| AE006914.1_148 |
96.842 |
1.23E-65 |
rvhB3 |
VF0488 |
Rvh T4SS |
Effector delivery system |
VFC0086 |
All sequenced Rickettsia genomes encode a P-T4SS similar to the vir archetype of Agrobacterium tumefaciens and related systems, and this T4SS is encoded across all genomes in the rickettsial families Rickettsiaceae, Anaplasmataceae, and Midichloriaceae; lacks a homolog of VirB5, the minor pilin subunit that is indispensable for pilus formation but not substrate transfer; A defining feature of the rvh T4SS is the proliferation of genes encoding RvhB6 proteins, which are predicted IM channel components of the VirB6/TrbL family that are required for substrate transfer in P-T4SSs;Three other components are encoded by duplicate genes within the rvh T4SS: RvhB4a and RvhB4b--homologous to VirB4 (IM ATPase), RvhB9a and RvhB9b--homologous to Vir9 (participating with VirB7 and VirB10 in the OM pore of the T4SS), two VirB8-like channel proteins, RvhB8a and RvhB8b |
(rvhB3) type IV secretion system protein VirB3 [Rvh T4SS (VF0488) - Effector delivery system (VFC0086)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_149 |
96.77 |
0.0 |
rvhB4a |
VF0488 |
Rvh T4SS |
Effector delivery system |
VFC0086 |
All sequenced Rickettsia genomes encode a P-T4SS similar to the vir archetype of Agrobacterium tumefaciens and related systems, and this T4SS is encoded across all genomes in the rickettsial families Rickettsiaceae, Anaplasmataceae, and Midichloriaceae; lacks a homolog of VirB5, the minor pilin subunit that is indispensable for pilus formation but not substrate transfer; A defining feature of the rvh T4SS is the proliferation of genes encoding RvhB6 proteins, which are predicted IM channel components of the VirB6/TrbL family that are required for substrate transfer in P-T4SSs;Three other components are encoded by duplicate genes within the rvh T4SS: RvhB4a and RvhB4b--homologous to VirB4 (IM ATPase), RvhB9a and RvhB9b--homologous to Vir9 (participating with VirB7 and VirB10 in the OM pore of the T4SS), two VirB8-like channel proteins, RvhB8a and RvhB8b |
(rvhB4a) type IV secretion system ATPase VirB4 [Rvh T4SS (VF0488) - Effector delivery system (VFC0086)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_150 |
82.312 |
0.0 |
rvhB6a |
VF0488 |
Rvh T4SS |
Effector delivery system |
VFC0086 |
All sequenced Rickettsia genomes encode a P-T4SS similar to the vir archetype of Agrobacterium tumefaciens and related systems, and this T4SS is encoded across all genomes in the rickettsial families Rickettsiaceae, Anaplasmataceae, and Midichloriaceae; lacks a homolog of VirB5, the minor pilin subunit that is indispensable for pilus formation but not substrate transfer; A defining feature of the rvh T4SS is the proliferation of genes encoding RvhB6 proteins, which are predicted IM channel components of the VirB6/TrbL family that are required for substrate transfer in P-T4SSs;Three other components are encoded by duplicate genes within the rvh T4SS: RvhB4a and RvhB4b--homologous to VirB4 (IM ATPase), RvhB9a and RvhB9b--homologous to Vir9 (participating with VirB7 and VirB10 in the OM pore of the T4SS), two VirB8-like channel proteins, RvhB8a and RvhB8b |
(rvhB6a) VirB6-like protein of the type IV secretion system [Rvh T4SS (VF0488) - Effector delivery system (VFC0086)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_151 |
85.884 |
0.0 |
rvhB6b |
VF0488 |
Rvh T4SS |
Effector delivery system |
VFC0086 |
All sequenced Rickettsia genomes encode a P-T4SS similar to the vir archetype of Agrobacterium tumefaciens and related systems, and this T4SS is encoded across all genomes in the rickettsial families Rickettsiaceae, Anaplasmataceae, and Midichloriaceae; lacks a homolog of VirB5, the minor pilin subunit that is indispensable for pilus formation but not substrate transfer; A defining feature of the rvh T4SS is the proliferation of genes encoding RvhB6 proteins, which are predicted IM channel components of the VirB6/TrbL family that are required for substrate transfer in P-T4SSs;Three other components are encoded by duplicate genes within the rvh T4SS: RvhB4a and RvhB4b--homologous to VirB4 (IM ATPase), RvhB9a and RvhB9b--homologous to Vir9 (participating with VirB7 and VirB10 in the OM pore of the T4SS), two VirB8-like channel proteins, RvhB8a and RvhB8b |
(rvhB6b) VirB6-like protein of the type IV secretion system [Rvh T4SS (VF0488) - Effector delivery system (VFC0086)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_152 |
82.033 |
0.0 |
rvhB6c |
VF0488 |
Rvh T4SS |
Effector delivery system |
VFC0086 |
All sequenced Rickettsia genomes encode a P-T4SS similar to the vir archetype of Agrobacterium tumefaciens and related systems, and this T4SS is encoded across all genomes in the rickettsial families Rickettsiaceae, Anaplasmataceae, and Midichloriaceae; lacks a homolog of VirB5, the minor pilin subunit that is indispensable for pilus formation but not substrate transfer; A defining feature of the rvh T4SS is the proliferation of genes encoding RvhB6 proteins, which are predicted IM channel components of the VirB6/TrbL family that are required for substrate transfer in P-T4SSs;Three other components are encoded by duplicate genes within the rvh T4SS: RvhB4a and RvhB4b--homologous to VirB4 (IM ATPase), RvhB9a and RvhB9b--homologous to Vir9 (participating with VirB7 and VirB10 in the OM pore of the T4SS), two VirB8-like channel proteins, RvhB8a and RvhB8b |
(rvhB6c) VirB6-like protein of the type IV secretion system [Rvh T4SS (VF0488) - Effector delivery system (VFC0086)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_153 |
84.263 |
0.0 |
rvhB6d |
VF0488 |
Rvh T4SS |
Effector delivery system |
VFC0086 |
All sequenced Rickettsia genomes encode a P-T4SS similar to the vir archetype of Agrobacterium tumefaciens and related systems, and this T4SS is encoded across all genomes in the rickettsial families Rickettsiaceae, Anaplasmataceae, and Midichloriaceae; lacks a homolog of VirB5, the minor pilin subunit that is indispensable for pilus formation but not substrate transfer; A defining feature of the rvh T4SS is the proliferation of genes encoding RvhB6 proteins, which are predicted IM channel components of the VirB6/TrbL family that are required for substrate transfer in P-T4SSs;Three other components are encoded by duplicate genes within the rvh T4SS: RvhB4a and RvhB4b--homologous to VirB4 (IM ATPase), RvhB9a and RvhB9b--homologous to Vir9 (participating with VirB7 and VirB10 in the OM pore of the T4SS), two VirB8-like channel proteins, RvhB8a and RvhB8b |
(rvhB6d) VirB6-like protein of the type IV secretion system [Rvh T4SS (VF0488) - Effector delivery system (VFC0086)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_154 |
87.955 |
0.0 |
rvhB6e |
VF0488 |
Rvh T4SS |
Effector delivery system |
VFC0086 |
All sequenced Rickettsia genomes encode a P-T4SS similar to the vir archetype of Agrobacterium tumefaciens and related systems, and this T4SS is encoded across all genomes in the rickettsial families Rickettsiaceae, Anaplasmataceae, and Midichloriaceae; lacks a homolog of VirB5, the minor pilin subunit that is indispensable for pilus formation but not substrate transfer; A defining feature of the rvh T4SS is the proliferation of genes encoding RvhB6 proteins, which are predicted IM channel components of the VirB6/TrbL family that are required for substrate transfer in P-T4SSs;Three other components are encoded by duplicate genes within the rvh T4SS: RvhB4a and RvhB4b--homologous to VirB4 (IM ATPase), RvhB9a and RvhB9b--homologous to Vir9 (participating with VirB7 and VirB10 in the OM pore of the T4SS), two VirB8-like channel proteins, RvhB8a and RvhB8b |
(rvhB6e) VirB6-like protein of the type IV secretion system [Rvh T4SS (VF0488) - Effector delivery system (VFC0086)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_253 |
91.597 |
2.13E-74 |
rvhB2 |
VF0488 |
Rvh T4SS |
Effector delivery system |
VFC0086 |
All sequenced Rickettsia genomes encode a P-T4SS similar to the vir archetype of Agrobacterium tumefaciens and related systems, and this T4SS is encoded across all genomes in the rickettsial families Rickettsiaceae, Anaplasmataceae, and Midichloriaceae; lacks a homolog of VirB5, the minor pilin subunit that is indispensable for pilus formation but not substrate transfer; A defining feature of the rvh T4SS is the proliferation of genes encoding RvhB6 proteins, which are predicted IM channel components of the VirB6/TrbL family that are required for substrate transfer in P-T4SSs;Three other components are encoded by duplicate genes within the rvh T4SS: RvhB4a and RvhB4b--homologous to VirB4 (IM ATPase), RvhB9a and RvhB9b--homologous to Vir9 (participating with VirB7 and VirB10 in the OM pore of the T4SS), two VirB8-like channel proteins, RvhB8a and RvhB8b |
(rvhB2) type IV secretion system protein [Rvh T4SS (VF0488) - Effector delivery system (VFC0086)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_400 |
96.4 |
0.0 |
rvhB9a |
VF0488 |
Rvh T4SS |
Effector delivery system |
VFC0086 |
All sequenced Rickettsia genomes encode a P-T4SS similar to the vir archetype of Agrobacterium tumefaciens and related systems, and this T4SS is encoded across all genomes in the rickettsial families Rickettsiaceae, Anaplasmataceae, and Midichloriaceae; lacks a homolog of VirB5, the minor pilin subunit that is indispensable for pilus formation but not substrate transfer; A defining feature of the rvh T4SS is the proliferation of genes encoding RvhB6 proteins, which are predicted IM channel components of the VirB6/TrbL family that are required for substrate transfer in P-T4SSs;Three other components are encoded by duplicate genes within the rvh T4SS: RvhB4a and RvhB4b--homologous to VirB4 (IM ATPase), RvhB9a and RvhB9b--homologous to Vir9 (participating with VirB7 and VirB10 in the OM pore of the T4SS), two VirB8-like channel proteins, RvhB8a and RvhB8b |
(rvhB9a) type IV secretion system protein VirB9-like conjugal transfer protein precursor [Rvh T4SS (VF0488) - Effector delivery system (VFC0086)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_401 |
85.345 |
1.11E-135 |
rvhB8a |
VF0488 |
Rvh T4SS |
Effector delivery system |
VFC0086 |
All sequenced Rickettsia genomes encode a P-T4SS similar to the vir archetype of Agrobacterium tumefaciens and related systems, and this T4SS is encoded across all genomes in the rickettsial families Rickettsiaceae, Anaplasmataceae, and Midichloriaceae; lacks a homolog of VirB5, the minor pilin subunit that is indispensable for pilus formation but not substrate transfer; A defining feature of the rvh T4SS is the proliferation of genes encoding RvhB6 proteins, which are predicted IM channel components of the VirB6/TrbL family that are required for substrate transfer in P-T4SSs;Three other components are encoded by duplicate genes within the rvh T4SS: RvhB4a and RvhB4b--homologous to VirB4 (IM ATPase), RvhB9a and RvhB9b--homologous to Vir9 (participating with VirB7 and VirB10 in the OM pore of the T4SS), two VirB8-like channel proteins, RvhB8a and RvhB8b |
(rvhB8a) VirB8-like protein of type IV secretion system [Rvh T4SS (VF0488) - Effector delivery system (VFC0086)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_403 |
90.123 |
3.13E-155 |
rvhB8b |
VF0488 |
Rvh T4SS |
Effector delivery system |
VFC0086 |
All sequenced Rickettsia genomes encode a P-T4SS similar to the vir archetype of Agrobacterium tumefaciens and related systems, and this T4SS is encoded across all genomes in the rickettsial families Rickettsiaceae, Anaplasmataceae, and Midichloriaceae; lacks a homolog of VirB5, the minor pilin subunit that is indispensable for pilus formation but not substrate transfer; A defining feature of the rvh T4SS is the proliferation of genes encoding RvhB6 proteins, which are predicted IM channel components of the VirB6/TrbL family that are required for substrate transfer in P-T4SSs;Three other components are encoded by duplicate genes within the rvh T4SS: RvhB4a and RvhB4b--homologous to VirB4 (IM ATPase), RvhB9a and RvhB9b--homologous to Vir9 (participating with VirB7 and VirB10 in the OM pore of the T4SS), two VirB8-like channel proteins, RvhB8a and RvhB8b |
(rvhB8b) VirB8-like protein of the Type IV secretion system [Rvh T4SS (VF0488) - Effector delivery system (VFC0086)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_404 |
91.772 |
5.27E-107 |
rvhB9b |
VF0488 |
Rvh T4SS |
Effector delivery system |
VFC0086 |
All sequenced Rickettsia genomes encode a P-T4SS similar to the vir archetype of Agrobacterium tumefaciens and related systems, and this T4SS is encoded across all genomes in the rickettsial families Rickettsiaceae, Anaplasmataceae, and Midichloriaceae; lacks a homolog of VirB5, the minor pilin subunit that is indispensable for pilus formation but not substrate transfer; A defining feature of the rvh T4SS is the proliferation of genes encoding RvhB6 proteins, which are predicted IM channel components of the VirB6/TrbL family that are required for substrate transfer in P-T4SSs;Three other components are encoded by duplicate genes within the rvh T4SS: RvhB4a and RvhB4b--homologous to VirB4 (IM ATPase), RvhB9a and RvhB9b--homologous to Vir9 (participating with VirB7 and VirB10 in the OM pore of the T4SS), two VirB8-like channel proteins, RvhB8a and RvhB8b |
(rvhB9b) VirB9-like protein precursor of the type IV secretion system [Rvh T4SS (VF0488) - Effector delivery system (VFC0086)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_405 |
86.128 |
0.0 |
rvhB10 |
VF0488 |
Rvh T4SS |
Effector delivery system |
VFC0086 |
All sequenced Rickettsia genomes encode a P-T4SS similar to the vir archetype of Agrobacterium tumefaciens and related systems, and this T4SS is encoded across all genomes in the rickettsial families Rickettsiaceae, Anaplasmataceae, and Midichloriaceae; lacks a homolog of VirB5, the minor pilin subunit that is indispensable for pilus formation but not substrate transfer; A defining feature of the rvh T4SS is the proliferation of genes encoding RvhB6 proteins, which are predicted IM channel components of the VirB6/TrbL family that are required for substrate transfer in P-T4SSs;Three other components are encoded by duplicate genes within the rvh T4SS: RvhB4a and RvhB4b--homologous to VirB4 (IM ATPase), RvhB9a and RvhB9b--homologous to Vir9 (participating with VirB7 and VirB10 in the OM pore of the T4SS), two VirB8-like channel proteins, RvhB8a and RvhB8b |
(rvhB10) VirB10-like protein of the type IV secretion system [Rvh T4SS (VF0488) - Effector delivery system (VFC0086)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_406 |
95.21 |
0.0 |
rvhB11 |
VF0488 |
Rvh T4SS |
Effector delivery system |
VFC0086 |
All sequenced Rickettsia genomes encode a P-T4SS similar to the vir archetype of Agrobacterium tumefaciens and related systems, and this T4SS is encoded across all genomes in the rickettsial families Rickettsiaceae, Anaplasmataceae, and Midichloriaceae; lacks a homolog of VirB5, the minor pilin subunit that is indispensable for pilus formation but not substrate transfer; A defining feature of the rvh T4SS is the proliferation of genes encoding RvhB6 proteins, which are predicted IM channel components of the VirB6/TrbL family that are required for substrate transfer in P-T4SSs;Three other components are encoded by duplicate genes within the rvh T4SS: RvhB4a and RvhB4b--homologous to VirB4 (IM ATPase), RvhB9a and RvhB9b--homologous to Vir9 (participating with VirB7 and VirB10 in the OM pore of the T4SS), two VirB8-like channel proteins, RvhB8a and RvhB8b |
