2. PATHOGENS
Basic Information
Accession number
GCA_000010465.1
Release date
2007-07-02
Organism
Staphylococcus aureus subsp. aureus str. Newman
Species name
Staphylococcus aureus
Assembly level
Complete Genome
Assembly name
ASM1046v1
Assembly submitter
Juntendo University School of Medicine, Department of Bacteriology
Assembly Type
haploid
Genome size
2.9 Mb
GC percent
33.0
Contig count
1
Collection date
-
Sample location
-
Host
-
Isolation source
-
Isolate type
-
Strain
Newman
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
AP009351.1_49 # 62383 # 63771 525.0 901.353 norC 98.92 ARO:3007010 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump NorC is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 61% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. Like NorA and NorB, NorC is regulated by mgrA, also known as NorR.
AP009351.1_82 # 103046 # 104404 850.0 871.692 tet(38) 99.78 ARO:3000565 protein homolog model tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Tet38 is a tetracycline efflux pump found in the Gram-positive Staphylococcus aureus. It is regulated by mgrA, which also regulates NorB.
AP009351.1_350 # 376522 # 376941 250.0 285.804 mepR 100.0 ARO:3000746 protein homolog model glycylcycline; tetracycline antibiotic antibiotic efflux multidrug and toxic compound extrusion (MATE) transporter MepR is an upstream repressor of MepA in Staphylococcus aureus. It is part of the mepRAB operon.
AP009351.1_351 # 377048 # 378403 850.0 885.174 mepA 100.0 ARO:3000026 protein homolog model glycylcycline; tetracycline antibiotic antibiotic efflux multidrug and toxic compound extrusion (MATE) transporter MepA is an efflux protein regulated by MepR and part of the MepRAB cluster. Its presence in Staphylococcus aureus led to multidrug resistance, while it has also been shown to decrease tigecycline susceptibility.
AP009351.1_680 # 736757 # 737200 270.0 301.212 mgrA 100.0 ARO:3000815 protein homolog model fluoroquinolone antibiotic; cephalosporin; penam; tetracycline antibiotic; peptide antibiotic; disinfecting agents and antiseptics antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump MgrA, also known as NorR, is a regulator for norA, norB, and tet38. It is a positive regulator for norA expression, but is a direct repressor for norB and an indirect repressor of tet38.
AP009351.1_689 # 744851 # 746017 700.0 763.066 Staphylococcus aureus norA 99.74 ARO:3004667 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump NorA gene cloned from Staphylococcus aureus conferred relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus and Escherichia coli. Had low or no resistance at all to hydrophobic ones such as nalidixic acid, oxolinic acid, and sparfloxacin in S. aureus and Escherichia coli.
AP009351.1_1374 # 1460237 # 1461592 880.0 911.753 arlS 100.0 ARO:3000839 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump ArlS is a protein histidine kinase that phosphorylates ArlR, a promoter for norA expression.
AP009351.1_1375 # 1461589 # 1462248 410.0 442.58 arlR 100.0 ARO:3000838 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump ArlR is a response regulator that binds to the norA promoter to activate expression. ArlR must first be phosphorylated by ArlS.
AP009351.1_1396 # 1507941 # 1509332 525.0 646.736 norC 70.77 ARO:3007010 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump NorC is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 61% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. Like NorA and NorB, NorC is regulated by mgrA, also known as NorR.
AP009351.1_2064 # 2193212 # 2194360 175.0 182.185 vanT gene in vanG cluster 33.88 ARO:3002972 protein homolog model glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanT Also known as vanTG, is a vanT variant found in the vanG gene cluster.
AP009351.1_2072 # 2202105 # 2204762 1500.0 1789.24 kdpD 98.64 ARO:3004047 protein homolog model aminoglycoside antibiotic antibiotic efflux kdpDE kdpD is a component of the two-component regulatory system, kdpDE. This system is involved in potassium transport and homeostasis, and has been implicated in virulence factor regulation along with kdpE.
AP009351.1_2156 # 2303758 # 2305200 800.0 955.666 Staphylococcus aureus LmrS 100.0 ARO:3004572 protein homolog model macrolide antibiotic; aminoglycoside antibiotic; oxazolidinone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MFS transporters are secondary active transporters with single-polypeptide chains containing 400-600 amino acids that transport small solutes across the membrane by using electrochemical gradients. LmrS has 14 transmembrane helices and, when expressed in E. coli, is capable of extruding a variety of antibiotics inclinding linezolid, trimethoprim, florfenicol, chlorampheniocol, erythromycin, streptomycin, kanamycin, and fusidic acid.
AP009351.1_2157 # 2305522 # 2305989 100.0 298.13 sepA 96.13 ARO:3007012 protein homolog model disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump sepA is a multidrug efflux pump that confers resistance to disinfecting agents and dyes.
AP009351.1_2158 # 2306094 # 2307437 200.0 870.537 sdrM 100.0 ARO:3007013 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump sdrM encodes an efflux pump that confers resistance to norfloxacin and ethidium bromide, making this a multidrug resistance gene.
AP009351.1_2320 # 2457367 # 2457786 260.0 288.886 Staphylococcus aureus FosB 100.0 ARO:3004661 protein homolog model phosphonic acid antibiotic antibiotic inactivation fosfomycin thiol transferase The Bacillus subtilis fosB gene encodes a fosfomycin resistance protein.
AP009351.1_2430 # 2576859 # 2578259 525.0 532.332 norC 59.18 ARO:3007010 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump NorC is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 61% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. Like NorA and NorB, NorC is regulated by mgrA, also known as NorR.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
AP009351.1_23 95.078 0.0 adsA VF0422 AdsA Immune modulation VFC0258 Harbors two 5'-nucleotidase motifs and a C-terminal LPXTG motif sorting signal (adsA) Adenosine synthase A [AdsA (VF0422) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_56 96.26 0.0 spa VF0017 SpA Exotoxin VFC0235 Belongs to MSCRAMMs family (spa) Immunoglobulin G binding protein A precursor [SpA (VF0017) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_95 64.302 0.0 lap VF0444 Lap Adherence VFC0001 Originally named surface protein p104, is a 104 kDa adhesion protein, present in every Listeria spp. except L. grayi (lap) Listeria adhesion protein Lap [Lap (VF0444) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AP009351.1_97 99.561 1.81E-167 cap8B VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8B) type 8 capsular polysaccharide synthesis protein Cap8B [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_98 98.819 0.0 cap8C VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8C) type 8 capsular polysaccharide synthesis protein Cap8C [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_99 99.835 0.0 cap8D VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8D) type 8 capsular polysaccharide synthesis protein Cap8D [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_100 99.708 0.0 cap8E VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8E) type 8 capsular polysaccharide synthesis protein Cap8E [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_101 100.0 0.0 cap8F VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8F) type 8 capsular polysaccharide synthesis protein Cap8F [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_102 99.733 0.0 cap8G VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8G) type 8 capsular polysaccharide synthesis protein Cap8G [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_107 99.501 0.0 cap8L VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8L) type 8 capsular polysaccharide synthesis protein Cap8L [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_108 99.459 3.1E-136 cap8M VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8M) type 8 capsular polysaccharide synthesis protein Cap8M [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_109 97.966 0.0 capN VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (capN) capsular polysaccharide type 5/8 biosynthesis epimerase CapN [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_110 98.571 0.0 cap8O VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8O) type 8 capsular polysaccharide synthesis protein Cap8O [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_111 99.738 0.0 cap8P VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8P) type 8 capsular polysaccharide synthesis protein Cap8P [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_112 100.0 6.52E-79 isdI VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdI) staphylobilin-forming heme oxygenase IsdI [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AP009351.1_169 74.057 0.0 coa VF0421 Staphylocoagulase Exoenzyme VFC0251 (coa) staphylocoagulase precursor [Staphylocoagulase (VF0421) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_223 100.0 8.66E-67 esxA VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esxA) type VII secretion system secreted protein EsxA [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_224 99.405 0.0 esaA VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaA) type VII secretion system protein EsaA [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_225 100.0 1.9E-110 essA VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (essA) type VII secretion system protein EssA, monotopic membrane protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_226 100.0 6.11E-54 esaB VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaB) type VII secretion system protein EsaB [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_227 100.0 0.0 essB VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (essB) type VII secretion system protein EssB, monotopic membrane protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_228 99.594 0.0 essC VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (essC) type VII secretion system protein EssC, FtsK/SpoIIIE family ATPase [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_229 99.231 2.79E-92 esxC VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esxC) type VII secretion system secreted protein EsxC [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_230 99.038 6.95E-73 esxB VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esxB) type VII secretion system secreted protein EsxB [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_231 99.107 3.87E-164 esaE VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaE) type VII secretion system chaperone protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_232 98.058 5.86E-72 esxD VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esxD) type VII secretion system secreted protein EsxD [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_233 94.951 0.0 esaD VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaD) type VII secretion system secreted protein, a nuclease toxin EsaD [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_234 82.822 2.27E-100 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_238 86.503 6.6E-105 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_239 75.152 2.22E-88 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_240 95.833 1.76E-28 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_241 80.808 2.42E-58 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_242 87.117 1.72E-103 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_244 89.759 1.23E-111 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_245 74.699 1.2E-90 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_246 84.848 5.88E-102 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_247 90.361 8.64E-111 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_248 80.723 2.39E-101 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_249 89.759 8.4E-107 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_250 82.099 1.65E-97 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_268 99.068 0.0 geh VF0012 Lipase Exoenzyme VFC0251 Organized as pre-pro-enzymes: the pre-region represents the signal peptide; secreted in the pro-lipase form. The pro-region protects the proteins from proteolytic degradation and acts as an intramolecular chaperone to facilitate translocation of the lipase (geh) glycerol ester hydrolase [Lipase (VF0012) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_412 68.584 1.94E-107 set16 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set16) superantigen-like protein SSL1 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_413 97.403 1.24E-164 set17 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set17) superantigen-like protein SSL2 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_414 97.753 0.0 set18 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set18) superantigen-like protein SSL3 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_415 84.545 0.0 set19 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set19) superantigen-like protein SSL4 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_416 97.863 2.52E-170 set20 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set20) superantigen-like protein SSL5 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_417 82.328 4.64E-135 set21 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set21) superantigen-like protein SSL6 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_418 92.208 2.53E-154 set22 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set22) superantigen-like protein SSL7 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_419 97.845 1.02E-165 set23 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set23) superantigen-like protein SSL8 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_420 93.103 2.6E-159 set24 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set24) superantigen-like protein SSL9 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_421 98.678 1.92E-164 set25 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set25) superantigen-like protein SSL10 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_424 63.043 1.22E-93 set26 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set26) superantigen-like protein SSL11 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_514 70.0 0.0 clpC VF0072 ClpC Stress survival VFC0282 27-kDa stress protein belongs to the Hsp100/Clp family; Regulation of Clp protease expression is mediated by CtsR, the product of the first gene in the ClpC operon (clpC) endopeptidase Clp ATP-binding chain C [ClpC (VF0072) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AP009351.1_537 74.619 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
AP009351.1_550 96.754 0.0 sdrC VF0019 SDr Adherence VFC0001 (sdrC) Ser-Asp rich fibrinogen-binding bone sialoprotein-binding protein [SDr (VF0019) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_551 96.14 0.0 sdrD VF0019 SDr Adherence VFC0001 (sdrD) Ser-Asp rich fibrinogen-binding bone sialoprotein-binding protein [SDr (VF0019) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_552 96.998 0.0 sdrE VF0019 SDr Adherence VFC0001 (sdrE) Ser-Asp rich fibrinogen-binding bone sialoprotein-binding protein [SDr (VF0019) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_761 77.835 4.73E-114 clpP VF0074 ClpP Stress survival VFC0282 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AP009351.1_779 95.163 0.0 clfA VF0004 Clumping factor Adherence VFC0001 Belongs to MSCRAMMs family; Ser-Asp rich fibrinogen-binding proteins (the proteins having the SD dipeptide repeats have so far been found only in S. aureus and S. epidermidis); The clfA and clfB genes are not allelic variants but are distinct genes. They are not closely linked, in contrast to the fnbA and fnbB genes (clfA) Clumping factor A, fibrinogen-binding protein [Clumping factor (VF0004) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_780 100.0 0.0 vWbp VF0420 VWbp Exoenzyme VFC0251 (vWbp) secreted von Willebrand factor-binding protein precursor [VWbp (VF0420) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AP009351.1_939 100.0 1.84E-78 sspC VF0006 Staphopain Exoenzyme VFC0251 Staphopains A (encoded by scpA) and B (encoded by sspB) are the major secreted cysteine proteases of S. aureus; A novel type of cysteine proteinase inhibitor, referred as staphostatins (ScpC, SspC), has been recently identified. They specifically inhibit cysteine proteinases (staphopains) (sspC) Staphostatin B [Staphopain (VF0006) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_940 99.237 0.0 sspB VF0006 Staphopain Exoenzyme VFC0251 Staphopains A (encoded by scpA) and B (encoded by sspB) are the major secreted cysteine proteases of S. aureus; A novel type of cysteine proteinase inhibitor, referred as staphostatins (ScpC, SspC), has been recently identified. They specifically inhibit cysteine proteinases (staphopains) (sspB) staphopain cysteine proteinase SspB [Staphopain (VF0006) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_941 97.024 0.0 sspA VF0023 V8 protease Exoenzyme VFC0251 A member of the glutamyl endopeptidase family of enzymes; narrow substrate specificity: cleaving peptide bonds exclusively on the carbonyl side of aspartate and glutamate residues; synthesized as a preproenzyme, the zymogen undergoes proteolytic activation via cleavage by the staphylococcal extracellular metalloprotease; The ssp gene encoding V8 protease is designated as sspA, and is followed by sspB, which encodes a cysteine protease, and sspC, which encodes a protein of unknown function (sspA) serine protease; V8 protease; glutamyl endopeptidase [V8 protease (VF0023) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_1085 100.0 0.0 isdB VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdB) iron-regulated surface determinant protein B, haemoglobin receptor [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AP009351.1_1086 100.0 0.0 isdA VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdA) iron-regulated surface determinant protein A [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AP009351.1_1087 100.0 1.4E-166 isdC VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdC) iron-regulated surface determinant protein C [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AP009351.1_1088 100.0 0.0 isdD VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdD) iron-regulated surface determinant protein D [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AP009351.1_1089 100.0 0.0 isdE VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdE) iron-regulated surface determinant protein E [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AP009351.1_1090 100.0 0.0 isdF VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdF) iron-regulated surface determinant protein F, ATP-binding-cassette-type transmembrane transporter [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AP009351.1_1091 100.0 0.0 srtB VF0015 Isd Nutritional/Metabolic factor VFC0272 (srtB) NPQTN specific sortase B [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AP009351.1_1092 100.0 4.18E-78 isdG VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdG) iron-regulated surface determinant protein G [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AP009351.1_1116 99.687 0.0 hly/hla VF0001 Alpha-hemolysin Exotoxin VFC0235 (hly/hla) Alpha-Hemolysin precursor [Alpha-hemolysin (VF0001) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_1187 72.464 9.19E-29 acpXL VF0367 LPS Immune modulation VFC0258 Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. (acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] Brucella melitensis
AP009351.1_1297 68.116 0.0 katA VF0454 KatA Stress survival VFC0282 (katA) catalase [KatA (VF0454) - Stress survival (VFC0282)] [Neisseria meningitidis MC58] Neisseria meningitidis
AP009351.1_1439 95.885 0.0 ebp VF0008 EbpS Adherence VFC0001 Belongs to MSCRAMMs family (ebp) cell surface elastin binding protein [EbpS (VF0008) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_1469 67.097 0.0 gndA VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AP009351.1_1518 62.376 9.78E-131 sigA/rpoV VF0257 SigA Regulation VFC0301 In M. tuberculosis, 13 sigma factor genes have been annotated in the genome, 9 of which belong to a special subfamily thought to direct extracytoplasmic functions and various other stress responses (temperature, oxidative stress, pH, and infection of macrophages); sigma A also known as RpoV, is the essential principal mycobacterial sigma factors, necessary for most mycobacterial housekeeping gene transcription; It was the first mycobacterial sigma factor to be associated with virulence (sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
AP009351.1_1675 100.0 0.0 harA VF0015 Isd Nutritional/Metabolic factor VFC0272 (harA) haptoglobin-binding heme uptake protein HarA [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AP009351.1_1772 82.769 0.0 lukF-PV VF0018 PVL Exotoxin VFC0235 PVL, together with gamma-hemolysin and other leukocidins such as LukE-LukD, belongs to the family of bicomponent synergohymenotropic toxins; pore-forming toxin rich in beta-sheet structures (lukF-PV) Panton-Valentine leukocidin chain F precursor [PVL (VF0018) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_1773 70.874 1.49E-163 hlgA VF0011 Gamma-hemolysin Exotoxin VFC0235 Three protein (HlgA, HlgB, HlgC) are virtually identical in sequence to leukocidin component S and F, thus gamma-hemolysin may act similarly to leukocidin; S component: HlgA, HlgC. F component: HlgB (hlgA) gamma-hemolysin chain II precursor [Gamma-hemolysin (VF0011) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_1949 88.832 0.0 eap/map VF0016 Eap/Map Adherence VFC0001 Belongs to MSCRAMMs family; unusual property: Eap can bind back to the S. aureus cell wall (eap/map) extracellular adherence protein Eap/Map [Eap/Map (VF0016) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_1950 100.0 1.02E-35 hlb VF0002 Beta-hemolysin Exotoxin VFC0235 (hlb) beta-hemolysin [Beta-hemolysin (VF0002) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus COL] Staphylococcus aureus
AP009351.1_1951 100.0 5.04E-80 scn VF0425 SCIN Immune modulation VFC0258 Located on the beta-hemolysin (hlb)-converting bacteriophages (scn) complement inhibitor SCIN [SCIN (VF0425) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_1952 100.0 6.93E-107 chp VF0424 CHIPS Immune modulation VFC0258 Located on the beta-hemolysin (hlb)-converting bacteriophages (chp) chemotaxis-inhibiting protein CHIPS [CHIPS (VF0424) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
AP009351.1_1954 98.16 6.55E-115 sak VF0021 Staphylokinase Exoenzyme VFC0251 Bacteria plasminogen activator: staphylokinase, strepokinase, act as cofactor molecules that contribute to exosite formation and enhance the substrate presentation to the enzyme; The gene for Staphylokinase is carried by certain prophages (sak) Staphylokinase precursor [Staphylokinase (VF0021) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_1957 98.054 0.0 sea VF0020 SE Exotoxin VFC0235 Constitutes a family of eight single-chain polypeptides (26-28kDa, 228-239 amino acid residues) with a typical disulfide loop; divided into two groups based on amino acid sequence homology: the first group consists of SEA,SEE, SED and SEH, and the second group including SEB, SEC, SEG (sea) staphylococcal enterotoxin A precursor [SE (VF0020) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2014 99.635 0.0 hlb VF0002 Beta-hemolysin Exotoxin VFC0235 (hlb) beta-hemolysin [Beta-hemolysin (VF0002) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus COL] Staphylococcus aureus
AP009351.1_2023 66.667 0.0 groEL VF0594 GroEL Adherence VFC0001 GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. (groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] Clostridium difficile
AP009351.1_2029 97.727 4.4E-25 hld VF0007 Delta-hemolysin Exotoxin VFC0235 (hld) delta-hemolysin [Delta-hemolysin (VF0007) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2103 60.8 1.13E-174 cap8P VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8P) type 8 capsular polysaccharide synthesis protein Cap8P [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2194 87.469 0.0 hysA VF0013 Hyaluronate lyase Exoenzyme VFC0251 (hysA) hyaluronate lyase precursor [Hyaluronate lyase (VF0013) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2280 61.421 4.46E-92 ureG VF0050 Urease Stress survival VFC0282 (ureG) urease accessory protein (ureG) [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] Helicobacter pylori
AP009351.1_2405 97.483 0.0 sbi VF0423 Sbi Immune modulation VFC0258 A secreted protein that is also associated with the bacterial envelope, lacks a C-terminal LPXTG sorting signal (sbi) IgG-binding protein SBI [Sbi (VF0423) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2406 100.0 0.0 hlgA VF0011 Gamma-hemolysin Exotoxin VFC0235 Three protein (HlgA, HlgB, HlgC) are virtually identical in sequence to leukocidin component S and F, thus gamma-hemolysin may act similarly to leukocidin; S component: HlgA, HlgC. F component: HlgB (hlgA) gamma-hemolysin chain II precursor [Gamma-hemolysin (VF0011) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2407 99.683 0.0 hlgC VF0011 Gamma-hemolysin Exotoxin VFC0235 Three protein (HlgA, HlgB, HlgC) are virtually identical in sequence to leukocidin component S and F, thus gamma-hemolysin may act similarly to leukocidin; S component: HlgA, HlgC. F component: HlgB (hlgC) gamma-hemolysin component C [Gamma-hemolysin (VF0011) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2408 100.0 0.0 hlgB VF0011 Gamma-hemolysin Exotoxin VFC0235 Three protein (HlgA, HlgB, HlgC) are virtually identical in sequence to leukocidin component S and F, thus gamma-hemolysin may act similarly to leukocidin; S component: HlgA, HlgC. F component: HlgB (hlgB) gamma-hemolysin component B [Gamma-hemolysin (VF0011) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2483 93.651 8.65E-88 fnbB VF0010 FnBPs Adherence VFC0001 Belongs to MSCRAMMs family; most strains of S. aureus express two related Fn-binding proteins FnBPA and FnBPB, which are encoded by closely linked genes (fnbB) fibronectin-binding protein B [FnBPs (VF0010) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2484 78.832 0.0 fnbB VF0010 FnBPs Adherence VFC0001 Belongs to MSCRAMMs family; most strains of S. aureus express two related Fn-binding proteins FnBPA and FnBPB, which are encoded by closely linked genes (fnbB) fibronectin-binding protein B [FnBPs (VF0010) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2485 93.651 8.65E-88 fnbB VF0010 FnBPs Adherence VFC0001 Belongs to MSCRAMMs family; most strains of S. aureus express two related Fn-binding proteins FnBPA and FnBPB, which are encoded by closely linked genes (fnbB) fibronectin-binding protein B [FnBPs (VF0010) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2486 82.503 0.0 fnbA VF0010 FnBPs Adherence VFC0001 Belongs to MSCRAMMs family; most strains of S. aureus express two related Fn-binding proteins FnBPA and FnBPB, which are encoded by closely linked genes (fnbA) fibronectin-binding protein A [FnBPs (VF0010) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2621 99.804 0.0 aur VF0024 Aureolysin Exoenzyme VFC0251 The aur gene encoding aureolysin is present in two allelic forms: type I and type II; low substrate specificity: cleaving peptide bonds on the N-terminal side of bulky, aliphatic, hydrophobic residues (aur) zinc metalloproteinase aureolysin [Aureolysin (VF0024) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2649 100.0 2.31E-134 icaR VF0014 Intercellular adhesion proteins Biofilm VFC0271 IcaA, icaB, icaC, icaD synthesize a polysaccharide, poly-n-succinyl-beta-1,6 glucosamine (PNSG) during infection (icaR) ica operon transcriptional regulator IcaR [Intercellular adhesion proteins (VF0014) - Biofilm (VFC0271)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2650 99.757 0.0 icaA VF0014 Intercellular adhesion proteins Biofilm VFC0271 IcaA, icaB, icaC, icaD synthesize a polysaccharide, poly-n-succinyl-beta-1,6 glucosamine (PNSG) during infection (icaA) N-acetylglucosaminyltransferase, involved in polysaccharide intercellular adhesin(PIA) synthesis [Intercellular adhesion proteins (VF0014) - Biofilm (VFC0271)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2651 100.0 2.55E-70 icaD VF0014 Intercellular adhesion proteins Biofilm VFC0271 IcaA, icaB, icaC, icaD synthesize a polysaccharide, poly-n-succinyl-beta-1,6 glucosamine (PNSG) during infection (icaD) intercellular adhesion protein D, involved in polysaccharide intercellular adhesin(PIA) synthesis [Intercellular adhesion proteins (VF0014) - Biofilm (VFC0271)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2652 100.0 0.0 icaB VF0014 Intercellular adhesion proteins Biofilm VFC0271 IcaA, icaB, icaC, icaD synthesize a polysaccharide, poly-n-succinyl-beta-1,6 glucosamine (PNSG) during infection (icaB) N-deacetylase, involved in polysaccharide intercellular adhesin(PIA) synthesis [Intercellular adhesion proteins (VF0014) - Biofilm (VFC0271)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2653 100.0 0.0 icaC VF0014 Intercellular adhesion proteins Biofilm VFC0271 IcaA, icaB, icaC, icaD synthesize a polysaccharide, poly-n-succinyl-beta-1,6 glucosamine (PNSG) during infection (icaC) intercellular adhesion protein C, involved in polysaccharide intercellular adhesin(PIA) synthesis [Intercellular adhesion proteins (VF0014) - Biofilm (VFC0271)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
AP009351.1_2654 100.0 0.0 lip VF0012 Lipase Exoenzyme VFC0251 Organized as pre-pro-enzymes: the pre-region represents the signal peptide; secreted in the pro-lipase form. The pro-region protects the proteins from proteolytic degradation and acts as an intramolecular chaperone to facilitate translocation of the lipase (lip) triacylglycerol lipase precursor [Lipase (VF0012) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus