| AE004092.2_104 |
100.0 |
3.31E-136 |
lepA |
VF0531 |
GAS pili |
Adherence |
VFC0001 |
The GAS pili are encoded in the variable FCT (fibronectin- and collagen-binding T-antigen) region. |
(lepA) signal peptidase I [GAS pili (VF0531) - Adherence (VFC0001)] [Streptococcus pyogenes MGAS5005] |
Streptococcus pyogenes |
| AE004092.2_105 |
100.0 |
0.0 |
fctA |
VF0531 |
GAS pili |
Adherence |
VFC0001 |
The GAS pili are encoded in the variable FCT (fibronectin- and collagen-binding T-antigen) region. |
(fctA) major pilin FctA [GAS pili (VF0531) - Adherence (VFC0001)] [Streptococcus pyogenes MGAS5005] |
Streptococcus pyogenes |
| AE004092.2_106 |
100.0 |
9.47E-179 |
srtC1 |
VF0531 |
GAS pili |
Adherence |
VFC0001 |
The GAS pili are encoded in the variable FCT (fibronectin- and collagen-binding T-antigen) region. |
(srtC1) sortase [GAS pili (VF0531) - Adherence (VFC0001)] [Streptococcus pyogenes MGAS5005] |
Streptococcus pyogenes |
| AE004092.2_107 |
100.0 |
1.47E-158 |
fctB |
VF0531 |
GAS pili |
Adherence |
VFC0001 |
The GAS pili are encoded in the variable FCT (fibronectin- and collagen-binding T-antigen) region. |
(fctB) minor pilin FctB [GAS pili (VF0531) - Adherence (VFC0001)] [Streptococcus pyogenes MGAS5005] |
Streptococcus pyogenes |
| AE004092.2_138 |
100.0 |
0.0 |
slo |
VF0250 |
SLO |
Exotoxin |
VFC0235 |
A member of the cholesterol-dependent cytolysin family, related to pneumolysin from S. pneumoniae |
(slo) streptolysin O precursor [SLO (VF0250) - Exotoxin (VFC0235)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_175 |
100.0 |
1.88E-174 |
speG |
VF0248 |
Spes |
Exotoxin |
VFC0235 |
Two prototypical streptococcal superantigens, SpeA and SpeC are both encoded on functional phage |
(speG) streptococcal exotoxin G precursor [Spes (VF0248) - Exotoxin (VFC0235)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_184 |
90.604 |
0.0 |
hasC |
VF0244 |
Hyaluronic acid capsule |
Immune modulation |
VFC0258 |
|
(hasC) UTP--glucose-1-phosphate uridylyltransferase HasC [Hyaluronic acid capsule (VF0244) - Immune modulation (VFC0258)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_312 |
61.979 |
5.69E-88 |
clpP |
VF0074 |
ClpP |
Stress survival |
VFC0282 |
21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes |
(clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| AE004092.2_335 |
100.0 |
4.31E-169 |
speJ |
VF0248 |
Spes |
Exotoxin |
VFC0235 |
Two prototypical streptococcal superantigens, SpeA and SpeC are both encoded on functional phage |
(speJ) streptococcal exotoxin J precursor [Spes (VF0248) - Exotoxin (VFC0235)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_347 |
76.299 |
5.61E-175 |
psaA |
VF0151 |
PsaA |
Nutritional/Metabolic factor |
VFC0272 |
Surface protein: lipid-attached; AdcABC is another ABC transporter for Zn2+ uptake |
(psaA) manganese ABC transporter, manganese-binding adhesion liprotein [PsaA (VF0151) - Nutritional/Metabolic factor (VFC0272)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| AE004092.2_472 |
69.444 |
0.0 |
tufA |
VF0460 |
EF-Tu |
Adherence |
VFC0001 |
|
(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| AE004092.2_552 |
100.0 |
7.84E-173 |
speC |
VF0248 |
Spes |
Exotoxin |
VFC0235 |
Two prototypical streptococcal superantigens, SpeA and SpeC are both encoded on functional phage |
(speC) streptococcal exotoxin C precursor, phage associated [Spes (VF0248) - Exotoxin (VFC0235)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_553 |
100.0 |
0.0 |
mf2 |
VF0252 |
Mitogenic factor |
Exoenzyme |
VFC0251 |
DNase B has been shown to be the same molecule as the streptococcal mitogenic factor (MF). It does not contribute significantly to the superantigenic activity of S. pyogenes when compared with other Spes |
(mf2) deoxyribonuclease, phage associated [Mitogenic factor (VF0252) - Exoenzyme (VFC0251)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_574 |
100.0 |
8.81E-33 |
sagA |
VF0251 |
SLS |
Exotoxin |
VFC0235 |
Oxygen stable, most potent cytotoxin; not immunogenic; unstable polypeptide bounds to carrier molecules, such as serum albumin, RNA core, or lipoteichoic acid; responsible for the beta-hemolysis surrounding colonies of GAS grown on blood agar plates; SagA serves as SLS toxin precursor and eight additional genes in an operon is required for toxin maturation and export. pro-SLS is converted into an active cytolysin by the actions of SagBCD, a trimeric oxazole/thiazole synthetase. |
(sagA) streptolysin S associated protein [SLS (VF0251) - Exotoxin (VFC0235)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_676 |
100.0 |
0.0 |
ideS/mac |
VF0284 |
IdeS |
Immune modulation |
VFC0258 |
A secreted 35 kDa protein, does not require processing or activation to exert its enzymatic activity; also described as a CD11b homolog protein, Mac, CD11b is the alpha chain of complement receptor 3 (CR3), which is the receptor on phagocytes that recognizes C3b |
(ideS/mac) immunoglobulin G-degrading enzyme [IdeS (VF0284) - Immune modulation (VFC0258)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_738 |
65.517 |
2.17E-142 |
wbtL |
VF0542 |
LPS |
Immune modulation |
VFC0258 |
The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion |
(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| AE004092.2_802 |
100.0 |
1.97E-165 |
speI |
VF0248 |
Spes |
Exotoxin |
VFC0235 |
Two prototypical streptococcal superantigens, SpeA and SpeC are both encoded on functional phage |
(speI) streptococcal exotoxin I precursor [Spes (VF0248) - Exotoxin (VFC0235)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_803 |
100.0 |
4.96E-178 |
speH |
VF0248 |
Spes |
Exotoxin |
VFC0235 |
Two prototypical streptococcal superantigens, SpeA and SpeC are both encoded on functional phage |
(speH) streptococcal exotoxin H precursor [Spes (VF0248) - Exotoxin (VFC0235)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_807 |
99.636 |
0.0 |
fbp54 |
VF0243 |
FBPs |
Adherence |
VFC0001 |
Surface protein: linked to the bacterial cell wall via C-terminal LPXTG motif; including PrtF1 (protein F1) also known as SfbI (streptococcal fibronectin binding proteinI), SfbII/SOF (serum opacity factor), FbaA, FbaB, FBP54 (fibronectin-binding protein 54), protein F2, PFBP (pyogene fibronectin-binding protein) |
(fbp54) fibronectin-bing protein Fbp54 [FBPs (VF0243) - Adherence (VFC0001)] [Streptococcus pyogenes MGAS6180] |
Streptococcus pyogenes |
| AE004092.2_820 |
100.0 |
0.0 |
hylA |
VF0246 |
Hyaluronidase |
Exoenzyme |
VFC0251 |
GAS are capable of producing two types of hyaluronidase, a bacteriophage associated enzyme and an extracellular hyaluronidase that is secreted from the cell; since the capsule of GAS is composed solely of hyaluronic acid, the hyaluronidase presumably benefits the phage by aiding in capsule penetration during its infection of or release from streptococci |
(hylA) hyaluronidase [Hyaluronidase (VF0246) - Exoenzyme (VFC0251)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_839 |
62.308 |
9.78E-57 |
msrA/B(pilB |
VF0456 |
MsrAB |
Stress survival |
VFC0282 |
Methionine sulfoxide reductases (Msr) are enzymes that catalyze the reduction of free and protein-bound methionine sulfoxide (MetSO) back to Met. Two structurally unrelated classes of Msrs have been described so far. MsrAs are stereo specific toward the S isomer on the sulfur of the sulfoxide function, whereas MsrBs are specific toward the R isomer |
(msrA/B(pilB)) trifunctional thioredoxin/methionine sulfoxide reductase A/B protein [MsrAB (VF0456) - Stress survival (VFC0282)] [Neisseria meningitidis MC58] |
Neisseria meningitidis |
| AE004092.2_1029 |
60.7 |
2.07E-107 |
cfa/cfb |
VF0280 |
CAMP factor |
Exotoxin |
VFC0235 |
CAMP factor, a pore-forming protein toxin of ~24 kDa gives rise to the so-called CAMP reaction, which consists of a zone of strong hemolysis that is observed when S. agalactiae is streaked next to Staphylococcus aureus on sheep blood agar. S. aureus secretes sphingomyelinase. Sheep red blood cells are rich in sphingomyelin and, upon exposure to sphingomyelinase, become greatly sensitized to CAMP factor, which then effects hemolysis. This co-hemolytic phenomenon was first described by Christie, Atkins, and Munch-Petersen, and the CAMP acronym represents these investigators' last names.; Paralogs of <iS. agalactiae</i> CAMP factor genes have been sequenced in a wide range of Gram-positive pathogens, including Streptococcus uberisand Cutibacterium acnes |
(cfa/cfb) cAMP factor [CAMP factor (VF0280) - Exotoxin (VFC0235)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE004092.2_1095 |
100.0 |
1.84E-155 |
grab |
VF0254 |
GRAB |
Others |
VFC0346 |
Surface protein: linked to the bacterial cell wall via C-terminal LPXTG motif; high affinity (Ka = 2.0 x 108M-1) for <term>alpha2-macroglobulin (alpha2M)</term>; encoded by grab gene that is present in most S. pyogene strains and is well conserved |
(grab) protein GRAB (protein G-related alpha 2M-binding protein) [GRAB (VF0254) - Others (VFC0346)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_1153 |
100.0 |
0.0 |
mf3 |
VF0252 |
Mitogenic factor |
Exoenzyme |
VFC0251 |
DNase B has been shown to be the same molecule as the streptococcal mitogenic factor (MF). It does not contribute significantly to the superantigenic activity of S. pyogenes when compared with other Spes |
(mf3) deoxyribonuclease [Mitogenic factor (VF0252) - Exoenzyme (VFC0251)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_1589 |
100.0 |
0.0 |
ska |
VF0247 |
Streptokinase |
Exoenzyme |
VFC0251 |
|
(ska) streptokinase A precursor [Streptokinase (VF0247) - Exoenzyme (VFC0251)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_1604 |
100.0 |
1.43E-173 |
smeZ |
VF0248 |
Spes |
Exotoxin |
VFC0235 |
Two prototypical streptococcal superantigens, SpeA and SpeC are both encoded on functional phage |
(smeZ) streptococcal mitogenic exotoxin Z [Spes (VF0248) - Exotoxin (VFC0235)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_1613 |
99.673 |
0.0 |
lmb |
VF0275 |
Lmb |
Adherence |
VFC0001 |
Lmb is an extracellular protein that was first identified in S. agalactiae. Homologs of this protein were reported in S. pyogenes and S. pneumonia and termed Lbp and AdcAII, respectively |
(lmb) laminin-binding surface protein [Lmb (VF0275) - Adherence (VFC0001)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE004092.2_1614 |
76.066 |
0.0 |
fbaA |
VF0243 |
FBPs |
Adherence |
VFC0001 |
Surface protein: linked to the bacterial cell wall via C-terminal LPXTG motif; including PrtF1 (protein F1) also known as SfbI (streptococcal fibronectin binding proteinI), SfbII/SOF (serum opacity factor), FbaA, FbaB, FBP54 (fibronectin-binding protein 54), protein F2, PFBP (pyogene fibronectin-binding protein) |
(fbaA) protein F2 like fibronectin-binding protein [FBPs (VF0243) - Adherence (VFC0001)] [Streptococcus pyogenes MGAS6180] |
Streptococcus pyogenes |
| AE004092.2_1615 |
100.0 |
0.0 |
scpA/scpB |
VF0245 |
C5a peptidase |
Adherence |
VFC0001 |
Surface protein: LPTTN motif |
(scpA/scpB) streptococcal C5a peptidase [C5a peptidase (VF0245) - Adherence (VFC0001)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_1617 |
100.0 |
0.0 |
sic |
VF0255 |
SIC |
Immune modulation |
VFC0258 |
A hypervariable extracellular protein, with the amount of polymorphism far exceeding that present in any bacterial protein except those directly associated with antibiotic resistance. This variation may arise from pressure from the immune system that makes it expedient for the bacteria to change their surface antigens |
(sic) inhibitor of complement-mediated lysis [SIC (VF0255) - Immune modulation (VFC0258)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_1618 |
100.0 |
0.0 |
emm |
VF0242 |
M protein |
Immune modulation |
VFC0258 |
Surface protein: LPXTG motif; M proteins are used for classification of S. pyogenes strains into M serotypes because of N-terminal hypervariable region that exhibits extensive sequence variability between strains |
(emm) M protein [M protein (VF0242) - Immune modulation (VFC0258)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_1632 |
100.0 |
0.0 |
speB |
VF0249 |
SpeB |
Exoenzyme |
VFC0251 |
|
(speB) pyrogenic exotoxin B [SpeB (VF0249) - Exoenzyme (VFC0251)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_1635 |
100.0 |
0.0 |
mf/spd |
VF0252 |
Mitogenic factor |
Exoenzyme |
VFC0251 |
DNase B has been shown to be the same molecule as the streptococcal mitogenic factor (MF). It does not contribute significantly to the superantigenic activity of S. pyogenes when compared with other Spes |
(mf/spd) deoxyribonuclease [Mitogenic factor (VF0252) - Exoenzyme (VFC0251)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_1655 |
67.238 |
0.0 |
groEL |
VF0594 |
GroEL |
Adherence |
VFC0001 |
GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. |
(groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] |
Clostridium difficile |
| AE004092.2_1762 |
100.0 |
0.0 |
hasA |
VF0244 |
Hyaluronic acid capsule |
Immune modulation |
VFC0258 |
|
(hasA) hyaluronan synthase HasA [Hyaluronic acid capsule (VF0244) - Immune modulation (VFC0258)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_1763 |
100.0 |
0.0 |
hasB |
VF0244 |
Hyaluronic acid capsule |
Immune modulation |
VFC0258 |
|
(hasB) UDP-glucose 6-dehydrogenase HasB [Hyaluronic acid capsule (VF0244) - Immune modulation (VFC0258)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE004092.2_1764 |
100.0 |
0.0 |
hasC |
VF0244 |
Hyaluronic acid capsule |
Immune modulation |
VFC0258 |
|
(hasC) UTP--glucose-1-phosphate uridylyltransferase HasC [Hyaluronic acid capsule (VF0244) - Immune modulation (VFC0258)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |