2. PATHOGENS
Basic Information
Accession number
GCA_000009445.1
Release date
2007-01-08
Organism
Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2
Species name
Mycobacterium tuberculosis
Assembly level
Complete Genome
Assembly name
ASM944v1
Assembly submitter
Garnier T., Unite Genetique Moleculaire Bacterienne, Institut Pasteur, 28,rue du Dr ROUX, PARIS, 75015, FRANCE. Garnier T., submitted on behalf of the Mycobacterium bovis sequencing teams, TB Research Group, Veterinary Laboratories Agency Weybridge, Woo...
Assembly Type
haploid
Genome size
4.4 Mb
GC percent
65.5
Contig count
1
Collection date
-
Sample location
-
Host
-
Isolation source
-
Isolate type
-
Strain
-
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
AM408590.1_308 # 342340 # 342885 300.0 365.925 AAC(2')-Ic 100.0 ARO:3002525 protein homolog model aminoglycoside antibiotic antibiotic inactivation AAC(2') AAC(2')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in M. tuberculosis and Mycobacterium tuberculosis variant bovis.
AM408590.1_2135 # 2309538 # 2310461 500.0 619.772 blaC 100.0 ARO:3007182 protein homolog model cephalosporin; cephamycin; penam; penem antibiotic inactivation class A Mycobacterium tuberculosis bla beta-lactamase blaC is a broad-spectrum class A beta-lactamase coded in the chromosome of Mycobacterium tuberculosis. It has been shown to hydrolyze a large number of beta-lactam antibiotics and is a major obstacle in the treatment of tuberculosis with such drugs.
AM408590.1_2895 # 3107025 # 3108617 1000.0 1044.65 efpA 99.81 ARO:3003955 protein homolog model rifamycin antibiotic; isoniazid-like antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump efpA is an MFS transporter found in Mycobacterium tuberculosis.
AM408590.1_3472 # 3760571 # 3761122 350.0 363.999 mfpA 100.0 ARO:3003035 protein homolog model fluoroquinolone antibiotic antibiotic target protection quinolone resistance protein (qnr) mfpA is a qnr homolog and a pentapeptide repeat protein that confers resistance to fluoroquinolones in Mycolicibacterium smegmatis.
AM408590.1_730 # 791216 # 794734 2300.0 2395.54 Mycobacterium tuberculosis rpoB mutants conferring resistance to rifampicin 100.0 ARO:3003283 protein variant model D516G, H526T, L511R rifamycin antibiotic antibiotic target alteration; antibiotic target replacement rifamycin-resistant beta-subunit of RNA polymerase (rpoB) Point mutations that occurs in Mycobacterium tuberculosis rpoB resulting in resistance to rifampicin.
AM408590.1_1405 # 1496835 # 1498091 750.0 842.803 Mycobacterium tuberculosis intrinsic murA conferring resistance to fosfomycin 100.0 ARO:3003784 protein variant model C117D phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant murA transferase Mycobacterium tuberculosis murA confers intrinsic resistance to fosfomycin. The presence of an aspartic acid residue in place of the critical cysteine at position 117 that enables fosfomycin binding is believed to be responsible for this intrinsic resistance.
AM408590.1_1928 # 2102610 # 2104001 800.0 934.48 Mycobacterium tuberculosis ndh with mutation conferring resistance to isoniazid 99.78 ARO:3003461 protein variant model G313R isoniazid-like antibiotic antibiotic target alteration antibiotic resistant ndh Point mutations in the Mycobacterium tuberculosis ndh gene shown clinically to confer resistance to isoniazid.
AM408590.1_1987 # 2154919 # 2157141 1400.0 1510.35 Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid 99.86 ARO:3003392 protein variant model R463L, A234G, A431V, G300W isoniazid-like antibiotic antibiotic target alteration isoniazid resistant katG katG is a catalase-peroxidase that catalyzes the activation of isoniazid. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. Mutations in katG results in inability to activate isoniazid. Over 280 different mutations have been documented in PubMed for katG, with mutations to Ser315 being the most prevalent.
AM408590.1_2111 # 2272333 # 2272893 300.0 375.941 Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide 99.46 ARO:3003394 protein variant model H57D pyrazine antibiotic antibiotic target alteration Pyrazinamide resistant pncA pncA is a pyrazinamidase/nicotinamidase. It catalyzes the activation of pyrazinamide. Some mutation within pncA are associated with loss of enzyme activity, resulting in pyrazinamide resistance.
AM408590.1_3897 # 4212266 # 4215550 2000.0 2172.51 Mycobacterium tuberculosis embC mutant conferring resistance to ethambutol 99.91 ARO:3003327 protein variant model T270I polyamine antibiotic antibiotic target alteration ethambutol resistant embC Point mutations in Mycobacterium tuberculosis embC that result in lower affinity between ethambutol and EmbC, resulting in resistance.
AM408590.1_3899 # 4218917 # 4222213 2000.0 2186.76 Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol 99.82 ARO:3003326 protein variant model E378A polyamine antibiotic antibiotic target alteration ethambutol resistant embB Point mutations that occur within Mycobacterium tuberculosis embB gene resulting in resistance to ethambutol.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
AM408590.1_169 100.0 0.0 fbpC VF0311 Antigen 85 Adherence VFC0001 Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp) (fbpC) Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_282 99.786 0.0 aftD VF0318 LAM Immune modulation VFC0258 A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) (aftD) alpha-(1->3)-arabinofuranosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_331 99.842 0.0 eccA3 VF0521 ESX-3 Effector delivery system VFC0086 (eccA3) Type VII secretion system protein EccA3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_332 100.0 0.0 eccB3 VF0521 ESX-3 Effector delivery system VFC0086 (eccB3) Type VII secretion system protein EccB3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_333 99.85 0.0 eccC3 VF0521 ESX-3 Effector delivery system VFC0086 (eccC3) Type VII secretion system protein EccC3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_334 100.0 2.51E-63 PE5 VF0521 ESX-3 Effector delivery system VFC0086 (PE5) PE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_335 100.0 0.0 PPE4 VF0521 ESX-3 Effector delivery system VFC0086 (PPE4) PPE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_336 100.0 8.84E-64 esxG VF1196 EsxG-EsxH Effector delivery system VFC0086 EsxG-EsxH heterodimer is secreted by ESX-3. (esxG) Type VII secretion system protein EsxG [EsxG-EsxH (VF1196) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_337 100.0 2.41E-66 esxH VF1196 EsxG-EsxH Effector delivery system VFC0086 EsxG-EsxH heterodimer is secreted by ESX-3. (esxH) Type VII secretion system protein ESXH (10 kDa antigen) (CFP-7) (protein TB10.4) [EsxG-EsxH (VF1196) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_338 100.0 0.0 espG3 VF0521 ESX-3 Effector delivery system VFC0086 (espG3) Type VII secretion system protein EspG3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_339 99.788 0.0 eccD3 VF0521 ESX-3 Effector delivery system VFC0086 (eccD3) Type IIV secretion system transmembrane protein EccD3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_340 100.0 0.0 mycP3 VF0521 ESX-3 Effector delivery system VFC0086 (mycP3) Type VII secretion system membrane-anchored mycosin MycP3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_341 99.698 0.0 eccE3 VF0521 ESX-3 Effector delivery system VFC0086 (eccE3) Type VII secretion system transmembrane protein EccE3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_344 100.0 0.0 stf0 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (stf0) hypothetical protein [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_402 100.0 7.04E-90 hspR VF0297 HspR Regulation VFC0301 (hspR) heat shock protein transcriptional repressor HspR [HspR (VF0297) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_482 100.0 1.03E-174 sodC VF0305 SodC Stress survival VFC0282 (sodC) superoxide dismutase [SodC (VF0305) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_490 64.272 0.0 groEL VF0594 GroEL Adherence VFC0001 GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. (groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] Clostridium difficile
AM408590.1_518 100.0 0.0 icl VF0253 Isocitrate lyase Others VFC0346 (icl) Isocitrate lyase Icl (isocitrase) (isocitratase) [Isocitrate lyase (VF0253) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_521 100.0 0.0 pcaA VF0285 PcaA Others VFC0346 Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate (pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_527 100.0 4.37E-137 hbhA VF0313 HbhA Adherence VFC0001 Surface-located protein (hbhA) iron-regulated heparin binding hemagglutinin hbhA (adhesin) [HbhA (VF0313) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_705 99.664 0.0 mmaA4 VF0314 MmaA4 Others VFC0346 (mmaA4) hydroxymycolate synthase MmaA4 [MmaA4 (VF0314) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_706 63.899 1.76E-135 pcaA VF0285 PcaA Others VFC0346 Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate (pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_707 72.125 8.16E-152 pcaA VF0285 PcaA Others VFC0346 Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate (pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_749 71.788 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
AM408590.1_824 100.0 0.0 phoP VF0286 PhoP Regulation VFC0301 Similar to the PhoP response regulator of S. enteric serovar Typhimurium that senses Mg2+ starvation and controls the expression of virulence genes (phoP) Possible two component system response transcriptional positive regulator PhoP [PhoP (VF0286) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_825 99.588 0.0 phoR VF0286 PhoP Regulation VFC0301 Similar to the PhoP response regulator of S. enteric serovar Typhimurium that senses Mg2+ starvation and controls the expression of virulence genes (phoR) Possible two component system response sensor kinase membrane associated PhoR [PhoP (VF0286) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1056 99.123 4.46E-162 mprA VF0298 MprAB Regulation VFC0301 MprB, sensor kinase, can undergo autophosphorylation. MprA, transcriptional factor, can accept phosphate from MprB or from small phosphodonors including acetyl phosphate (mprA) two-component response regulator MrpA [MprAB (VF0298) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1057 99.802 0.0 mprB VF0298 MprAB Regulation VFC0301 MprB, sensor kinase, can undergo autophosphorylation. MprA, transcriptional factor, can accept phosphate from MprB or from small phosphodonors including acetyl phosphate (mprB) two component histidine-protein kinase/phosphatase MprB [MprAB (VF0298) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1116 91.489 1.15E-59 esxN VF0402 ESX-5 Effector delivery system VFC0086 (esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1250 99.838 0.0 narG VF0302 Nitrate reductase Nutritional/Metabolic factor VFC0272 NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein (narG) nitrate reductase subunit alpha [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1251 100.0 0.0 narH VF0302 Nitrate reductase Nutritional/Metabolic factor VFC0272 NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein (narH) nitrate reductase subunit beta [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1252 99.005 7.9E-144 narJ VF0302 Nitrate reductase Nutritional/Metabolic factor VFC0272 NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein (narJ) nitrate reductase subunit delta [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1253 99.593 0.0 narI VF0302 Nitrate reductase Nutritional/Metabolic factor VFC0272 NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein (narI) nitrate reductase subunit gamma [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1271 65.224 0.0 pks2 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1275 62.003 0.0 fadD28 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1283 68.966 2.2E-29 PE18 VF0402 ESX-5 Effector delivery system VFC0086 (PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1286 91.489 9.57E-60 esxN VF0402 ESX-5 Effector delivery system VFC0086 (esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1309 100.0 1.29E-158 sigE VF0295 SigE Regulation VFC0301 SigE activity is downregulated by an anti-sigma factor, RseA, that is encoded by a gene Rv1222, adjacent to sigE (sigE) ECF RNA polymerase sigma factor SigE [SigE (VF0295) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1435 100.0 1.05E-54 mbtL VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtL) Acyl carrier protein (ACP) MbtL [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1436 100.0 0.0 mbtM VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtM) Probable fatty acyl-AMP ligase MbtM [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1437 100.0 0.0 mbtN VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtN) Acyl-CoA dehydrogenase MbtN [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1438 100.0 3.18E-157 mbtK VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtK) Lysine N-acetyltransferase MbtK [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1477 68.041 2.09E-24 PE5 VF0521 ESX-3 Effector delivery system VFC0086 (PE5) PE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1606 64.014 0.0 fadD28 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1612 70.024 0.0 pks2 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1614 65.47 0.0 fadD28 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1705 100.0 0.0 capA VF0318 LAM Immune modulation VFC0258 A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) (capA) mannosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1723 99.214 0.0 PE_PGRS30 VF0316 PE/PE-PGRS Immune modulation VFC0258 PE family members are characterized by highly conserved N-terminal Pro-Glu motif, PE-PGRS proteins have tandem repetitions of Gly-Gly-Ala or Gly-Gly-Asn termed the PGRS domain (polymorphic GC-rich repetitive sequence) near C-terminal; PE family members have been found in all the sequenced Mycobacterium genomes, although their number is highly variable (PE_PGRS30) PE-PGRS family protein PE_PGRS30 [PE/PE-PGRS (VF0316) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1735 60.592 5.6E-154 pks1 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (pks1) polyketide synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1833 71.624 0.0 plcA VF0320 Phospholipase C Exotoxin VFC0235 Phospholipases can be divided into four groups depending on the position of the bond they hydrolyse on the phospholipid substrate: phospholipases A1, A2, C and D (plcA) membrane-associated phospholipase A [Phospholipase C (VF0320) - Exotoxin (VFC0235)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1853 99.802 0.0 eccB5 VF0402 ESX-5 Effector delivery system VFC0086 (eccB5) ESX-5 type VII secretion system protein EccB5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1854 99.856 0.0 eccC5 VF0402 ESX-5 Effector delivery system VFC0086 (eccC5) ESX-5 type VII secretion system FtsK/SpoIIIE family protein EccC5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1855 100.0 0.0 cyp143 VF0402 ESX-5 Effector delivery system VFC0086 (cyp143) cytochrome P450 Cyp143 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1856 100.0 1.24E-45 Rv1786 VF0402 ESX-5 Effector delivery system VFC0086 (Rv1786) ferredoxin [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1857 99.178 0.0 PPE25 VF0402 ESX-5 Effector delivery system VFC0086 (PPE25) PPE family protein PPE25 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1858 100.0 1.16E-62 PE18 VF0402 ESX-5 Effector delivery system VFC0086 (PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1859 100.0 0.0 PPE26 VF0402 ESX-5 Effector delivery system VFC0086 (PPE26) PPE family protein PPE26 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1860 100.0 0.0 PPE27 VF0402 ESX-5 Effector delivery system VFC0086 (PPE27) PPE family protein PPE27 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1861 100.0 2.0E-62 PE19 VF0402 ESX-5 Effector delivery system VFC0086 (PE19) PE family protein PE19 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1863 100.0 1.0E-65 esxN VF0402 ESX-5 Effector delivery system VFC0086 (esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1864 100.0 0.0 Rv1794 VF0402 ESX-5 Effector delivery system VFC0086 (Rv1794) ESX-5 locus protein [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1865 99.801 0.0 eccD5 VF0402 ESX-5 Effector delivery system VFC0086 (eccD5) ESX-5 type VII secretion system EccD5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1866 100.0 0.0 mycP5 VF0402 ESX-5 Effector delivery system VFC0086 (mycP5) ESX-5 type VII secretion system subtilisin-like serine protease MycP5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1867 100.0 0.0 eccE5 VF0402 ESX-5 Effector delivery system VFC0086 (eccE5) ESX-5 type VII secretion system EccE5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1868 100.0 0.0 eccA5 VF0402 ESX-5 Effector delivery system VFC0086 (eccA5) ESX-5 type VII secretion system AAA+ ATPase EccA5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1882 100.0 3.94E-171 mgtC VF0289 MgtC Nutritional/Metabolic factor VFC0272 Homology to MgtC of Salmonella enterica, which is essential for the survival of S.enterica within macrophages (mgtC) Possible Mg2+ transport P-type ATPase C MgtC [MgtC (VF0289) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1916 61.017 5.29E-21 gndA VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AM408590.1_1961 99.677 0.0 fbpB VF0311 Antigen 85 Adherence VFC0001 Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp) (fbpB) Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_1987 99.865 0.0 katG VF0303 KatG Stress survival VFC0282 (katG) catalase-peroxidase [KatG (VF0303) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2095 62.254 0.0 devS VF0317 DevRS Regulation VFC0301 A two-component system consists of a histidine sensor kinase and a response regulator; phosphorylation-based signalling has been established for five of eleven systems in M. tuberculosis, RegX3-SenX3, TrcR-TrcS, MprA-MprB, PrrA-PrrB and DevR-DevS (DosR-DosS) (devS) two component sensor histidine kinase DevS [DevRS (VF0317) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2099 100.0 1.49E-104 hspX VF0301 HspX Stress survival VFC0282 (hspX) Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3) [HspX (VF0301) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2245 100.0 0.0 mptC VF0318 LAM Immune modulation VFC0258 A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) (mptC) alpha-(1-2)-phosphatidylinositol mannoside mannosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2416 98.305 1.7E-38 esxN VF0402 ESX-5 Effector delivery system VFC0086 (esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2438 98.592 1.63E-49 mbtH VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtH) putative protein MbtH [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2439 100.0 0.0 mbtG VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtG) Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2440 99.863 0.0 mbtF VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtF) Peptide synthetase MbtF (peptide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2441 100.0 0.0 mbtE VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtE) Peptide synthetase MbtE (peptide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2442 100.0 0.0 mbtD VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtD) Polyketide synthetase MbtD (polyketide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2443 100.0 0.0 mbtC VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtC) Polyketide synthetase MbtC (polyketide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2444 99.859 0.0 mbtB VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtB) Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2445 100.0 0.0 mbtA VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtA) Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2446 100.0 0.0 mbtJ VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtJ) Putative acetyl hydrolase MbtJ [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2447 100.0 0.0 mbtI VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtI) Isochorismate synthase MbtI [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2489 100.0 2.49E-146 ahpC VF0306 AhpC Stress survival VFC0282 (ahpC) alkyl hydroperoxide reductase subunit AhpC [AhpC (VF0306) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2491 100.0 1.15E-145 PPE41 VF0402 ESX-5 Effector delivery system VFC0086 (PPE41) PPE family protein PPE41 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2509 67.303 0.0 Rv2953 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2953) trans-acting enoyl reductase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2644 100.0 0.0 relA VF0287 RelA Regulation VFC0301 (relA) Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) [RelA (VF0287) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2750 100.0 0.0 sigA/rpoV VF0257 SigA Regulation VFC0301 In M. tuberculosis, 13 sigma factor genes have been annotated in the genome, 9 of which belong to a special subfamily thought to direct extracytoplasmic functions and various other stress responses (temperature, oxidative stress, pH, and infection of macrophages); sigma A also known as RpoV, is the essential principal mycobacterial sigma factors, necessary for most mycobacterial housekeeping gene transcription; It was the first mycobacterial sigma factor to be associated with virulence (sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2757 62.857 7.43E-135 sigA/rpoV VF0257 SigA Regulation VFC0301 In M. tuberculosis, 13 sigma factor genes have been annotated in the genome, 9 of which belong to a special subfamily thought to direct extracytoplasmic functions and various other stress responses (temperature, oxidative stress, pH, and infection of macrophages); sigma A also known as RpoV, is the essential principal mycobacterial sigma factors, necessary for most mycobacterial housekeeping gene transcription; It was the first mycobacterial sigma factor to be associated with virulence (sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2758 100.0 1.59E-166 ideR VF0300 IdeR Regulation VFC0301 A DNA binding protein interacts with a conserved DNA sequence requires the binding of Fe2+ or related divalent cations (ideR) Iron-dependent repressor and activator IdeR [IdeR (VF0300) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2981 100.0 0.0 tesA VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (tesA) thioesterase TesA [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2982 99.828 0.0 fadD26 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD26) fatty-acid--CoA ligase FadD26 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2983 99.627 0.0 ppsA VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ppsA) phthiocerol synthesis polyketide synthase type I PpsA [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2984 99.87 0.0 ppsB VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ppsB) phthiocerol synthesis polyketide synthase type I PpsB [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2985 100.0 0.0 ppsC VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ppsC) phthiocerol synthesis polyketide synthase type I PpsC [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2986 99.891 0.0 ppsD VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ppsD) phthiocerol synthesis polyketide synthase type I PpsD [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2987 99.933 0.0 ppsE VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ppsE) phthiocerol synthesis polyketide synthase type I PpsE [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2988 99.698 0.0 ddrA VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ddrA) daunorubicin ABC transporter ATP-binding protein DrrA [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2989 100.0 0.0 ddrB VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ddrB) daunorubicin ABC transporter permease DrrB [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2990 100.0 0.0 drrC VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (drrC) daunorubicin ABC transporter permease DrrC [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2991 100.0 0.0 papA5 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (papA5) phthiocerol/phthiodiolone dimycocerosyl transferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2992 99.953 0.0 mas VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (mas) multifunctional mycocerosic acid synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2993 99.828 0.0 fadD28 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2994 100.0 0.0 mmpL7 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (mmpL7) transmembrane transport protein MmpL7 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_2998 100.0 4.35E-170 lppx VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (lppx) lipoprotein LppX [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3001 100.0 0.0 fadD22 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD22) p-hydroxybenzoyl--AMP ligase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3002 100.0 1.87E-148 Rv2949c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2949c) chorismate pyruvate-lyase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3003 99.838 0.0 fadD29 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD29) long-chain-fatty-acid--AMP ligase FadD29 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3004 100.0 0.0 Rv2951c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2951c) phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3005 100.0 0.0 Rv2952 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2952) phthiotriol/phenolphthiotriol dimycocerosates methyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3006 100.0 0.0 Rv2953 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2953) trans-acting enoyl reductase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3007 99.585 0.0 Rv2954c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2954c) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3008 100.0 0.0 Rv2955c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2955c) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3009 99.588 0.0 Rv2956 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2956) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3010 100.0 0.0 Rv2957 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2957) PGL/p-HBAD biosynthesis glycosyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3011 83.288 0.0 Rv2958c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2958c) PGL/p-HBAD biosynthesis glycosyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3012 100.0 0.0 Rv2959c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2959c) rhamnosyl O-methyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3014 100.0 0.0 Rv2962c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2962c) PGL/p-HBAD biosynthesis rhamnosyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3076 84.375 8.56E-57 esxH VF1196 EsxG-EsxH Effector delivery system VFC0086 EsxG-EsxH heterodimer is secreted by ESX-3. (esxH) Type VII secretion system protein ESXH (10 kDa antigen) (CFP-7) (protein TB10.4) [EsxG-EsxH (VF1196) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3077 91.753 6.03E-47 esxG VF1196 EsxG-EsxH Effector delivery system VFC0086 EsxG-EsxH heterodimer is secreted by ESX-3. (esxG) Type VII secretion system protein EsxG [EsxG-EsxH (VF1196) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3079 80.392 3.98E-32 PE5 VF0521 ESX-3 Effector delivery system VFC0086 (PE5) PE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3189 99.827 0.0 devS VF0317 DevRS Regulation VFC0301 A two-component system consists of a histidine sensor kinase and a response regulator; phosphorylation-based signalling has been established for five of eleven systems in M. tuberculosis, RegX3-SenX3, TrcR-TrcS, MprA-MprB, PrrA-PrrB and DevR-DevS (DosR-DosS) (devS) two component sensor histidine kinase DevS [DevRS (VF0317) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3190 100.0 9.56E-155 devR/dosR VF0317 DevRS Regulation VFC0301 A two-component system consists of a histidine sensor kinase and a response regulator; phosphorylation-based signalling has been established for five of eleven systems in M. tuberculosis, RegX3-SenX3, TrcR-TrcS, MprA-MprB, PrrA-PrrB and DevR-DevS (DosR-DosS) (devR/dosR) two component transcriptional regulator DevR [DevRS (VF0317) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3290 100.0 4.28E-162 sigH VF0296 SigH Regulation VFC0301 Similar to the sigma R of Streptomyces species; sigma H activity is regulated at the posttranslational level by a cystein-containing anti-sigma factor RsrA, encoded by a gene in the sigH operon; the ability of RshA to inhibit SigH-dependent transcription is redox-dependent (sigH) ECF RNA polymerase sigma factor SigH [SigH (VF0296) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3354 100.0 9.74E-175 sigF VF0294 SigF Regulation VFC0301 (sigF) RNA polymerase sigma factor SigF [SigF (VF0294) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3384 100.0 4.28E-162 sigH VF0296 SigH Regulation VFC0301 Similar to the sigma R of Streptomyces species; sigma H activity is regulated at the posttranslational level by a cystein-containing anti-sigma factor RsrA, encoded by a gene in the sigH operon; the ability of RshA to inhibit SigH-dependent transcription is redox-dependent (sigH) ECF RNA polymerase sigma factor SigH [SigH (VF0296) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3503 72.822 8.33E-159 pcaA VF0285 PcaA Others VFC0346 Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate (pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3529 100.0 9.92E-74 whiB3 VF0288 WhiB3 Regulation VFC0301 Seven members of the WhiB family in M. tuberculosis H37Rv, homolog of the Streptomyces coelicolor whiB gene, a transcription factor whose function is required for sporulation process (whiB3) redox-responsive transcriptional regulator WhiB3 [WhiB3 (VF0288) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3582 65.517 1.01E-25 PE18 VF0402 ESX-5 Effector delivery system VFC0086 (PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3594 99.639 0.0 lipF VF0307 LipF Nutritional/Metabolic factor VFC0272 (lipF) Probable esterase/lipase LipF [LipF (VF0307) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3709 100.0 9.1E-100 panD VF0319 PanC/PanD Nutritional/Metabolic factor VFC0272 (panD) aspartate 1-decarboxylase [PanC/PanD (VF0319) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3710 100.0 0.0 panC VF0319 PanC/PanD Nutritional/Metabolic factor VFC0272 (panC) pantothenate synthetase [PanC/PanD (VF0319) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3720 99.457 5.84E-134 espD VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espD) ESX-1 type VII secretion system EspD [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3721 100.0 1.42E-73 espC VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espC) ESX-1 type VII secretion system EspC [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3722 99.49 0.0 espA VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espA) ESX-1 type VII secretion system EspA [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3749 60.256 2.63E-17 PE18 VF0402 ESX-5 Effector delivery system VFC0086 (PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3897 99.909 0.0 embC VF0318 LAM Immune modulation VFC0258 A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) (embC) arabinosyltransferase C [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3907 100.0 0.0 fbpD VF0311 Antigen 85 Adherence VFC0001 Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp) (fbpD) MPT51/MPB51 antigen [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3908 100.0 0.0 fbpA VF0311 Antigen 85 Adherence VFC0001 Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp) (fbpA) Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3909 99.841 0.0 aftB VF0318 LAM Immune modulation VFC0258 A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) (aftB) terminal beta-(1->2)-arabinofuranosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3914 100.0 0.0 erp VF0312 Erp Others VFC0346 Surface-located protein;No homologue of Erp has been found in other bacterial species, making Erp a mycobacterial signature (erp) exported repetitive protein precursor Erp [Erp (VF0312) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3925 99.755 0.0 papA2 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (papA2) trehalose-2-sulfate acyltransferase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3929 99.816 0.0 mmpL8 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (mmpL8) integral membrane transport protein MmpL8 [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3930 100.0 0.0 papA1 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (papA1) acyltransferase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3931 99.952 0.0 pks2 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3932 66.207 0.0 fadD28 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3956 99.517 7.2E-154 sodA VF0304 SodA Stress survival VFC0282 (sodA) superoxide dismutase [SodA (VF0304) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3959 100.0 6.88E-98 espR VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espR) ESX-1 transcriptional regulator EspR [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3975 96.172 0.0 espE VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espE) ESX-1 secretion-associated protein EspE [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3976 100.0 3.55E-71 espF VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espF) ESX-1 secretion-associated protein EspF [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3977 100.0 0.0 espG1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espG1) ESX-1 secretion-associated protein EspG1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3978 100.0 2.46E-132 espH VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espH) ESX-1 secretion-associated protein EspH [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3979 99.825 0.0 eccA1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (eccA1) ESX-1 type VII secretion system AAA+ ATPase EccA1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3980 100.0 0.0 eccB1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (eccB1) ESX-1 type VII secretion system protein EccB1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3981 100.0 0.0 eccCa1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (eccCa1) ESX-1 type VII secretion system FtsK/SpoIIIE family protein EccCa1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3982 99.792 0.0 eccCb1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (eccCb1) ESX-1 type VII secretion system FtsK/SpoIIIE family protein EccCb1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3983 100.0 6.08E-81 espL VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espL) ESX-1 secretion associated protein EspL [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3984 98.696 0.0 espB VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espB) ESX-1 type VII secretion system EspB [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3985 100.0 0.0 eccE1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (eccE1) ESX-1 type VII secretion system EccE1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_3986 99.552 0.0 mycP1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (mycP1) ESX-1 type VII secretion system subtilisin-like serine protease MycP1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AM408590.1_4008 100.0 0.0 cpnT VF1197 CpnT Effector delivery system VFC0086 Secreted by ESX-5; CpnT is a two-domain protein in which the toxic activity resides in the C-terminus. (cpnT) NAD+ glycohydrolase [CpnT (VF1197) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis