2. PATHOGENS
Basic Information
Accession number
GCA_000003955.1
Release date
2009-05-29
Organism
Bacillus cereus AH1273
Species name
Bacillus cereus
Assembly level
Chromosome
Assembly name
ASM395v1
Assembly submitter
Naval Medical Research Center
Assembly Type
haploid
Genome size
5.8 Mb
GC percent
35.0
Contig count
412
Collection date
-
Sample location
-
Host
-
Isolation source
-
Isolate type
-
Strain
AH1273
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
CM000741.1_240 # 232577 # 233746 175.0 192.971 vanT gene in vanG cluster 31.88 ARO:3002972 protein homolog model glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanT Also known as vanTG, is a vanT variant found in the vanG gene cluster.
CM000741.1_515 # 528578 # 529840 50.0 123.25 vanW gene in vanI cluster 33.49 ARO:3003724 protein homolog model glycopeptide antibiotic antibiotic target alteration vanW; glycopeptide resistance gene cluster Also known as vanWI, is a vanW variant found in the vanI gene cluster.
CM000741.1_807 # 840269 # 841216 350.0 583.178 BcIII 88.54 ARO:3007101 protein homolog model cephalosporin; penem antibiotic inactivation class A Bacillus cereus Bc beta-lactamase Bacillus cereus beta-lactamase III is a class A beta-lactamase that breaks down a number of penicillins and cephalosporins in Bacillus cereus.
CM000741.1_1930 # 1896226 # 1896642 225.0 265.003 FosB 87.68 ARO:3000172 protein homolog model phosphonic acid antibiotic antibiotic inactivation fosfomycin thiol transferase A thiol transferase that leads to the resistance of fosfomycin. Contrasting FosA, FosB is dependent on the cofactor Magnesium (II) and uses either bacillithiol or L-cysteine to open up the epoxide ring of fosfomycin.
CM000741.1_1957 # 1918895 # 1919635 50.0 100.138 vanY gene in vanM cluster 40.97 ARO:3002961 protein homolog model glycopeptide antibiotic antibiotic target alteration vanY; glycopeptide resistance gene cluster Also known as vanYM, is a vanY variant found in the vanM gene cluster.
CM000741.1_1980 # 1938537 # 1939712 175.0 223.016 vanT gene in vanG cluster 35.5 ARO:3002972 protein homolog model glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanT Also known as vanTG, is a vanT variant found in the vanG gene cluster.
CM000741.1_2388 # 2335313 # 2336359 350.0 579.326 BcI 89.87 ARO:3002877 protein homolog model cephalosporin; penem antibiotic inactivation class A Bacillus cereus Bc beta-lactamase Bacillus cereus beta-lactamase I is a class A beta-lactamase that breaks down a number of penicillins and cephalosporins in the Bacillus cereus strain 569/H/9.
CM000741.1_2557 # 2511365 # 2512300 350.0 478.789 BcIII 73.1 ARO:3007101 protein homolog model cephalosporin; penem antibiotic inactivation class A Bacillus cereus Bc beta-lactamase Bacillus cereus beta-lactamase III is a class A beta-lactamase that breaks down a number of penicillins and cephalosporins in Bacillus cereus.
CM000741.1_2895 # 2826639 # 2828582 400.0 583.948 tetB(P) 45.61 ARO:3000195 protein homolog model tetracycline antibiotic antibiotic target protection tetracycline-resistant ribosomal protection protein TetB(P) is a tetracycline ribosomal protection protein found on the same operon as tetA(P), a tetracycline efflux protein.
CM000741.1_3033 # 2961264 # 2961989 50.0 148.288 vanY gene in vanB cluster 34.71 ARO:3002956 protein homolog model glycopeptide antibiotic antibiotic target alteration vanY; glycopeptide resistance gene cluster Also known as vanYB, is a vanY variant found in the vanB gene cluster.
CM000741.1_3174 # 3093231 # 3094010 450.0 456.062 BcII 91.46 ARO:3002878 protein homolog model cephalosporin; penam antibiotic inactivation subclass B1 Bacillus cereus Bc beta-lactamase Bacillus cereus beta-lactamase II is a zinc metallo-beta-lactamase that hydrolyzes a large number of penicillins and cephalosporins in the Bacillus cereus strain 5/B/6.
CM000741.1_3258 # 3170703 # 3171614 50.0 114.39 vanW gene in vanI cluster 44.72 ARO:3003724 protein homolog model glycopeptide antibiotic antibiotic target alteration vanW; glycopeptide resistance gene cluster Also known as vanWI, is a vanW variant found in the vanI gene cluster.
CM000741.1_4213 # 4080819 # 4081598 50.0 110.923 vanY gene in vanB cluster 33.85 ARO:3002956 protein homolog model glycopeptide antibiotic antibiotic target alteration vanY; glycopeptide resistance gene cluster Also known as vanYB, is a vanY variant found in the vanB gene cluster.
CM000741.1_4572 # 4394714 # 4395574 50.0 347.051 vanY gene in vanF cluster 57.53 ARO:3002958 protein homolog model glycopeptide antibiotic antibiotic target alteration vanY; glycopeptide resistance gene cluster Also known as vanYF, is a vanY variant found in the vanF gene cluster.
CM000741.1_4675 # 4496203 # 4496532 75.0 79.337 qacJ 41.25 ARO:3007014 protein homolog model disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump qacJ is a small multidrug resistance (SMR) efflux pump that confers resistance to quaternary ammonium compounds.
CM000741.1_5461 # 5264590 # 5264967 75.0 119.013 qacG 60.75 ARO:3007015 protein homolog model disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump qacG is a small multidrug resistance efflux pump that confers resistance to benzalkonium chloride and ethidium bromide.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
CM000741.1_81 78.589 0.0 clpC VF0072 ClpC Stress survival VFC0282 27-kDa stress protein belongs to the Hsp100/Clp family; Regulation of Clp protease expression is mediated by CtsR, the product of the first gene in the ClpC operon (clpC) endopeptidase Clp ATP-binding chain C [ClpC (VF0072) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
CM000741.1_107 74.112 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
CM000741.1_256 73.143 0.0 groEL VF0594 GroEL Adherence VFC0001 GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. (groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] Clostridium difficile
CM000741.1_461 78.302 1.08E-45 hal VF0587 Hal Nutritional/Metabolic factor VFC0272 Includes an N-terminal near-iron transporter (NEAT) domain, several internal leucine-rich repeat (LRR) regions, and a C-terminal sortase-like cell wall anchor (hal) heme-acquisition leucine-rich repeat protein [Hal (VF0587) - Nutritional/Metabolic factor (VFC0272)] [Bacillus anthracis str. Sterne] Bacillus anthracis
CM000741.1_584 92.866 0.0 inhA VF0536 InhA Exoenzyme VFC0251 (inhA) immune inhibitor A metalloprotease [InhA (VF0536) - Exoenzyme (VFC0251)] [Bacillus anthracis str. Sterne] Bacillus anthracis
CM000741.1_843 89.98 0.0 alo VF0534 ALO Exotoxin VFC0235 (alo) thiol-activated cytolysin [ALO (VF0534) - Exotoxin (VFC0235)] [Bacillus anthracis str. Sterne] Bacillus anthracis
CM000741.1_867 74.433 0.0 BAS_RS06430 VF0536 InhA Exoenzyme VFC0251 (BAS_RS06430) immune inhibitor A [InhA (VF0536) - Exoenzyme (VFC0251)] [Bacillus anthracis str. Sterne] Bacillus anthracis
CM000741.1_967 61.027 1.25E-152 lplA1 VF0347 LplA1 Nutritional/Metabolic factor VFC0272 (lplA1) lipoate protein ligase [LplA1 (VF0347) - Nutritional/Metabolic factor (VFC0272)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
CM000741.1_1005 66.268 0.0 icl VF0253 Isocitrate lyase Others VFC0346 (icl) Isocitrate lyase Icl (isocitrase) (isocitratase) [Isocitrate lyase (VF0253) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CM000741.1_1258 93.893 1.83E-177 ilsA VF0585 IlsA Nutritional/Metabolic factor VFC0272 The three conserved domains: NEAT (NEAr iron Transporter), LRR (Leucine-Rich Repeat) and SLH (Surface Layer Homology); specifically expressed in the insect hemocoel and under iron-depleted conditions (ilsA) NEAT domain-containing leucine-rich repeat protein [IlsA (VF0585) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] Bacillus cereus
CM000741.1_1259 89.076 0.0 ilsA VF0585 IlsA Nutritional/Metabolic factor VFC0272 The three conserved domains: NEAT (NEAr iron Transporter), LRR (Leucine-Rich Repeat) and SLH (Surface Layer Homology); specifically expressed in the insect hemocoel and under iron-depleted conditions (ilsA) NEAT domain-containing leucine-rich repeat protein [IlsA (VF0585) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] Bacillus cereus
CM000741.1_1787 94.819 0.0 nheA VF0533 Nhe Exotoxin VFC0235 The respective HBL and NHE proteins share 23~40% sequence identity (nheA) non-hemolytic enterotoxin A [Nhe (VF0533) - Exotoxin (VFC0235)] [Bacillus cereus ATCC 10987] Bacillus cereus
CM000741.1_1788 98.259 0.0 nheB VF0533 Nhe Exotoxin VFC0235 The respective HBL and NHE proteins share 23~40% sequence identity (nheB) non-hemolytic enterotoxin B [Nhe (VF0533) - Exotoxin (VFC0235)] [Bacillus cereus ATCC 10987] Bacillus cereus
CM000741.1_1789 94.15 0.0 nheC VF0533 Nhe Exotoxin VFC0235 The respective HBL and NHE proteins share 23~40% sequence identity (nheC) non-hemolytic enterotoxin C [Nhe (VF0533) - Exotoxin (VFC0235)] [Bacillus cereus ATCC 10987] Bacillus cereus
CM000741.1_1880 95.017 0.0 asbA VF0584 Petrobactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore;the biosynthetic pathway for petrobactin (the asb operon), the petrobactin-iron complex receptor (FhuA), import permeases (FpuB/FatC/FatD), ATPases (FpuC/FatE), and the petrobactin exporter (ApeX) (asbA) petrobactin biosynthesis protein AsbA [Petrobactin (VF0584) - Nutritional/Metabolic factor (VFC0272)] [Bacillus anthracis str. Sterne] Bacillus anthracis
CM000741.1_1881 86.579 0.0 asbB VF0584 Petrobactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore;the biosynthetic pathway for petrobactin (the asb operon), the petrobactin-iron complex receptor (FhuA), import permeases (FpuB/FatC/FatD), ATPases (FpuC/FatE), and the petrobactin exporter (ApeX) (asbB) petrobactin biosynthesis protein AsbB [Petrobactin (VF0584) - Nutritional/Metabolic factor (VFC0272)] [Bacillus anthracis str. Sterne] Bacillus anthracis
CM000741.1_1882 94.66 0.0 asbC VF0584 Petrobactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore;the biosynthetic pathway for petrobactin (the asb operon), the petrobactin-iron complex receptor (FhuA), import permeases (FpuB/FatC/FatD), ATPases (FpuC/FatE), and the petrobactin exporter (ApeX) (asbC) 3,4-dihydroxybenzoic acid-AMP ligase AsbC [Petrobactin (VF0584) - Nutritional/Metabolic factor (VFC0272)] [Bacillus anthracis str. Sterne] Bacillus anthracis
CM000741.1_1883 96.429 1.66E-54 asbD VF0584 Petrobactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore;the biosynthetic pathway for petrobactin (the asb operon), the petrobactin-iron complex receptor (FhuA), import permeases (FpuB/FatC/FatD), ATPases (FpuC/FatE), and the petrobactin exporter (ApeX) (asbD) petrobactin biosynthesis protein AsbD [Petrobactin (VF0584) - Nutritional/Metabolic factor (VFC0272)] [Bacillus anthracis str. Sterne] Bacillus anthracis
CM000741.1_1884 95.107 0.0 asbE VF0584 Petrobactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore;the biosynthetic pathway for petrobactin (the asb operon), the petrobactin-iron complex receptor (FhuA), import permeases (FpuB/FatC/FatD), ATPases (FpuC/FatE), and the petrobactin exporter (ApeX) (asbE) petrobactin biosynthesis protein AsbE [Petrobactin (VF0584) - Nutritional/Metabolic factor (VFC0272)] [Bacillus anthracis str. Sterne] Bacillus anthracis
CM000741.1_1885 94.643 0.0 asbF VF0584 Petrobactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore;the biosynthetic pathway for petrobactin (the asb operon), the petrobactin-iron complex receptor (FhuA), import permeases (FpuB/FatC/FatD), ATPases (FpuC/FatE), and the petrobactin exporter (ApeX) (asbF) petrobactin biosynthesis 3-dehydroshikimate dehydratase AsbF [Petrobactin (VF0584) - Nutritional/Metabolic factor (VFC0272)] [Bacillus anthracis str. Sterne] Bacillus anthracis
CM000741.1_2018 60.606 0.0 narH VF0302 Nitrate reductase Nutritional/Metabolic factor VFC0272 NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein (narH) nitrate reductase subunit beta [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CM000741.1_2076 93.184 0.0 essC VF0581 T7SS Effector delivery system VFC0086 Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. (essC) type VII secretion system protein EssC [T7SS (VF0581) - Effector delivery system (VFC0086)] [Bacillus anthracis str. Sterne] Bacillus anthracis
CM000741.1_2077 77.778 2.13E-50 esxB VF0581 T7SS Effector delivery system VFC0086 Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. (esxB) type VII secretion system protein EsxB [T7SS (VF0581) - Effector delivery system (VFC0086)] [Bacillus anthracis str. Sterne] Bacillus anthracis
CM000741.1_2082 93.793 2.4E-98 BAS_RS10600 VF0581 T7SS Effector delivery system VFC0086 Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. (BAS_RS10600) type VII secretion system protein [T7SS (VF0581) - Effector delivery system (VFC0086)] [Bacillus anthracis str. Sterne] Bacillus anthracis
CM000741.1_2083 95.833 5.79E-60 esxL VF0581 T7SS Effector delivery system VFC0086 Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. (esxL) type VII secretion system protein EsxL [T7SS (VF0581) - Effector delivery system (VFC0086)] [Bacillus anthracis str. Sterne] Bacillus anthracis
CM000741.1_2234 89.655 2.1E-164 dhbA VF0586 Bacillibactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore (dhbA) 2,3-dihydroxybenzoate-2,3-dehydrogenase, DhbA [Bacillibactin (VF0586) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] Bacillus cereus
CM000741.1_2235 92.481 0.0 dhbC VF0586 Bacillibactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore (dhbC) isochorismate synthase DhbC [Bacillibactin (VF0586) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] Bacillus cereus
CM000741.1_2236 94.424 0.0 dhbE VF0586 Bacillibactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore (dhbE) 2,3-dihydroxybenzoate adenylase DhbE [Bacillibactin (VF0586) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] Bacillus cereus
CM000741.1_2237 95.286 0.0 dhbB VF0586 Bacillibactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore (dhbB) isochorismatase, DhbB [Bacillibactin (VF0586) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] Bacillus cereus
CM000741.1_2238 91.488 0.0 dhbF VF0586 Bacillibactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore (dhbF) non-ribosomal peptide synthetase, DhbF [Bacillibactin (VF0586) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] Bacillus cereus
CM000741.1_2239 63.934 5.92E-26 mbtH VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtH) putative protein MbtH [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CM000741.1_2634 69.948 3.17E-100 clpP VF0074 ClpP Stress survival VFC0282 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
CM000741.1_3360 63.093 0.0 ureB VF0050 Urease Stress survival VFC0282 (ureB) urease beta subunit UreB, urea amidohydrolase [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] Helicobacter pylori
CM000741.1_3363 63.452 2.79E-97 ureG VF0050 Urease Stress survival VFC0282 (ureG) urease accessory protein (ureG) [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] Helicobacter pylori
CM000741.1_3551 62.185 5.19E-110 cpsA/uppS VF0361 Capsule Immune modulation VFC0258 The biosynthesis of capsular polysaccharides by E. faecalis is encoded by the csp operon, which includes 11 open reading frames (cpsA to cpsK). However, only 7 open reading frames in the cps operon are essential for capsule production (cpsC, cpsD, cpsE, cpsG, cpsI, cpsJ, and cpsK); Previous genetic evidence demonstrated that E. faecalis isolates can be classified in 1 of 3 capsule operon polymorphisms. CPS 1 presents only cpsA and cpsB. CPS 2 presents all 11 genes in the cps operon. CPS 5 presents all genes except for cpsF. Furthermore, CPS 2 and 5 express the capsular polysaccharide, whereas CPS 1 does not. (cpsA/uppS) undecaprenyl diphosphate synthase [Capsule (VF0361) - Immune modulation (VFC0258)] [Enterococcus faecalis V583] Enterococcus faecalis
CM000741.1_4025 63.036 2.7E-131 sigA/rpoV VF0257 SigA Regulation VFC0301 In M. tuberculosis, 13 sigma factor genes have been annotated in the genome, 9 of which belong to a special subfamily thought to direct extracytoplasmic functions and various other stress responses (temperature, oxidative stress, pH, and infection of macrophages); sigma A also known as RpoV, is the essential principal mycobacterial sigma factors, necessary for most mycobacterial housekeeping gene transcription; It was the first mycobacterial sigma factor to be associated with virulence (sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CM000741.1_4039 74.596 0.0 lap VF0444 Lap Adherence VFC0001 Originally named surface protein p104, is a 104 kDa adhesion protein, present in every Listeria spp. except L. grayi (lap) Listeria adhesion protein Lap [Lap (VF0444) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
CM000741.1_4818 96.574 0.0 alo VF0534 ALO Exotoxin VFC0235 (alo) thiol-activated cytolysin [ALO (VF0534) - Exotoxin (VFC0235)] [Bacillus anthracis str. Sterne] Bacillus anthracis
CM000741.1_4834 76.923 3.48E-55 clpP VF0074 ClpP Stress survival VFC0282 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
CM000741.1_4878 63.333 5.35E-174 cps4I VF0144 Capsule Immune modulation VFC0258 Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages (cps4I) capsular polysaccharide biosynthesis protein Cps4I [Capsule (VF0144) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4] Streptococcus pneumoniae
CM000741.1_4957 90.404 0.0 capB VF0141 Capsule Immune modulation VFC0258 Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 (capB) CapB, involved in Poly-gamma-glutamate synthesis [Capsule (VF0141) - Immune modulation (VFC0258)] [Bacillus anthracis] Bacillus anthracis
CM000741.1_4958 91.946 9.0E-96 capC VF0141 Capsule Immune modulation VFC0258 Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 (capC) CapC, involved in Poly-gamma-glutamate synthesis [Capsule (VF0141) - Immune modulation (VFC0258)] [Bacillus anthracis] Bacillus anthracis
CM000741.1_4959 86.104 0.0 capA VF0141 Capsule Immune modulation VFC0258 Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 (capA) CapA, required for Poly-gamma-glutamate transport [Capsule (VF0141) - Immune modulation (VFC0258)] [Bacillus anthracis] Bacillus anthracis
CM000741.1_4960 82.833 0.0 dep/capD VF0141 Capsule Immune modulation VFC0258 Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 (dep/capD) gamma-glutamyltranspeptidase, required for polyglutamate anchoring to peptidoglycan [Capsule (VF0141) - Immune modulation (VFC0258)] [Bacillus anthracis] Bacillus anthracis
CM000741.1_5753 84.738 0.0 hblC VF0532 HBL Exotoxin VFC0235 This enterotoxin is toxic only as a ternary complex. Neither any binary combination of the components nor any individual component is toxic in its own right (hblC) Hemolysin BL lytic component L2 [HBL (VF0532) - Exotoxin (VFC0235)] [Bacillus cereus ATCC 14579] Bacillus cereus
CM000741.1_5754 94.089 0.0 hblD VF0532 HBL Exotoxin VFC0235 This enterotoxin is toxic only as a ternary complex. Neither any binary combination of the components nor any individual component is toxic in its own right (hblD) Hemolysin BL lytic component L1 [HBL (VF0532) - Exotoxin (VFC0235)] [Bacillus cereus ATCC 14579] Bacillus cereus
CM000741.1_5755 70.33 0.0 hblA VF0532 HBL Exotoxin VFC0235 This enterotoxin is toxic only as a ternary complex. Neither any binary combination of the components nor any individual component is toxic in its own right (hblA) Hemolysin BL binding component precursor [HBL (VF0532) - Exotoxin (VFC0235)] [Bacillus cereus ATCC 14579] Bacillus cereus
CM000741.1_5756 87.768 0.0 hblA VF0532 HBL Exotoxin VFC0235 This enterotoxin is toxic only as a ternary complex. Neither any binary combination of the components nor any individual component is toxic in its own right (hblA) Hemolysin BL binding component precursor [HBL (VF0532) - Exotoxin (VFC0235)] [Bacillus cereus ATCC 14579] Bacillus cereus
CM000741.1_5854 91.572 0.0 BAS_RS06430 VF0536 InhA Exoenzyme VFC0251 (BAS_RS06430) immune inhibitor A [InhA (VF0536) - Exoenzyme (VFC0251)] [Bacillus anthracis str. Sterne] Bacillus anthracis
CM000741.1_5858 77.778 1.18E-21 cylS VF0356 Cytolysin Exotoxin VFC0235 Production and activation of cytolysin involves the products of a complex operon of eight genes and that this operon can be located on either pheromone-responsive plasmids or on the chromosome within a pathogenicity island; most of this gene locus is absent in E. faecalis V583 due to a 17-kbp deletion; Cytolysin expression is regulated by one of the subunits (CylLS'') through a quorum-sensing autoinduction mechanism (cylS) CylS; cytolysin subunit [Cytolysin (VF0356) - Exotoxin (VFC0235)] [Enterococcus faecalis str. MMH594] Enterococcus faecalis
CM000741.1_5859 75.556 2.2E-21 cylS VF0356 Cytolysin Exotoxin VFC0235 Production and activation of cytolysin involves the products of a complex operon of eight genes and that this operon can be located on either pheromone-responsive plasmids or on the chromosome within a pathogenicity island; most of this gene locus is absent in E. faecalis V583 due to a 17-kbp deletion; Cytolysin expression is regulated by one of the subunits (CylLS'') through a quorum-sensing autoinduction mechanism (cylS) CylS; cytolysin subunit [Cytolysin (VF0356) - Exotoxin (VFC0235)] [Enterococcus faecalis str. MMH594] Enterococcus faecalis