| AE009952.1_16 |
60.422 |
0.0 |
icl |
VF0253 |
Isocitrate lyase |
Others |
VFC0346 |
|
(icl) Isocitrate lyase Icl (isocitrase) (isocitratase) [Isocitrate lyase (VF0253) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| AE009952.1_35 |
82.558 |
1.05E-113 |
hcp1 |
VF0480 |
T6SS |
Effector delivery system |
VFC0086 |
|
(hcp1) HcpA-like protein [T6SS (VF0480) - Effector delivery system (VFC0086)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966] |
Aeromonas hydrophila |
| AE009952.1_36 |
63.804 |
1.01E-73 |
vipA |
VF0480 |
T6SS |
Effector delivery system |
VFC0086 |
|
(vipA) Type VI secretion system contractile sheath small subunit TssB/VipA [T6SS (VF0480) - Effector delivery system (VFC0086)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966] |
Aeromonas hydrophila |
| AE009952.1_37 |
81.224 |
0.0 |
vipB |
VF0480 |
T6SS |
Effector delivery system |
VFC0086 |
|
(vipB) Type VI secretion system contractile sheath large subunit TssC/VipB [T6SS (VF0480) - Effector delivery system (VFC0086)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966] |
Aeromonas hydrophila |
| AE009952.1_78 |
79.221 |
0.0 |
rfaD |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(rfaD) ADP-L-glycero-D-mannoheptose-6-epimerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE009952.1_79 |
65.043 |
9.38E-161 |
rfaF |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(rfaF) ADP-heptose-LPS heptosyltransferase II [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE009952.1_255 |
69.056 |
0.0 |
clpB |
VF0480 |
T6SS |
Effector delivery system |
VFC0086 |
|
(clpB) type VI secretion system ATPase ClpV1 [T6SS (VF0480) - Effector delivery system (VFC0086)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966] |
Aeromonas hydrophila |
| AE009952.1_256 |
61.066 |
3.37E-105 |
tssL |
VF0579 |
T6SS |
Effector delivery system |
VFC0086 |
|
(tssL) Type VI secretion system protein TssL [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] |
Shigella sonnei |
| AE009952.1_258 |
60.927 |
8.08E-64 |
atsK |
VF0480 |
T6SS |
Effector delivery system |
VFC0086 |
|
(atsK) Type VI secretion system protein [T6SS (VF0480) - Effector delivery system (VFC0086)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966] |
Aeromonas hydrophila |
| AE009952.1_261 |
62.041 |
2.43E-109 |
atsH |
VF0480 |
T6SS |
Effector delivery system |
VFC0086 |
|
(atsH) Type VI secretion system protein [T6SS (VF0480) - Effector delivery system (VFC0086)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966] |
Aeromonas hydrophila |
| AE009952.1_349 |
63.095 |
9.44E-165 |
rffG |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(rffG) dTDP-glucose 46-dehydratase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE009952.1_350 |
64.828 |
1.5E-140 |
wbtL |
VF0542 |
LPS |
Immune modulation |
VFC0258 |
The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion |
(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| AE009952.1_459 |
81.726 |
0.0 |
tufA |
VF0460 |
EF-Tu |
Adherence |
VFC0001 |
|
(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| AE009952.1_511 |
60.539 |
7.53E-169 |
ssaN |
VF0321 |
TTSS (SPI-2 encode) |
Effector delivery system |
VFC0086 |
SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. |
(ssaN) type III secretion system ATPase SsaN [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| AE009952.1_525 |
68.627 |
1.25E-138 |
chuU |
VF0227 |
Chu |
Nutritional/Metabolic factor |
VFC0272 |
ChuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains |
(chuU) heme permease protein ChuU [Chu (VF0227) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] |
Escherichia coli (UPEC) |
| AE009952.1_527 |
67.059 |
5.23E-170 |
chuS |
VF0234 |
Chu |
Nutritional/Metabolic factor |
VFC0272 |
ChuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains |
(chuS) heme oxygenase ChuS [Chu (VF0234) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli O157:H7 str. EDL933] |
Escherichia coli (EHEC) |
| AE009952.1_528 |
70.644 |
0.0 |
chuA |
VF0227 |
Chu |
Nutritional/Metabolic factor |
VFC0272 |
ChuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains |
(chuA) Outer membrane heme/hemoglobin receptor ChuA [Chu (VF0227) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] |
Escherichia coli (UPEC) |
| AE009952.1_551 |
99.842 |
0.0 |
yapK |
VF0508 |
YapK |
Adherence |
VFC0001 |
Sharing a high level of sequence identity with YapV |
(yapK) autotransporter protein YapK [YapK (VF0508) - Adherence (VFC0001)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_590 |
74.669 |
0.0 |
htpB |
VF0159 |
Hsp60 |
Adherence |
VFC0001 |
|
(htpB) Hsp60, 60K heat shock protein HtpB [Hsp60 (VF0159) - Adherence (VFC0001)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] |
Legionella pneumophila |
| AE009952.1_812 |
92.169 |
0.0 |
rpoS |
VF0112 |
RpoS |
Regulation |
VFC0301 |
|
(rpoS) RNA polymerase sigma factor RpoS [RpoS (VF0112) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| AE009952.1_847 |
66.891 |
0.0 |
katA |
VF0168 |
KatAB |
Stress survival |
VFC0282 |
|
(katA) catalase/(hydro)peroxidase [KatAB (VF0168) - Stress survival (VFC0282)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] |
Legionella pneumophila |
| AE009952.1_862 |
75.0 |
5.96E-30 |
csrA |
VF0261 |
CsrA |
Regulation |
VFC0301 |
Belongs to a highly conserved family of global regulators that typically control stationary phase traits post-transcriptionally |
(csrA) carbon storage regulator CsrA [CsrA (VF0261) - Regulation (VFC0301)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] |
Legionella pneumophila |
| AE009952.1_866 |
72.515 |
5.76E-95 |
luxS |
VF0406 |
AI-2 |
Biofilm |
VFC0271 |
AI-2 is produced and detected by a wide variety of bacteria and is presumed to facilitate interspecies communications. |
(luxS) S-ribosylhomocysteinase [AI-2 (VF0406) - Biofilm (VFC0271)] [Vibrio cholerae O1 biovar El Tor str. N16961] |
Vibrio cholerae |
| AE009952.1_925 |
79.167 |
4.14E-114 |
gmhA/lpcA |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(gmhA/lpcA) phosphoheptose isomerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE009952.1_1004 |
63.731 |
1.81E-95 |
clpP |
VF0074 |
ClpP |
Stress survival |
VFC0282 |
21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes |
(clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| AE009952.1_1028 |
83.365 |
0.0 |
acrB |
VF0568 |
AcrAB |
Antimicrobial activity/Competitive advantage |
VFC0325 |
|
(acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_1029 |
74.142 |
0.0 |
acrA |
VF0568 |
AcrAB |
Antimicrobial activity/Competitive advantage |
VFC0325 |
|
(acrA) acriflavine resistance protein A [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_1043 |
91.051 |
0.0 |
rfbF |
VF0392 |
O-antigen |
Immune modulation |
VFC0258 |
Clinical Y. enterocolitica isolates from humans predominantly belong to serotypes O:3, O:9, O:8 and O:5,27; Y. enterocolitica O antigen expression is temperature regulated. |
(rfbF) glucose-1-phosphate cytidylyltransferase [O-antigen (VF0392) - Immune modulation (VFC0258)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1044 |
78.595 |
0.0 |
rfbG |
VF0392 |
O-antigen |
Immune modulation |
VFC0258 |
Clinical Y. enterocolitica isolates from humans predominantly belong to serotypes O:3, O:9, O:8 and O:5,27; Y. enterocolitica O antigen expression is temperature regulated. |
(rfbG) CDP-glucose 4,6-dehydratase [O-antigen (VF0392) - Immune modulation (VFC0258)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1055 |
90.566 |
4.48E-105 |
gmd |
VF0392 |
O-antigen |
Immune modulation |
VFC0258 |
Clinical Y. enterocolitica isolates from humans predominantly belong to serotypes O:3, O:9, O:8 and O:5,27; Y. enterocolitica O antigen expression is temperature regulated. |
(gmd) GDP-mannose 4,6-dehydratase [O-antigen (VF0392) - Immune modulation (VFC0258)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1056 |
85.849 |
2.8E-143 |
gmd |
VF0392 |
O-antigen |
Immune modulation |
VFC0258 |
Clinical Y. enterocolitica isolates from humans predominantly belong to serotypes O:3, O:9, O:8 and O:5,27; Y. enterocolitica O antigen expression is temperature regulated. |
(gmd) GDP-mannose 4,6-dehydratase [O-antigen (VF0392) - Immune modulation (VFC0258)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1057 |
84.424 |
0.0 |
YE_RS15425 |
VF0392 |
O-antigen |
Immune modulation |
VFC0258 |
Clinical Y. enterocolitica isolates from humans predominantly belong to serotypes O:3, O:9, O:8 and O:5,27; Y. enterocolitica O antigen expression is temperature regulated. |
(YE_RS15425) GDP-L-fucose synthase [O-antigen (VF0392) - Immune modulation (VFC0258)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1058 |
81.385 |
0.0 |
YE_RS15420 |
VF0392 |
O-antigen |
Immune modulation |
VFC0258 |
Clinical Y. enterocolitica isolates from humans predominantly belong to serotypes O:3, O:9, O:8 and O:5,27; Y. enterocolitica O antigen expression is temperature regulated. |
(YE_RS15420) mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase [O-antigen (VF0392) - Immune modulation (VFC0258)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1060 |
81.798 |
0.0 |
cpsG |
VF0392 |
O-antigen |
Immune modulation |
VFC0258 |
Clinical Y. enterocolitica isolates from humans predominantly belong to serotypes O:3, O:9, O:8 and O:5,27; Y. enterocolitica O antigen expression is temperature regulated. |
(cpsG) phosphomannomutase CpsG [O-antigen (VF0392) - Immune modulation (VFC0258)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1114 |
100.0 |
0.0 |
yapC |
VF0510 |
YapC |
Adherence |
VFC0001 |
A homologue of TibA, an adhesin/invasin ETEC |
(yapC) autotransporter protein YapC [YapC (VF0510) - Adherence (VFC0001)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_1187 |
86.986 |
5.78E-93 |
fur |
VF0113 |
Fur |
Regulation |
VFC0301 |
|
(fur) ferric iron uptake transcriptional regulator [Fur (VF0113) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| AE009952.1_1261 |
69.018 |
3.27E-148 |
yplA |
VF0622 |
YplA |
Exotoxin |
VFC0235 |
Substrate of the flagellar TTS system, can additionally be secreted by the Ysa and Ysc TTS systems |
(yplA) DUF2974 domain-containing protein [YplA (VF0622) - Exotoxin (VFC0235)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1268 |
64.398 |
2.87E-90 |
algU |
VF0091 |
Alginate |
Biofilm |
VFC0271 |
Alginate production is frequently referred to as mucoidy because colonies producing alginate have a wet glistening (mucoid) appearance, which is very different from that of colonies not producing alginate; most of the alginate biosynthetic genes are clustered in the algD operon; Alginate production is highly regulated. Regulatory genes are located in two areas far removed from the biosynthetic genes, with one exception algC |
(algU) alginate biosynthesis protein AlgZ/FimS [Alginate (VF0091) - Biofilm (VFC0271)] [Pseudomonas aeruginosa PAO1] |
Pseudomonas aeruginosa |
| AE009952.1_1303 |
100.0 |
3.19E-132 |
ail |
VF0132 |
Ail |
Invasion |
VFC0083 |
Ail is expressed in pathogenic Y.enterocolitica strains and Y.pseudotuberculosis, but generally the Y.pestis inv gene is inactivated by an insertion sequence, in strain CO92 it is intact; belongs to Ail/OmpX/PagC/Lom family, a family of outermembrane proteins (OMPs), including Ail, S. typhimurium Rck,PagC,or E. coli OmpX. Particular members of the family are responsible for conferring resistance to complement-mediated killing, survival in macrophages, and adhesion and invasion of host cells |
(ail) attachment invasion locus protein [Ail (VF0132) - Invasion (VFC0083)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_1408 |
67.387 |
0.0 |
acrB |
VF0568 |
AcrAB |
Antimicrobial activity/Competitive advantage |
VFC0325 |
|
(acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_1504 |
60.116 |
0.0 |
STM0272 |
VF0974 |
SCI (Salmonella centrisome island)/SPI-6 T6SS |
Effector delivery system |
VFC0086 |
"The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1, |
|
|
| AE009952.1_1511 |
77.193 |
1.11E-94 |
STM0273 |
VF0974 |
SCI (Salmonella centrisome island)/SPI-6 T6SS |
Effector delivery system |
VFC0086 |
"The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1, |
|
|
| AE009952.1_1512 |
80.331 |
0.0 |
STM0274 |
VF0974 |
SCI (Salmonella centrisome island)/SPI-6 T6SS |
Effector delivery system |
VFC0086 |
"The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1, |
|
|
| AE009952.1_1664 |
60.823 |
0.0 |
rfbK1 |
VF0560 |
Capsule |
Immune modulation |
VFC0258 |
The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. |
(rfbK1) O9 family phosphomannomutase RfbK1 [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_1707 |
77.459 |
9.4E-140 |
flmH |
VF0473 |
Polar flagella |
Motility |
VFC0204 |
Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments |
(flmH) short chain dehydrogenase/reductase family oxidoreductase [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119] |
Aeromonas hydrophila |
| AE009952.1_1708 |
66.216 |
1.55E-28 |
acpXL |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE009952.1_1738 |
62.069 |
0.0 |
phoQ |
VF0111 |
PhoPQ |
Regulation |
VFC0301 |
|
(phoQ) sensor protein PhoQ [PhoPQ (VF0111) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| AE009952.1_1739 |
79.279 |
5.23E-133 |
phoP |
VF0111 |
PhoPQ |
Regulation |
VFC0301 |
|
(phoP) response regulator in two-component regulatory system with PhoQ [PhoPQ (VF0111) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| AE009952.1_1764 |
63.319 |
3.88E-85 |
mgtC |
VF1365 |
MgtC |
Nutritional/Metabolic factor |
VFC0272 |
An inner membrane protein; anti-virulence protein CigR inhibits the virulence functions of MgtC at early times inside macrophages |
(mgtC) Salmonella virulence protein MgtC [MgtC (VF1365) - Nutritional/Metabolic factor (VFC0272)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| AE009952.1_1765 |
72.667 |
0.0 |
mgtB |
VF0106 |
MgtB |
Nutritional/Metabolic factor |
VFC0272 |
A magnesium transporter |
(mgtB) Mg2+ transport protein [MgtB (VF0106) - Nutritional/Metabolic factor (VFC0272)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| AE009952.1_1766 |
97.531 |
6.62E-55 |
flhD |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flhD) flagellar transcriptional activator FlhD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1767 |
95.855 |
1.74E-139 |
flhC |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flhC) flagellar biosynthesis transcription activator FlhC [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1768 |
95.932 |
0.0 |
motA |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(motA) flagellar motor protein MotA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1769 |
76.744 |
0.0 |
motB |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(motB) flagellar motor protein MotB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1770 |
83.657 |
0.0 |
cheA |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(cheA) chemotaxis protein CheA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1771 |
95.758 |
4.06E-111 |
cheW |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(cheW) purine-binding chemotaxis protein CheW [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1776 |
99.583 |
3.77E-161 |
yapJ |
VF0509 |
YapJ |
Adherence |
VFC0001 |
Sharing a high level of sequence identity with YapV |
(yapJ) autotransporter protein YapJ [YapJ (VF0509) - Adherence (VFC0001)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_1777 |
99.903 |
0.0 |
yapJ |
VF0509 |
YapJ |
Adherence |
VFC0001 |
Sharing a high level of sequence identity with YapV |
(yapJ) autotransporter protein YapJ [YapJ (VF0509) - Adherence (VFC0001)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_1780 |
85.278 |
0.0 |
cheD |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(cheD) methyl-accepting chemotaxis protein CheD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1782 |
93.617 |
0.0 |
cheR |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(cheR) chemotaxis methyltransferase CheR [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1783 |
95.415 |
0.0 |
cheB |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(cheB) chemotaxis-specific methylesterase CheB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1784 |
96.899 |
1.04E-88 |
cheY |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(cheY) chemotaxis regulatory protein CheY [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1785 |
95.794 |
4.86E-152 |
cheZ |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(cheZ) chemotaxis regulator CheZ [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_1893 |
68.586 |
6.65E-101 |
sodB |
VF0169 |
SodB |
Stress survival |
VFC0282 |
|
(sodB) superoxide dismutase [SodB (VF0169) - Stress survival (VFC0282)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] |
Legionella pneumophila |
| AE009952.1_2232 |
79.859 |
1.9E-176 |
kdsA |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE009952.1_2340 |
100.0 |
0.0 |
ybtS |
VF0136 |
Yersiniabactin |
Nutritional/Metabolic factor |
VFC0272 |
One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host |
(ybtS) salicylate synthase Irp9 [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_2341 |
100.0 |
0.0 |
ybtX |
VF0136 |
Yersiniabactin |
Nutritional/Metabolic factor |
VFC0272 |
One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host |
(ybtX) putative signal transducer [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_2342 |
100.0 |
0.0 |
ybtQ |
VF0136 |
Yersiniabactin |
Nutritional/Metabolic factor |
VFC0272 |
One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host |
(ybtQ) yersiniabactin ABC transporter ATP-binding/permease protein YbtQ [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_2343 |
100.0 |
0.0 |
ybtP |
VF0564 |
Ybt |
Nutritional/Metabolic factor |
VFC0272 |
Ybt is the most common virulence factor associated with human K. pneumoniae infections |
(ybtP) yersiniabactin ABC transporter ATP-binding/permease protein YbtP [Ybt (VF0564) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_2344 |
100.0 |
0.0 |
ybtA |
VF0136 |
Yersiniabactin |
Nutritional/Metabolic factor |
VFC0272 |
One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host |
(ybtA) transcriptional regulator YbtA [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_2345 |
100.0 |
0.0 |
irp2 |
VF0136 |
Yersiniabactin |
Nutritional/Metabolic factor |
VFC0272 |
One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host |
(irp2) yersiniabactin biosynthetic protein Irp2 [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_2346 |
100.0 |
0.0 |
irp1 |
VF0136 |
Yersiniabactin |
Nutritional/Metabolic factor |
VFC0272 |
One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host |
(irp1) yersiniabactin biosynthetic protein Irp1 [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_2347 |
100.0 |
0.0 |
ybtU |
VF0136 |
Yersiniabactin |
Nutritional/Metabolic factor |
VFC0272 |
One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host |
(ybtU) yersiniabactin biosynthetic protein YbtU [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_2348 |
100.0 |
0.0 |
ybtT |
VF0136 |
Yersiniabactin |
Nutritional/Metabolic factor |
VFC0272 |
One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host |
(ybtT) type II thioesterase YbtT [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_2349 |
100.0 |
0.0 |
ybtE |
VF0136 |
Yersiniabactin |
Nutritional/Metabolic factor |
VFC0272 |
One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host |
(ybtE) yersiniabactin siderophore biosynthetic protein [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_2350 |
100.0 |
0.0 |
fyuA/psn |
VF0136 |
Yersiniabactin |
Nutritional/Metabolic factor |
VFC0272 |
One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host |
(fyuA/psn) pesticin/yersiniabactin receptor protein [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_2415 |
88.757 |
1.09E-115 |
fliZ |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliZ) alternative sigma factor regulatory protein [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2416 |
95.417 |
1.24E-168 |
fliA |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliA) flagellar biosynthesis sigma factor [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2418 |
78.97 |
0.0 |
fliD |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliD) flagellar capping protein FliD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2419 |
89.394 |
3.32E-85 |
fliS |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliS) flagellar protein FliS [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2420 |
85.0 |
1.97E-64 |
fliT |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliT) flagellar protein FliT [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2427 |
95.146 |
3.85E-66 |
fliE |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliE) flagellar hook-basal body complex protein FliE [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2428 |
90.0 |
0.0 |
fliF |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliF) flagellar M-ring protein FliF [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2429 |
98.788 |
0.0 |
fliG |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliG) flagellar motor switch protein G [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2430 |
84.167 |
1.32E-147 |
fliH |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliH) flagellar assembly protein H [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2431 |
91.471 |
0.0 |
fliI |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliI) flagellum-specific ATP synthase FliI [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2432 |
88.435 |
5.92E-91 |
fliJ |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliJ) flagellar protein FliJ [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2433 |
60.129 |
8.42E-141 |
fliK |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliK) flagellar hook-length control protein FliK [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2434 |
87.179 |
2.78E-91 |
fliL |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliL) flagellar basal body protein FliL [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2435 |
94.895 |
0.0 |
fliM |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliM) flagellar motor switch protein FliM [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2436 |
91.304 |
1.2E-88 |
fliN |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliN) flagellar motor switch protein FliN [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2437 |
63.068 |
5.5E-56 |
fliO |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliO) flagellar protein FliO [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2438 |
93.852 |
2.11E-161 |
fliP |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliP) flagellar biosynthetic protein FliP [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2439 |
94.382 |
1.74E-45 |
fliQ |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliQ) flagellar biosynthetic protein FliQ [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2440 |
88.462 |
1.19E-146 |
fliR |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliR) flagellar biosynthetic protein FliR [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2451 |
85.846 |
0.0 |
flgL |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgL) flagellar hook-associated protein 3 FlgL [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2452 |
88.768 |
0.0 |
flgK |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgK) flagellar hook-associated protein 1 FlgK [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2453 |
85.358 |
0.0 |
flgJ |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgJ) <beta>-N-acetylglucosaminidase [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2454 |
93.298 |
0.0 |
flgI |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgI) flagellar P-ring protein precursor FlgI [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2455 |
92.07 |
3.43E-149 |
flgH |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgH) flagellar L-ring protein precursor FlgH [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2456 |
94.397 |
2.55E-162 |
flgG |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgG) flagellar basal-body rod protein FlgG [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2457 |
91.787 |
1.47E-138 |
flgF |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgF) flagellar basal-body rod protein FlgF [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2458 |
87.383 |
0.0 |
flgE |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgE) flagellar hook protein FlgE [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2459 |
84.211 |
1.97E-128 |
flgD |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgD) flagellar basal-body rod modification protein FlgD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2460 |
96.269 |
6.0E-94 |
flgC |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgC) flagellar basal-body rod protein FlgC [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2461 |
96.35 |
5.08E-97 |
flgB |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgB) flagellar basal-body rod protein FlgB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2462 |
78.355 |
3.7E-121 |
flgA |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgA) periplasmic flagellar chaperone protein FlgA required for P-ring assembly [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2463 |
87.629 |
3.77E-58 |
flgM |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgM) negative regulator of flagellin synthesis [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2464 |
84.828 |
6.19E-87 |
flgN |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgN) flagella synthesis protein FlgN [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2468 |
73.05 |
1.1E-69 |
flhE |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flhE) flagellar biosynthesis protein FlhE [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2469 |
95.809 |
0.0 |
flhA |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flhA) flagellar biosynthesis protein FlhA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2470 |
92.228 |
0.0 |
flhB |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flhB) flagellar biosynthetic protein FlhB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_2555 |
99.416 |
0.0 |
invB/ifp |
VF0574 |
Invasin B/Ifp |
Invasion |
VFC0083 |
|
(invB/ifp) invasin B protein, intimin family [Invasin B/Ifp (VF0574) - Invasion (VFC0083)] [Yersinia pseudotuberculosis IP 31758] |
Yersinia pseudotuberculosis |
| AE009952.1_2576 |
87.393 |
0.0 |
gndA |
VF0560 |
Capsule |
Immune modulation |
VFC0258 |
The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. |
(gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_2577 |
64.31 |
1.08E-142 |
galF |
VF0560 |
Capsule |
Immune modulation |
VFC0258 |
The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. |
(galF) GalU regulator GalF [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_2578 |
71.379 |
6.3E-159 |
galU |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(galU) glucosephosphate uridylyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE009952.1_2631 |
62.05 |
5.99E-158 |
tssG |
VF0569 |
T6SS |
Effector delivery system |
VFC0086 |
Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif |
(tssG) type VI secretion system baseplate subunit TssG [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_2632 |
75.298 |
0.0 |
tssF |
VF0569 |
T6SS |
Effector delivery system |
VFC0086 |
Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif |
(tssF) type VI secretion system baseplate subunit TssF [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_2641 |
63.514 |
8.54E-24 |
vgrG/tssI |
VF0569 |
T6SS |
Effector delivery system |
VFC0086 |
Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif |
(vgrG/tssI) type VI secretion system tip protein VgrG [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_2644 |
69.481 |
0.0 |
vgrG/tssI |
VF0569 |
T6SS |
Effector delivery system |
VFC0086 |
Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif |
(vgrG/tssI) type VI secretion system tip protein VgrG [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_2645 |
73.379 |
0.0 |
clpV/tssH |
VF0569 |
T6SS |
Effector delivery system |
VFC0086 |
Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif |
(clpV/tssH) type VI secretion system ATPase TssH [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_2646 |
90.184 |
1.97E-112 |
hcp/tssD |
VF0569 |
T6SS |
Effector delivery system |
VFC0086 |
Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif |
(hcp/tssD) type VI secretion system protein, Hcp family [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_2649 |
66.0 |
0.0 |
vasE/tssK |
VF0569 |
T6SS |
Effector delivery system |
VFC0086 |
Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif |
(vasE/tssK) type VI secretion system baseplate subunit TssK [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_2650 |
78.988 |
0.0 |
vipB/tssC |
VF0569 |
T6SS |
Effector delivery system |
VFC0086 |
Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif |
(vipB/tssC) type VI secretion system contractile sheath large subunit VipB [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_2651 |
74.691 |
2.9E-87 |
vipA/tssB |
VF0569 |
T6SS |
Effector delivery system |
VFC0086 |
Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif |
(vipA/tssB) type VI secretion system contractile sheath small subunit VipA [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_2666 |
98.715 |
0.0 |
cnf |
VF0393 |
CNFy |
Exotoxin |
VFC0235 |
Highly similar (>68%) to the CNF toxins found mainly in E. coli strains (CNF1-3) |
(cnf) cytotoxic necrotizing factor [CNFy (VF0393) - Exotoxin (VFC0235)] [Yersinia pseudotuberculosis YPIII] |
Yersinia pseudotuberculosis |
| AE009952.1_2668 |
97.458 |
1.29E-78 |
cnf |
VF0393 |
CNFy |
Exotoxin |
VFC0235 |
Highly similar (>68%) to the CNF toxins found mainly in E. coli strains (CNF1-3) |
(cnf) cytotoxic necrotizing factor [CNFy (VF0393) - Exotoxin (VFC0235)] [Yersinia pseudotuberculosis YPIII] |
Yersinia pseudotuberculosis |
| AE009952.1_2682 |
73.938 |
0.0 |
ompA |
VF0236 |
OmpA |
Invasion |
VFC0083 |
Major outer membrane protein in E. coli, homologous to Neisseria Opa proteins which have been shown to be involved in invasion of eukaryotic cells |
(ompA) outer membrane protein A [OmpA (VF0236) - Invasion (VFC0083)] [Escherichia coli O18:K1:H7 str. RS218] |
Escherichia coli (NMEC) |
| AE009952.1_2715 |
74.704 |
1.24E-137 |
nueA |
VF0473 |
Polar flagella |
Motility |
VFC0204 |
Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments |
(nueA) NeuA protein [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119] |
Aeromonas hydrophila |
| AE009952.1_2720 |
65.0 |
0.0 |
msbA |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(msbA) lipid transporter ATP-binding/permease [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE009952.1_2813 |
100.0 |
0.0 |
psaC |
VF0134 |
Myf/pH6 antigen |
Adherence |
VFC0001 |
Myf in Y.enterocolitica and its homolog pH 6 antigen in Y.pestis and Y.pseudotuberculosis; belongs to a class of adhesins that are secreted/assembled via a so-called chaperone/usher pathway: myfA/psaA encodes the main fibriallar subunit, myfB/psaB and myfC/psaC are required for transport of the subunit across the bacterial membrane and assembly of the subunit into fibrillae, MyfB/PsaB is a member of the PapB family of periplasmic chaperones and could act as a chaperone for MyfA/PsaA, while MyfC/PsaC could act as an usher in the outer membrane. MyfE/PsaE and MyfF/PsaF (two component) are required for transcription of myfA/psaA |
(psaC) outer membrane usher protein PsaC [Myf/pH6 antigen (VF0134) - Adherence (VFC0001)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_2814 |
100.0 |
0.0 |
psaB |
VF0134 |
Myf/pH6 antigen |
Adherence |
VFC0001 |
Myf in Y.enterocolitica and its homolog pH 6 antigen in Y.pestis and Y.pseudotuberculosis; belongs to a class of adhesins that are secreted/assembled via a so-called chaperone/usher pathway: myfA/psaA encodes the main fibriallar subunit, myfB/psaB and myfC/psaC are required for transport of the subunit across the bacterial membrane and assembly of the subunit into fibrillae, MyfB/PsaB is a member of the PapB family of periplasmic chaperones and could act as a chaperone for MyfA/PsaA, while MyfC/PsaC could act as an usher in the outer membrane. MyfE/PsaE and MyfF/PsaF (two component) are required for transcription of myfA/psaA |
(psaB) chaperone protein PsaB [Myf/pH6 antigen (VF0134) - Adherence (VFC0001)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_2815 |
100.0 |
2.78E-118 |
psaA |
VF0134 |
Myf/pH6 antigen |
Adherence |
VFC0001 |
Myf in Y.enterocolitica and its homolog pH 6 antigen in Y.pestis and Y.pseudotuberculosis; belongs to a class of adhesins that are secreted/assembled via a so-called chaperone/usher pathway: myfA/psaA encodes the main fibriallar subunit, myfB/psaB and myfC/psaC are required for transport of the subunit across the bacterial membrane and assembly of the subunit into fibrillae, MyfB/PsaB is a member of the PapB family of periplasmic chaperones and could act as a chaperone for MyfA/PsaA, while MyfC/PsaC could act as an usher in the outer membrane. MyfE/PsaE and MyfF/PsaF (two component) are required for transcription of myfA/psaA |
(psaA) pH 6 antigen (antigen 4) (adhesin) [Myf/pH6 antigen (VF0134) - Adherence (VFC0001)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_2816 |
100.0 |
1.32E-117 |
psaF |
VF0134 |
Myf/pH6 antigen |
Adherence |
VFC0001 |
Myf in Y.enterocolitica and its homolog pH 6 antigen in Y.pestis and Y.pseudotuberculosis; belongs to a class of adhesins that are secreted/assembled via a so-called chaperone/usher pathway: myfA/psaA encodes the main fibriallar subunit, myfB/psaB and myfC/psaC are required for transport of the subunit across the bacterial membrane and assembly of the subunit into fibrillae, MyfB/PsaB is a member of the PapB family of periplasmic chaperones and could act as a chaperone for MyfA/PsaA, while MyfC/PsaC could act as an usher in the outer membrane. MyfE/PsaE and MyfF/PsaF (two component) are required for transcription of myfA/psaA |
(psaF) PsaF [Myf/pH6 antigen (VF0134) - Adherence (VFC0001)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_2817 |
100.0 |
1.14E-159 |
psaE |
VF0134 |
Myf/pH6 antigen |
Adherence |
VFC0001 |
Myf in Y.enterocolitica and its homolog pH 6 antigen in Y.pestis and Y.pseudotuberculosis; belongs to a class of adhesins that are secreted/assembled via a so-called chaperone/usher pathway: myfA/psaA encodes the main fibriallar subunit, myfB/psaB and myfC/psaC are required for transport of the subunit across the bacterial membrane and assembly of the subunit into fibrillae, MyfB/PsaB is a member of the PapB family of periplasmic chaperones and could act as a chaperone for MyfA/PsaA, while MyfC/PsaC could act as an usher in the outer membrane. MyfE/PsaE and MyfF/PsaF (two component) are required for transcription of myfA/psaA |
(psaE) regulatory protein PsaE [Myf/pH6 antigen (VF0134) - Adherence (VFC0001)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_2898 |
91.204 |
1.07E-145 |
rcsB |
VF0571 |
RcsAB |
Regulation |
VFC0301 |
|
(rcsB) transcriptional regulator RcsB [RcsAB (VF0571) - Regulation (VFC0301)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_2909 |
68.499 |
0.0 |
katA |
VF0454 |
KatA |
Stress survival |
VFC0282 |
|
(katA) catalase [KatA (VF0454) - Stress survival (VFC0282)] [Neisseria meningitidis MC58] |
Neisseria meningitidis |
| AE009952.1_3037 |
67.528 |
9.85E-126 |
IlpA |
VF0513 |
IlpA |
Adherence |
VFC0001 |
|
(IlpA) immunogenic lipoprotein A [IlpA (VF0513) - Adherence (VFC0001)] [Vibrio vulnificus YJ016] |
Vibrio vulnificus |
| AE009952.1_3052 |
62.953 |
9.37E-174 |
lpxB |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lpxB) lipid-A-disaccharide synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE009952.1_3053 |
65.649 |
5.65E-130 |
lpxA |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lpxA) UDP-N-acetylglucosamine acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE009952.1_3055 |
67.953 |
1.11E-164 |
lpxD |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lpxD) UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE009952.1_3128 |
70.769 |
1.77E-66 |
yst1G |
VF0635 |
Yst1 T2SS |
Effector delivery system |
VFC0086 |
The Yts1 T2SS seems to be present in all high-pathogenicity Y. enterocolitica species (serotypes O:8, O:13, O:20, O:21) but not in low-pathogenic Y. enterocolitica isolates (e.g., O:3, O:9). |
(yst1G) type II secretion system major pseudopilin GspG [Yst1 T2SS (VF0635) - Effector delivery system (VFC0086)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| AE009952.1_3135 |
61.317 |
1.88E-110 |
mig-5 |
VF0396 |
Mig-5 |
Antimicrobial activity/Competitive advantage |
VFC0325 |
|
(mig-5) putative carbonic anhydrase [Mig-5 (VF0396) - Antimicrobial activity/Competitive advantage (VFC0325)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| AE009952.1_3273 |
70.149 |
2.38E-90 |
vgrG/tssI |
VF0569 |
T6SS |
Effector delivery system |
VFC0086 |
Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif |
(vgrG/tssI) type VI secretion system tip protein VgrG [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_3278 |
72.637 |
8.64E-93 |
vgrG/tssI |
VF0569 |
T6SS |
Effector delivery system |
VFC0086 |
Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif |
(vgrG/tssI) type VI secretion system tip protein VgrG [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_3281 |
70.18 |
0.0 |
vgrG/tssI |
VF0569 |
T6SS |
Effector delivery system |
VFC0086 |
Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif |
(vgrG/tssI) type VI secretion system tip protein VgrG [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_3282 |
73.893 |
0.0 |
clpV/tssH |
VF0569 |
T6SS |
Effector delivery system |
VFC0086 |
Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif |
(clpV/tssH) type VI secretion system ATPase TssH [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_3283 |
90.184 |
1.97E-112 |
hcp/tssD |
VF0569 |
T6SS |
Effector delivery system |
VFC0086 |
Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif |
(hcp/tssD) type VI secretion system protein, Hcp family [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_3286 |
66.0 |
0.0 |
vasE/tssK |
VF0569 |
T6SS |
Effector delivery system |
VFC0086 |
Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif |
(vasE/tssK) type VI secretion system baseplate subunit TssK [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_3287 |
78.988 |
0.0 |
vipB/tssC |
VF0569 |
T6SS |
Effector delivery system |
VFC0086 |
Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif |
(vipB/tssC) type VI secretion system contractile sheath large subunit VipB [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_3288 |
74.691 |
2.9E-87 |
vipA/tssB |
VF0569 |
T6SS |
Effector delivery system |
VFC0086 |
Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif |
(vipA/tssB) type VI secretion system contractile sheath small subunit VipA [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_3301 |
70.231 |
0.0 |
iucA |
VF0565 |
Aerobactin |
Nutritional/Metabolic factor |
VFC0272 |
Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae |
(iucA) aerobactin Synthetase IucA [Aerobactin (VF0565) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_3302 |
65.372 |
7.26E-155 |
iucB |
VF0123 |
Aerobactin |
Nutritional/Metabolic factor |
VFC0272 |
A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae |
(iucB) aerobactin synthesis protein IucB [Aerobactin (VF0123) - Nutritional/Metabolic factor (VFC0272)] [Shigella flexneri 2a str. 301] |
Shigella flexneri |
| AE009952.1_3303 |
66.205 |
0.0 |
iucC |
VF0565 |
Aerobactin |
Nutritional/Metabolic factor |
VFC0272 |
Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae |
(iucC) aerobactin siderophore biosynthesis protein IucC [Aerobactin (VF0565) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_3304 |
62.884 |
0.0 |
iucD |
VF0565 |
Aerobactin |
Nutritional/Metabolic factor |
VFC0272 |
Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae |
(iucD) lysine 6-monooxygenase IucD [Aerobactin (VF0565) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_3305 |
69.601 |
0.0 |
iutA |
VF0565 |
Aerobactin |
Nutritional/Metabolic factor |
VFC0272 |
Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae |
(iutA) ferric aerobactin receptor IutA [Aerobactin (VF0565) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE009952.1_3338 |
64.299 |
0.0 |
yapJ |
VF0509 |
YapJ |
Adherence |
VFC0001 |
Sharing a high level of sequence identity with YapV |
(yapJ) autotransporter protein YapJ [YapJ (VF0509) - Adherence (VFC0001)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_3339 |
98.036 |
0.0 |
yapV |
VF0507 |
YapV |
Adherence |
VFC0001 |
|
(yapV) autotransporter protein YapV [YapV (VF0507) - Adherence (VFC0001)] [Yersinia pestis KIM 10] |
Yersinia pestis |
| AE009952.1_3340 |
100.0 |
0.0 |
yapV |
VF0507 |
YapV |
Adherence |
VFC0001 |
|
(yapV) autotransporter protein YapV [YapV (VF0507) - Adherence (VFC0001)] [Yersinia pestis KIM 10] |
Yersinia pestis |
| AE009952.1_3359 |
60.598 |
1.11E-151 |
flgI |
VF0474 |
Lateral flagella |
Motility |
VFC0204 |
|
(flgI) flagellar basal body P-ring protein [Lateral flagella (VF0474) - Motility (VFC0204)] [Aeromonas salmonicida subsp. salmonicida A449] |
Aeromonas salmonicida |
| AE009952.1_3361 |
65.9 |
5.36E-124 |
lfgG |
VF0474 |
Lateral flagella |
Motility |
VFC0204 |
|
(lfgG) lateral flagellar basal-body rod protein LfgG [Lateral flagella (VF0474) - Motility (VFC0204)] [Aeromonas salmonicida subsp. salmonicida A449] |
Aeromonas salmonicida |
| AE009952.1_3379 |
62.78 |
3.23E-87 |
fliP |
VF0474 |
Lateral flagella |
Motility |
VFC0204 |
|
(fliP) flagellar biosynthesis protein FliP [Lateral flagella (VF0474) - Motility (VFC0204)] [Aeromonas salmonicida subsp. salmonicida A449] |
Aeromonas salmonicida |
| AE009952.1_3383 |
61.085 |
3.41E-180 |
lfhA |
VF0474 |
Lateral flagella |
Motility |
VFC0204 |
|
(lfhA) lateral flagellar biosynthesis protein [Lateral flagella (VF0474) - Motility (VFC0204)] [Aeromonas salmonicida subsp. salmonicida A449] |
Aeromonas salmonicida |
| AE009952.1_3434 |
70.601 |
0.0 |
rfaE |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(rfaE) ADP-heptose synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE009952.1_3523 |
76.316 |
2.78E-180 |
lpxC |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lpxC) UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE009952.1_3576 |
63.883 |
0.0 |
hsiC1/vipB/tssC |
VF0334 |
HSI-1 |
Effector delivery system |
VFC0086 |
HSI-1 is highly homologous to a group of genes found in many Gram-negative proteobacteria that have been termed the IcmF-associated homologous protein (IAHP) cluster and encodes a secretory system that may play a general role in mediating host interaction |
(hsiC1/vipB/tssC) type VI secretion system tubule-forming protein VipB [HSI-1 (VF0334) - Effector delivery system (VFC0086)] [Pseudomonas aeruginosa PAO1] |
Pseudomonas aeruginosa |
| AE009952.1_3742 |
100.0 |
0.0 |
yapE |
VF0505 |
YapE |
Adherence |
VFC0001 |
YapE requires proteolytic cleavage by the omptin Pla (plasminogen activator protease) |
(yapE) autotransporter protein YapE [YapE (VF0505) - Adherence (VFC0001)] [Yersinia pestis CO92] |
Yersinia pestis |
| AE009952.1_3782 |
78.455 |
0.0 |
invC/ilp |
VF0575 |
Invasin C/Ilp |
Invasion |
VFC0083 |
|
(invC/ilp) intimin-like invasin C protein [Invasin C/Ilp (VF0575) - Invasion (VFC0083)] [Yersinia pseudotuberculosis IP 31758] |
Yersinia pseudotuberculosis |
| AE009952.1_3829 |
64.84 |
1.85E-100 |
rpe |
VF0543 |
Capsule |
Immune modulation |
VFC0258 |
Group 4 capsule; high molecular weight (HMW) O-antigen capsule |
(rpe) ribulose-phosphate 3-epimerase [Capsule (VF0543) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| AE009952.1_3846 |
67.327 |
8.78E-101 |
vfr |
VF0082 |
Type IV pili |
Adherence |
VFC0001 |
PilA, B, C, D, E, F, M, N, O, P, Q, T, U, V, W, X, Y1, Y2, Z, and fimT, U, V are involved in the biogenesis and mechanical function of pili, pilG, H, I, K, chpA, B, C, D, E, pilS, R, fimS, rpoN, algR, algU, and vfr are involved in transcriptional regulation and chemosensory pathways that control the expression or activity of the twitching motility of the pili |
(vfr) cAMP-regulatory protein [Type IV pili (VF0082) - Adherence (VFC0001)] [Pseudomonas aeruginosa PAO1] |
Pseudomonas aeruginosa |
| AE009952.1_3874 |
79.644 |
0.0 |
tufA |
VF0460 |
EF-Tu |
Adherence |
VFC0001 |
|
(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| AF074611.1_63 |
100.0 |
0.0 |
ymt |
VF0137 |
Ymt |
Exotoxin |
VFC0235 |
Unique to Y. pestis; belongs to a family of phospholipase D enzymes, characterized by conserved HKD (HXKX4DX6GG/S, X: any amino acid) catalytic motifs; Ymt is not a secreted exotoxin, but is released upon bacterial lysis in vivo. The exact action of Ymt in the pathogenesis of Y. pestis has not been clarified, but Ymt is universally considered unnecessary for the virulence of Y. pestis in mice. |
(ymt) murine toxin [Ymt (VF0137) - Exotoxin (VFC0235)] [Yersinia pestis CO92] |
Yersinia pestis |
| AF074611.1_88 |
100.0 |
0.0 |
caf1R |
VF0138 |
F1 antigen |
Immune modulation |
VFC0258 |
Virulence factors unique to Y. pestis, |
(caf1R) F1 operon positive regulatory protein [F1 antigen (VF0138) - Immune modulation (VFC0258)] [Yersinia pestis CO92] |
Yersinia pestis |
| AF074611.1_89 |
100.0 |
0.0 |
caf1M |
VF0138 |
F1 antigen |
Immune modulation |
VFC0258 |
Virulence factors unique to Y. pestis, |
(caf1M) F1 chaperone protein [F1 antigen (VF0138) - Immune modulation (VFC0258)] [Yersinia pestis CO92] |
Yersinia pestis |
| AF074611.1_90 |
100.0 |
0.0 |
caf1A |
VF0138 |
F1 antigen |
Immune modulation |
VFC0258 |
Virulence factors unique to Y. pestis, |
(caf1A) F1 capsule anchoring protein [F1 antigen (VF0138) - Immune modulation (VFC0258)] [Yersinia pestis CO92] |
Yersinia pestis |
| AF074611.1_91 |
100.0 |
3.19E-121 |
caf1 |
VF0138 |
F1 antigen |
Immune modulation |
VFC0258 |
Virulence factors unique to Y. pestis, |
(caf1) putative F1 capsule antigen [F1 antigen (VF0138) - Immune modulation (VFC0258)] [Yersinia pestis CO92] |
Yersinia pestis |