| AE009948.1_392 |
87.119 |
0.0 |
hasC |
VF0244 |
Hyaluronic acid capsule |
Immune modulation |
VFC0258 |
|
(hasC) UTP--glucose-1-phosphate uridylyltransferase HasC [Hyaluronic acid capsule (VF0244) - Immune modulation (VFC0258)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| AE009948.1_628 |
100.0 |
0.0 |
GBS_RS03565 |
VF0527 |
PI-1 |
Adherence |
VFC0001 |
The genes encoding pili are located within 2 distinct loci, denoted pilus islands 1 and 2 (PI-1 and PI-2), the latter having 2 allelic variants (PI-2a and PI-2b); Each pilus island (PI) comprises 3 genes that encode structural proteins with a characteristic LPXTG anchoring motif recognised by sortase transpeptidases: backbone (Bkb) subunit (forming the polymeric shaft of the pilus), ancillary subunit 1 (An1, the functional tip), and ancillary subunit 2 (An2, the C-terminal anchor following attachment to peptidoglycan in the cell wall by sortase A) |
(GBS_RS03565) major subunit protein [PI-1 (VF0527) - Adherence (VFC0001)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_629 |
100.0 |
0.0 |
GBS_RS03570 |
VF0527 |
PI-1 |
Adherence |
VFC0001 |
The genes encoding pili are located within 2 distinct loci, denoted pilus islands 1 and 2 (PI-1 and PI-2), the latter having 2 allelic variants (PI-2a and PI-2b); Each pilus island (PI) comprises 3 genes that encode structural proteins with a characteristic LPXTG anchoring motif recognised by sortase transpeptidases: backbone (Bkb) subunit (forming the polymeric shaft of the pilus), ancillary subunit 1 (An1, the functional tip), and ancillary subunit 2 (An2, the C-terminal anchor following attachment to peptidoglycan in the cell wall by sortase A) |
(GBS_RS03570) LPXTG cell wall anchor domain-containing protein [PI-1 (VF0527) - Adherence (VFC0001)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_630 |
99.672 |
0.0 |
srtC1 |
VF0527 |
PI-1 |
Adherence |
VFC0001 |
The genes encoding pili are located within 2 distinct loci, denoted pilus islands 1 and 2 (PI-1 and PI-2), the latter having 2 allelic variants (PI-2a and PI-2b); Each pilus island (PI) comprises 3 genes that encode structural proteins with a characteristic LPXTG anchoring motif recognised by sortase transpeptidases: backbone (Bkb) subunit (forming the polymeric shaft of the pilus), ancillary subunit 1 (An1, the functional tip), and ancillary subunit 2 (An2, the C-terminal anchor following attachment to peptidoglycan in the cell wall by sortase A) |
(srtC1) class C sortase [PI-1 (VF0527) - Adherence (VFC0001)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_631 |
100.0 |
0.0 |
srtC2 |
VF0527 |
PI-1 |
Adherence |
VFC0001 |
The genes encoding pili are located within 2 distinct loci, denoted pilus islands 1 and 2 (PI-1 and PI-2), the latter having 2 allelic variants (PI-2a and PI-2b); Each pilus island (PI) comprises 3 genes that encode structural proteins with a characteristic LPXTG anchoring motif recognised by sortase transpeptidases: backbone (Bkb) subunit (forming the polymeric shaft of the pilus), ancillary subunit 1 (An1, the functional tip), and ancillary subunit 2 (An2, the C-terminal anchor following attachment to peptidoglycan in the cell wall by sortase A) |
(srtC2) class C sortase [PI-1 (VF0527) - Adherence (VFC0001)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_632 |
100.0 |
0.0 |
GBS_RS03585 |
VF0527 |
PI-1 |
Adherence |
VFC0001 |
The genes encoding pili are located within 2 distinct loci, denoted pilus islands 1 and 2 (PI-1 and PI-2), the latter having 2 allelic variants (PI-2a and PI-2b); Each pilus island (PI) comprises 3 genes that encode structural proteins with a characteristic LPXTG anchoring motif recognised by sortase transpeptidases: backbone (Bkb) subunit (forming the polymeric shaft of the pilus), ancillary subunit 1 (An1, the functional tip), and ancillary subunit 2 (An2, the C-terminal anchor following attachment to peptidoglycan in the cell wall by sortase A) |
(GBS_RS03585) tip adhesin protein [PI-1 (VF0527) - Adherence (VFC0001)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_642 |
100.0 |
9.3E-71 |
cylX |
VF0279 |
Beta-haemolysin/cytolysin |
Exotoxin |
VFC0235 |
Lyses not only red blood cells but a broad range of eukaryotic cell types; surface associated protein that can be extracted from the cells by non-ionic detergent, starch or albumin |
(cylX) acetyl coenzyme A (CoA) carboxylase CylX [Beta-haemolysin/cytolysin (VF0279) - Exotoxin (VFC0235)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_643 |
100.0 |
0.0 |
cylD |
VF0279 |
Beta-haemolysin/cytolysin |
Exotoxin |
VFC0235 |
Lyses not only red blood cells but a broad range of eukaryotic cell types; surface associated protein that can be extracted from the cells by non-ionic detergent, starch or albumin |
(cylD) malonyl-CoA-ACP transacylase CylD [Beta-haemolysin/cytolysin (VF0279) - Exotoxin (VFC0235)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_644 |
99.583 |
1.49E-177 |
cylG |
VF0279 |
Beta-haemolysin/cytolysin |
Exotoxin |
VFC0235 |
Lyses not only red blood cells but a broad range of eukaryotic cell types; surface associated protein that can be extracted from the cells by non-ionic detergent, starch or albumin |
(cylG) 3-ketoacyl-ACP-reductase CylG [Beta-haemolysin/cytolysin (VF0279) - Exotoxin (VFC0235)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_645 |
100.0 |
6.92E-67 |
acpC |
VF0279 |
Beta-haemolysin/cytolysin |
Exotoxin |
VFC0235 |
Lyses not only red blood cells but a broad range of eukaryotic cell types; surface associated protein that can be extracted from the cells by non-ionic detergent, starch or albumin |
(acpC) acyl carrier protein AcpC [Beta-haemolysin/cytolysin (VF0279) - Exotoxin (VFC0235)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_646 |
100.0 |
3.79E-117 |
cylZ |
VF0279 |
Beta-haemolysin/cytolysin |
Exotoxin |
VFC0235 |
Lyses not only red blood cells but a broad range of eukaryotic cell types; surface associated protein that can be extracted from the cells by non-ionic detergent, starch or albumin |
(cylZ) 3R-hydroxymyristoyl ACP dehydratase CylZ [Beta-haemolysin/cytolysin (VF0279) - Exotoxin (VFC0235)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_647 |
100.0 |
0.0 |
cylA |
VF0279 |
Beta-haemolysin/cytolysin |
Exotoxin |
VFC0235 |
Lyses not only red blood cells but a broad range of eukaryotic cell types; surface associated protein that can be extracted from the cells by non-ionic detergent, starch or albumin |
(cylA) ABC (ATP-binding cassette) transporter CylA [Beta-haemolysin/cytolysin (VF0279) - Exotoxin (VFC0235)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_648 |
99.658 |
0.0 |
cylB |
VF0279 |
Beta-haemolysin/cytolysin |
Exotoxin |
VFC0235 |
Lyses not only red blood cells but a broad range of eukaryotic cell types; surface associated protein that can be extracted from the cells by non-ionic detergent, starch or albumin |
(cylB) ABC (ATP-binding cassette) transporter CylB [Beta-haemolysin/cytolysin (VF0279) - Exotoxin (VFC0235)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_649 |
99.85 |
0.0 |
cylE |
VF0279 |
Beta-haemolysin/cytolysin |
Exotoxin |
VFC0235 |
Lyses not only red blood cells but a broad range of eukaryotic cell types; surface associated protein that can be extracted from the cells by non-ionic detergent, starch or albumin |
(cylE) haemolysin CylE [Beta-haemolysin/cytolysin (VF0279) - Exotoxin (VFC0235)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_650 |
100.0 |
0.0 |
cylF |
VF0279 |
Beta-haemolysin/cytolysin |
Exotoxin |
VFC0235 |
Lyses not only red blood cells but a broad range of eukaryotic cell types; surface associated protein that can be extracted from the cells by non-ionic detergent, starch or albumin |
(cylF) putative aminomethyltransferase CylF [Beta-haemolysin/cytolysin (VF0279) - Exotoxin (VFC0235)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_651 |
99.863 |
0.0 |
cylI |
VF0279 |
Beta-haemolysin/cytolysin |
Exotoxin |
VFC0235 |
Lyses not only red blood cells but a broad range of eukaryotic cell types; surface associated protein that can be extracted from the cells by non-ionic detergent, starch or albumin |
(cylI) putative 3-ketoacyl-ACP synthase CylI [Beta-haemolysin/cytolysin (VF0279) - Exotoxin (VFC0235)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_652 |
98.015 |
0.0 |
cylJ |
VF0279 |
Beta-haemolysin/cytolysin |
Exotoxin |
VFC0235 |
Lyses not only red blood cells but a broad range of eukaryotic cell types; surface associated protein that can be extracted from the cells by non-ionic detergent, starch or albumin |
(cylJ) glycosyltransferase CylJ [Beta-haemolysin/cytolysin (VF0279) - Exotoxin (VFC0235)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_653 |
98.429 |
6.01E-139 |
cylK |
VF0279 |
Beta-haemolysin/cytolysin |
Exotoxin |
VFC0235 |
Lyses not only red blood cells but a broad range of eukaryotic cell types; surface associated protein that can be extracted from the cells by non-ionic detergent, starch or albumin |
(cylK) putative phosphopantetheinyl transferase CylK [Beta-haemolysin/cytolysin (VF0279) - Exotoxin (VFC0235)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_744 |
70.455 |
0.0 |
tufA |
VF0460 |
EF-Tu |
Adherence |
VFC0001 |
|
(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| AE009948.1_883 |
61.765 |
3.83E-57 |
msrA/B(pilB |
VF0456 |
MsrAB |
Stress survival |
VFC0282 |
Methionine sulfoxide reductases (Msr) are enzymes that catalyze the reduction of free and protein-bound methionine sulfoxide (MetSO) back to Met. Two structurally unrelated classes of Msrs have been described so far. MsrAs are stereo specific toward the S isomer on the sulfur of the sulfoxide function, whereas MsrBs are specific toward the R isomer |
(msrA/B(pilB)) trifunctional thioredoxin/methionine sulfoxide reductase A/B protein [MsrAB (VF0456) - Stress survival (VFC0282)] [Neisseria meningitidis MC58] |
Neisseria meningitidis |
| AE009948.1_1124 |
98.547 |
0.0 |
neuA |
VF0274 |
Capsule |
Immune modulation |
VFC0258 |
GBS can be subclassified into serotypes according to the immunologic type of the polysaccharide capsule. Of the nine serotypes described so far, the type Ia, Ib, II, III and V are responsible for the majority of invasive human GBS disease; serotype III is particularly important because it causes the majority of infection to neonates |
(neuA) N-acylneuraminate cytidylyltransferase [Capsule (VF0274) - Immune modulation (VFC0258)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1125 |
99.522 |
1.84E-150 |
GBS_RS06540 |
VF0274 |
Capsule |
Immune modulation |
VFC0258 |
GBS can be subclassified into serotypes according to the immunologic type of the polysaccharide capsule. Of the nine serotypes described so far, the type Ia, Ib, II, III and V are responsible for the majority of invasive human GBS disease; serotype III is particularly important because it causes the majority of infection to neonates |
(GBS_RS06540) acetyltransferase [Capsule (VF0274) - Immune modulation (VFC0258)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1126 |
98.698 |
0.0 |
neuC |
VF0274 |
Capsule |
Immune modulation |
VFC0258 |
GBS can be subclassified into serotypes according to the immunologic type of the polysaccharide capsule. Of the nine serotypes described so far, the type Ia, Ib, II, III and V are responsible for the majority of invasive human GBS disease; serotype III is particularly important because it causes the majority of infection to neonates |
(neuC) UDP-N-acetylglucosamine 2-epimerase [Capsule (VF0274) - Immune modulation (VFC0258)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1127 |
99.707 |
0.0 |
neuB |
VF0274 |
Capsule |
Immune modulation |
VFC0258 |
GBS can be subclassified into serotypes according to the immunologic type of the polysaccharide capsule. Of the nine serotypes described so far, the type Ia, Ib, II, III and V are responsible for the majority of invasive human GBS disease; serotype III is particularly important because it causes the majority of infection to neonates |
(neuB) N-acetylneuraminate synthase [Capsule (VF0274) - Immune modulation (VFC0258)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1128 |
98.069 |
0.0 |
GBS_RS06555 |
VF0274 |
Capsule |
Immune modulation |
VFC0258 |
GBS can be subclassified into serotypes according to the immunologic type of the polysaccharide capsule. Of the nine serotypes described so far, the type Ia, Ib, II, III and V are responsible for the majority of invasive human GBS disease; serotype III is particularly important because it causes the majority of infection to neonates |
(GBS_RS06555) oligosaccharide flippase family protein [Capsule (VF0274) - Immune modulation (VFC0258)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1129 |
96.226 |
0.0 |
GBS_RS06560 |
VF0274 |
Capsule |
Immune modulation |
VFC0258 |
GBS can be subclassified into serotypes according to the immunologic type of the polysaccharide capsule. Of the nine serotypes described so far, the type Ia, Ib, II, III and V are responsible for the majority of invasive human GBS disease; serotype III is particularly important because it causes the majority of infection to neonates |
(GBS_RS06560) glycosyltransferase family 52 [Capsule (VF0274) - Immune modulation (VFC0258)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1135 |
65.19 |
5.38E-75 |
GBS_RS06580 |
VF0274 |
Capsule |
Immune modulation |
VFC0258 |
GBS can be subclassified into serotypes according to the immunologic type of the polysaccharide capsule. Of the nine serotypes described so far, the type Ia, Ib, II, III and V are responsible for the majority of invasive human GBS disease; serotype III is particularly important because it causes the majority of infection to neonates |
(GBS_RS06580) multidrug MFS transporter [Capsule (VF0274) - Immune modulation (VFC0258)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1136 |
99.329 |
1.27E-109 |
GBS_RS06585 |
VF0274 |
Capsule |
Immune modulation |
VFC0258 |
GBS can be subclassified into serotypes according to the immunologic type of the polysaccharide capsule. Of the nine serotypes described so far, the type Ia, Ib, II, III and V are responsible for the majority of invasive human GBS disease; serotype III is particularly important because it causes the majority of infection to neonates |
(GBS_RS06585) UDP-N-acetylglucosamine--LPS N-acetylglucosamine transferase [Capsule (VF0274) - Immune modulation (VFC0258)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1137 |
99.784 |
0.0 |
GBS_RS06590 |
VF0274 |
Capsule |
Immune modulation |
VFC0258 |
GBS can be subclassified into serotypes according to the immunologic type of the polysaccharide capsule. Of the nine serotypes described so far, the type Ia, Ib, II, III and V are responsible for the majority of invasive human GBS disease; serotype III is particularly important because it causes the majority of infection to neonates |
(GBS_RS06590) sugar transferase [Capsule (VF0274) - Immune modulation (VFC0258)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1138 |
98.276 |
3.43E-167 |
GBS_RS06595 |
VF0274 |
Capsule |
Immune modulation |
VFC0258 |
GBS can be subclassified into serotypes according to the immunologic type of the polysaccharide capsule. Of the nine serotypes described so far, the type Ia, Ib, II, III and V are responsible for the majority of invasive human GBS disease; serotype III is particularly important because it causes the majority of infection to neonates |
(GBS_RS06595) tyrosine-protein kinase [Capsule (VF0274) - Immune modulation (VFC0258)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1139 |
99.565 |
1.36E-164 |
GBS_RS06600 |
VF0274 |
Capsule |
Immune modulation |
VFC0258 |
GBS can be subclassified into serotypes according to the immunologic type of the polysaccharide capsule. Of the nine serotypes described so far, the type Ia, Ib, II, III and V are responsible for the majority of invasive human GBS disease; serotype III is particularly important because it causes the majority of infection to neonates |
(GBS_RS06600) capsular polysaccharide biosynthesis protein CpsC [Capsule (VF0274) - Immune modulation (VFC0258)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1140 |
99.588 |
0.0 |
GBS_RS06605 |
VF0274 |
Capsule |
Immune modulation |
VFC0258 |
GBS can be subclassified into serotypes according to the immunologic type of the polysaccharide capsule. Of the nine serotypes described so far, the type Ia, Ib, II, III and V are responsible for the majority of invasive human GBS disease; serotype III is particularly important because it causes the majority of infection to neonates |
(GBS_RS06605) tyrosine-protein phosphatase CpsB [Capsule (VF0274) - Immune modulation (VFC0258)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1141 |
99.175 |
0.0 |
GBS_RS06610 |
VF0274 |
Capsule |
Immune modulation |
VFC0258 |
GBS can be subclassified into serotypes according to the immunologic type of the polysaccharide capsule. Of the nine serotypes described so far, the type Ia, Ib, II, III and V are responsible for the majority of invasive human GBS disease; serotype III is particularly important because it causes the majority of infection to neonates |
(GBS_RS06610) LCP family protein [Capsule (VF0274) - Immune modulation (VFC0258)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1156 |
76.867 |
0.0 |
fbp54 |
VF0243 |
FBPs |
Adherence |
VFC0001 |
Surface protein: linked to the bacterial cell wall via C-terminal LPXTG motif; including PrtF1 (protein F1) also known as SfbI (streptococcal fibronectin binding proteinI), SfbII/SOF (serum opacity factor), FbaA, FbaB, FBP54 (fibronectin-binding protein 54), protein F2, PFBP (pyogene fibronectin-binding protein) |
(fbp54) fibronectin-bing protein Fbp54 [FBPs (VF0243) - Adherence (VFC0001)] [Streptococcus pyogenes MGAS6180] |
Streptococcus pyogenes |
| AE009948.1_1163 |
97.668 |
0.0 |
hylB |
VF0281 |
Hyaluronidase |
Exoenzyme |
VFC0251 |
|
(hylB) hyaluronidase [Hyaluronidase (VF0281) - Exoenzyme (VFC0251)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1166 |
63.793 |
3.05E-139 |
wbtL |
VF0542 |
LPS |
Immune modulation |
VFC0258 |
The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion |
(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| AE009948.1_1201 |
99.02 |
0.0 |
lmb |
VF0275 |
Lmb |
Adherence |
VFC0001 |
Lmb is an extracellular protein that was first identified in S. agalactiae. Homologs of this protein were reported in S. pyogenes and S. pneumonia and termed Lbp and AdcAII, respectively |
(lmb) laminin-binding surface protein [Lmb (VF0275) - Adherence (VFC0001)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1203 |
97.744 |
0.0 |
scpA/scpB |
VF0278 |
C5a peptidase |
Adherence |
VFC0001 |
All group A streptococcal serotypes and group B, C, and G streptococci of human origin produce the C5a peptidase. The enzyme is highly conserved. |
(scpA/scpB) streptococcal C5a peptidase [C5a peptidase (VF0278) - Adherence (VFC0001)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1367 |
99.351 |
0.0 |
pilC |
VF0528 |
PI-2a |
Adherence |
VFC0001 |
|
(pilC) minor subunit PilC [PI-2a (VF0528) - Adherence (VFC0001)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1368 |
99.32 |
0.0 |
srtC4 |
VF0528 |
PI-2a |
Adherence |
VFC0001 |
|
(srtC4) class C sortase [PI-2a (VF0528) - Adherence (VFC0001)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1369 |
97.27 |
0.0 |
srtC3 |
VF0528 |
PI-2a |
Adherence |
VFC0001 |
|
(srtC3) class C sortase [PI-2a (VF0528) - Adherence (VFC0001)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1371 |
97.336 |
0.0 |
pilA |
VF0528 |
PI-2a |
Adherence |
VFC0001 |
|
(pilA) tip adhesin PilA [PI-2a (VF0528) - Adherence (VFC0001)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_1489 |
74.757 |
1.46E-172 |
psaA |
VF0151 |
PsaA |
Nutritional/Metabolic factor |
VFC0272 |
Surface protein: lipid-attached; AdcABC is another ABC transporter for Zn2+ uptake |
(psaA) manganese ABC transporter, manganese-binding adhesion liprotein [PsaA (VF0151) - Nutritional/Metabolic factor (VFC0272)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| AE009948.1_1538 |
62.371 |
7.03E-89 |
clpP |
VF0074 |
ClpP |
Stress survival |
VFC0282 |
21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes |
(clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| AE009948.1_1976 |
100.0 |
0.0 |
cfa/cfb |
VF0280 |
CAMP factor |
Exotoxin |
VFC0235 |
CAMP factor, a pore-forming protein toxin of ~24 kDa gives rise to the so-called CAMP reaction, which consists of a zone of strong hemolysis that is observed when S. agalactiae is streaked next to Staphylococcus aureus on sheep blood agar. S. aureus secretes sphingomyelinase. Sheep red blood cells are rich in sphingomyelin and, upon exposure to sphingomyelinase, become greatly sensitized to CAMP factor, which then effects hemolysis. This co-hemolytic phenomenon was first described by Christie, Atkins, and Munch-Petersen, and the CAMP acronym represents these investigators' last names.; Paralogs of <iS. agalactiae</i> CAMP factor genes have been sequenced in a wide range of Gram-positive pathogens, including Streptococcus uberisand Cutibacterium acnes |
(cfa/cfb) cAMP factor [CAMP factor (VF0280) - Exotoxin (VFC0235)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| AE009948.1_2005 |
68.501 |
0.0 |
groEL |
VF0594 |
GroEL |
Adherence |
VFC0001 |
GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. |
(groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] |
Clostridium difficile |