| AE004439.1_33 |
62.5 |
0.0 |
katA |
VF0454 |
KatA |
Stress survival |
VFC0282 |
|
(katA) catalase [KatA (VF0454) - Stress survival (VFC0282)] [Neisseria meningitidis MC58] |
Neisseria meningitidis |
| AE004439.1_106 |
65.254 |
3.09E-109 |
lpxH |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lpxH) UDP-2,3-diacylglucosamine pyrophosphohydrolase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_127 |
92.188 |
8.35E-133 |
gmhA/lpcA |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(gmhA/lpcA) phosphoheptose isomerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_153 |
91.475 |
0.0 |
lpxC |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lpxC) UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_192 |
68.161 |
5.52E-111 |
neuA |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(neuA) acylneuraminate cytidylyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_293 |
87.278 |
0.0 |
galE |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(galE) UDP-glucose 4-epimerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_360 |
67.424 |
3.38E-63 |
fur |
VF0113 |
Fur |
Regulation |
VFC0301 |
|
(fur) ferric iron uptake transcriptional regulator [Fur (VF0113) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| AE004439.1_370 |
76.752 |
0.0 |
msbB |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(msbB) lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_470 |
82.768 |
0.0 |
wecA |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(wecA) undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_514 |
66.416 |
0.0 |
lsgA |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lsgA) lipopolysaccharide biosynthesis transporter [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_518 |
61.433 |
5.64E-125 |
lsgE |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lsgE) glycosyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_519 |
76.779 |
3.79E-154 |
lsgF |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lsgF) glycosyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_532 |
80.386 |
0.0 |
kpsF |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(kpsF) KpsF/GutQ family sugar isomerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_565 |
89.753 |
0.0 |
kdsA |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_781 |
65.423 |
0.0 |
hcsB' |
VF0043 |
Capsule |
Immune modulation |
VFC0258 |
H.influenzae can express one or none of six antigenically distinct polysacchaide capsules, designated a through f; Bacteria expressing the type b capsule polyribosyl ribitol phosphate (PRP) account for the overwhelming majority of invasive disease isolates; The most systemic isolates express the type b capsule, whereas most respiratory tract isolates are uncapsulated (referred to as non-typable) |
(hcsB') HcsB' [Capsule (VF0043) - Immune modulation (VFC0258)] [Haemophilus influenzae str. 1007] |
Haemophilus influenzae |
| AE004439.1_785 |
61.499 |
1.55E-179 |
ugd |
VF0560 |
Capsule |
Immune modulation |
VFC0258 |
The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. |
(ugd) UDP-glucose 6-dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| AE004439.1_788 |
63.662 |
1.27E-167 |
bexC' |
VF0043 |
Capsule |
Immune modulation |
VFC0258 |
H.influenzae can express one or none of six antigenically distinct polysacchaide capsules, designated a through f; Bacteria expressing the type b capsule polyribosyl ribitol phosphate (PRP) account for the overwhelming majority of invasive disease isolates; The most systemic isolates express the type b capsule, whereas most respiratory tract isolates are uncapsulated (referred to as non-typable) |
(bexC') BexC' [Capsule (VF0043) - Immune modulation (VFC0258)] [Haemophilus influenzae str. 1007] |
Haemophilus influenzae |
| AE004439.1_789 |
65.769 |
5.32E-134 |
ctrC |
VF0079 |
Capsule |
Immune modulation |
VFC0258 |
The meningococcal capsule-synthesis (cps) gene cluster consists of five regions:; region A harbors the polysaccharide synthesis operon (sia, syn genes); region B contains lip genes responsible for lipid modification; region C harbors ctr genes necessary for polysaccharide transport; region D is involved in lipopolysaccharide synthesis; region D' is a truncated duplication of the region D; region E contains the tex gene homologue; on-off switching of expression via a poly-cytidine tract within siaD |
(ctrC) capsule polysaccharide export inner-membrane protein CtrC [Capsule (VF0079) - Immune modulation (VFC0258)] [Neisseria meningitidis MC58] |
Neisseria meningitidis |
| AE004439.1_790 |
77.465 |
2.17E-129 |
bexA |
VF0043 |
Capsule |
Immune modulation |
VFC0258 |
H.influenzae can express one or none of six antigenically distinct polysacchaide capsules, designated a through f; Bacteria expressing the type b capsule polyribosyl ribitol phosphate (PRP) account for the overwhelming majority of invasive disease isolates; The most systemic isolates express the type b capsule, whereas most respiratory tract isolates are uncapsulated (referred to as non-typable) |
(bexA) ATP-dependent polysaccharide export protein BexA [Capsule (VF0043) - Immune modulation (VFC0258)] [Haemophilus influenzae str. 1007] |
Haemophilus influenzae |
| AE004439.1_795 |
63.912 |
6.57E-146 |
ompP5 |
VF0041 |
P5 protein |
Adherence |
VFC0001 |
Major outer membrane protein, shares homology with E. coli OmpA; antigenically variable from one train to another |
(ompP5) outer membrane protein P5 (ompA), human factor H binding protein [P5 protein (VF0041) - Adherence (VFC0001)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_868 |
75.591 |
1.58E-141 |
kdsB |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(kdsB) 3-deoxy-manno-octulosonate cytidylyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_870 |
65.337 |
2.88E-157 |
lpxK |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lpxK) tetraacyldisaccharide 4'-kinase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_871 |
79.447 |
0.0 |
msbA |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(msbA) lipid transporter ATP-binding/permease [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_894 |
85.924 |
0.0 |
rfaE |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(rfaE) ADP-heptose synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_895 |
75.884 |
0.0 |
htrB |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(htrB) lipid A biosynthesis lauroyl acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_1017 |
78.066 |
0.0 |
tviB |
VF0465 |
Capsule |
Immune modulation |
VFC0258 |
A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. |
(tviB) Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB [Capsule (VF0465) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] |
Acinetobacter baumannii |
| AE004439.1_1021 |
66.867 |
9.26E-172 |
cap8E |
VF0003 |
Capsule |
Immune modulation |
VFC0258 |
Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans |
(cap8E) type 8 capsular polysaccharide synthesis protein Cap8E [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] |
Staphylococcus aureus |
| AE004439.1_1044 |
64.412 |
5.08E-174 |
rffG |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(rffG) dTDP-glucose 46-dehydratase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_1069 |
73.653 |
3.15E-94 |
luxS |
VF0406 |
AI-2 |
Biofilm |
VFC0271 |
AI-2 is produced and detected by a wide variety of bacteria and is presumed to facilitate interspecies communications. |
(luxS) S-ribosylhomocysteinase [AI-2 (VF0406) - Biofilm (VFC0271)] [Vibrio cholerae O1 biovar El Tor str. N16961] |
Vibrio cholerae |
| AE004439.1_1090 |
88.0 |
0.0 |
manB/yhxB |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(manB/yhxB) phosphomannomutase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_1124 |
75.803 |
0.0 |
htpB |
VF0159 |
Hsp60 |
Adherence |
VFC0001 |
|
(htpB) Hsp60, 60K heat shock protein HtpB [Hsp60 (VF0159) - Adherence (VFC0001)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] |
Legionella pneumophila |
| AE004439.1_1173 |
61.244 |
9.74E-95 |
vfr |
VF0082 |
Type IV pili |
Adherence |
VFC0001 |
PilA, B, C, D, E, F, M, N, O, P, Q, T, U, V, W, X, Y1, Y2, Z, and fimT, U, V are involved in the biogenesis and mechanical function of pili, pilG, H, I, K, chpA, B, C, D, E, pilS, R, fimS, rpoN, algR, algU, and vfr are involved in transcriptional regulation and chemosensory pathways that control the expression or activity of the twitching motility of the pili |
(vfr) cAMP-regulatory protein [Type IV pili (VF0082) - Adherence (VFC0001)] [Pseudomonas aeruginosa PAO1] |
Pseudomonas aeruginosa |
| AE004439.1_1303 |
68.421 |
4.63E-26 |
csrA |
VF0261 |
CsrA |
Regulation |
VFC0301 |
Belongs to a highly conserved family of global regulators that typically control stationary phase traits post-transcriptionally |
(csrA) carbon storage regulator CsrA [CsrA (VF0261) - Regulation (VFC0301)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] |
Legionella pneumophila |
| AE004439.1_1305 |
85.085 |
0.0 |
galU |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(galU) glucosephosphate uridylyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_1310 |
66.472 |
4.54E-171 |
waaQ |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(waaQ) heptosyltransferase-like protein [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_1318 |
72.334 |
0.0 |
opsX/rfaC |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(opsX/rfaC) heptosyltransferase I [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_1321 |
64.871 |
0.0 |
kdtA |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(kdtA) 3-deoxy-d-manno-octulosonic-acid transferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_1322 |
72.332 |
6.12E-142 |
lgtF |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lgtF) beta-1,4-glucosyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_1358 |
90.968 |
0.0 |
rfaD |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(rfaD) ADP-L-glycero-D-mannoheptose-6-epimerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_1374 |
80.203 |
0.0 |
tufA |
VF0460 |
EF-Tu |
Adherence |
VFC0001 |
|
(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| AE004439.1_1641 |
63.514 |
7.3E-99 |
rpe |
VF0543 |
Capsule |
Immune modulation |
VFC0258 |
Group 4 capsule; high molecular weight (HMW) O-antigen capsule |
(rpe) ribulose-phosphate 3-epimerase [Capsule (VF0543) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| AE004439.1_1686 |
83.249 |
1.3E-114 |
orfM |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(orfM) deoxyribonucleotide triphosphate pyrophosphatase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_1767 |
79.442 |
0.0 |
tufA |
VF0460 |
EF-Tu |
Adherence |
VFC0001 |
|
(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| AE004439.1_1810 |
61.257 |
5.11E-86 |
algU |
VF0091 |
Alginate |
Biofilm |
VFC0271 |
Alginate production is frequently referred to as mucoidy because colonies producing alginate have a wet glistening (mucoid) appearance, which is very different from that of colonies not producing alginate; most of the alginate biosynthetic genes are clustered in the algD operon; Alginate production is highly regulated. Regulatory genes are located in two areas far removed from the biosynthetic genes, with one exception algC |
(algU) alginate biosynthesis protein AlgZ/FimS [Alginate (VF0091) - Biofilm (VFC0271)] [Pseudomonas aeruginosa PAO1] |
Pseudomonas aeruginosa |
| AE004439.1_1864 |
81.214 |
0.0 |
rfaF |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(rfaF) ADP-heptose-LPS heptosyltransferase II [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_1937 |
74.684 |
2.13E-130 |
flmH |
VF0473 |
Polar flagella |
Motility |
VFC0204 |
Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments |
(flmH) short chain dehydrogenase/reductase family oxidoreductase [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119] |
Aeromonas hydrophila |
| AE004439.1_1938 |
66.176 |
6.01E-27 |
acpXL |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE004439.1_1994 |
62.694 |
1.05E-92 |
clpP |
VF0074 |
ClpP |
Stress survival |
VFC0282 |
21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes |
(clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| AE004439.1_2012 |
85.417 |
0.0 |
lpxD |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lpxD) UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_2014 |
79.008 |
4.69E-159 |
lpxA |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lpxA) UDP-N-acetylglucosamine acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| AE004439.1_2015 |
80.206 |
0.0 |
lpxB |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lpxB) lipid-A-disaccharide synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |