0594 |
GroEL |
Adherence |
VFC0001 |
GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. |
(groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] |
Clostridium difficile |
| CM000714.1_587 |
98.827 |
0.0 |
inhA |
VF0536 |
InhA |
Exoenzyme |
VFC0251 |
|
(inhA) immune inhibitor A metalloprotease [InhA (VF0536) - Exoenzyme (VFC0251)] [Bacillus anthracis str. Sterne] |
Bacillus anthracis |
| CM000714.1_995 |
61.027 |
6.92E-153 |
lplA1 |
VF0347 |
LplA1 |
Nutritional/Metabolic factor |
VFC0272 |
|
(lplA1) lipoate protein ligase [LplA1 (VF0347) - Nutritional/Metabolic factor (VFC0272)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CM000714.1_1025 |
66.507 |
0.0 |
icl |
VF0253 |
Isocitrate lyase |
Others |
VFC0346 |
|
(icl) Isocitrate lyase Icl (isocitrase) (isocitratase) [Isocitrate lyase (VF0253) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| CM000714.1_1166 |
96.231 |
0.0 |
BAS_RS06430 |
VF0536 |
InhA |
Exoenzyme |
VFC0251 |
|
(BAS_RS06430) immune inhibitor A [InhA (VF0536) - Exoenzyme (VFC0251)] [Bacillus anthracis str. Sterne] |
Bacillus anthracis |
| CM000714.1_1213 |
97.781 |
0.0 |
ilsA |
VF0585 |
IlsA |
Nutritional/Metabolic factor |
VFC0272 |
The three conserved domains: NEAT (NEAr iron Transporter), LRR (Leucine-Rich Repeat) and SLH (Surface Layer Homology); specifically expressed in the insect hemocoel and under iron-depleted conditions |
(ilsA) NEAT domain-containing leucine-rich repeat protein [IlsA (VF0585) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] |
Bacillus cereus |
| CM000714.1_1767 |
93.872 |
0.0 |
nheC |
VF0533 |
Nhe |
Exotoxin |
VFC0235 |
The respective HBL and NHE proteins share 23~40% sequence identity |
(nheC) non-hemolytic enterotoxin C [Nhe (VF0533) - Exotoxin (VFC0235)] [Bacillus cereus ATCC 10987] |
Bacillus cereus |
| CM000714.1_1768 |
99.005 |
0.0 |
nheB |
VF0533 |
Nhe |
Exotoxin |
VFC0235 |
The respective HBL and NHE proteins share 23~40% sequence identity |
(nheB) non-hemolytic enterotoxin B [Nhe (VF0533) - Exotoxin (VFC0235)] [Bacillus cereus ATCC 10987] |
Bacillus cereus |
| CM000714.1_1769 |
97.668 |
0.0 |
nheA |
VF0533 |
Nhe |
Exotoxin |
VFC0235 |
The respective HBL and NHE proteins share 23~40% sequence identity |
(nheA) non-hemolytic enterotoxin A [Nhe (VF0533) - Exotoxin (VFC0235)] [Bacillus cereus ATCC 10987] |
Bacillus cereus |
| CM000714.1_1985 |
99.31 |
4.1E-104 |
BAS_RS10600 |
VF0581 |
T7SS |
Effector delivery system |
VFC0086 |
Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. |
(BAS_RS10600) type VII secretion system protein [T7SS (VF0581) - Effector delivery system (VFC0086)] [Bacillus anthracis str. Sterne] |
Bacillus anthracis |
| CM000714.1_1988 |
100.0 |
3.22E-63 |
esxB |
VF0581 |
T7SS |
Effector delivery system |
VFC0086 |
Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. |
(esxB) type VII secretion system protein EsxB [T7SS (VF0581) - Effector delivery system (VFC0086)] [Bacillus anthracis str. Sterne] |
Bacillus anthracis |
| CM000714.1_1989 |
98.352 |
0.0 |
essC |
VF0581 |
T7SS |
Effector delivery system |
VFC0086 |
Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. |
(essC) type VII secretion system protein EssC [T7SS (VF0581) - Effector delivery system (VFC0086)] [Bacillus anthracis str. Sterne] |
Bacillus anthracis |
| CM000714.1_2123 |
65.574 |
1.89E-27 |
mbtH |
VF0299 |
Mycobactin |
Nutritional/Metabolic factor |
VFC0272 |
Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. |
(mbtH) putative protein MbtH [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| CM000714.1_2124 |
96.31 |
0.0 |
dhbF |
VF0586 |
Bacillibactin |
Nutritional/Metabolic factor |
VFC0272 |
Catechol-based siderophore |
(dhbF) non-ribosomal peptide synthetase, DhbF [Bacillibactin (VF0586) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] |
Bacillus cereus |
| CM000714.1_2125 |
90.236 |
0.0 |
dhbB |
VF0586 |
Bacillibactin |
Nutritional/Metabolic factor |
VFC0272 |
Catechol-based siderophore |
(dhbB) isochorismatase, DhbB [Bacillibactin (VF0586) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] |
Bacillus cereus |
| CM000714.1_2126 |
98.327 |
0.0 |
dhbE |
VF0586 |
Bacillibactin |
Nutritional/Metabolic factor |
VFC0272 |
Catechol-based siderophore |
(dhbE) 2,3-dihydroxybenzoate adenylase DhbE [Bacillibactin (VF0586) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] |
Bacillus cereus |
| CM000714.1_2127 |
96.742 |
0.0 |
dhbC |
VF0586 |
Bacillibactin |
Nutritional/Metabolic factor |
VFC0272 |
Catechol-based siderophore |
(dhbC) isochorismate synthase DhbC [Bacillibactin (VF0586) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] |
Bacillus cereus |
| CM000714.1_2128 |
100.0 |
0.0 |
dhbA |
VF0586 |
Bacillibactin |
Nutritional/Metabolic factor |
VFC0272 |
Catechol-based siderophore |
(dhbA) 2,3-dihydroxybenzoate-2,3-dehydrogenase, DhbA [Bacillibactin (VF0586) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] |
Bacillus cereus |
| CM000714.1_2541 |
69.43 |
1.64E-101 |
clpP |
VF0074 |
ClpP |
Stress survival |
VFC0282 |
21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes |
(clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CM000714.1_2746 |
76.998 |
0.0 |
BAS_RS06430 |
VF0536 |
InhA |
Exoenzyme |
VFC0251 |
|
(BAS_RS06430) immune inhibitor A [InhA (VF0536) - Exoenzyme (VFC0251)] [Bacillus anthracis str. Sterne] |
Bacillus anthracis |
| CM000714.1_2938 |
62.5 |
1.62E-123 |
rfbF |
VF0392 |
O-antigen |
Immune modulation |
VFC0258 |
Clinical Y. enterocolitica isolates from humans predominantly belong to serotypes O:3, O:9, O:8 and O:5,27; Y. enterocolitica O antigen expression is temperature regulated. |
(rfbF) glucose-1-phosphate cytidylyltransferase [O-antigen (VF0392) - Immune modulation (VFC0258)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| CM000714.1_3011 |
95.117 |
0.0 |
alo |
VF0534 |
ALO |
Exotoxin |
VFC0235 |
|
(alo) thiol-activated cytolysin [ALO (VF0534) - Exotoxin (VFC0235)] [Bacillus anthracis str. Sterne] |
Bacillus anthracis |
| CM000714.1_3390 |
60.924 |
3.2E-108 |
cpsA/uppS |
VF0361 |
Capsule |
Immune modulation |
VFC0258 |
The biosynthesis of capsular polysaccharides by E. faecalis is encoded by the csp operon, which includes 11 open reading frames (cpsA to cpsK). However, only 7 open reading frames in the cps operon are essential for capsule production (cpsC, cpsD, cpsE, cpsG, cpsI, cpsJ, and cpsK); Previous genetic evidence demonstrated that E. faecalis isolates can be classified in 1 of 3 capsule operon polymorphisms. CPS 1 presents only cpsA and cpsB. CPS 2 presents all 11 genes in the cps operon. CPS 5 presents all genes except for cpsF. Furthermore, CPS 2 and 5 express the capsular polysaccharide, whereas CPS 1 does not. |
(cpsA/uppS) undecaprenyl diphosphate synthase [Capsule (VF0361) - Immune modulation (VFC0258)] [Enterococcus faecalis V583] |
Enterococcus faecalis |
| CM000714.1_3976 |
63.036 |
2.27E-131 |
sigA/rpoV |
VF0257 |
SigA |
Regulation |
VFC0301 |
In M. tuberculosis, 13 sigma factor genes have been annotated in the genome, 9 of which belong to a special subfamily thought to direct extracytoplasmic functions and various other stress responses (temperature, oxidative stress, pH, and infection of macrophages); sigma A also known as RpoV, is the essential principal mycobacterial sigma factors, necessary for most mycobacterial housekeeping gene transcription; It was the first mycobacterial sigma factor to be associated with virulence |
(sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| CM000714.1_4030 |
73.903 |
0.0 |
lap |
VF0444 |
Lap |
Adherence |
VFC0001 |
Originally named surface protein p104, is a 104 kDa adhesion protein, present in every Listeria spp. except L. grayi |
(lap) Listeria adhesion protein Lap [Lap (VF0444) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CM000714.1_4848 |
63.333 |
9.5E-175 |
cps4I |
VF0144 |
Capsule |
Immune modulation |
VFC0258 |
Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages |
(cps4I) capsular polysaccharide biosynthesis protein Cps4I [Capsule (VF0144) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CM000714.1_5017 |
63.194 |
8.85E-130 |
galE |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(galE) UDP-glucose 4-epimerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |