2. PATHOGENS
Basic Information
Accession number
GCA_000009005.1
Release date
2005-11-24
Organism
Staphylococcus aureus RF122
Species name
Staphylococcus aureus
Assembly level
Complete Genome
Assembly name
ASM900v1
Assembly submitter
Univ. Minnesota
Assembly Type
haploid
Genome size
2.7 Mb
GC percent
33.0
Contig count
1
Collection date
-
Sample location
-
Host
Bos taurus (cow)
Isolation source
-
Isolate type
-
Strain
RF122
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
AJ938182.1_44 # 54631 # 56019 525.0 905.59 norC 100.0 ARO:3007010 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump NorC is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 61% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. Like NorA and NorB, NorC is regulated by mgrA, also known as NorR.
AJ938182.1_78 # 95230 # 96588 850.0 871.307 tet(38) 99.78 ARO:3000565 protein homolog model tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Tet38 is a tetracycline efflux pump found in the Gram-positive Staphylococcus aureus. It is regulated by mgrA, which also regulates NorB.
AJ938182.1_294 # 334241 # 334660 250.0 285.804 mepR 100.0 ARO:3000746 protein homolog model glycylcycline; tetracycline antibiotic antibiotic efflux multidrug and toxic compound extrusion (MATE) transporter MepR is an upstream repressor of MepA in Staphylococcus aureus. It is part of the mepRAB operon.
AJ938182.1_295 # 334767 # 336122 850.0 868.611 mepA 97.78 ARO:3000026 protein homolog model glycylcycline; tetracycline antibiotic antibiotic efflux multidrug and toxic compound extrusion (MATE) transporter MepA is an efflux protein regulated by MepR and part of the MepRAB cluster. Its presence in Staphylococcus aureus led to multidrug resistance, while it has also been shown to decrease tigecycline susceptibility.
AJ938182.1_645 # 700739 # 701182 270.0 301.212 mgrA 100.0 ARO:3000815 protein homolog model fluoroquinolone antibiotic; cephalosporin; penam; tetracycline antibiotic; peptide antibiotic; disinfecting agents and antiseptics antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump MgrA, also known as NorR, is a regulator for norA, norB, and tet38. It is a positive regulator for norA expression, but is a direct repressor for norB and an indirect repressor of tet38.
AJ938182.1_654 # 708751 # 709917 700.0 744.577 Staphylococcus aureus norA 97.16 ARO:3004667 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump NorA gene cloned from Staphylococcus aureus conferred relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus and Escherichia coli. Had low or no resistance at all to hydrophobic ones such as nalidixic acid, oxolinic acid, and sparfloxacin in S. aureus and Escherichia coli.
AJ938182.1_1287 # 1387390 # 1388745 880.0 907.131 arlS 99.56 ARO:3000839 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump ArlS is a protein histidine kinase that phosphorylates ArlR, a promoter for norA expression.
AJ938182.1_1288 # 1388742 # 1389401 410.0 442.58 arlR 100.0 ARO:3000838 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump ArlR is a response regulator that binds to the norA promoter to activate expression. ArlR must first be phosphorylated by ArlS.
AJ938182.1_1316 # 1423403 # 1424794 525.0 636.336 norC 69.89 ARO:3007010 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump NorC is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 61% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. Like NorA and NorB, NorC is regulated by mgrA, also known as NorR.
AJ938182.1_1967 # 2087509 # 2088657 175.0 181.415 vanT gene in vanG cluster 33.33 ARO:3002972 protein homolog model glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanT Also known as vanTG, is a vanT variant found in the vanG gene cluster.
AJ938182.1_1975 # 2096397 # 2099054 1500.0 1792.7 kdpD 98.76 ARO:3004047 protein homolog model aminoglycoside antibiotic antibiotic efflux kdpDE kdpD is a component of the two-component regulatory system, kdpDE. This system is involved in potassium transport and homeostasis, and has been implicated in virulence factor regulation along with kdpE.
AJ938182.1_2059 # 2193362 # 2194804 800.0 937.947 Staphylococcus aureus LmrS 97.29 ARO:3004572 protein homolog model macrolide antibiotic; aminoglycoside antibiotic; oxazolidinone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MFS transporters are secondary active transporters with single-polypeptide chains containing 400-600 amino acids that transport small solutes across the membrane by using electrochemical gradients. LmrS has 14 transmembrane helices and, when expressed in E. coli, is capable of extruding a variety of antibiotics inclinding linezolid, trimethoprim, florfenicol, chlorampheniocol, erythromycin, streptomycin, kanamycin, and fusidic acid.
AJ938182.1_2060 # 2195127 # 2195594 100.0 295.434 sepA 95.48 ARO:3007012 protein homolog model disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump sepA is a multidrug efflux pump that confers resistance to disinfecting agents and dyes.
AJ938182.1_2061 # 2195699 # 2197042 200.0 860.136 sdrM 98.88 ARO:3007013 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump sdrM encodes an efflux pump that confers resistance to norfloxacin and ethidium bromide, making this a multidrug resistance gene.
AJ938182.1_2328 # 2460439 # 2461839 525.0 535.413 norC 59.61 ARO:3007010 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump NorC is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 61% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. Like NorA and NorB, NorC is regulated by mgrA, also known as NorR.
AJ938182.1_297 # 336753 # 338111 800.0 899.042 Staphylococcus aureus GlpT with mutation conferring resistance to fosfomycin 99.12 ARO:3003901 protein variant model L27F, A100V phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant GlpT Mutations to the active importer GlpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria.
AJ938182.1_1996 # 2117188 # 2118453 800.0 841.647 Staphylococcus aureus murA with mutation conferring resistance to fosfomycin 99.29 ARO:3003776 protein variant model E291D, T396N phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant murA transferase murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations confers fosfomycin resistance.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
AJ938182.1_23 94.56 0.0 adsA VF0422 AdsA Immune modulation VFC0258 Harbors two 5'-nucleotidase motifs and a C-terminal LPXTG motif sorting signal (adsA) Adenosine synthase A [AdsA (VF0422) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_51 100.0 2.07E-37 spa VF0017 SpA Exotoxin VFC0235 Belongs to MSCRAMMs family (spa) Immunoglobulin G binding protein A precursor [SpA (VF0017) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_52 98.095 0.0 spa VF0017 SpA Exotoxin VFC0235 Belongs to MSCRAMMs family (spa) Immunoglobulin G binding protein A precursor [SpA (VF0017) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_93 64.302 0.0 lap VF0444 Lap Adherence VFC0001 Originally named surface protein p104, is a 104 kDa adhesion protein, present in every Listeria spp. except L. grayi (lap) Listeria adhesion protein Lap [Lap (VF0444) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AJ938182.1_95 97.807 3.08E-165 cap8B VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8B) type 8 capsular polysaccharide synthesis protein Cap8B [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_96 99.606 0.0 cap8C VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8C) type 8 capsular polysaccharide synthesis protein Cap8C [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_97 99.176 0.0 cap8D VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8D) type 8 capsular polysaccharide synthesis protein Cap8D [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_98 99.708 0.0 cap8E VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8E) type 8 capsular polysaccharide synthesis protein Cap8E [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_99 98.374 0.0 cap8F VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8F) type 8 capsular polysaccharide synthesis protein Cap8F [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_100 99.465 0.0 cap8G VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8G) type 8 capsular polysaccharide synthesis protein Cap8G [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_101 98.329 0.0 cap8H VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8H) type 8 capsular polysaccharide synthesis protein Cap8H [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_102 98.922 0.0 cap8I VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8I) type 8 capsular polysaccharide synthesis protein Cap8I [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_103 99.459 1.99E-134 cap8J VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8J) type 8 capsular polysaccharide synthesis protein Cap8J [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_104 99.272 0.0 cap8K VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8K) type 8 capsular polysaccharide synthesis protein Cap8K [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_105 98.504 0.0 cap8L VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8L) type 8 capsular polysaccharide synthesis protein Cap8L [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_106 99.459 3.1E-136 cap8M VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8M) type 8 capsular polysaccharide synthesis protein Cap8M [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_107 97.966 0.0 capN VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (capN) capsular polysaccharide type 5/8 biosynthesis epimerase CapN [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_108 98.81 0.0 cap8O VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8O) type 8 capsular polysaccharide synthesis protein Cap8O [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_109 98.688 0.0 cap8P VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8P) type 8 capsular polysaccharide synthesis protein Cap8P [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_110 97.222 7.69E-49 isdI VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdI) staphylobilin-forming heme oxygenase IsdI [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AJ938182.1_176 73.899 0.0 coa VF0421 Staphylocoagulase Exoenzyme VFC0251 (coa) staphylocoagulase precursor [Staphylocoagulase (VF0421) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_232 100.0 8.66E-67 esxA VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esxA) type VII secretion system secreted protein EsxA [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_233 99.306 0.0 esaA VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaA) type VII secretion system protein EsaA [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_234 96.721 9.01E-38 essA VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (essA) type VII secretion system protein EssA, monotopic membrane protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_235 100.0 6.11E-54 esaB VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaB) type VII secretion system protein EsaB [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_236 100.0 0.0 essB VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (essB) type VII secretion system protein EssB, monotopic membrane protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_237 99.121 0.0 essC VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (essC) type VII secretion system protein EssC, FtsK/SpoIIIE family ATPase [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_238 96.154 1.49E-89 esxC VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esxC) type VII secretion system secreted protein EsxC [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_239 97.115 8.13E-72 esxB VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esxB) type VII secretion system secreted protein EsxB [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_240 97.768 8.03E-162 esaE VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaE) type VII secretion system chaperone protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_241 97.143 1.43E-72 esxD VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esxD) type VII secretion system secreted protein EsxD [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_242 98.911 0.0 esaD VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaD) type VII secretion system secreted protein, a nuclease toxin EsaD [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_243 77.778 2.46E-38 esaD VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaD) type VII secretion system secreted protein, a nuclease toxin EsaD [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_244 93.252 2.42E-110 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_248 92.638 9.3E-111 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_249 90.361 2.79E-111 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_250 85.802 6.21E-105 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_268 97.063 0.0 geh VF0012 Lipase Exoenzyme VFC0251 Organized as pre-pro-enzymes: the pre-region represents the signal peptide; secreted in the pro-lipase form. The pro-region protects the proteins from proteolytic degradation and acts as an intramolecular chaperone to facilitate translocation of the lipase (geh) glycerol ester hydrolase [Lipase (VF0012) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_368 97.436 1.42E-169 tsst-1 VF0022 TSST-1 Exotoxin VFC0235 Encoded by tst present on staphylococcal pathogenicity island 1 (SaPI1); produced by approximately 20% of natural isolates; lacks disulfide loop and shows no significant homology to any of the other streptococcal and staphylococcal superantigens (tsst-1) toxic shock syndrome toxin-1 [TSST-1 (VF0022) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus N315] Staphylococcus aureus
AJ938182.1_371 96.992 0.0 sec VF0020 SE Exotoxin VFC0235 Constitutes a family of eight single-chain polypeptides (26-28kDa, 228-239 amino acid residues) with a typical disulfide loop; divided into two groups based on amino acid sequence homology: the first group consists of SEA,SEE, SED and SEH, and the second group including SEB, SEC, SEG (sec) staphylococcal enterotoxin C precursor [SE (VF0020) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_372 99.583 1.78E-175 sell VF0020 SE Exotoxin VFC0235 Constitutes a family of eight single-chain polypeptides (26-28kDa, 228-239 amino acid residues) with a typical disulfide loop; divided into two groups based on amino acid sequence homology: the first group consists of SEA,SEE, SED and SEH, and the second group including SEB, SEC, SEG (sell) staphylococcal enterotoxin L precursor [SE (VF0020) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_382 78.761 9.43E-126 set16 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set16) superantigen-like protein SSL1 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_383 98.268 4.71E-168 set17 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set17) superantigen-like protein SSL2 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_384 93.539 0.0 set18 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set18) superantigen-like protein SSL3 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_385 90.952 6.87E-140 set20 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set20) superantigen-like protein SSL5 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_386 85.714 1.57E-142 set22 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set22) superantigen-like protein SSL7 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_387 96.552 7.85E-163 set23 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set23) superantigen-like protein SSL8 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_388 94.828 1.13E-161 set24 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set24) superantigen-like protein SSL9 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_389 90.995 8.48E-133 set25 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set25) superantigen-like protein SSL10 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_392 93.939 3.23E-159 set26 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set26) superantigen-like protein SSL11 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_481 70.0 0.0 clpC VF0072 ClpC Stress survival VFC0282 27-kDa stress protein belongs to the Hsp100/Clp family; Regulation of Clp protease expression is mediated by CtsR, the product of the first gene in the ClpC operon (clpC) endopeptidase Clp ATP-binding chain C [ClpC (VF0072) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AJ938182.1_504 74.619 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
AJ938182.1_518 94.595 7.97E-19 sdrC VF0019 SDr Adherence VFC0001 (sdrC) Ser-Asp rich fibrinogen-binding bone sialoprotein-binding protein [SDr (VF0019) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_519 67.391 1.04E-33 sdrC VF0019 SDr Adherence VFC0001 (sdrC) Ser-Asp rich fibrinogen-binding bone sialoprotein-binding protein [SDr (VF0019) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_520 93.678 3.32E-114 sdrC VF0019 SDr Adherence VFC0001 (sdrC) Ser-Asp rich fibrinogen-binding bone sialoprotein-binding protein [SDr (VF0019) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_522 85.989 0.0 sdrE VF0019 SDr Adherence VFC0001 (sdrE) Ser-Asp rich fibrinogen-binding bone sialoprotein-binding protein [SDr (VF0019) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_729 77.835 4.73E-114 clpP VF0074 ClpP Stress survival VFC0282 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AJ938182.1_751 65.43 0.0 vWbp VF0420 VWbp Exoenzyme VFC0251 (vWbp) secreted von Willebrand factor-binding protein precursor [VWbp (VF0420) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AJ938182.1_790 67.949 3.83E-154 lukS-PV VF0018 PVL Exotoxin VFC0235 PVL, together with gamma-hemolysin and other leukocidins such as LukE-LukD, belongs to the family of bicomponent synergohymenotropic toxins; pore-forming toxin rich in beta-sheet structures (lukS-PV) Panton-Valentine leukocidin chain S precursor [PVL (VF0018) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_791 78.882 0.0 lukF-PV VF0018 PVL Exotoxin VFC0235 PVL, together with gamma-hemolysin and other leukocidins such as LukE-LukD, belongs to the family of bicomponent synergohymenotropic toxins; pore-forming toxin rich in beta-sheet structures (lukF-PV) Panton-Valentine leukocidin chain F precursor [PVL (VF0018) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_923 100.0 1.84E-78 sspC VF0006 Staphopain Exoenzyme VFC0251 Staphopains A (encoded by scpA) and B (encoded by sspB) are the major secreted cysteine proteases of S. aureus; A novel type of cysteine proteinase inhibitor, referred as staphostatins (ScpC, SspC), has been recently identified. They specifically inhibit cysteine proteinases (staphopains) (sspC) Staphostatin B [Staphopain (VF0006) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_924 98.728 0.0 sspB VF0006 Staphopain Exoenzyme VFC0251 Staphopains A (encoded by scpA) and B (encoded by sspB) are the major secreted cysteine proteases of S. aureus; A novel type of cysteine proteinase inhibitor, referred as staphostatins (ScpC, SspC), has been recently identified. They specifically inhibit cysteine proteinases (staphopains) (sspB) staphopain cysteine proteinase SspB [Staphopain (VF0006) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_925 98.239 0.0 sspA VF0023 V8 protease Exoenzyme VFC0251 A member of the glutamyl endopeptidase family of enzymes; narrow substrate specificity: cleaving peptide bonds exclusively on the carbonyl side of aspartate and glutamate residues; synthesized as a preproenzyme, the zymogen undergoes proteolytic activation via cleavage by the staphylococcal extracellular metalloprotease; The ssp gene encoding V8 protease is designated as sspA, and is followed by sspB, which encodes a cysteine protease, and sspC, which encodes a protein of unknown function (sspA) serine protease; V8 protease; glutamyl endopeptidase [V8 protease (VF0023) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_1004 94.109 0.0 isdB VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdB) iron-regulated surface determinant protein B, haemoglobin receptor [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AJ938182.1_1005 97.714 0.0 isdA VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdA) iron-regulated surface determinant protein A [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AJ938182.1_1006 99.119 9.22E-166 isdC VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdC) iron-regulated surface determinant protein C [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AJ938182.1_1007 96.648 0.0 isdD VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdD) iron-regulated surface determinant protein D [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AJ938182.1_1008 99.658 0.0 isdE VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdE) iron-regulated surface determinant protein E [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AJ938182.1_1009 99.065 0.0 isdF VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdF) iron-regulated surface determinant protein F, ATP-binding-cassette-type transmembrane transporter [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AJ938182.1_1010 99.18 0.0 srtB VF0015 Isd Nutritional/Metabolic factor VFC0272 (srtB) NPQTN specific sortase B [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AJ938182.1_1011 100.0 4.18E-78 isdG VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdG) iron-regulated surface determinant protein G [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AJ938182.1_1035 100.0 0.0 hly/hla VF0001 Alpha-hemolysin Exotoxin VFC0235 (hly/hla) Alpha-Hemolysin precursor [Alpha-hemolysin (VF0001) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_1107 72.464 9.19E-29 acpXL VF0367 LPS Immune modulation VFC0258 Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. (acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] Brucella melitensis
AJ938182.1_1208 68.116 0.0 katA VF0454 KatA Stress survival VFC0282 (katA) catalase [KatA (VF0454) - Stress survival (VFC0282)] [Neisseria meningitidis MC58] Neisseria meningitidis
AJ938182.1_1360 96.914 0.0 ebp VF0008 EbpS Adherence VFC0001 Belongs to MSCRAMMs family (ebp) cell surface elastin binding protein [EbpS (VF0008) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_1399 67.097 0.0 gndA VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AJ938182.1_1449 62.376 9.78E-131 sigA/rpoV VF0257 SigA Regulation VFC0301 In M. tuberculosis, 13 sigma factor genes have been annotated in the genome, 9 of which belong to a special subfamily thought to direct extracytoplasmic functions and various other stress responses (temperature, oxidative stress, pH, and infection of macrophages); sigma A also known as RpoV, is the essential principal mycobacterial sigma factors, necessary for most mycobacterial housekeeping gene transcription; It was the first mycobacterial sigma factor to be associated with virulence (sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AJ938182.1_1607 90.499 0.0 harA VF0015 Isd Nutritional/Metabolic factor VFC0272 (harA) haptoglobin-binding heme uptake protein HarA [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AJ938182.1_1608 96.899 1.13E-177 harA VF0015 Isd Nutritional/Metabolic factor VFC0272 (harA) haptoglobin-binding heme uptake protein HarA [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AJ938182.1_1683 75.556 0.0 hysA VF0013 Hyaluronate lyase Exoenzyme VFC0251 (hysA) hyaluronate lyase precursor [Hyaluronate lyase (VF0013) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_1707 82.769 0.0 lukF-PV VF0018 PVL Exotoxin VFC0235 PVL, together with gamma-hemolysin and other leukocidins such as LukE-LukD, belongs to the family of bicomponent synergohymenotropic toxins; pore-forming toxin rich in beta-sheet structures (lukF-PV) Panton-Valentine leukocidin chain F precursor [PVL (VF0018) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_1708 70.55 9.07E-163 hlgA VF0011 Gamma-hemolysin Exotoxin VFC0235 Three protein (HlgA, HlgB, HlgC) are virtually identical in sequence to leukocidin component S and F, thus gamma-hemolysin may act similarly to leukocidin; S component: HlgA, HlgC. F component: HlgB (hlgA) gamma-hemolysin chain II precursor [Gamma-hemolysin (VF0011) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_1716 70.32 1.5E-111 selk VF0020 SE Exotoxin VFC0235 Constitutes a family of eight single-chain polypeptides (26-28kDa, 228-239 amino acid residues) with a typical disulfide loop; divided into two groups based on amino acid sequence homology: the first group consists of SEA,SEE, SED and SEH, and the second group including SEB, SEC, SEG (selk) staphylococcal enterotoxin K precursor [SE (VF0020) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_1893 80.78 0.0 eap/map VF0016 Eap/Map Adherence VFC0001 Belongs to MSCRAMMs family; unusual property: Eap can bind back to the S. aureus cell wall (eap/map) extracellular adherence protein Eap/Map [Eap/Map (VF0016) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_1894 99.697 0.0 hlb VF0002 Beta-hemolysin Exotoxin VFC0235 (hlb) beta-hemolysin [Beta-hemolysin (VF0002) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus COL] Staphylococcus aureus
AJ938182.1_1926 66.856 0.0 groEL VF0594 GroEL Adherence VFC0001 GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. (groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] Clostridium difficile
AJ938182.1_2007 60.8 8.62E-175 cap8P VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8P) type 8 capsular polysaccharide synthesis protein Cap8P [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_2094 89.343 0.0 hysA VF0013 Hyaluronate lyase Exoenzyme VFC0251 (hysA) hyaluronate lyase precursor [Hyaluronate lyase (VF0013) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_2175 61.421 1.91E-91 ureG VF0050 Urease Stress survival VFC0282 (ureG) urease accessory protein (ureG) [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] Helicobacter pylori
AJ938182.1_2302 91.304 0.0 sbi VF0423 Sbi Immune modulation VFC0258 A secreted protein that is also associated with the bacterial envelope, lacks a C-terminal LPXTG sorting signal (sbi) IgG-binding protein SBI [Sbi (VF0423) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_2303 99.353 0.0 hlgA VF0011 Gamma-hemolysin Exotoxin VFC0235 Three protein (HlgA, HlgB, HlgC) are virtually identical in sequence to leukocidin component S and F, thus gamma-hemolysin may act similarly to leukocidin; S component: HlgA, HlgC. F component: HlgB (hlgA) gamma-hemolysin chain II precursor [Gamma-hemolysin (VF0011) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_2304 99.048 0.0 hlgC VF0011 Gamma-hemolysin Exotoxin VFC0235 Three protein (HlgA, HlgB, HlgC) are virtually identical in sequence to leukocidin component S and F, thus gamma-hemolysin may act similarly to leukocidin; S component: HlgA, HlgC. F component: HlgB (hlgC) gamma-hemolysin component C [Gamma-hemolysin (VF0011) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_2305 98.127 0.0 hlgB VF0011 Gamma-hemolysin Exotoxin VFC0235 Three protein (HlgA, HlgB, HlgC) are virtually identical in sequence to leukocidin component S and F, thus gamma-hemolysin may act similarly to leukocidin; S component: HlgA, HlgC. F component: HlgB (hlgB) gamma-hemolysin component B [Gamma-hemolysin (VF0011) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_2376 83.301 0.0 fnbA VF0010 FnBPs Adherence VFC0001 Belongs to MSCRAMMs family; most strains of S. aureus express two related Fn-binding proteins FnBPA and FnBPB, which are encoded by closely linked genes (fnbA) fibronectin-binding protein A [FnBPs (VF0010) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_2513 99.804 0.0 aur VF0024 Aureolysin Exoenzyme VFC0251 The aur gene encoding aureolysin is present in two allelic forms: type I and type II; low substrate specificity: cleaving peptide bonds on the N-terminal side of bulky, aliphatic, hydrophobic residues (aur) zinc metalloproteinase aureolysin [Aureolysin (VF0024) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_2546 99.462 8.26E-134 icaR VF0014 Intercellular adhesion proteins Biofilm VFC0271 IcaA, icaB, icaC, icaD synthesize a polysaccharide, poly-n-succinyl-beta-1,6 glucosamine (PNSG) during infection (icaR) ica operon transcriptional regulator IcaR [Intercellular adhesion proteins (VF0014) - Biofilm (VFC0271)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_2547 99.515 0.0 icaA VF0014 Intercellular adhesion proteins Biofilm VFC0271 IcaA, icaB, icaC, icaD synthesize a polysaccharide, poly-n-succinyl-beta-1,6 glucosamine (PNSG) during infection (icaA) N-acetylglucosaminyltransferase, involved in polysaccharide intercellular adhesin(PIA) synthesis [Intercellular adhesion proteins (VF0014) - Biofilm (VFC0271)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_2548 98.966 0.0 icaB VF0014 Intercellular adhesion proteins Biofilm VFC0271 IcaA, icaB, icaC, icaD synthesize a polysaccharide, poly-n-succinyl-beta-1,6 glucosamine (PNSG) during infection (icaB) N-deacetylase, involved in polysaccharide intercellular adhesin(PIA) synthesis [Intercellular adhesion proteins (VF0014) - Biofilm (VFC0271)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_2549 99.714 0.0 icaC VF0014 Intercellular adhesion proteins Biofilm VFC0271 IcaA, icaB, icaC, icaD synthesize a polysaccharide, poly-n-succinyl-beta-1,6 glucosamine (PNSG) during infection (icaC) intercellular adhesion protein C, involved in polysaccharide intercellular adhesin(PIA) synthesis [Intercellular adhesion proteins (VF0014) - Biofilm (VFC0271)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AJ938182.1_2550 97.794 0.0 lip VF0012 Lipase Exoenzyme VFC0251 Organized as pre-pro-enzymes: the pre-region represents the signal peptide; secreted in the pro-lipase form. The pro-region protects the proteins from proteolytic degradation and acts as an intramolecular chaperone to facilitate translocation of the lipase (lip) triacylglycerol lipase precursor [Lipase (VF0012) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus