2. PATHOGENS
Basic Information
Accession number
GCA_000006155.2
Release date
2002-05-09
Organism
Bacillus anthracis str. A2012
Species name
Bacillus anthracis
Assembly level
Chromosome
Assembly name
ASM615v2
Assembly submitter
J. Craig Venter Institute
Assembly Type
haploid
Genome size
5.4 Mb
GC percent
35.0
Contig count
3
Collection date
-
Sample location
-
Host
-
Isolation source
-
Isolate type
-
Strain
A2012
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
AAAC01000001.1_830 # 779138 # 780307 175.0 186.808 vanT gene in vanG cluster 30.79 ARO:3002972 protein homolog model glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanT Also known as vanTG, is a vanT variant found in the vanG gene cluster.
AAAC01000001.1_1205 # 1128032 # 1129294 50.0 124.79 vanW gene in vanI cluster 29.05 ARO:3003724 protein homolog model glycopeptide antibiotic antibiotic target alteration vanW; glycopeptide resistance gene cluster Also known as vanWI, is a vanW variant found in the vanI gene cluster.
AAAC01000001.1_2141 # 1983694 # 1984590 500.0 551.206 mphL 86.91 ARO:3003072 protein homolog model macrolide antibiotic antibiotic inactivation macrolide phosphotransferase (MPH) mphL is a chromosomally-encoded macrolide phosphotransferases that inactivate 14- and 15-membered macrolides such as erythromycin, clarithromycin, azithromycin.
AAAC01000001.1_2595 # 2400165 # 2400581 225.0 263.848 FosB 89.13 ARO:3000172 protein homolog model phosphonic acid antibiotic antibiotic inactivation fosfomycin thiol transferase A thiol transferase that leads to the resistance of fosfomycin. Contrasting FosA, FosB is dependent on the cofactor Magnesium (II) and uses either bacillithiol or L-cysteine to open up the epoxide ring of fosfomycin.
AAAC01000001.1_2624 # 2422282 # 2423022 50.0 102.064 vanY gene in vanA cluster 40.0 ARO:3002955 protein homolog model glycopeptide antibiotic antibiotic target alteration vanY; glycopeptide resistance gene cluster Also known as vanYA, is a vanY variant found in the vanA gene cluster.
AAAC01000001.1_2633 # 2430161 # 2431387 175.0 221.09 vanT gene in vanG cluster 34.38 ARO:3002972 protein homolog model glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanT Also known as vanTG, is a vanT variant found in the vanG gene cluster.
AAAC01000001.1_3063 # 2804978 # 2805898 600.0 629.017 Bla1 99.67 ARO:3000090 protein homolog model penam antibiotic inactivation class A Bacillus anthracis Bla beta-lactamase Bla1 is a chromosomal-encoded beta-lactamase, found in Bacillus anthracis, which hydrolyzes penicillins.
AAAC01000001.1_3085 # 2824648 # 2825379 50.0 106.301 vanY gene in vanM cluster 38.93 ARO:3002961 protein homolog model glycopeptide antibiotic antibiotic target alteration vanY; glycopeptide resistance gene cluster Also known as vanYM, is a vanY variant found in the vanM gene cluster.
AAAC01000001.1_3619 # 3274755 # 3276698 400.0 571.237 tetB(P) 45.02 ARO:3000195 protein homolog model tetracycline antibiotic antibiotic target protection tetracycline-resistant ribosomal protection protein TetB(P) is a tetracycline ribosomal protection protein found on the same operon as tetA(P), a tetracycline efflux protein.
AAAC01000001.1_3764 # 3399712 # 3400266 350.0 378.637 SatA 100.0 ARO:3005045 protein homolog model nucleoside antibiotic antibiotic inactivation streptothricin acetyltransferase (SAT) SatA is part of the Streptothricin acetyltransferase gene family. It confers resistance to nucleoside antibiotics.
AAAC01000001.1_4151 # 3758210 # 3759121 50.0 114.005 vanW gene in vanI cluster 45.08 ARO:3003724 protein homolog model glycopeptide antibiotic antibiotic target alteration vanW; glycopeptide resistance gene cluster Also known as vanWI, is a vanW variant found in the vanI gene cluster.
AAAC01000001.1_4657 # 4229061 # 4229480 250.0 290.812 FosB2 100.0 ARO:3005100 protein homolog model phosphonic acid antibiotic antibiotic inactivation fosfomycin thiol transferase Subtype of FosB (ARO:3000172). Present in multiple species.
AAAC01000001.1_5279 # 4763739 # 4764518 50.0 114.39 vanY gene in vanB cluster 34.87 ARO:3002956 protein homolog model glycopeptide antibiotic antibiotic target alteration vanY; glycopeptide resistance gene cluster Also known as vanYB, is a vanY variant found in the vanB gene cluster.
AAAC01000001.1_5623 # 5067134 # 5067994 50.0 335.88 vanY gene in vanF cluster 58.82 ARO:3002958 protein homolog model glycopeptide antibiotic antibiotic target alteration vanY; glycopeptide resistance gene cluster Also known as vanYF, is a vanY variant found in the vanF gene cluster.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
AAAC01000001.1_241 78.238 2.44E-113 clpP VF0074 ClpP Stress survival VFC0282 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AAAC01000001.1_289 62.778 6.85E-173 cps4I VF0144 Capsule Immune modulation VFC0258 Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages (cps4I) capsular polysaccharide biosynthesis protein Cps4I [Capsule (VF0144) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4] Streptococcus pneumoniae
AAAC01000001.1_362 60.476 9.92E-97 cps4I VF0144 Capsule Immune modulation VFC0258 Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages (cps4I) capsular polysaccharide biosynthesis protein Cps4I [Capsule (VF0144) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4] Streptococcus pneumoniae
AAAC01000001.1_363 60.227 1.62E-33 cap8P VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8P) type 8 capsular polysaccharide synthesis protein Cap8P [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AAAC01000001.1_367 71.094 2.32E-141 cap8O VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8O) type 8 capsular polysaccharide synthesis protein Cap8O [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AAAC01000001.1_562 60.831 1.65E-153 galE VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (galE) UDP-glucose 4-epimerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
AAAC01000001.1_675 78.463 0.0 clpC VF0072 ClpC Stress survival VFC0282 27-kDa stress protein belongs to the Hsp100/Clp family; Regulation of Clp protease expression is mediated by CtsR, the product of the first gene in the ClpC operon (clpC) endopeptidase Clp ATP-binding chain C [ClpC (VF0072) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AAAC01000001.1_744 67.234 0.0 gndA VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AAAC01000001.1_845 80.13 6.48E-174 groEL VF0594 GroEL Adherence VFC0001 GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. (groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] Clostridium difficile
AAAC01000001.1_1142 100.0 0.0 hal VF0587 Hal Nutritional/Metabolic factor VFC0272 Includes an N-terminal near-iron transporter (NEAT) domain, several internal leucine-rich repeat (LRR) regions, and a C-terminal sortase-like cell wall anchor (hal) heme-acquisition leucine-rich repeat protein [Hal (VF0587) - Nutritional/Metabolic factor (VFC0272)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_1143 85.202 0.0 hal VF0587 Hal Nutritional/Metabolic factor VFC0272 Includes an N-terminal near-iron transporter (NEAT) domain, several internal leucine-rich repeat (LRR) regions, and a C-terminal sortase-like cell wall anchor (hal) heme-acquisition leucine-rich repeat protein [Hal (VF0587) - Nutritional/Metabolic factor (VFC0272)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_1181 65.385 5.09E-7 bfmR VF0463 BfmRS Regulation VFC0301 Two-component system: BfmS sensor kinase acts as a BfmR phosphatase to negatively regulate BfmR activity in certain conditions (bfmR) biofilm-controlling response regulator [BfmRS (VF0463) - Regulation (VFC0301)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
AAAC01000001.1_1278 100.0 0.0 inhA VF0536 InhA Exoenzyme VFC0251 (inhA) immune inhibitor A metalloprotease [InhA (VF0536) - Exoenzyme (VFC0251)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_1284 65.761 5.82E-82 hlb VF0002 Beta-hemolysin Exotoxin VFC0235 (hlb) beta-hemolysin [Beta-hemolysin (VF0002) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus COL] Staphylococcus aureus
AAAC01000001.1_1666 61.027 7.31E-153 lplA1 VF0347 LplA1 Nutritional/Metabolic factor VFC0272 (lplA1) lipoate protein ligase [LplA1 (VF0347) - Nutritional/Metabolic factor (VFC0272)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AAAC01000001.1_1849 100.0 0.0 BAS_RS06430 VF0536 InhA Exoenzyme VFC0251 (BAS_RS06430) immune inhibitor A [InhA (VF0536) - Exoenzyme (VFC0251)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_1899 89.744 9.05E-40 ilsA VF0585 IlsA Nutritional/Metabolic factor VFC0272 The three conserved domains: NEAT (NEAr iron Transporter), LRR (Leucine-Rich Repeat) and SLH (Surface Layer Homology); specifically expressed in the insect hemocoel and under iron-depleted conditions (ilsA) NEAT domain-containing leucine-rich repeat protein [IlsA (VF0585) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] Bacillus cereus
AAAC01000001.1_1900 87.413 5.16E-86 ilsA VF0585 IlsA Nutritional/Metabolic factor VFC0272 The three conserved domains: NEAT (NEAr iron Transporter), LRR (Leucine-Rich Repeat) and SLH (Surface Layer Homology); specifically expressed in the insect hemocoel and under iron-depleted conditions (ilsA) NEAT domain-containing leucine-rich repeat protein [IlsA (VF0585) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] Bacillus cereus
AAAC01000001.1_2440 97.927 0.0 nheA VF0533 Nhe Exotoxin VFC0235 The respective HBL and NHE proteins share 23~40% sequence identity (nheA) non-hemolytic enterotoxin A [Nhe (VF0533) - Exotoxin (VFC0235)] [Bacillus cereus ATCC 10987] Bacillus cereus
AAAC01000001.1_2441 98.507 0.0 nheB VF0533 Nhe Exotoxin VFC0235 The respective HBL and NHE proteins share 23~40% sequence identity (nheB) non-hemolytic enterotoxin B [Nhe (VF0533) - Exotoxin (VFC0235)] [Bacillus cereus ATCC 10987] Bacillus cereus
AAAC01000001.1_2442 94.754 0.0 nheC VF0533 Nhe Exotoxin VFC0235 The respective HBL and NHE proteins share 23~40% sequence identity (nheC) non-hemolytic enterotoxin C [Nhe (VF0533) - Exotoxin (VFC0235)] [Bacillus cereus ATCC 10987] Bacillus cereus
AAAC01000001.1_2531 100.0 0.0 asbA VF0584 Petrobactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore;the biosynthetic pathway for petrobactin (the asb operon), the petrobactin-iron complex receptor (FhuA), import permeases (FpuB/FatC/FatD), ATPases (FpuC/FatE), and the petrobactin exporter (ApeX) (asbA) petrobactin biosynthesis protein AsbA [Petrobactin (VF0584) - Nutritional/Metabolic factor (VFC0272)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_2532 100.0 0.0 asbB VF0584 Petrobactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore;the biosynthetic pathway for petrobactin (the asb operon), the petrobactin-iron complex receptor (FhuA), import permeases (FpuB/FatC/FatD), ATPases (FpuC/FatE), and the petrobactin exporter (ApeX) (asbB) petrobactin biosynthesis protein AsbB [Petrobactin (VF0584) - Nutritional/Metabolic factor (VFC0272)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_2533 100.0 0.0 asbC VF0584 Petrobactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore;the biosynthetic pathway for petrobactin (the asb operon), the petrobactin-iron complex receptor (FhuA), import permeases (FpuB/FatC/FatD), ATPases (FpuC/FatE), and the petrobactin exporter (ApeX) (asbC) 3,4-dihydroxybenzoic acid-AMP ligase AsbC [Petrobactin (VF0584) - Nutritional/Metabolic factor (VFC0272)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_2534 100.0 1.24E-62 asbD VF0584 Petrobactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore;the biosynthetic pathway for petrobactin (the asb operon), the petrobactin-iron complex receptor (FhuA), import permeases (FpuB/FatC/FatD), ATPases (FpuC/FatE), and the petrobactin exporter (ApeX) (asbD) petrobactin biosynthesis protein AsbD [Petrobactin (VF0584) - Nutritional/Metabolic factor (VFC0272)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_2535 100.0 0.0 asbE VF0584 Petrobactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore;the biosynthetic pathway for petrobactin (the asb operon), the petrobactin-iron complex receptor (FhuA), import permeases (FpuB/FatC/FatD), ATPases (FpuC/FatE), and the petrobactin exporter (ApeX) (asbE) petrobactin biosynthesis protein AsbE [Petrobactin (VF0584) - Nutritional/Metabolic factor (VFC0272)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_2536 100.0 0.0 asbF VF0584 Petrobactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore;the biosynthetic pathway for petrobactin (the asb operon), the petrobactin-iron complex receptor (FhuA), import permeases (FpuB/FatC/FatD), ATPases (FpuC/FatE), and the petrobactin exporter (ApeX) (asbF) petrobactin biosynthesis 3-dehydroshikimate dehydratase AsbF [Petrobactin (VF0584) - Nutritional/Metabolic factor (VFC0272)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_2742 100.0 5.84E-29 essC VF0581 T7SS Effector delivery system VFC0086 Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. (essC) type VII secretion system protein EssC [T7SS (VF0581) - Effector delivery system (VFC0086)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_2743 98.113 1.46E-30 essC VF0581 T7SS Effector delivery system VFC0086 Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. (essC) type VII secretion system protein EssC [T7SS (VF0581) - Effector delivery system (VFC0086)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_2744 99.885 0.0 essC VF0581 T7SS Effector delivery system VFC0086 Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. (essC) type VII secretion system protein EssC [T7SS (VF0581) - Effector delivery system (VFC0086)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_2745 100.0 9.34E-153 essC VF0581 T7SS Effector delivery system VFC0086 Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. (essC) type VII secretion system protein EssC [T7SS (VF0581) - Effector delivery system (VFC0086)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_2746 100.0 1.82E-64 essC VF0581 T7SS Effector delivery system VFC0086 Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. (essC) type VII secretion system protein EssC [T7SS (VF0581) - Effector delivery system (VFC0086)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_2747 100.0 3.22E-63 esxB VF0581 T7SS Effector delivery system VFC0086 Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. (esxB) type VII secretion system protein EsxB [T7SS (VF0581) - Effector delivery system (VFC0086)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_2756 90.909 2.98E-46 BAS_RS10600 VF0581 T7SS Effector delivery system VFC0086 Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. (BAS_RS10600) type VII secretion system protein [T7SS (VF0581) - Effector delivery system (VFC0086)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_2757 100.0 7.34E-49 BAS_RS10600 VF0581 T7SS Effector delivery system VFC0086 Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. (BAS_RS10600) type VII secretion system protein [T7SS (VF0581) - Effector delivery system (VFC0086)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_2758 100.0 0.0 esxL VF0581 T7SS Effector delivery system VFC0086 Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. (esxL) type VII secretion system protein EsxL [T7SS (VF0581) - Effector delivery system (VFC0086)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_2923 91.473 4.29E-167 dhbA VF0586 Bacillibactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore (dhbA) 2,3-dihydroxybenzoate-2,3-dehydrogenase, DhbA [Bacillibactin (VF0586) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] Bacillus cereus
AAAC01000001.1_2924 94.236 0.0 dhbC VF0586 Bacillibactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore (dhbC) isochorismate synthase DhbC [Bacillibactin (VF0586) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] Bacillus cereus
AAAC01000001.1_2925 96.654 0.0 dhbE VF0586 Bacillibactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore (dhbE) 2,3-dihydroxybenzoate adenylase DhbE [Bacillibactin (VF0586) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] Bacillus cereus
AAAC01000001.1_2926 91.246 0.0 dhbB VF0586 Bacillibactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore (dhbB) isochorismatase, DhbB [Bacillibactin (VF0586) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] Bacillus cereus
AAAC01000001.1_2927 94.702 0.0 dhbF VF0586 Bacillibactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore (dhbF) non-ribosomal peptide synthetase, DhbF [Bacillibactin (VF0586) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] Bacillus cereus
AAAC01000001.1_2928 91.654 0.0 dhbF VF0586 Bacillibactin Nutritional/Metabolic factor VFC0272 Catechol-based siderophore (dhbF) non-ribosomal peptide synthetase, DhbF [Bacillibactin (VF0586) - Nutritional/Metabolic factor (VFC0272)] [Bacillus cereus ATCC 10987] Bacillus cereus
AAAC01000001.1_2929 63.934 3.53E-26 mbtH VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtH) putative protein MbtH [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AAAC01000001.1_3371 70.652 1.57E-96 clpP VF0074 ClpP Stress survival VFC0282 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AAAC01000001.1_3925 99.414 0.0 alo VF0534 ALO Exotoxin VFC0235 (alo) thiol-activated cytolysin [ALO (VF0534) - Exotoxin (VFC0235)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AAAC01000001.1_4509 61.345 7.89E-109 cpsA/uppS VF0361 Capsule Immune modulation VFC0258 The biosynthesis of capsular polysaccharides by E. faecalis is encoded by the csp operon, which includes 11 open reading frames (cpsA to cpsK). However, only 7 open reading frames in the cps operon are essential for capsule production (cpsC, cpsD, cpsE, cpsG, cpsI, cpsJ, and cpsK); Previous genetic evidence demonstrated that E. faecalis isolates can be classified in 1 of 3 capsule operon polymorphisms. CPS 1 presents only cpsA and cpsB. CPS 2 presents all 11 genes in the cps operon. CPS 5 presents all genes except for cpsF. Furthermore, CPS 2 and 5 express the capsular polysaccharide, whereas CPS 1 does not. (cpsA/uppS) undecaprenyl diphosphate synthase [Capsule (VF0361) - Immune modulation (VFC0258)] [Enterococcus faecalis V583] Enterococcus faecalis
AAAC01000001.1_5054 63.036 2.77E-131 sigA/rpoV VF0257 SigA Regulation VFC0301 In M. tuberculosis, 13 sigma factor genes have been annotated in the genome, 9 of which belong to a special subfamily thought to direct extracytoplasmic functions and various other stress responses (temperature, oxidative stress, pH, and infection of macrophages); sigma A also known as RpoV, is the essential principal mycobacterial sigma factors, necessary for most mycobacterial housekeeping gene transcription; It was the first mycobacterial sigma factor to be associated with virulence (sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AAAC01000001.1_5134 73.813 0.0 lap VF0444 Lap Adherence VFC0001 Originally named surface protein p104, is a 104 kDa adhesion protein, present in every Listeria spp. except L. grayi (lap) Listeria adhesion protein Lap [Lap (VF0444) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AE011190.1_107 100.0 0.0 bslA VF0411 BslA Adherence VFC0001 (bslA) s-layer protein [BslA (VF0411) - Adherence (VFC0001)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AE011190.1_123 100.0 0.0 cya VF0142 Anthrax toxin Exotoxin VFC0235 AtxA, a pXO1 gene required for transcription of the three toxin genes, also positively regulated encapsulation; the expression of atxA gene is not controlled by CO2 (cya) calmodulin sensitive adenylate cyclase, edema factor [Anthrax toxin (VF0142) - Exotoxin (VFC0235)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AE011190.1_128 100.0 0.0 AAD32423 VF0332 AtxA Regulation VFC0301 (AAD32423) pXO1-119 [AtxA (VF0332) - Regulation (VFC0301)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AE011190.1_138 100.0 0.0 pagA VF0142 Anthrax toxin Exotoxin VFC0235 AtxA, a pXO1 gene required for transcription of the three toxin genes, also positively regulated encapsulation; the expression of atxA gene is not controlled by CO2 (pagA) anthrax toxin moiety, protective antigen [Anthrax toxin (VF0142) - Exotoxin (VFC0235)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AE011190.1_143 99.876 0.0 lef VF0142 Anthrax toxin Exotoxin VFC0235 AtxA, a pXO1 gene required for transcription of the three toxin genes, also positively regulated encapsulation; the expression of atxA gene is not controlled by CO2 (lef) anthrax toxin lethal factor precursor [Anthrax toxin (VF0142) - Exotoxin (VFC0235)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AE011191.1_61 99.785 0.0 dep/capD VF0141 Capsule Immune modulation VFC0258 Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 (dep/capD) gamma-glutamyltranspeptidase, required for polyglutamate anchoring to peptidoglycan [Capsule (VF0141) - Immune modulation (VFC0258)] [Bacillus anthracis] Bacillus anthracis
AE011191.1_62 100.0 0.0 capA VF0141 Capsule Immune modulation VFC0258 Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 (capA) CapA, required for Poly-gamma-glutamate transport [Capsule (VF0141) - Immune modulation (VFC0258)] [Bacillus anthracis] Bacillus anthracis
AE011191.1_63 100.0 2.58E-102 capC VF0141 Capsule Immune modulation VFC0258 Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 (capC) CapC, involved in Poly-gamma-glutamate synthesis [Capsule (VF0141) - Immune modulation (VFC0258)] [Bacillus anthracis] Bacillus anthracis
AE011191.1_64 100.0 0.0 capB VF0141 Capsule Immune modulation VFC0258 Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 (capB) CapB, involved in Poly-gamma-glutamate synthesis [Capsule (VF0141) - Immune modulation (VFC0258)] [Bacillus anthracis] Bacillus anthracis
AE011191.1_72 60.156 5.45E-50 AAD32423 VF0332 AtxA Regulation VFC0301 (AAD32423) pXO1-119 [AtxA (VF0332) - Regulation (VFC0301)] [Bacillus anthracis str. Sterne] Bacillus anthracis
AE011191.1_73 61.333 3.81E-55 AAD32423 VF0332 AtxA Regulation VFC0301 (AAD32423) pXO1-119 [AtxA (VF0332) - Regulation (VFC0301)] [Bacillus anthracis str. Sterne] Bacillus anthracis