2. PATHOGENS
Basic Information
Accession number
GCA_000007445.1
Release date
2002-12-06
Organism
Escherichia coli CFT073
Species name
Escherichia coli
Assembly level
Complete Genome
Assembly name
ASM744v1
Assembly submitter
Genetics Laboratory, University of Wisconsin - Madison
Assembly Type
haploid
Genome size
5.2 Mb
GC percent
50.5
Contig count
1
Collection date
-
Sample location
-
Host
-
Isolation source
-
Isolate type
-
Strain
CFT073
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
AE014075.1_82 # 88195 # 89139 500.0 655.981 leuO 100.0 ARO:3003843 protein homolog model nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump leuO, a LysR family transcription factor, exists in a wide variety of bacteria of the family Enterobacteriaceae and is involved in the regulation of as yet unidentified genes affecting the stress response and pathogenesis expression. LeuO is also an activator of the MdtNOP efflux pump.
AE014075.1_423 # 473874 # 474968 250.0 266.929 vanG 39.5 ARO:3002909 protein homolog model glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; Van ligase VanG is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis.
AE014075.1_503 # 555904 # 559053 1900.0 2134.76 acrB 99.9 ARO:3000216 protein homolog model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter.
AE014075.1_504 # 559076 # 560269 670.0 795.808 Escherichia coli acrA 99.75 ARO:3004043 protein homolog model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrA is a subunit of the AcrAB-TolC multidrug efflux system found in E. coli.
AE014075.1_686 # 761791 # 762468 400.0 450.669 kdpE 99.55 ARO:3003841 protein homolog model aminoglycoside antibiotic antibiotic efflux kdpDE kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding.
AE014075.1_818 # 904567 # 905799 700.0 786.949 Escherichia coli mdfA 97.07 ARO:3001328 protein homolog model tetracycline antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter.
AE014075.1_932 # 1017580 # 1019328 1000.0 1189.48 msbA 99.66 ARO:3003950 protein homolog model nitroimidazole antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A, a major component of the bacterial outer cell membrane, and is the only bacterial ABC transporter that is essential for cell viability.
AE014075.1_1171 # 1257763 # 1258989 700.0 805.438 mdtG 99.51 ARO:3001329 protein homolog model phosphonic acid antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump The MdtG protein, also named YceE, appears to be a member of the major facilitator superfamily of transporters, and it has been reported, when overexpressed, to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon.
AE014075.1_1183 # 1267618 # 1268826 750.0 801.201 mdtH 100.0 ARO:3001216 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug resistance protein MdtH.
AE014075.1_1499 # 1537480 # 1537893 240.0 276.944 H-NS 100.0 ARO:3000676 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; cephalosporin; cephamycin; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE, mdtE, and emrK as well as nearby genes of many RND-type multidrug exporters.
AE014075.1_1734 # 1795479 # 1795862 230.0 265.003 marA 99.21 ARO:3000263 protein homolog model fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux; reduced permeability to antibiotic resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF.
AE014075.1_1771 # 1833515 # 1833844 150.0 187.193 Klebsiella pneumoniae KpnF 85.32 ARO:3004583 protein homolog model macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic; disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump KpnF subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan.
AE014075.1_1772 # 1833831 # 1834196 150.0 181.8 Klebsiella pneumoniae KpnE 81.36 ARO:3004580 protein homolog model macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic; disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump KpnE subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan.
AE014075.1_2097 # 2163791 # 2164123 190.0 216.083 Escherichia coli emrE 98.18 ARO:3004039 protein homolog model macrolide antibiotic antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump Member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation.
AE014075.1_2279 # 2386589 # 2387755 700.0 792.341 ugd 99.23 ARO:3003577 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin.
AE014075.1_2323 # 2440602 # 2441849 725.0 824.698 mdtA 98.8 ARO:3000792 protein homolog model aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC.
AE014075.1_2324 # 2441849 # 2444971 1800.0 2080.45 mdtB 99.9 ARO:3000793 protein homolog model aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex.
AE014075.1_2325 # 2444972 # 2448049 1800.0 2051.94 mdtC 98.83 ARO:3000794 protein homolog model aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB, MdtC can form a homomultimer complex that results in a functioning efflux complex with a narrower drug specificity. mdtC corresponds to 3 loci in Pseudomonas aeruginosa PAO1 (gene name: muxC/muxB) and 3 loci in Pseudomonas aeruginosa LESB58.
AE014075.1_2327 # 2449462 # 2450865 850.0 925.62 baeS 96.15 ARO:3000829 protein homolog model aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity, BaeS is not necessary for overexpressed BaeR to confer resistance.
AE014075.1_2328 # 2450862 # 2451584 450.0 486.493 baeR 100.0 ARO:3000828 protein homolog model aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes.
AE014075.1_2464 # 2593915 # 2595558 1050.0 1106.66 YojI 99.63 ARO:3003952 protein homolog model peptide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI.
AE014075.1_2505 # 2653453 # 2654421 550.0 662.914 PmrF 99.38 ARO:3003578 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58.
AE014075.1_2508 # 2657290 # 2658942 400.0 734.947 ArnT 64.07 ARO:3005053 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase ArnT is involved in Cell Wall Biosynthesis, specifically 4-amino-4-deoxy-L-arabinose (Ara4N). It confers resistance to peptide antibiotics.
AE014075.1_2605 # 2763026 # 2764564 900.0 1021.92 emrY 99.8 ARO:3000254 protein homolog model tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB.
AE014075.1_2606 # 2764564 # 2765727 600.0 712.22 emrK 98.86 ARO:3000206 protein homolog model tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC, it mediates multidrug efflux.
AE014075.1_2607 # 2766143 # 2766757 390.0 417.157 evgA 100.0 ARO:3000832 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump EvgA, when phosphorylated, is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner, it can be phosphorylated in the absence of EvgS when overexpressed.
AE014075.1_2608 # 2766762 # 2770355 2300.0 2404.4 evgS 96.57 ARO:3000833 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump EvgS is a sensor protein that phosphorylates the regulatory protein EvgA. evgS corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58.
AE014075.1_2689 # 2858361 # 2861474 1900.0 2121.67 acrD 99.71 ARO:3000491 protein homolog model aminoglycoside antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrD is an aminoglycoside efflux pump expressed in E. coli. Its expression can be induced by indole, and is regulated by baeRS and cpxAR.
AE014075.1_2910 # 3091317 # 3091847 280.0 361.303 emrR 100.0 ARO:3000516 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression.
AE014075.1_2911 # 3091974 # 3093146 675.0 791.186 emrA 99.74 ARO:3000027 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump EmrA is a membrane fusion protein, providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli, a Gram-negative bacterium.
AE014075.1_2912 # 3093163 # 3094701 900.0 1028.08 emrB 99.8 ARO:3000074 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP), nalidixic acid, and thioloactomycin.
AE014075.1_2922 # 3101427 # 3101612 100.0 109.383 rsmA 85.25 ARO:3005069 protein homolog model fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump rsmA is a gene that regulates virulence of Pseudomonas aeruginosa. However, its negative effect on MexEF-OprN overexpression has been noted to confer resistance to various antibiotics. It's Escherichia coli homolog is csrA.
AE014075.1_3398 # 3614906 # 3616387 900.0 986.482 TolC 99.39 ARO:3000237 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex.
AE014075.1_3423 # 3643903 # 3644724 500.0 543.117 bacA 99.63 ARO:3002986 protein homolog model peptide antibiotic antibiotic target alteration undecaprenyl pyrophosphate related proteins The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin.
AE014075.1_3616 # 3844571 # 3845233 380.0 451.825 AcrS 98.18 ARO:3000656 protein homolog model fluoroquinolone antibiotic; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux.
AE014075.1_3617 # 3845632 # 3846789 675.0 781.556 AcrE 99.48 ARO:3000499 protein homolog model fluoroquinolone antibiotic; cephalosporin; cephamycin; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrE is a membrane fusion protein, similar to AcrA.
AE014075.1_3618 # 3846801 # 3849905 1900.0 2087.77 AcrF 99.42 ARO:3000502 protein homolog model fluoroquinolone antibiotic; cephalosporin; cephamycin; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrF is a inner membrane transporter, similar to AcrB.
AE014075.1_3705 # 3917508 # 3918140 400.0 434.491 CRP 99.52 ARO:3000518 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump CRP is a global regulator that represses MdtEF multidrug efflux pump expression.
AE014075.1_3873 # 4097977 # 4099134 675.0 776.548 mdtE 99.74 ARO:3000795 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA.
AE014075.1_3874 # 4099159 # 4102272 1850.0 2097.78 mdtF 99.52 ARO:3000796 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtF is the multidrug inner membrane transporter for the MdtEF-TolC efflux complex.
AE014075.1_3876 # 4102635 # 4103363 470.0 498.049 gadW 100.0 ARO:3003838 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and, in situations where GadX is missing, activates gadA and gadBC.
AE014075.1_3877 # 4103732 # 4104556 450.0 526.554 gadX 93.07 ARO:3000508 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance.
AE014075.1_4350 # 4623260 # 4624633 890.0 926.391 cpxA 100.0 ARO:3000830 protein homolog model aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR, which promotes efflux complex expression.
AE014075.1_4547 # 4858723 # 4860189 875.0 974.156 mdtP 97.75 ARO:3003550 protein homolog model nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
AE014075.1_4548 # 4860186 # 4862237 1300.0 1370.53 mdtO 97.36 ARO:3003549 protein homolog model nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
AE014075.1_4549 # 4862237 # 4863268 600.0 682.174 mdtN 99.13 ARO:3003548 protein homolog model nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
AE014075.1_4582 # 4892483 # 4894126 1000.0 1100.12 eptA 96.16 ARO:3003576 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine, resulting in a less negative cell membrane and decreased binding of polymyxin B.
AE014075.1_4679 # 4986532 # 4987665 725.0 775.778 EC-5 100.0 ARO:3006880 protein homolog model cephalosporin antibiotic inactivation EC beta-lactamase EC-5 is a EC beta-lactamase.
AE014075.1_89 # 95240 # 97006 500.0 597.43 Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics 53.29 ARO:3004446 protein variant model D350N, S357N cephalosporin; cephamycin; penam antibiotic target alteration Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics PBP3 is a penicillin-binding protein and beta-lactam resistance enzyme encoded by the ftsI gene in Haemophilus influenzae. Mutations in ftsI confer resistance to beta-lactam antibiotics.
AE014075.1_2491 # 2637569 # 2638927 850.0 919.842 Escherichia coli GlpT with mutation conferring resistance to fosfomycin 99.78 ARO:3003889 protein variant model E448K phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant GlpT Point mutations to the active importer GlpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria.
AE014075.1_3686 # 3901533 # 3902717 700.0 797.734 Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin 99.75 ARO:3003369 protein variant model R234F elfamycin antibiotic antibiotic target alteration elfamycin resistant EF-Tu Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin.
AE014075.1_4419 # 4708192 # 4709376 700.0 795.808 Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin 99.75 ARO:3003369 protein variant model R234F elfamycin antibiotic antibiotic target alteration elfamycin resistant EF-Tu Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin.
AE014075.1_505 # 560411 # 561058 375.0 446.047 Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime 100.0 ARO:3003807 protein overexpression model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. The mutations associated with this model are specific to E. coli.
AE014075.1_1733 # 1795024 # 1795458 210.0 289.656 Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline 98.61 ARO:3003378 protein overexpression model Y137H, G103S fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB.
AE014075.1_4521 # 4829619 # 4829942 200.0 220.32 Escherichia coli soxS with mutation conferring antibiotic resistance 100.0 ARO:3003511 protein overexpression model fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux; reduced permeability to antibiotic ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability.
AE014075.1_4522 # 4830028 # 4830492 300.0 310.457 Escherichia coli soxR with mutation conferring antibiotic resistance 99.35 ARO:3003381 protein overexpression model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
AE014075.1_101 77.303 0.0 lpxC VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxC) UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
AE014075.1_193 65.089 3.14E-160 lpxD VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxD) UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
AE014075.1_195 67.557 1.62E-132 lpxA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxA) UDP-N-acetylglucosamine acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
AE014075.1_196 63.281 7.82E-176 lpxB VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxB) lipid-A-disaccharide synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
AE014075.1_214 67.528 8.68E-126 IlpA VF0513 IlpA Adherence VFC0001 (IlpA) immunogenic lipoprotein A [IlpA (VF0513) - Adherence (VFC0001)] [Vibrio vulnificus YJ016] Vibrio vulnificus
AE014075.1_308 100.0 0.0 pic VF0232 Pic Effector delivery system VFC0086 Homologous to the Pic protein identified in Shigella flexneri and enteroaggregative E. coli (pic) Pic serine protease precursor, autotransporter [Pic (VF0232) - Effector delivery system (VFC0086)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_323 74.479 8.28E-108 gmhA/lpcA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (gmhA/lpcA) phosphoheptose isomerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
AE014075.1_342 100.0 0.0 vat VF1112 Vat Effector delivery system VFC0086 A ~110 kDa secreted protein exported by the Type Va secretion system and belongs to the class II cytotoxic SPATEs which comprise O-glycoprotases that cleave mucin and other O-glycoproteins present not only on epithelial cells but also on the surface of hematopoietic cells; identified in both APEC and UPEC strains (vat) vacuolating autotransporter toxin [Vat (VF1112) - Effector delivery system (VFC0086)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_345 98.305 6.19E-177 yagV/ecpE VF0404 ECP Adherence VFC0001 (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
AE014075.1_346 99.452 0.0 yagW/ecpD VF0404 ECP Adherence VFC0001 (yagW/ecpD) polymerized tip adhesin of ECP fibers [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
AE014075.1_347 98.335 0.0 yagX/ecpC VF0404 ECP Adherence VFC0001 (yagX/ecpC) E. coli common pilus usher EcpC [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
AE014075.1_348 97.748 5.76E-164 yagY/ecpB VF0404 ECP Adherence VFC0001 (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
AE014075.1_349 98.974 7.58E-137 yagZ/ecpA VF0404 ECP Adherence VFC0001 (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
AE014075.1_350 100.0 2.02E-133 ykgK/ecpR VF0404 ECP Adherence VFC0001 (ykgK/ecpR) regulator protein EcpR [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
AE014075.1_360 99.788 0.0 fdeC VF0506 FdeC Adherence VFC0001 (fdeC) adhesin FdeC [FdeC (VF0506) - Adherence (VFC0001)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
AE014075.1_478 66.495 8.54E-98 clpP VF0074 ClpP Stress survival VFC0282 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AE014075.1_503 91.611 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_504 84.887 0.0 acrA VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrA) acriflavine resistance protein A [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_541 73.77 2.75E-174 allS VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allS) DNA-binding transcriptional activator AllS [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_542 74.375 2.21E-91 allA VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allA) ureidoglycolate hydrolase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_543 86.194 1.18E-176 allR VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allR) DNA-binding transcriptional repressor AllR [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_548 91.391 0.0 allB VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allB) allantoinase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_552 80.44 0.0 allC VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allC) allantoate amidohydrolase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_553 83.381 0.0 allD VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allD) ureidoglycolate dehydrogenase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_575 99.565 0.0 ibeB VF0237 Ibes Invasion VFC0083 IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC [Ibes (VF0237) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
AE014075.1_586 100.0 7.19E-157 entD VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entD) phosphopantetheinyl transferase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_587 100.0 0.0 fepA VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepA) ferrienterobactin outer membrane transporter [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_588 100.0 0.0 fes VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fes) enterobactin/ferric enterobactin esterase [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_590 100.0 0.0 entF VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entF) enterobactin synthase multienzyme complex component, ATP-dependent [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_591 100.0 0.0 fepE VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepE) LPS O-antigen length regulator [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_592 100.0 0.0 fepC VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_593 100.0 0.0 fepG VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepG) iron-enterobactin ABC transporter permease [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_594 100.0 0.0 fepD VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepD) ferrienterobactin ABC transporter permease [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_595 100.0 0.0 entS VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entS) enterobactin exporter, iron-regulated [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_596 100.0 0.0 fepB VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_597 100.0 0.0 entC VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entC) isochorismate synthase 1 [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_598 100.0 0.0 entE VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entE) 2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_599 100.0 0.0 entB VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entB) isochorismatase [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_600 100.0 0.0 entA VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entA) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase EntA [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_678 99.315 1.76E-107 fur VF0113 Fur Regulation VFC0301 (fur) ferric iron uptake transcriptional regulator [Fur (VF0113) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
AE014075.1_932 66.955 0.0 msbA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (msbA) lipid transporter ATP-binding/permease [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
AE014075.1_937 69.88 3.14E-126 nueA VF0473 Polar flagella Motility VFC0204 Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments (nueA) NeuA protein [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119] Aeromonas hydrophila
AE014075.1_969 96.286 0.0 ompA VF0236 OmpA Invasion VFC0083 Major outer membrane protein in E. coli, homologous to Neisseria Opa proteins which have been shown to be involved in invasion of eukaryotic cells (ompA) outer membrane protein A [OmpA (VF0236) - Invasion (VFC0083)] [Escherichia coli O18:K1:H7 str. RS218] Escherichia coli (NMEC)
AE014075.1_1098 100.0 1.47E-51 sfaC VF0222 S fimbriae Adherence VFC0001 Encoded by sfa operon composed of nine genes (sfaC) S fimbrial switch regulatory protein SfaC [S fimbriae (VF0222) - Adherence (VFC0001)] [Escherichia coli UTI89] Escherichia coli (UPEC)
AE014075.1_1099 100.0 2.77E-78 C_RS05810 VF0224 F1C fimbriae Adherence VFC0001 A nonhemagglutinating adherence factor and is expressed by approximately 14% of the E. coli known to cause urinary tract infections and 7% of E. coli fecal isolates; genetically homologous to S fimbriae, but differ in their receptor specificity (C_RS05810) S/F1C fimbrial major subunit operon transcriptional regulator [F1C fimbriae (VF0224) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_1101 100.0 1.51E-129 focA VF0224 F1C fimbriae Adherence VFC0001 A nonhemagglutinating adherence factor and is expressed by approximately 14% of the E. coli known to cause urinary tract infections and 7% of E. coli fecal isolates; genetically homologous to S fimbriae, but differ in their receptor specificity (focA) F1C major fimbrial subunit precursor [F1C fimbriae (VF0224) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_1102 100.0 9.73E-112 focI VF0224 F1C fimbriae Adherence VFC0001 A nonhemagglutinating adherence factor and is expressed by approximately 14% of the E. coli known to cause urinary tract infections and 7% of E. coli fecal isolates; genetically homologous to S fimbriae, but differ in their receptor specificity (focI) Putative minor F1C fimbrial subunit precursor [F1C fimbriae (VF0224) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_1103 100.0 7.4E-174 focC VF0224 F1C fimbriae Adherence VFC0001 A nonhemagglutinating adherence factor and is expressed by approximately 14% of the E. coli known to cause urinary tract infections and 7% of E. coli fecal isolates; genetically homologous to S fimbriae, but differ in their receptor specificity (focC) F1C periplasmic chaperone [F1C fimbriae (VF0224) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_1104 100.0 0.0 focD VF0224 F1C fimbriae Adherence VFC0001 A nonhemagglutinating adherence factor and is expressed by approximately 14% of the E. coli known to cause urinary tract infections and 7% of E. coli fecal isolates; genetically homologous to S fimbriae, but differ in their receptor specificity (focD) F1C fimbrial usher [F1C fimbriae (VF0224) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_1105 100.0 2.71E-129 focF VF0224 F1C fimbriae Adherence VFC0001 A nonhemagglutinating adherence factor and is expressed by approximately 14% of the E. coli known to cause urinary tract infections and 7% of E. coli fecal isolates; genetically homologous to S fimbriae, but differ in their receptor specificity (focF) F1C minor fimbrial subunit F precursor [F1C fimbriae (VF0224) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_1106 100.0 5.08E-119 focG VF0224 F1C fimbriae Adherence VFC0001 A nonhemagglutinating adherence factor and is expressed by approximately 14% of the E. coli known to cause urinary tract infections and 7% of E. coli fecal isolates; genetically homologous to S fimbriae, but differ in their receptor specificity (focG) F1C minor fimbrial subunit protein G presursor [F1C fimbriae (VF0224) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_1107 100.0 0.0 focH VF0224 F1C fimbriae Adherence VFC0001 A nonhemagglutinating adherence factor and is expressed by approximately 14% of the E. coli known to cause urinary tract infections and 7% of E. coli fecal isolates; genetically homologous to S fimbriae, but differ in their receptor specificity (focH) F1C Putative fimbrial adhesin precursor [F1C fimbriae (VF0224) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_1108 100.0 0.0 sfaY VF0224 F1C fimbriae Adherence VFC0001 A nonhemagglutinating adherence factor and is expressed by approximately 14% of the E. coli known to cause urinary tract infections and 7% of E. coli fecal isolates; genetically homologous to S fimbriae, but differ in their receptor specificity (sfaY) transcriptional regulator SfaY [F1C fimbriae (VF0224) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_1109 100.0 1.12E-125 sfaX VF0224 F1C fimbriae Adherence VFC0001 A nonhemagglutinating adherence factor and is expressed by approximately 14% of the E. coli known to cause urinary tract infections and 7% of E. coli fecal isolates; genetically homologous to S fimbriae, but differ in their receptor specificity (sfaX) HTH-type transcriptional regulator SfaX [F1C fimbriae (VF0224) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_1111 100.0 0.0 iroN VF0230 Salmochelin siderophore Nutritional/Metabolic factor VFC0272 Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi (iroN) salmochelin receptor IroN [Salmochelin siderophore (VF0230) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_1112 100.0 0.0 iroE VF0230 Salmochelin siderophore Nutritional/Metabolic factor VFC0272 Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi (iroE) esterase [Salmochelin siderophore (VF0230) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_1113 100.0 0.0 iroD VF0230 Salmochelin siderophore Nutritional/Metabolic factor VFC0272 Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi (iroD) esterase [Salmochelin siderophore (VF0230) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_1114 100.0 0.0 iroC VF0230 Salmochelin siderophore Nutritional/Metabolic factor VFC0272 Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi (iroC) ATP binding cassette transporter [Salmochelin siderophore (VF0230) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_1115 100.0 0.0 iroB VF0230 Salmochelin siderophore Nutritional/Metabolic factor VFC0272 Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi (iroB) glucosyltransferase IroB [Salmochelin siderophore (VF0230) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_1156 99.639 0.0 cgsG VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (cgsG) curli production assembly/transport protein CsgG [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
AE014075.1_1157 99.275 1.6E-99 cgsF VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (cgsF) curli production assembly/transport protein CsgF [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
AE014075.1_1158 100.0 5.13E-95 cgsE VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (cgsE) curli production assembly/transport protein CsgE [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
AE014075.1_1159 100.0 9.54E-163 cgsD VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (cgsD) transcriptional regulator CsgD [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
AE014075.1_1160 99.338 5.32E-106 csgB VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (csgB) curlin minor subunit CsgB [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
AE014075.1_1161 99.342 1.03E-104 csgA VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (csgA) curlin major subunit CsgA [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
AE014075.1_1162 99.091 1.94E-75 csgC VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (csgC) curli assembly protein CsgC [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
AE014075.1_1190 62.0 1.7E-34 flgM VF0394 Flagella Motility VFC0204 (flgM) negative regulator of flagellin synthesis [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_1192 71.533 1.67E-73 flgB VF0394 Flagella Motility VFC0204 (flgB) flagellar basal-body rod protein FlgB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_1193 83.582 7.9E-82 flgC VF0394 Flagella Motility VFC0204 (flgC) flagellar basal-body rod protein FlgC [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_1194 74.257 1.07E-102 flgD VF0394 Flagella Motility VFC0204 (flgD) flagellar basal-body rod modification protein FlgD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_1195 63.723 0.0 flgE VF0394 Flagella Motility VFC0204 (flgE) flagellar hook protein FlgE [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_1196 66.135 3.44E-120 flgF VF0394 Flagella Motility VFC0204 (flgF) flagellar basal-body rod protein FlgF [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_1197 86.923 7.79E-170 flgG VF0394 Flagella Motility VFC0204 (flgG) flagellar basal-body rod protein FlgG [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_1198 80.734 9.16E-122 flgH VF0394 Flagella Motility VFC0204 (flgH) flagellar L-ring protein precursor FlgH [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_1199 78.082 0.0 flgI VF0394 Flagella Motility VFC0204 (flgI) flagellar P-ring protein precursor FlgI [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_1200 60.458 2.39E-129 flgJ VF0394 Flagella Motility VFC0204 (flgJ) <beta>-N-acetylglucosaminidase [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_1202 60.123 6.45E-141 flgL VF0394 Flagella Motility VFC0204 (flgL) flagellar hook-associated protein 3 FlgL [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_1211 71.837 2.31E-124 flmH VF0473 Polar flagella Motility VFC0204 Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments (flmH) short chain dehydrogenase/reductase family oxidoreductase [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119] Aeromonas hydrophila
AE014075.1_1212 61.538 1.93E-27 acpXL VF0367 LPS Immune modulation VFC0258 Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. (acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] Brucella melitensis
AE014075.1_1325 85.01 0.0 phoQ VF0111 PhoPQ Regulation VFC0301 (phoQ) sensor protein PhoQ [PhoPQ (VF0111) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
AE014075.1_1326 93.722 1.14E-157 phoP VF0111 PhoPQ Regulation VFC0301 (phoP) response regulator in two-component regulatory system with PhoQ [PhoPQ (VF0111) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
AE014075.1_1472 81.979 3.22E-179 kdsA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
AE014075.1_1498 73.958 2.16E-159 galU VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (galU) glucosephosphate uridylyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
AE014075.1_1632 60.839 2.48E-41 cheD VF0394 Flagella Motility VFC0204 (cheD) methyl-accepting chemotaxis protein CheD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_1715 64.414 8.51E-102 focC VF0224 F1C fimbriae Adherence VFC0001 A nonhemagglutinating adherence factor and is expressed by approximately 14% of the E. coli known to cause urinary tract infections and 7% of E. coli fecal isolates; genetically homologous to S fimbriae, but differ in their receptor specificity (focC) F1C periplasmic chaperone [F1C fimbriae (VF0224) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_1716 66.31 2.41E-76 fimA VF0566 Type I fimbriae Adherence VFC0001 Type I fimbriae are expressed in 90% of both clinical and environmental K. pneumoniae isolates as well as almost all members of the Enterobacteriaceae.; Type I fimbriae are filamentous, membrane-bound, adhesive structures composed primarily of FimA subunits, with the FimH subunit on the tip. (fimA) type 1 major fimbrial subunit precursor [Type I fimbriae (VF0566) - Adherence (VFC0001)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_1827 67.539 7.96E-100 sodB VF0169 SodB Stress survival VFC0282 (sodB) superoxide dismutase [SodB (VF0169) - Stress survival (VFC0282)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
AE014075.1_1891 79.487 1.5E-34 espL1 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espL1) Type III secretion system effector espL1 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
AE014075.1_2046 85.362 0.0 flhA VF0394 Flagella Motility VFC0204 (flhA) flagellar biosynthesis protein FlhA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2047 65.172 1.59E-178 flhB VF0394 Flagella Motility VFC0204 (flhB) flagellar biosynthetic protein FlhB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2048 77.67 1.61E-108 cheZ VF0394 Flagella Motility VFC0204 (cheZ) chemotaxis regulator CheZ [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2049 90.698 4.14E-84 cheY VF0394 Flagella Motility VFC0204 (cheY) chemotaxis regulatory protein CheY [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2050 86.246 0.0 cheB VF0394 Flagella Motility VFC0204 (cheB) chemotaxis-specific methylesterase CheB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2051 72.464 1.53E-146 cheR VF0394 Flagella Motility VFC0204 (cheR) chemotaxis methyltransferase CheR [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2054 85.093 3.74E-98 cheW VF0394 Flagella Motility VFC0204 (cheW) purine-binding chemotaxis protein CheW [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2055 73.669 0.0 cheA VF0394 Flagella Motility VFC0204 (cheA) chemotaxis protein CheA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2056 68.038 6.5E-150 motB VF0394 Flagella Motility VFC0204 (motB) flagellar motor protein MotB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2057 81.356 0.0 motA VF0394 Flagella Motility VFC0204 (motA) flagellar motor protein MotA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2058 82.902 5.06E-117 flhC VF0394 Flagella Motility VFC0204 (flhC) flagellar biosynthesis transcription activator FlhC [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2059 72.414 5.04E-52 flhD VF0394 Flagella Motility VFC0204 (flhD) flagellar transcriptional activator FlhD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2084 83.613 4.37E-145 fliA VF0394 Flagella Motility VFC0204 (fliA) flagellar biosynthesis sigma factor [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2099 63.196 0.0 fliF VF0394 Flagella Motility VFC0204 (fliF) flagellar M-ring protein FliF [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2100 83.587 0.0 fliG VF0394 Flagella Motility VFC0204 (fliG) flagellar motor switch protein G [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2102 83.48 0.0 fliI VF0394 Flagella Motility VFC0204 (fliI) flagellum-specific ATP synthase FliI [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2106 84.384 0.0 fliM VF0394 Flagella Motility VFC0204 (fliM) flagellar motor switch protein FliM [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2107 75.362 8.22E-70 fliN VF0394 Flagella Motility VFC0204 (fliN) flagellar motor switch protein FliN [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2109 83.983 1.41E-140 fliP VF0394 Flagella Motility VFC0204 (fliP) flagellar biosynthetic protein FliP [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2110 77.528 1.94E-37 fliQ VF0394 Flagella Motility VFC0204 (fliQ) flagellar biosynthetic protein FliQ [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2111 68.605 4.31E-108 fliR VF0394 Flagella Motility VFC0204 (fliR) flagellar biosynthetic protein FliR [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
AE014075.1_2112 67.633 2.11E-102 rcsA VF0571 RcsAB Regulation VFC0301 (rcsA) transcriptional activator for ctr capsule biosynthesis [RcsAB (VF0571) - Regulation (VFC0301)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2138 100.0 0.0 tcpC VF0413 TcpC Immune modulation VFC0258 (tcpC) Tir domain containing protein TcpC [TcpC (VF0413) - Immune modulation (VFC0258)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_2160 99.77 0.0 ybtS VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (ybtS) salicylate synthase Irp9 [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
AE014075.1_2161 99.765 0.0 ybtX VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (ybtX) putative signal transducer [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
AE014075.1_2162 99.5 0.0 ybtQ VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (ybtQ) yersiniabactin ABC transporter ATP-binding/permease protein YbtQ [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
AE014075.1_2163 100.0 0.0 ybtP VF0564 Ybt Nutritional/Metabolic factor VFC0272 Ybt is the most common virulence factor associated with human K. pneumoniae infections (ybtP) yersiniabactin ABC transporter ATP-binding/permease protein YbtP [Ybt (VF0564) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2164 99.373 0.0 ybtA VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (ybtA) transcriptional regulator YbtA [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
AE014075.1_2165 99.575 0.0 irp2 VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (irp2) yersiniabactin biosynthetic protein Irp2 [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
AE014075.1_2167 94.797 0.0 irp2 VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (irp2) yersiniabactin biosynthetic protein Irp2 [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
AE014075.1_2168 99.721 0.0 irp1 VF0564 Ybt Nutritional/Metabolic factor VFC0272 Ybt is the most common virulence factor associated with human K. pneumoniae infections (irp1) yersiniabactin polyketide synthase HMWP1 [Ybt (VF0564) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2169 99.309 0.0 irp1 VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (irp1) yersiniabactin biosynthetic protein Irp1 [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
AE014075.1_2170 99.602 0.0 irp1 VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (irp1) yersiniabactin biosynthetic protein Irp1 [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
AE014075.1_2171 99.727 0.0 ybtU VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (ybtU) yersiniabactin biosynthetic protein YbtU [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
AE014075.1_2172 99.251 0.0 ybtT VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (ybtT) type II thioesterase YbtT [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
AE014075.1_2173 100.0 0.0 ybtE VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (ybtE) yersiniabactin siderophore biosynthetic protein [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
AE014075.1_2174 98.936 9.32E-62 ybtE VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (ybtE) yersiniabactin siderophore biosynthetic protein [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
AE014075.1_2175 99.851 0.0 fyuA VF0564 Ybt Nutritional/Metabolic factor VFC0272 Ybt is the most common virulence factor associated with human K. pneumoniae infections (fyuA) yersiniabactin receptor FyuA [Ybt (VF0564) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2188 99.412 4.2E-126 clbS VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbS) colibactin self-protection protein ClbS [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2189 100.0 0.0 clbQ VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbQ) colibactin biosynthesis thioesterase ClbQ [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2190 100.0 0.0 clbP VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbP) precolibactin peptidase ClbP [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2191 100.0 0.0 clbO VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbO) colibactin polyketide synthase ClbO [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2192 99.723 0.0 clbN VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbN) colibactin non-ribosomal peptide synthetase ClbN [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2193 99.906 0.0 clbN VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbN) colibactin non-ribosomal peptide synthetase ClbN [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2194 99.791 0.0 clbM VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbM) precolibactin export MATE transporter ClbM [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2195 100.0 0.0 clbL VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbL) colibactin biosynthesis amidase ClbL [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2196 99.861 0.0 clbK VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbK) colibactin hybrid non-ribosomal peptide synthetase/type I polyketide synthase ClbK [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2197 99.86 0.0 clbJ VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbJ) colibactin non-ribosomal peptide synthetase ClbJ [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2198 100.0 0.0 clbI VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbI) colibactin polyketide synthase ClbI [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2199 99.937 0.0 clbH VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbH) colibactin non-ribosomal peptide synthetase ClbH [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2200 100.0 0.0 clbG VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbG) colibactin biosynthesis acyltransferase ClbG [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2201 99.202 0.0 clbF VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbF) colibactin biosynthesis dehydrogenase ClbF [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2202 100.0 2.62E-55 clbE VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbE) colibactin biosynthesis aminomalonyl-acyl carrier protein ClbE [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2203 100.0 0.0 clbD VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbD) colibactin biosynthesis dehydrogenase ClbD [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2204 99.885 0.0 clbC VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbC) colibactin polyketide synthase ClbC [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2205 100.0 0.0 clbB VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbB) colibactin hybrid non-ribosomal peptide synthetase/type I polyketide synthase ClbB [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2206 99.947 0.0 clbB VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbB) colibactin hybrid non-ribosomal peptide synthetase/type I polyketide synthase ClbB [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2208 100.0 0.0 clbA VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbA) colibactin biosynthesis phosphopantetheinyl transferase ClbA [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
AE014075.1_2279 82.732 0.0 ugd VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (ugd) UDP-glucose 6-dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2280 95.299 0.0 gndA VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2281 76.484 0.0 rfbK1 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (rfbK1) O9 family phosphomannomutase RfbK1 [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2290 89.189 0.0 galF VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (galF) GalU regulator GalF [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2295 64.454 0.0 wcaJ VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (wcaJ) undecaprenyl-phosphate glucose phosphotransferase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2296 76.264 0.0 rfbK1 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (rfbK1) O9 family phosphomannomutase RfbK1 [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2297 61.441 0.0 KP1_RS17280 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17280) mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2298 61.671 0.0 KP1_RS17295 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17295) glycosyltransferase WbuB [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2300 77.987 0.0 KP1_RS17305 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17305) GDP-L-fucose synthase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2301 88.919 0.0 gmd VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gmd) GDP-mannose 4,6-dehydratase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2310 67.333 5.5E-72 KP1_RS17340 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17340) polysaccharide export protein [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2311 62.559 6.16E-100 KP1_RS17340 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17340) polysaccharide export protein [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2470 96.759 1.41E-152 rcsB VF0571 RcsAB Regulation VFC0301 (rcsB) transcriptional regulator RcsB [RcsAB (VF0571) - Regulation (VFC0301)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2689 64.735 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_2722 72.777 0.0 sinH VF0400 SinH Adherence VFC0001 N-terminal 350 residues exhibits homology with invasin of Yersinia pseudotuberculosis (49.5% identity) and intimin of E. coli O111 (enteropathogenic E. coli) (48% identity). The amino termini of invasin and intimin serve as membrane-spanning anchors in the bacterial outer membrane. (sinH) intimin-like protein [SinH (VF0400) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
AE014075.1_2780 65.969 5.37E-91 algU VF0091 Alginate Biofilm VFC0271 Alginate production is frequently referred to as mucoidy because colonies producing alginate have a wet glistening (mucoid) appearance, which is very different from that of colonies not producing alginate; most of the alginate biosynthetic genes are clustered in the algD operon; Alginate production is highly regulated. Regulatory genes are located in two areas far removed from the biosynthetic genes, with one exception algC (algU) alginate biosynthesis protein AlgZ/FimS [Alginate (VF0091) - Biofilm (VFC0271)] [Pseudomonas aeruginosa PAO1] Pseudomonas aeruginosa
AE014075.1_2916 73.684 8.46E-97 luxS VF0406 AI-2 Biofilm VFC0271 AI-2 is produced and detected by a wide variety of bacteria and is presumed to facilitate interspecies communications. (luxS) S-ribosylhomocysteinase [AI-2 (VF0406) - Biofilm (VFC0271)] [Vibrio cholerae O1 biovar El Tor str. N16961] Vibrio cholerae
AE014075.1_2922 76.667 1.4E-30 csrA VF0261 CsrA Regulation VFC0301 Belongs to a highly conserved family of global regulators that typically control stationary phase traits post-transcriptionally (csrA) carbon storage regulator CsrA [CsrA (VF0261) - Regulation (VFC0301)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
AE014075.1_2973 100.0 1.27E-121 rpoS VF0112 RpoS Regulation VFC0301 (rpoS) RNA polymerase sigma factor RpoS [RpoS (VF0112) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
AE014075.1_2974 98.485 4.89E-88 rpoS VF0112 RpoS Regulation VFC0301 (rpoS) RNA polymerase sigma factor RpoS [RpoS (VF0112) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
AE014075.1_3042 73.006 2.72E-88 vipA/tssB VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (vipA/tssB) type VI secretion system contractile sheath small subunit VipA [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_3043 78.21 0.0 vipB/tssC VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (vipB/tssC) type VI secretion system contractile sheath large subunit VipB [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_3047 84.663 1.07E-104 hcp/tssD VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (hcp/tssD) type VI secretion system protein, Hcp family [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_3048 72.323 0.0 clpV/tssH VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (clpV/tssH) type VI secretion system ATPase TssH [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_3210 100.0 2.41E-128 hlyC VF0225 Alpha-Hemolysin Exotoxin VFC0235 Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation; The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains (hlyC) Hemolysin C [Alpha-Hemolysin (VF0225) - Exotoxin (VFC0235)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3211 100.0 0.0 hlyA VF0225 Alpha-Hemolysin Exotoxin VFC0235 Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation; The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains (hlyA) Hemolysin A [Alpha-Hemolysin (VF0225) - Exotoxin (VFC0235)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3212 100.0 0.0 hlyB VF0225 Alpha-Hemolysin Exotoxin VFC0235 Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation; The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains (hlyB) Hemolysin B [Alpha-Hemolysin (VF0225) - Exotoxin (VFC0235)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3213 100.0 0.0 hlyD VF0225 Alpha-Hemolysin Exotoxin VFC0235 Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation; The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains (hlyD) Hemolysin D [Alpha-Hemolysin (VF0225) - Exotoxin (VFC0235)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3219 100.0 1.04E-125 papX VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papX) PapX protein regulates flagellum synthesis to repress motility [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3220 100.0 0.0 papG VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papG) P pilus tip adhesin PapG [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3221 100.0 5.66E-121 papF VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papF) P pilus minor subunit PapF [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3222 100.0 4.07E-129 papE VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papE) P pilus minor subunit PapE [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3223 100.0 1.39E-131 papK VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papK) P pilus minor subunit PapK [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3224 100.0 1.03E-142 papJ VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papJ) P pilus assembly protein PapJ [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3225 100.0 6.64E-180 papD VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papD) chaperone protein PapD [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3226 100.0 0.0 papC VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papC) usher protein PapC [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3227 100.0 5.42E-147 papH VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papH) P pilus termination subunit PapH [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3228 100.0 1.98E-136 papA VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papA) P pilus major subunit PapA [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3229 98.889 1.0E-63 papB VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papB) regulatory protein PapB [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3230 100.0 8.13E-52 papI VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papI) regulatory protein PapI [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3251 100.0 0.0 sat VF0231 Sat Effector delivery system VFC0086 Belongs to SPATE (serine protease autotransporters to Enterobacteriaceae) proteins (eight known SPATE proteins: Sat of UPEC, Pet of EAEC, EspC of EPEC, Pic of EAEC and Shigella, SigA of Shigella, SepA of Shigella, Tsh of avian E. coli, and EspP of EHEC); reside within PAI II of E. coli CFT073 (sat) Aecreted auto transpoter toxin [Sat (VF0231) - Effector delivery system (VFC0086)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3252 100.0 0.0 iutA VF0229 Aerobactin Nutritional/Metabolic factor VFC0272 A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport (iutA) ferric aerobactin receptor precusor IutA [Aerobactin (VF0229) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3253 100.0 0.0 iucD VF0229 Aerobactin Nutritional/Metabolic factor VFC0272 A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport (iucD) L-lysine 6-monooxygenase IucD [Aerobactin (VF0229) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3254 100.0 0.0 iucC VF0229 Aerobactin Nutritional/Metabolic factor VFC0272 A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport (iucC) aerobactin siderophore biosynthesis protein IucC [Aerobactin (VF0229) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3255 100.0 0.0 iucB VF0229 Aerobactin Nutritional/Metabolic factor VFC0272 A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport (iucB) aerobactin siderophore biosynthesis protein IucB [Aerobactin (VF0229) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3256 100.0 0.0 iucA VF0229 Aerobactin Nutritional/Metabolic factor VFC0272 A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport (iucA) aerobactin siderophore biosynthesis protein IucD [Aerobactin (VF0229) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3302 98.777 0.0 kpsF VF0239 K1 capsule Invasion VFC0083 The K1 capsular polysaccharide are predominant (approximately 80%) among isolates from neonatal E. coli meningitis; the K1 capsule, an alpha-2,8-linked polymer of sialic acid (polySia), are encoded by the kps gene cluster which is divided into three functional regions. The central region 2 (neuE, -C, -A, -B, -D) is unique for a given polysaccharide antigen and encoding genes responsible for the synthesis of the K-specific serotype. In contrast, genes in regions 1 and 3 are conserved among E. coli synthesizing serologically distinct capsules. Region 1 contains six genes (kpsF, -E, -D, -U, -C and -S). Region 3 contains two genes (kpsM and kpsT). The gene products from these regions are needed for transport of the capsular polysaccharide across the cytoplasmic membrane (KpsM and KpsT) and assembly onto the cell's surface (KpsD and KpsE) (kpsF) Polysialic acid capsule expression protein [K1 capsule (VF0239) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
AE014075.1_3303 99.476 0.0 kpsE VF0239 K1 capsule Invasion VFC0083 The K1 capsular polysaccharide are predominant (approximately 80%) among isolates from neonatal E. coli meningitis; the K1 capsule, an alpha-2,8-linked polymer of sialic acid (polySia), are encoded by the kps gene cluster which is divided into three functional regions. The central region 2 (neuE, -C, -A, -B, -D) is unique for a given polysaccharide antigen and encoding genes responsible for the synthesis of the K-specific serotype. In contrast, genes in regions 1 and 3 are conserved among E. coli synthesizing serologically distinct capsules. Region 1 contains six genes (kpsF, -E, -D, -U, -C and -S). Region 3 contains two genes (kpsM and kpsT). The gene products from these regions are needed for transport of the capsular polysaccharide across the cytoplasmic membrane (KpsM and KpsT) and assembly onto the cell's surface (KpsD and KpsE) (kpsE) Capsule polysaccharide export inner-membrane protein [K1 capsule (VF0239) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
AE014075.1_3304 99.462 0.0 kpsD VF0239 K1 capsule Invasion VFC0083 The K1 capsular polysaccharide are predominant (approximately 80%) among isolates from neonatal E. coli meningitis; the K1 capsule, an alpha-2,8-linked polymer of sialic acid (polySia), are encoded by the kps gene cluster which is divided into three functional regions. The central region 2 (neuE, -C, -A, -B, -D) is unique for a given polysaccharide antigen and encoding genes responsible for the synthesis of the K-specific serotype. In contrast, genes in regions 1 and 3 are conserved among E. coli synthesizing serologically distinct capsules. Region 1 contains six genes (kpsF, -E, -D, -U, -C and -S). Region 3 contains two genes (kpsM and kpsT). The gene products from these regions are needed for transport of the capsular polysaccharide across the cytoplasmic membrane (KpsM and KpsT) and assembly onto the cell's surface (KpsD and KpsE) (kpsD) Polysialic acid transport protein precursor [K1 capsule (VF0239) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
AE014075.1_3305 96.748 2.31E-179 kpsU VF0239 K1 capsule Invasion VFC0083 The K1 capsular polysaccharide are predominant (approximately 80%) among isolates from neonatal E. coli meningitis; the K1 capsule, an alpha-2,8-linked polymer of sialic acid (polySia), are encoded by the kps gene cluster which is divided into three functional regions. The central region 2 (neuE, -C, -A, -B, -D) is unique for a given polysaccharide antigen and encoding genes responsible for the synthesis of the K-specific serotype. In contrast, genes in regions 1 and 3 are conserved among E. coli synthesizing serologically distinct capsules. Region 1 contains six genes (kpsF, -E, -D, -U, -C and -S). Region 3 contains two genes (kpsM and kpsT). The gene products from these regions are needed for transport of the capsular polysaccharide across the cytoplasmic membrane (KpsM and KpsT) and assembly onto the cell's surface (KpsD and KpsE) (kpsU) 3-deoxy-manno-octulosonate cytidylyltransferase [K1 capsule (VF0239) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
AE014075.1_3306 95.407 0.0 kpsC VF0239 K1 capsule Invasion VFC0083 The K1 capsular polysaccharide are predominant (approximately 80%) among isolates from neonatal E. coli meningitis; the K1 capsule, an alpha-2,8-linked polymer of sialic acid (polySia), are encoded by the kps gene cluster which is divided into three functional regions. The central region 2 (neuE, -C, -A, -B, -D) is unique for a given polysaccharide antigen and encoding genes responsible for the synthesis of the K-specific serotype. In contrast, genes in regions 1 and 3 are conserved among E. coli synthesizing serologically distinct capsules. Region 1 contains six genes (kpsF, -E, -D, -U, -C and -S). Region 3 contains two genes (kpsM and kpsT). The gene products from these regions are needed for transport of the capsular polysaccharide across the cytoplasmic membrane (KpsM and KpsT) and assembly onto the cell's surface (KpsD and KpsE) (kpsC) Capsule polysaccharide export protein [K1 capsule (VF0239) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
AE014075.1_3307 97.954 0.0 kpsS VF0239 K1 capsule Invasion VFC0083 The K1 capsular polysaccharide are predominant (approximately 80%) among isolates from neonatal E. coli meningitis; the K1 capsule, an alpha-2,8-linked polymer of sialic acid (polySia), are encoded by the kps gene cluster which is divided into three functional regions. The central region 2 (neuE, -C, -A, -B, -D) is unique for a given polysaccharide antigen and encoding genes responsible for the synthesis of the K-specific serotype. In contrast, genes in regions 1 and 3 are conserved among E. coli synthesizing serologically distinct capsules. Region 1 contains six genes (kpsF, -E, -D, -U, -C and -S). Region 3 contains two genes (kpsM and kpsT). The gene products from these regions are needed for transport of the capsular polysaccharide across the cytoplasmic membrane (KpsM and KpsT) and assembly onto the cell's surface (KpsD and KpsE) (kpsS) Capsule polysaccharide export protein [K1 capsule (VF0239) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
AE014075.1_3313 71.56 1.95E-120 kpsT VF0239 K1 capsule Invasion VFC0083 The K1 capsular polysaccharide are predominant (approximately 80%) among isolates from neonatal E. coli meningitis; the K1 capsule, an alpha-2,8-linked polymer of sialic acid (polySia), are encoded by the kps gene cluster which is divided into three functional regions. The central region 2 (neuE, -C, -A, -B, -D) is unique for a given polysaccharide antigen and encoding genes responsible for the synthesis of the K-specific serotype. In contrast, genes in regions 1 and 3 are conserved among E. coli synthesizing serologically distinct capsules. Region 1 contains six genes (kpsF, -E, -D, -U, -C and -S). Region 3 contains two genes (kpsM and kpsT). The gene products from these regions are needed for transport of the capsular polysaccharide across the cytoplasmic membrane (KpsM and KpsT) and assembly onto the cell's surface (KpsD and KpsE) (kpsT) Polysialic acid transport ATP-binding protein [K1 capsule (VF0239) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
AE014075.1_3314 96.124 0.0 kpsM VF0239 K1 capsule Invasion VFC0083 The K1 capsular polysaccharide are predominant (approximately 80%) among isolates from neonatal E. coli meningitis; the K1 capsule, an alpha-2,8-linked polymer of sialic acid (polySia), are encoded by the kps gene cluster which is divided into three functional regions. The central region 2 (neuE, -C, -A, -B, -D) is unique for a given polysaccharide antigen and encoding genes responsible for the synthesis of the K-specific serotype. In contrast, genes in regions 1 and 3 are conserved among E. coli synthesizing serologically distinct capsules. Region 1 contains six genes (kpsF, -E, -D, -U, -C and -S). Region 3 contains two genes (kpsM and kpsT). The gene products from these regions are needed for transport of the capsular polysaccharide across the cytoplasmic membrane (KpsM and KpsT) and assembly onto the cell's surface (KpsD and KpsE) (kpsM) Polysialic acid transport protein [K1 capsule (VF0239) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
AE014075.1_3316 92.424 2.27E-125 gspL VF0333 T2SS Effector delivery system VFC0086 T2SS encoded by genes of the general secretion pathway (gsp) is widely distributed in Gram-negative bacteria. The known E.coli T2SS, responsible for chitinase secretion, encoded by the yhe genes at 74.5 min of the MG1655 chromosome is absent in all four sequenced Shigella genomes; A novel set of gsp genes are located on the S. dysenteriae Sd197 and S. boydii Sb227 chromosomes. The Sb227 T2SS is likely to be inactive due to a frameshift in gspC and a nonsense mutation in gspD. Those genes show significant similarity to those from ETEC and Vibrio cholerae responsible for secreting the E.coli heat labile toxin (Ltx) and cholera toxin (Ctx), respectively. While Shiga toxin has an overall similar structure to Ctx and Ltx. (gspL) general secretion pathway protein L [T2SS (VF0333) - Effector delivery system (VFC0086)] [Shigella dysenteriae Sd197] Shigella dysenteriae
AE014075.1_3317 93.564 9.22E-133 gspL VF0333 T2SS Effector delivery system VFC0086 T2SS encoded by genes of the general secretion pathway (gsp) is widely distributed in Gram-negative bacteria. The known E.coli T2SS, responsible for chitinase secretion, encoded by the yhe genes at 74.5 min of the MG1655 chromosome is absent in all four sequenced Shigella genomes; A novel set of gsp genes are located on the S. dysenteriae Sd197 and S. boydii Sb227 chromosomes. The Sb227 T2SS is likely to be inactive due to a frameshift in gspC and a nonsense mutation in gspD. Those genes show significant similarity to those from ETEC and Vibrio cholerae responsible for secreting the E.coli heat labile toxin (Ltx) and cholera toxin (Ctx), respectively. While Shiga toxin has an overall similar structure to Ctx and Ltx. (gspL) general secretion pathway protein L [T2SS (VF0333) - Effector delivery system (VFC0086)] [Shigella dysenteriae Sd197] Shigella dysenteriae
AE014075.1_3318 98.54 5.49E-98 gspK VF0333 T2SS Effector delivery system VFC0086 T2SS encoded by genes of the general secretion pathway (gsp) is widely distributed in Gram-negative bacteria. The known E.coli T2SS, responsible for chitinase secretion, encoded by the yhe genes at 74.5 min of the MG1655 chromosome is absent in all four sequenced Shigella genomes; A novel set of gsp genes are located on the S. dysenteriae Sd197 and S. boydii Sb227 chromosomes. The Sb227 T2SS is likely to be inactive due to a frameshift in gspC and a nonsense mutation in gspD. Those genes show significant similarity to those from ETEC and Vibrio cholerae responsible for secreting the E.coli heat labile toxin (Ltx) and cholera toxin (Ctx), respectively. While Shiga toxin has an overall similar structure to Ctx and Ltx. (gspK) general secretion pathway protein K [T2SS (VF0333) - Effector delivery system (VFC0086)] [Shigella dysenteriae Sd197] Shigella dysenteriae
AE014075.1_3416 71.002 0.0 rfaE VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaE) ADP-heptose synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
AE014075.1_3434 60.251 1.17E-104 sigA/rpoV VF0257 SigA Regulation VFC0301 In M. tuberculosis, 13 sigma factor genes have been annotated in the genome, 9 of which belong to a special subfamily thought to direct extracytoplasmic functions and various other stress responses (temperature, oxidative stress, pH, and infection of macrophages); sigma A also known as RpoV, is the essential principal mycobacterial sigma factors, necessary for most mycobacterial housekeeping gene transcription; It was the first mycobacterial sigma factor to be associated with virulence (sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AE014075.1_3617 68.533 0.0 acrA VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrA) acriflavine resistance protein A [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_3618 77.898 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_3675 71.111 2.32E-68 exeG VF0478 Exe T2SS Effector delivery system VFC0086 (exeG) general secretion pathway protein G [Exe T2SS (VF0478) - Effector delivery system (VFC0086)] [Aeromonas hydrophila ML09-119] Aeromonas hydrophila
AE014075.1_3686 80.153 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
AE014075.1_3705 66.832 1.28E-99 vfr VF0082 Type IV pili Adherence VFC0001 PilA, B, C, D, E, F, M, N, O, P, Q, T, U, V, W, X, Y1, Y2, Z, and fimT, U, V are involved in the biogenesis and mechanical function of pili, pilG, H, I, K, chpA, B, C, D, E, pilS, R, fimS, rpoN, algR, algU, and vfr are involved in transcriptional regulation and chemosensory pathways that control the expression or activity of the twitching motility of the pili (vfr) cAMP-regulatory protein [Type IV pili (VF0082) - Adherence (VFC0001)] [Pseudomonas aeruginosa PAO1] Pseudomonas aeruginosa
AE014075.1_3728 63.964 5.49E-101 rpe VF0543 Capsule Immune modulation VFC0258 Group 4 capsule; high molecular weight (HMW) O-antigen capsule (rpe) ribulose-phosphate 3-epimerase [Capsule (VF0543) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
AE014075.1_3859 100.0 0.0 chuS VF0227 Chu Nutritional/Metabolic factor VFC0272 ChuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains (chuS) heme oxygenase ChuS [Chu (VF0227) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3860 100.0 0.0 chuA VF0227 Chu Nutritional/Metabolic factor VFC0272 ChuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains (chuA) Outer membrane heme/hemoglobin receptor ChuA [Chu (VF0227) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3861 100.0 0.0 chuT VF0227 Chu Nutritional/Metabolic factor VFC0272 ChuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains (chuT) periplasmic heme-binding protein ChuT [Chu (VF0227) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3862 100.0 0.0 chuW VF0227 Chu Nutritional/Metabolic factor VFC0272 ChuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains (chuW) Putative oxygen independent coproporphyrinogen III oxidase [Chu (VF0227) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3863 100.0 2.24E-123 chuX VF0227 Chu Nutritional/Metabolic factor VFC0272 ChuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains (chuX) putative heme-binding protein ChuX [Chu (VF0227) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3864 100.0 2.54E-153 chuY VF0227 Chu Nutritional/Metabolic factor VFC0272 ChuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains (chuY) ChuY [Chu (VF0227) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3865 100.0 0.0 chuU VF0227 Chu Nutritional/Metabolic factor VFC0272 ChuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains (chuU) heme permease protein ChuU [Chu (VF0227) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3866 100.0 0.0 chuV VF0227 Chu Nutritional/Metabolic factor VFC0272 ChuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains (chuV) ATP-binding hydrophilic protein ChuV [Chu (VF0227) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_3874 70.727 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_3978 78.571 0.0 rfaD VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaD) ADP-L-glycero-D-mannoheptose-6-epimerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
AE014075.1_3979 63.506 4.74E-158 rfaF VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaF) ADP-heptose-LPS heptosyltransferase II [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
AE014075.1_4075 64.923 9.59E-151 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AE014075.1_4210 66.964 9.94E-174 rffG VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rffG) dTDP-glucose 46-dehydratase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
AE014075.1_4211 66.894 1.06E-142 wbtL VF0542 LPS Immune modulation VFC0258 The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion (wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
AE014075.1_4220 98.056 0.0 aslA VF0238 AslA Invasion VFC0083 Homology to aslA of E. coli K12; based on its protein sequence, AslA is predicted to be a member of the arylsulfatase family of enzymes that contains highly conserved sulfatase motifs, but E. coli AslA failed to exhibit in vitro arylsulfatase activity (aslA) putative arylsulfatase [AslA (VF0238) - Invasion (VFC0083)] [Escherichia coli O18:K1:H7 str. RS218] Escherichia coli (NMEC)
AE014075.1_4398 100.0 0.0 ibeC VF0237 Ibes Invasion VFC0083 IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. (ibeC) phosphoethanolamine transferase CptA [Ibes (VF0237) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
AE014075.1_4419 80.153 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
AE014075.1_4452 62.061 0.0 icl VF0253 Isocitrate lyase Others VFC0346 (icl) Isocitrate lyase Icl (isocitrase) (isocitratase) [Isocitrate lyase (VF0253) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AE014075.1_4580 85.634 0.0 pmrB VF1355 PmrAB Regulation VFC0301 (pmrB) sensory kinase PmrB [PmrAB (VF1355) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
AE014075.1_4581 91.441 1.42E-151 pmrA VF1355 PmrAB Regulation VFC0301 (pmrA) response regulator PmrA [PmrAB (VF1355) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
AE014075.1_4629 100.0 0.0 papG VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papG) P pilus tip adhesin PapG [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4630 100.0 5.66E-121 papF VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papF) P pilus minor subunit PapF [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4631 100.0 4.07E-129 papE VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papE) P pilus minor subunit PapE [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4632 100.0 1.39E-131 papK VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papK) P pilus minor subunit PapK [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4633 100.0 1.03E-142 papJ VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papJ) P pilus assembly protein PapJ [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4634 100.0 6.64E-180 papD VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papD) chaperone protein PapD [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4635 100.0 0.0 papC VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papC) usher protein PapC [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4636 100.0 5.42E-147 papH VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papH) P pilus termination subunit PapH [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4637 100.0 3.54E-135 papA VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papA) P pilus major subunit PapA [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4638 98.889 1.0E-63 papB VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papB) regulatory protein PapB [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4639 100.0 1.07E-51 papI VF0220 P fimbriae Adherence VFC0001 Mannose-resistant (MRHA); Pap pili expression is tightly regulated in response to several environmental and nutritional factors, also controlled by a methylation-dependent phase variation mechanims; The pap operon is a useful example of pilus assembly since it contains many conserved features:; PapD, a conserved chaperone molecule with an Ig-like domain, is necessary to transport several pilus subunits from the cytoplasmic membrane to the outer membrane; PapD-subunit complexes are targeted to the PapC outer membrane usher, which forms a pore through which the the pili are translocated across the OM; The major subunit is PapA, which is assembled into a 6.8-nm thick helical rod that is anchored in the OM by PapH; At the distal end of the pilus rod is a 2-nm linear tip fibrillum composed of a PapE, which is adapted to the PapA rod by PapK. PapG is joined to the PapE tip fibrillum by the adapter protein PapF (papI) regulatory protein PapI [P fimbriae (VF0220) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4670 75.568 0.0 htpB VF0159 Hsp60 Adherence VFC0001 (htpB) Hsp60, 60K heat shock protein HtpB [Hsp60 (VF0159) - Adherence (VFC0001)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
AE014075.1_4812 100.0 7.38E-152 fimB VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4813 100.0 7.59E-149 fimE VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimE) Type 1 fimbriae Regulatory protein fimE [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4814 100.0 5.22E-128 fimA VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimA) Type-1 fimbrial protein, A chain precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4815 100.0 4.41E-124 fimI VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4816 100.0 0.0 fimC VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4817 100.0 0.0 fimD VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4818 100.0 4.38E-130 fimF VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimF) FimF protein precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4819 100.0 2.65E-122 fimG VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimG) FimG protein precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4820 100.0 0.0 fimH VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimH) FimH protein precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
AE014075.1_4849 69.41 0.0 cheD VF0394 Flagella Motility VFC0204 (cheD) methyl-accepting chemotaxis protein CheD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica