| AE008917.1_57 |
100.0 |
0.0 |
bmaB/omaA |
VF1340 |
BmaB/OmaA |
Adherence |
VFC0001 |
Monomeric autotransporter that shares significant sequence similarities with BmaC |
(bmaB/omaA) autotransporter outer membrane beta-barrel domain-containing protein [BmaB/OmaA (VF1340) - Adherence (VFC0001)] [Brucella melitensis bv. 1 str. 16M] |
Brucella suis |
| AE008917.1_59 |
100.0 |
0.0 |
bigB |
VF1345 |
BigB |
Adherence |
VFC0001 |
|
(bigB) adhesin with a bacterial immunoglobulin-like domain [BigB (VF1345) - Adherence (VFC0001)] [Brucella melitensis bv. 1 str. 16M] |
Brucella abortus |
| AE008917.1_62 |
95.935 |
9.36E-76 |
bigA |
VF1344 |
BigA |
Adherence |
VFC0001 |
|
(bigA) adhesin with a bacterial immunoglobulin-like domain [BigA (VF1344) - Adherence (VFC0001)] [Brucella canis ATCC 23365] |
Brucella abortus |
| AE008917.1_63 |
99.215 |
0.0 |
bigA |
VF1344 |
BigA |
Adherence |
VFC0001 |
|
(bigA) adhesin with a bacterial immunoglobulin-like domain [BigA (VF1344) - Adherence (VFC0001)] [Brucella canis ATCC 23365] |
Brucella abortus |
| AE008917.1_66 |
100.0 |
1.22E-107 |
BPE005 |
VF0695 |
T4SS secreted effectors |
Effector delivery system |
VFC0086 |
|
(BPE005) type IV secretion system effector, cyclic nucleotide-binding domain-containing protein [T4SS secreted effectors (VF0695) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_118 |
100.0 |
0.0 |
bspF |
VF0695 |
T4SS secreted effectors |
Effector delivery system |
VFC0086 |
|
(bspF) type IV secretion system effector, GNAT family N-acetyltransferase [T4SS secreted effectors (VF0695) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_365 |
100.0 |
0.0 |
bspE |
VF0695 |
T4SS secreted effectors |
Effector delivery system |
VFC0086 |
|
(bspE) type IV secretion system effector BspE [T4SS secreted effectors (VF0695) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_384 |
100.0 |
1.34E-75 |
vceA |
VF0695 |
T4SS secreted effectors |
Effector delivery system |
VFC0086 |
|
(vceA) Type IV secretion system effector VceA [T4SS secreted effectors (VF0695) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_405 |
66.341 |
0.0 |
icl |
VF0253 |
Isocitrate lyase |
Others |
VFC0346 |
|
(icl) Isocitrate lyase Icl (isocitrase) (isocitratase) [Isocitrate lyase (VF0253) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| AE008917.1_491 |
100.0 |
7.49E-123 |
bspL |
VF0695 |
T4SS secreted effectors |
Effector delivery system |
VFC0086 |
|
(bspL) type IV secretion system effector BspL [T4SS secreted effectors (VF0695) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_502 |
100.0 |
0.0 |
lpsB/lpcC |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(lpsB/lpcC) Lipopolysaccharide core biosynthesis mannosyltransferase LpcC [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_529 |
100.0 |
1.83E-142 |
sepA |
VF0695 |
T4SS secreted effectors |
Effector delivery system |
VFC0086 |
|
(sepA) type IV secretion system effector SepA [T4SS secreted effectors (VF0695) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_575 |
100.0 |
0.0 |
lpxC |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(lpxC) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_634 |
61.809 |
1.66E-86 |
ureG |
VF0050 |
Urease |
Stress survival |
VFC0282 |
|
(ureG) urease accessory protein (ureG) [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] |
Helicobacter pylori |
| AE008917.1_724 |
100.0 |
1.3E-130 |
ricA |
VF0695 |
T4SS secreted effectors |
Effector delivery system |
VFC0086 |
|
(ricA) type IV secretion system effector RicA, Rab2 interacting conserved protein A [T4SS secreted effectors (VF0695) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_728 |
100.0 |
7.41E-176 |
BPE275 |
VF0695 |
T4SS secreted effectors |
Effector delivery system |
VFC0086 |
|
(BPE275) type IV secretion system effector, rhomboid family intramembrane serine protease [T4SS secreted effectors (VF0695) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_731 |
75.0 |
0.0 |
tufA |
VF0460 |
EF-Tu |
Adherence |
VFC0001 |
|
(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| AE008917.1_744 |
75.0 |
0.0 |
tufA |
VF0460 |
EF-Tu |
Adherence |
VFC0001 |
|
(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| AE008917.1_821 |
100.0 |
0.0 |
lpxD |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(lpxD) UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_822 |
100.0 |
1.39E-115 |
fabZ |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(fabZ) (3R)-hydroxymyristoyl ACP dehydratase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_823 |
100.0 |
0.0 |
lpxA |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(lpxA) UDP-N-acetylglucosamine acyltransferase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_825 |
100.0 |
0.0 |
lpxB |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(lpxB) lipid-A-disaccharide synthase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_840 |
100.0 |
0.0 |
kdsA |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_933 |
100.0 |
0.0 |
vceC |
VF0695 |
T4SS secreted effectors |
Effector delivery system |
VFC0086 |
|
(vceC) type IV secretion system effector VceC [T4SS secreted effectors (VF0695) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_946 |
100.0 |
0.0 |
BPE043 |
VF0695 |
T4SS secreted effectors |
Effector delivery system |
VFC0086 |
|
(BPE043) type IV secretion system effector [T4SS secreted effectors (VF0695) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_981 |
100.0 |
0.0 |
wbdA |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(wbdA) mannosyltransferase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_982 |
100.0 |
0.0 |
wboA |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(wboA) glycosyltransferase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1097 |
100.0 |
1.52E-64 |
acpXL |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1101 |
100.0 |
0.0 |
htrB |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(htrB) lipid A biosynthesis lauroyl acyltransferase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1122 |
100.0 |
3.59E-96 |
bspC |
VF0695 |
T4SS secreted effectors |
Effector delivery system |
VFC0086 |
|
(bspC) type IV secretion system effector BspC [T4SS secreted effectors (VF0695) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1202 |
100.0 |
0.0 |
lpxE |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(lpxE) phosphatidylglycerophosphatase B [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1207 |
99.315 |
0.0 |
btpB |
VF0522 |
BtpB |
Immune modulation |
VFC0258 |
Translocated into host cells; may be the substrates for the VirB T4SS |
(btpB) Tir domain containing protein BtpB [BtpB (VF0522) - Immune modulation (VFC0258)] [Brucella suis 1330] |
Brucella suis |
| AE008917.1_1250 |
100.0 |
4.12E-136 |
bspB |
VF0695 |
T4SS secreted effectors |
Effector delivery system |
VFC0086 |
|
(bspB) type IV secretion system effector BspB [T4SS secreted effectors (VF0695) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1282 |
100.0 |
3.12E-137 |
bspA |
VF0695 |
T4SS secreted effectors |
Effector delivery system |
VFC0086 |
|
(bspA) type IV secretion system effector, DUF2062 domain-containing protein [T4SS secreted effectors (VF0695) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1319 |
100.0 |
0.0 |
lpsA |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(lpsA) glycosyltransferase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1386 |
100.0 |
0.0 |
wbpZ |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(wbpZ) mannosyltransferase C [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1387 |
100.0 |
0.0 |
manAoAg |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(manAoAg) mannose-6-phosphate isomerase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1388 |
100.0 |
0.0 |
manCoAg |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(manCoAg) mannose-1-phosphate guanylyltransferase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1389 |
100.0 |
0.0 |
pmm |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(pmm) phosphomannomutase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1395 |
100.0 |
0.0 |
wbkA |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(wbkA) mannosyltransferase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1401 |
100.0 |
0.0 |
gmd |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(gmd) GDP-mannose 4,6-dehydratase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1402 |
100.0 |
0.0 |
per |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(per) perosamine synthetase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1403 |
100.0 |
0.0 |
wzm |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(wzm) O-antigen export system permease protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1404 |
100.0 |
0.0 |
wzt |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(wzt) O-antigen export system ATP-binding protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1405 |
100.0 |
0.0 |
wbkB |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(wbkB) perosamine synthetase WbkB [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1406 |
100.0 |
0.0 |
wbkC |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(wbkC) GDP-mannose 4,6-dehydratase / GDP-4-amino-4,6-dideoxy-D-mannose formyltransferase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1411 |
100.0 |
0.0 |
wbpL |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(wbpL) undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1461 |
100.0 |
9.63E-50 |
acpXL |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1635 |
60.808 |
0.0 |
ureB |
VF0050 |
Urease |
Stress survival |
VFC0282 |
|
(ureB) urease beta subunit UreB, urea amidohydrolase [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] |
Helicobacter pylori |
| AE008917.1_1654 |
100.0 |
0.0 |
btpA |
VF0412 |
BtpA/Btp1/TcpB |
Immune modulation |
VFC0258 |
Translocated by Brucella into host cells; may be substrates of the VirB T4SS |
(btpA) Tir domain containing protein BtpA [BtpA/Btp1/TcpB (VF0412) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1815 |
100.0 |
0.0 |
cgs |
VF0366 |
CbetaG |
Immune modulation |
VFC0258 |
Cyclic beta-1,2-glucan synthase (Cgs), the enzyme responsible for the synthesis of cyclic beta-1,2-glucans, is a 320-kDa polytopic integral inner membrane protein with six transmembrane-spanning segments |
(cgs) cyclic beta 1-2 glucan synthetase [CbetaG (VF0366) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1852 |
99.148 |
0.0 |
btaE |
VF1342 |
BtaE |
Adherence |
VFC0001 |
Both the BmaC and BtaE adhesins are consistently associated with the new cell pole, suggesting that, in Brucella, the new pole is functionally differentiated for adhesion |
(btaE) Trimeric autotransporter adhesin, YadA-like family protein [BtaE (VF1342) - Adherence (VFC0001)] [Brucella melitensis biovar Abortus 2308] |
Brucella suis |
| AE008917.1_1853 |
93.281 |
0.0 |
btaE |
VF1342 |
BtaE |
Adherence |
VFC0001 |
Both the BmaC and BtaE adhesins are consistently associated with the new cell pole, suggesting that, in Brucella, the new pole is functionally differentiated for adhesion |
(btaE) Trimeric autotransporter adhesin, YadA-like family protein [BtaE (VF1342) - Adherence (VFC0001)] [Brucella melitensis biovar Abortus 2308] |
Brucella suis |
| AE008917.1_1866 |
100.0 |
0.0 |
pgm |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(pgm) phosphoglucomutase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_1884 |
100.0 |
0.0 |
kdsB |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(kdsB) 3-deoxy-manno-octulosonate cytidylyltransferase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_2009 |
100.0 |
0.0 |
bvrS |
VF0368 |
BvrR-BvrS |
Regulation |
VFC0301 |
Homologous to the ChvI/ExoS and ChvI/ChvG two-component regulatory systems of Sinorhizobium meliloti and Agrobacterium tumefaciens respectively. Like their Brucella counterpart, the S. meliloti ChvI/ExoS and A. tumefaciens ChvI/ChvG two component regulatory systems also regulate genes involved in modulating cell envelope properties (outer membrane protein composition and lipid A modifications), but, more importantly, the genes that comprise the ChvI/ExoS and ChvI/ChvG regulons are essential for the establishment and maintenance of the symbiotic state of S. meliloti with its plant host and disease production by A. tumefaciens in its plant host. |
(bvrS) stimulus-sensing domain-containing protein [BvrR-BvrS (VF0368) - Regulation (VFC0301)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008917.1_2010 |
100.0 |
2.84E-178 |
bvrR |
VF0368 |
BvrR-BvrS |
Regulation |
VFC0301 |
Homologous to the ChvI/ExoS and ChvI/ChvG two-component regulatory systems of Sinorhizobium meliloti and Agrobacterium tumefaciens respectively. Like their Brucella counterpart, the S. meliloti ChvI/ExoS and A. tumefaciens ChvI/ChvG two component regulatory systems also regulate genes involved in modulating cell envelope properties (outer membrane protein composition and lipid A modifications), but, more importantly, the genes that comprise the ChvI/ExoS and ChvI/ChvG regulons are essential for the establishment and maintenance of the symbiotic state of S. meliloti with its plant host and disease production by A. tumefaciens in its plant host. |
(bvrR) response regulator transcription factor [BvrR-BvrS (VF0368) - Regulation (VFC0301)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_24 |
100.0 |
3.95E-178 |
virB1 |
VF0365 |
VirB type IV secretion system |
Effector delivery system |
VFC0086 |
Phagosome acidification is required for intracellular expression of the VirB type IV secretion system; the LuxR family regulator VjbR regulated the virB operon directly by bounding a fragment of the virB promoter containing an 18 bp palindromic motif |
(virB1) type IV secretion system attachment mediating protein VirB1 Homolog [VirB type IV secretion system (VF0365) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_25 |
100.0 |
2.67E-72 |
virB2 |
VF0365 |
VirB type IV secretion system |
Effector delivery system |
VFC0086 |
Phagosome acidification is required for intracellular expression of the VirB type IV secretion system; the LuxR family regulator VjbR regulated the virB operon directly by bounding a fragment of the virB promoter containing an 18 bp palindromic motif |
(virB2) type IV secretion system protein VirB2 [VirB type IV secretion system (VF0365) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_26 |
100.0 |
2.15E-83 |
virB3 |
VF0365 |
VirB type IV secretion system |
Effector delivery system |
VFC0086 |
Phagosome acidification is required for intracellular expression of the VirB type IV secretion system; the LuxR family regulator VjbR regulated the virB operon directly by bounding a fragment of the virB promoter containing an 18 bp palindromic motif |
(virB3) type IV secretion system protein VirB3 [VirB type IV secretion system (VF0365) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_27 |
100.0 |
0.0 |
virB4 |
VF0365 |
VirB type IV secretion system |
Effector delivery system |
VFC0086 |
Phagosome acidification is required for intracellular expression of the VirB type IV secretion system; the LuxR family regulator VjbR regulated the virB operon directly by bounding a fragment of the virB promoter containing an 18 bp palindromic motif |
(virB4) type IV secretion system protein ATPase VirB4 [VirB type IV secretion system (VF0365) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_28 |
100.0 |
0.0 |
virB5 |
VF0365 |
VirB type IV secretion system |
Effector delivery system |
VFC0086 |
Phagosome acidification is required for intracellular expression of the VirB type IV secretion system; the LuxR family regulator VjbR regulated the virB operon directly by bounding a fragment of the virB promoter containing an 18 bp palindromic motif |
(virB5) type IV secretion system protein VirB5 [VirB type IV secretion system (VF0365) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_29 |
100.0 |
0.0 |
virB6 |
VF0365 |
VirB type IV secretion system |
Effector delivery system |
VFC0086 |
Phagosome acidification is required for intracellular expression of the VirB type IV secretion system; the LuxR family regulator VjbR regulated the virB operon directly by bounding a fragment of the virB promoter containing an 18 bp palindromic motif |
(virB6) type IV secretion system channel protein VirB6 [VirB type IV secretion system (VF0365) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_30 |
100.0 |
2.82E-36 |
virB7 |
VF0365 |
VirB type IV secretion system |
Effector delivery system |
VFC0086 |
Phagosome acidification is required for intracellular expression of the VirB type IV secretion system; the LuxR family regulator VjbR regulated the virB operon directly by bounding a fragment of the virB promoter containing an 18 bp palindromic motif |
(virB7) type IV secretion system protein VirB7 [VirB type IV secretion system (VF0365) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_31 |
100.0 |
0.0 |
virB8 |
VF0365 |
VirB type IV secretion system |
Effector delivery system |
VFC0086 |
Phagosome acidification is required for intracellular expression of the VirB type IV secretion system; the LuxR family regulator VjbR regulated the virB operon directly by bounding a fragment of the virB promoter containing an 18 bp palindromic motif |
(virB8) type IV secretion system protein VirB8 [VirB type IV secretion system (VF0365) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_32 |
99.595 |
0.0 |
virB9 |
VF0365 |
VirB type IV secretion system |
Effector delivery system |
VFC0086 |
Phagosome acidification is required for intracellular expression of the VirB type IV secretion system; the LuxR family regulator VjbR regulated the virB operon directly by bounding a fragment of the virB promoter containing an 18 bp palindromic motif |
(virB9) type IV secretion system channel protein VirB9 [VirB type IV secretion system (VF0365) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_33 |
100.0 |
0.0 |
virB10 |
VF0365 |
VirB type IV secretion system |
Effector delivery system |
VFC0086 |
Phagosome acidification is required for intracellular expression of the VirB type IV secretion system; the LuxR family regulator VjbR regulated the virB operon directly by bounding a fragment of the virB promoter containing an 18 bp palindromic motif |
(virB10) type IV secretion system channel protein VirB10 [VirB type IV secretion system (VF0365) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_34 |
100.0 |
0.0 |
virB11 |
VF0365 |
VirB type IV secretion system |
Effector delivery system |
VFC0086 |
Phagosome acidification is required for intracellular expression of the VirB type IV secretion system; the LuxR family regulator VjbR regulated the virB operon directly by bounding a fragment of the virB promoter containing an 18 bp palindromic motif |
(virB11) type IV secretion system protein ATPase VirB11 [VirB type IV secretion system (VF0365) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_35 |
100.0 |
4.63E-126 |
virB12 |
VF0365 |
VirB type IV secretion system |
Effector delivery system |
VFC0086 |
Phagosome acidification is required for intracellular expression of the VirB type IV secretion system; the LuxR family regulator VjbR regulated the virB operon directly by bounding a fragment of the virB promoter containing an 18 bp palindromic motif |
(virB12) type IV secretion system protein VirB12 [VirB type IV secretion system (VF0365) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_52 |
66.703 |
0.0 |
mgtB |
VF0106 |
MgtB |
Nutritional/Metabolic factor |
VFC0272 |
A magnesium transporter |
(mgtB) Mg2+ transport protein [MgtB (VF0106) - Nutritional/Metabolic factor (VFC0272)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| AE008918.1_73 |
69.776 |
0.0 |
entE |
VF0467 |
Acinetobactin |
Nutritional/Metabolic factor |
VFC0272 |
|
(entE) non-ribosomal peptide synthetase adenylate-forming enzyme of acinetobactin synthesis [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] |
Acinetobacter baumannii |
| AE008918.1_74 |
66.207 |
1.18E-152 |
basF |
VF0467 |
Acinetobactin |
Nutritional/Metabolic factor |
VFC0272 |
|
(basF) aryl carrier protein BasF [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] |
Acinetobacter baumannii |
| AE008918.1_145 |
99.094 |
0.0 |
bmaC |
VF1341 |
BmaC |
Adherence |
VFC0001 |
|
(bmaC) autotransporter outer membrane beta-barrel domain-containing protein [BmaC (VF1341) - Adherence (VFC0001)] [Brucella suis 1330] |
Brucella suis |
| AE008918.1_146 |
99.685 |
0.0 |
bmaC |
VF1341 |
BmaC |
Adherence |
VFC0001 |
|
(bmaC) autotransporter outer membrane beta-barrel domain-containing protein [BmaC (VF1341) - Adherence (VFC0001)] [Brucella suis 1330] |
Brucella suis |
| AE008918.1_148 |
77.477 |
3.01E-120 |
fliF |
VF0373 |
Flagella |
Motility |
VFC0204 |
B. bacilliformis is highly motile due to the expression of multiple unipolar flagella. It has been suggested that nonmotile variants bind poorly and do not invade erythrocytes. But B. henselae, B. quintana, and B. tribocorum are nonflagellated but capable of invading erythrocytes, flagella cannot be essential for the process of erythrocyte invasion in these species. |
(fliF) flagellar M-ring protein FliF [Flagella (VF0373) - Motility (VFC0204)] [Bartonella bacilliformis KC583] |
Bartonella bacilliformis |
| AE008918.1_162 |
80.682 |
1.68E-45 |
fliQ |
VF0373 |
Flagella |
Motility |
VFC0204 |
B. bacilliformis is highly motile due to the expression of multiple unipolar flagella. It has been suggested that nonmotile variants bind poorly and do not invade erythrocytes. But B. henselae, B. quintana, and B. tribocorum are nonflagellated but capable of invading erythrocytes, flagella cannot be essential for the process of erythrocyte invasion in these species. |
(fliQ) flagellar biosynthetic protein FliQ [Flagella (VF0373) - Motility (VFC0204)] [Bartonella bacilliformis KC583] |
Bartonella bacilliformis |
| AE008918.1_164 |
74.703 |
0.0 |
flhA |
VF0373 |
Flagella |
Motility |
VFC0204 |
B. bacilliformis is highly motile due to the expression of multiple unipolar flagella. It has been suggested that nonmotile variants bind poorly and do not invade erythrocytes. But B. henselae, B. quintana, and B. tribocorum are nonflagellated but capable of invading erythrocytes, flagella cannot be essential for the process of erythrocyte invasion in these species. |
(flhA) flagellar biosynthesis protein FlhA [Flagella (VF0373) - Motility (VFC0204)] [Bartonella bacilliformis KC583] |
Bartonella bacilliformis |
| AE008918.1_567 |
62.195 |
1.3E-65 |
sodCI |
VF0109 |
SodCI |
Stress survival |
VFC0282 |
Encoded on the lysogenic phage Gifsy-2 |
(sodCI) Gifsy-2 prophage: superoxide dismutase precursor (Cu-Zn) [SodCI (VF0109) - Stress survival (VFC0282)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| AE008918.1_802 |
61.594 |
4.6E-55 |
msrA/B(pilB |
VF0456 |
MsrAB |
Stress survival |
VFC0282 |
Methionine sulfoxide reductases (Msr) are enzymes that catalyze the reduction of free and protein-bound methionine sulfoxide (MetSO) back to Met. Two structurally unrelated classes of Msrs have been described so far. MsrAs are stereo specific toward the S isomer on the sulfur of the sulfoxide function, whereas MsrBs are specific toward the R isomer |
(msrA/B(pilB)) trifunctional thioredoxin/methionine sulfoxide reductase A/B protein [MsrAB (VF0456) - Stress survival (VFC0282)] [Neisseria meningitidis MC58] |
Neisseria meningitidis |
| AE008918.1_831 |
64.045 |
6.28E-172 |
gmd |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(gmd) GDP-mannose 4,6-dehydratase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_876 |
60.606 |
0.0 |
katA |
VF0454 |
KatA |
Stress survival |
VFC0282 |
|
(katA) catalase [KatA (VF0454) - Stress survival (VFC0282)] [Neisseria meningitidis MC58] |
Neisseria meningitidis |
| AE008918.1_882 |
100.0 |
0.0 |
manBcore |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(manBcore) phosphomannomutase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_883 |
100.0 |
0.0 |
manCcore |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(manCcore) mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_1006 |
100.0 |
0.0 |
lpxK |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(lpxK) tetraacyldisaccharide 4'-kinase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_1007 |
100.0 |
0.0 |
waaA/kdtA |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(waaA/kdtA) lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_1025 |
66.163 |
0.0 |
htpB |
VF0159 |
Hsp60 |
Adherence |
VFC0001 |
|
(htpB) Hsp60, 60K heat shock protein HtpB [Hsp60 (VF0159) - Adherence (VFC0001)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] |
Legionella pneumophila |
| AE008918.1_1046 |
99.235 |
0.0 |
bmaA |
VF1339 |
BmaA |
Adherence |
VFC0001 |
Monomeric autotransporter that shares significant sequence similarities with BmaC;the bmaA and bmaC loci from Brucella melitensis are pseudogenes |
(bmaA) autotransporter outer membrane beta-barrel domain-containing protein [BmaA (VF1339) - Adherence (VFC0001)] [Brucella suis 1330] |
Brucella suis |
| AE008918.1_1047 |
97.656 |
1.05E-72 |
bmaA |
VF1339 |
BmaA |
Adherence |
VFC0001 |
Monomeric autotransporter that shares significant sequence similarities with BmaC;the bmaA and bmaC loci from Brucella melitensis are pseudogenes |
(bmaA) autotransporter outer membrane beta-barrel domain-containing protein [BmaA (VF1339) - Adherence (VFC0001)] [Brucella suis 1330] |
Brucella suis |
| AE008918.1_1057 |
76.132 |
1.73E-123 |
fliP |
VF0373 |
Flagella |
Motility |
VFC0204 |
B. bacilliformis is highly motile due to the expression of multiple unipolar flagella. It has been suggested that nonmotile variants bind poorly and do not invade erythrocytes. But B. henselae, B. quintana, and B. tribocorum are nonflagellated but capable of invading erythrocytes, flagella cannot be essential for the process of erythrocyte invasion in these species. |
(fliP) flagellar biosynthetic protein FliP [Flagella (VF0373) - Motility (VFC0204)] [Bartonella bacilliformis KC583] |
Bartonella bacilliformis |
| AE008918.1_1061 |
70.361 |
0.0 |
flgI |
VF0373 |
Flagella |
Motility |
VFC0204 |
B. bacilliformis is highly motile due to the expression of multiple unipolar flagella. It has been suggested that nonmotile variants bind poorly and do not invade erythrocytes. But B. henselae, B. quintana, and B. tribocorum are nonflagellated but capable of invading erythrocytes, flagella cannot be essential for the process of erythrocyte invasion in these species. |
(flgI) flagellar P-ring protein FlgI [Flagella (VF0373) - Motility (VFC0204)] [Bartonella bacilliformis KC583] |
Bartonella bacilliformis |
| AE008918.1_1063 |
64.885 |
1.02E-122 |
flgG |
VF0373 |
Flagella |
Motility |
VFC0204 |
B. bacilliformis is highly motile due to the expression of multiple unipolar flagella. It has been suggested that nonmotile variants bind poorly and do not invade erythrocytes. But B. henselae, B. quintana, and B. tribocorum are nonflagellated but capable of invading erythrocytes, flagella cannot be essential for the process of erythrocyte invasion in these species. |
(flgG) flagellar basal-body rod protein FlgG [Flagella (VF0373) - Motility (VFC0204)] [Bartonella bacilliformis KC583] |
Bartonella bacilliformis |
| AE008918.1_1065 |
61.765 |
1.76E-58 |
flgC |
VF0373 |
Flagella |
Motility |
VFC0204 |
B. bacilliformis is highly motile due to the expression of multiple unipolar flagella. It has been suggested that nonmotile variants bind poorly and do not invade erythrocytes. But B. henselae, B. quintana, and B. tribocorum are nonflagellated but capable of invading erythrocytes, flagella cannot be essential for the process of erythrocyte invasion in these species. |
(flgC) flagellar basal-body rod protein FlgC [Flagella (VF0373) - Motility (VFC0204)] [Bartonella bacilliformis KC583] |
Bartonella bacilliformis |
| AE008918.1_1082 |
67.391 |
1.03E-180 |
fliI |
VF0373 |
Flagella |
Motility |
VFC0204 |
B. bacilliformis is highly motile due to the expression of multiple unipolar flagella. It has been suggested that nonmotile variants bind poorly and do not invade erythrocytes. But B. henselae, B. quintana, and B. tribocorum are nonflagellated but capable of invading erythrocytes, flagella cannot be essential for the process of erythrocyte invasion in these species. |
(fliI) flagellar specific ATP synthase [Flagella (VF0373) - Motility (VFC0204)] [Bartonella bacilliformis KC583] |
Bartonella bacilliformis |
| AE008918.1_1086 |
68.276 |
8.9E-155 |
motA |
VF0373 |
Flagella |
Motility |
VFC0204 |
B. bacilliformis is highly motile due to the expression of multiple unipolar flagella. It has been suggested that nonmotile variants bind poorly and do not invade erythrocytes. But B. henselae, B. quintana, and B. tribocorum are nonflagellated but capable of invading erythrocytes, flagella cannot be essential for the process of erythrocyte invasion in these species. |
(motA) lateral flagellar motor protein MotA [Flagella (VF0373) - Motility (VFC0204)] [Bartonella bacilliformis KC583] |
Bartonella bacilliformis |
| AE008918.1_1088 |
100.0 |
6.84E-105 |
BPE123 |
VF0695 |
T4SS secreted effectors |
Effector delivery system |
VFC0086 |
|
(BPE123) type IV secretion system effector [T4SS secreted effectors (VF0695) - Effector delivery system (VFC0086)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| AE008918.1_1093 |
61.582 |
6.78E-150 |
flhB |
VF0373 |
Flagella |
Motility |
VFC0204 |
B. bacilliformis is highly motile due to the expression of multiple unipolar flagella. It has been suggested that nonmotile variants bind poorly and do not invade erythrocytes. But B. henselae, B. quintana, and B. tribocorum are nonflagellated but capable of invading erythrocytes, flagella cannot be essential for the process of erythrocyte invasion in these species. |
(flhB) flagellar biosynthetic protein FlhB [Flagella (VF0373) - Motility (VFC0204)] [Bartonella bacilliformis KC583] |
Bartonella bacilliformis |