(rvhB11) type IV secretion system ATPase VirB11 [Rvh T4SS (VF0488) - Effector delivery system (VFC0086)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_407 |
95.093 |
0.0 |
rvhD4 |
VF0488 |
Rvh T4SS |
Effector delivery system |
VFC0086 |
All sequenced Rickettsia genomes encode a P-T4SS similar to the vir archetype of Agrobacterium tumefaciens and related systems, and this T4SS is encoded across all genomes in the rickettsial families Rickettsiaceae, Anaplasmataceae, and Midichloriaceae; lacks a homolog of VirB5, the minor pilin subunit that is indispensable for pilus formation but not substrate transfer; A defining feature of the rvh T4SS is the proliferation of genes encoding RvhB6 proteins, which are predicted IM channel components of the VirB6/TrbL family that are required for substrate transfer in P-T4SSs;Three other components are encoded by duplicate genes within the rvh T4SS: RvhB4a and RvhB4b--homologous to VirB4 (IM ATPase), RvhB9a and RvhB9b--homologous to Vir9 (participating with VirB7 and VirB10 in the OM pore of the T4SS), two VirB8-like channel proteins, RvhB8a and RvhB8b |
(rvhD4) type IV secretion system component VirD4 [Rvh T4SS (VF0488) - Effector delivery system (VFC0086)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_481 |
61.449 |
5.75E-158 |
cps4J |
VF0144 |
Capsule |
Immune modulation |
VFC0258 |
Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages |
(cps4J) capsular polysaccharide biosynthesis protein Cps4J [Capsule (VF0144) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| AE006914.1_698 |
63.934 |
0.0 |
sca4 |
VF0502 |
Sca4 |
Others |
VFC0346 |
Lack the beta domain, no recognizable homology between Sca4 proteins and other Sca families, so it is unclear how Sca4 is translocated out of the rickettsial cell |
(sca4) cell surface antigen Sca4 [Sca4 (VF0502) - Others (VFC0346)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_801 |
81.935 |
1.42E-88 |
pat2 |
VF0494 |
Phospholipase A2 |
Exotoxin |
VFC0235 |
Two PLA2 enzymes (pat1 and pat2) have divergent evolutionary histories and discordant selective constraints, with pat2 deleted from most other non-TG rickettsiae genomes, while pat1 homologs are encoded in all sequenced Rickettsia genomes; Pat1 and Pat2 may be rvh T4SS substrates |
(pat2) esterase of alpha/beta hydrolase family [Phospholipase A2 (VF0494) - Exotoxin (VFC0235)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_802 |
82.09 |
8.27E-118 |
pat2 |
VF0494 |
Phospholipase A2 |
Exotoxin |
VFC0235 |
Two PLA2 enzymes (pat1 and pat2) have divergent evolutionary histories and discordant selective constraints, with pat2 deleted from most other non-TG rickettsiae genomes, while pat1 homologs are encoded in all sequenced Rickettsia genomes; Pat1 and Pat2 may be rvh T4SS substrates |
(pat2) esterase of alpha/beta hydrolase family [Phospholipase A2 (VF0494) - Exotoxin (VFC0235)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_940 |
100.0 |
0.0 |
rickA |
VF0490 |
RickA |
Motility |
VFC0204 |
Spotted fever group Rickettsia differ from other pathogens in possessing two actin-polymerizing proteins: RickA, an activator of the host Arp2/3 complex, and Sca2, a mimic of host formins; RickA generating short, curved actin tails early during infection and Sca2 generating long, straight actin tails later in infection; considered a likely substrate of the rvh T4SS because of the lack of N-terminal Sec secretion signal and transmembrane spanning regions |
(rickA) WASP, N-WASP, MENA proteins [RickA (VF0490) - Motility (VFC0204)] [Rickettsia conorii str. Malish 7] |
Rickettsia conorii |
| AE006914.1_953 |
78.296 |
0.0 |
pat1 |
VF0494 |
Phospholipase A2 |
Exotoxin |
VFC0235 |
Two PLA2 enzymes (pat1 and pat2) have divergent evolutionary histories and discordant selective constraints, with pat2 deleted from most other non-TG rickettsiae genomes, while pat1 homologs are encoded in all sequenced Rickettsia genomes; Pat1 and Pat2 may be rvh T4SS substrates |
(pat1) patatin-like phospholipase [Phospholipase A2 (VF0494) - Exotoxin (VFC0235)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_1001 |
60.456 |
0.0 |
htpB |
VF0159 |
Hsp60 |
Adherence |
VFC0001 |
|
(htpB) Hsp60, 60K heat shock protein HtpB [Hsp60 (VF0159) - Adherence (VFC0001)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] |
Legionella pneumophila |
| AE006914.1_1041 |
74.745 |
0.0 |
tufA |
VF0460 |
EF-Tu |
Adherence |
VFC0001 |
|
(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| AE006914.1_1126 |
71.79 |
0.0 |
ompB |
VF0493 |
ROmpB/Sca5 |
Invasion |
VFC0083 |
A high degree of conservation in both the spotted fever group and typhus group; rOmpB is expressed as a pre-protein (168 kDa) and cleaved to release the passenger domain (120 kDa) from the beta-barrel translocation domain (32 kDa), leaving the mature 120-kDa domain associated with the outer leaflet of the outer membrane |
(ompB) outer membrane protein OmpB [ROmpB/Sca5 (VF0493) - Invasion (VFC0083)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_1193 |
89.789 |
0.0 |
tlyC |
VF0489 |
TlyC |
Exoenzyme |
VFC0251 |
|
(tlyC) hemolysin C [TlyC (VF0489) - Exoenzyme (VFC0251)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_1269 |
91.213 |
0.0 |
rvhB4b |
VF0488 |
Rvh T4SS |
Effector delivery system |
VFC0086 |
All sequenced Rickettsia genomes encode a P-T4SS similar to the vir archetype of Agrobacterium tumefaciens and related systems, and this T4SS is encoded across all genomes in the rickettsial families Rickettsiaceae, Anaplasmataceae, and Midichloriaceae; lacks a homolog of VirB5, the minor pilin subunit that is indispensable for pilus formation but not substrate transfer; A defining feature of the rvh T4SS is the proliferation of genes encoding RvhB6 proteins, which are predicted IM channel components of the VirB6/TrbL family that are required for substrate transfer in P-T4SSs;Three other components are encoded by duplicate genes within the rvh T4SS: RvhB4a and RvhB4b--homologous to VirB4 (IM ATPase), RvhB9a and RvhB9b--homologous to Vir9 (participating with VirB7 and VirB10 in the OM pore of the T4SS), two VirB8-like channel proteins, RvhB8a and RvhB8b |
(rvhB4b) type IV secretion system protein VirB4 precursor [Rvh T4SS (VF0488) - Effector delivery system (VFC0086)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_1323 |
81.0 |
3.99E-120 |
pld |
VF0491 |
Pld |
Exotoxin |
VFC0235 |
|
(pld) phospholipase D [Pld (VF0491) - Exotoxin (VFC0235)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_1327 |
90.016 |
0.0 |
ompA |
VF0492 |
ROmpA/Sca0 |
Adherence |
VFC0001 |
Conserved throughout the spotted fever group |
(ompA) surface cell antigen 0 (Sca0), autotransporter [ROmpA/Sca0 (VF0492) - Adherence (VFC0001)] [Rickettsia rickettsii str. Sheila Smith] |
Rickettsia rickettsii |
| AE006914.1_1337 |
69.65 |
8.81E-108 |
adr1 |
VF0496 |
Adr1 |
Immune modulation |
VFC0258 |
"An integral outer-membrane protein containing eight membrane-embedded beta-strands and four ""loop"" regions that are exposed to extracellular milieu; belongs to a family of gram-negative outer membrane proteins embodied by E. coli OmpX. Some members of this protein family, namely Yersinia enterolitica Ail and Salmonella typhimurium Rck." |
(adr1) outer-membrane protein Adr1 [Adr1 (VF0496) - Immune modulation (VFC0258)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |
| AE006914.1_1338 |
76.211 |
5.93E-120 |
adr2 |
VF0497 |
Adr2 |
Immune modulation |
VFC0258 |
In all Rickettsia genomes, two Adr paralogs are encoded adjacent to one another and share ~45% aa identity |
(adr2) outer-membrane protein Adr2 [Adr2 (VF0497) - Immune modulation (VFC0258)] [Rickettsia typhi str. Wilmington] |
Rickettsia typhi |