2. PATHOGENS
Basic Information
Accession number
GCA_000011665.1
Release date
2004-08-03
Organism
Streptococcus pyogenes MGAS10394
Species name
Streptococcus pyogenes
Assembly level
Complete Genome
Assembly name
ASM1166v1
Assembly submitter
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health
Assembly Type
haploid
Genome size
1.9 Mb
GC percent
38.5
Contig count
1
Collection date
-
Sample location
-
Host
-
Isolation source
-
Isolate type
-
Strain
MGAS10394
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
CP000003.1_222 # 232992 # 234698 750.0 772.311 patA 65.96 ARO:3000024 protein homolog model fluoroquinolone antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump PatA is an ABC transporter of Streptococcus pneumoniae that interacts with PatB to confer fluoroquinolone resistance.
CP000003.1_223 # 234701 # 236485 750.0 832.017 patB 66.78 ARO:3000025 protein homolog model fluoroquinolone antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump PatB is an ABC transporter of Streptococcus pneumoniae that interacts with PatA to confer fluoroquinolone resistance..
CP000003.1_1141 # 1167541 # 1168758 800.0 811.601 mel 100.0 ARO:3000616 protein homolog model macrolide antibiotic; streptogramin antibiotic antibiotic target protection msr-type ABC-F protein Mel, a homolog of MsrA, is an ABC-F subfamily protein associated with macrolide resistance. It is expressed on the same operon as mefA and mefE, both MFS-type efflux proteins that confer macrolide resistance.
CP000003.1_1468 # 1488759 # 1489502 50.0 106.686 vanY gene in vanB cluster 30.74 ARO:3002956 protein homolog model glycopeptide antibiotic antibiotic target alteration vanY; glycopeptide resistance gene cluster Also known as vanYB, is a vanY variant found in the vanB gene cluster.
CP000003.1_1493 # 1522050 # 1523150 175.0 176.022 vanT gene in vanG cluster 33.06 ARO:3002972 protein homolog model glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanT Also known as vanTG, is a vanT variant found in the vanG gene cluster.
CP000003.1_1760 # 1816764 # 1817984 800.0 813.142 lmrP 99.26 ARO:3003969 protein homolog model macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump lmrP is a proton motive force-dependent drug transporter that is part of the MFS efflux pump family.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
CP000003.1_159 67.097 0.0 sfbI/prtF1 VF0243 FBPs Adherence VFC0001 Surface protein: linked to the bacterial cell wall via C-terminal LPXTG motif; including PrtF1 (protein F1) also known as SfbI (streptococcal fibronectin binding proteinI), SfbII/SOF (serum opacity factor), FbaA, FbaB, FBP54 (fibronectin-binding protein 54), protein F2, PFBP (pyogene fibronectin-binding protein) (sfbI/prtF1) fibronectin-binding protein PrtF1/SfbI [FBPs (VF0243) - Adherence (VFC0001)] [Streptococcus pyogenes MGAS6180] Streptococcus pyogenes
CP000003.1_188 99.299 0.0 slo VF0250 SLO Exotoxin VFC0235 A member of the cholesterol-dependent cytolysin family, related to pneumolysin from S. pneumoniae (slo) streptolysin O precursor [SLO (VF0250) - Exotoxin (VFC0235)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_214 100.0 4.61E-45 speG VF0248 Spes Exotoxin VFC0235 Two prototypical streptococcal superantigens, SpeA and SpeC are both encoded on functional phage (speG) streptococcal exotoxin G precursor [Spes (VF0248) - Exotoxin (VFC0235)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_219 90.604 0.0 hasC VF0244 Hyaluronic acid capsule Immune modulation VFC0258 (hasC) UTP--glucose-1-phosphate uridylyltransferase HasC [Hyaluronic acid capsule (VF0244) - Immune modulation (VFC0258)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_345 61.979 5.69E-88 clpP VF0074 ClpP Stress survival VFC0282 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
CP000003.1_377 76.623 3.86E-175 psaA VF0151 PsaA Nutritional/Metabolic factor VFC0272 Surface protein: lipid-attached; AdcABC is another ABC transporter for Zn2+ uptake (psaA) manganese ABC transporter, manganese-binding adhesion liprotein [PsaA (VF0151) - Nutritional/Metabolic factor (VFC0272)] [Streptococcus pneumoniae TIGR4] Streptococcus pneumoniae
CP000003.1_504 69.697 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
CP000003.1_552 100.0 8.81E-33 sagA VF0251 SLS Exotoxin VFC0235 Oxygen stable, most potent cytotoxin; not immunogenic; unstable polypeptide bounds to carrier molecules, such as serum albumin, RNA core, or lipoteichoic acid; responsible for the beta-hemolysis surrounding colonies of GAS grown on blood agar plates; SagA serves as SLS toxin precursor and eight additional genes in an operon is required for toxin maturation and export. pro-SLS is converted into an active cytolysin by the actions of SagBCD, a trimeric oxazole/thiazole synthetase. (sagA) streptolysin S associated protein [SLS (VF0251) - Exotoxin (VFC0235)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_656 81.818 0.0 ideS/mac VF0284 IdeS Immune modulation VFC0258 A secreted 35 kDa protein, does not require processing or activation to exert its enzymatic activity; also described as a CD11b homolog protein, Mac, CD11b is the alpha chain of complement receptor 3 (CR3), which is the receptor on phagocytes that recognizes C3b (ideS/mac) immunoglobulin G-degrading enzyme [IdeS (VF0284) - Immune modulation (VFC0258)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_709 75.49 8.87E-49 speI VF0248 Spes Exotoxin VFC0235 Two prototypical streptococcal superantigens, SpeA and SpeC are both encoded on functional phage (speI) streptococcal exotoxin I precursor [Spes (VF0248) - Exotoxin (VFC0235)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_729 65.862 1.75E-142 wbtL VF0542 LPS Immune modulation VFC0258 The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion (wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
CP000003.1_735 99.455 0.0 fbp54 VF0243 FBPs Adherence VFC0001 Surface protein: linked to the bacterial cell wall via C-terminal LPXTG motif; including PrtF1 (protein F1) also known as SfbI (streptococcal fibronectin binding proteinI), SfbII/SOF (serum opacity factor), FbaA, FbaB, FBP54 (fibronectin-binding protein 54), protein F2, PFBP (pyogene fibronectin-binding protein) (fbp54) fibronectin-bing protein Fbp54 [FBPs (VF0243) - Adherence (VFC0001)] [Streptococcus pyogenes MGAS6180] Streptococcus pyogenes
CP000003.1_749 99.006 0.0 hylA VF0246 Hyaluronidase Exoenzyme VFC0251 GAS are capable of producing two types of hyaluronidase, a bacteriophage associated enzyme and an extracellular hyaluronidase that is secreted from the cell; since the capsule of GAS is composed solely of hyaluronic acid, the hyaluronidase presumably benefits the phage by aiding in capsule penetration during its infection of or release from streptococci (hylA) hyaluronidase [Hyaluronidase (VF0246) - Exoenzyme (VFC0251)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_763 62.308 2.61E-56 msrA/B(pilB VF0456 MsrAB Stress survival VFC0282 Methionine sulfoxide reductases (Msr) are enzymes that catalyze the reduction of free and protein-bound methionine sulfoxide (MetSO) back to Met. Two structurally unrelated classes of Msrs have been described so far. MsrAs are stereo specific toward the S isomer on the sulfur of the sulfoxide function, whereas MsrBs are specific toward the R isomer (msrA/B(pilB)) trifunctional thioredoxin/methionine sulfoxide reductase A/B protein [MsrAB (VF0456) - Stress survival (VFC0282)] [Neisseria meningitidis MC58] Neisseria meningitidis
CP000003.1_1045 84.082 5.36E-140 grab VF0254 GRAB Others VFC0346 Surface protein: linked to the bacterial cell wall via C-terminal LPXTG motif; high affinity (Ka = 2.0 x 108M-1) for <term>alpha2-macroglobulin (alpha2M)</term>; encoded by grab gene that is present in most S. pyogene strains and is well conserved (grab) protein GRAB (protein G-related alpha 2M-binding protein) [GRAB (VF0254) - Others (VFC0346)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_1170 98.81 0.0 mf2 VF0252 Mitogenic factor Exoenzyme VFC0251 DNase B has been shown to be the same molecule as the streptococcal mitogenic factor (MF). It does not contribute significantly to the superantigenic activity of S. pyogenes when compared with other Spes (mf2) deoxyribonuclease, phage associated [Mitogenic factor (VF0252) - Exoenzyme (VFC0251)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_1171 99.574 4.34E-172 speC VF0248 Spes Exotoxin VFC0235 Two prototypical streptococcal superantigens, SpeA and SpeC are both encoded on functional phage (speC) streptococcal exotoxin C precursor, phage associated [Spes (VF0248) - Exotoxin (VFC0235)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_1510 91.729 0.0 mf3 VF0252 Mitogenic factor Exoenzyme VFC0251 DNase B has been shown to be the same molecule as the streptococcal mitogenic factor (MF). It does not contribute significantly to the superantigenic activity of S. pyogenes when compared with other Spes (mf3) deoxyribonuclease [Mitogenic factor (VF0252) - Exoenzyme (VFC0251)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_1653 90.682 0.0 ska VF0247 Streptokinase Exoenzyme VFC0251 (ska) streptokinase A precursor [Streptokinase (VF0247) - Exoenzyme (VFC0251)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_1669 93.562 6.86E-153 smeZ VF0248 Spes Exotoxin VFC0235 Two prototypical streptococcal superantigens, SpeA and SpeC are both encoded on functional phage (smeZ) streptococcal mitogenic exotoxin Z [Spes (VF0248) - Exotoxin (VFC0235)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_1677 99.673 0.0 lmb VF0275 Lmb Adherence VFC0001 Lmb is an extracellular protein that was first identified in S. agalactiae. Homologs of this protein were reported in S. pyogenes and S. pneumonia and termed Lbp and AdcAII, respectively (lmb) laminin-binding surface protein [Lmb (VF0275) - Adherence (VFC0001)] [Streptococcus agalactiae NEM316] Streptococcus agalactiae
CP000003.1_1678 98.302 0.0 scpA/scpB VF0245 C5a peptidase Adherence VFC0001 Surface protein: LPTTN motif (scpA/scpB) streptococcal C5a peptidase [C5a peptidase (VF0245) - Adherence (VFC0001)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_1693 99.497 0.0 speB VF0249 SpeB Exoenzyme VFC0251 (speB) pyrogenic exotoxin B [SpeB (VF0249) - Exoenzyme (VFC0251)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_1696 100.0 0.0 mf/spd VF0252 Mitogenic factor Exoenzyme VFC0251 DNase B has been shown to be the same molecule as the streptococcal mitogenic factor (MF). It does not contribute significantly to the superantigenic activity of S. pyogenes when compared with other Spes (mf/spd) deoxyribonuclease [Mitogenic factor (VF0252) - Exoenzyme (VFC0251)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_1717 67.238 0.0 groEL VF0594 GroEL Adherence VFC0001 GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. (groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] Clostridium difficile
CP000003.1_1824 99.523 0.0 hasA VF0244 Hyaluronic acid capsule Immune modulation VFC0258 (hasA) hyaluronan synthase HasA [Hyaluronic acid capsule (VF0244) - Immune modulation (VFC0258)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_1825 99.254 0.0 hasB VF0244 Hyaluronic acid capsule Immune modulation VFC0258 (hasB) UDP-glucose 6-dehydrogenase HasB [Hyaluronic acid capsule (VF0244) - Immune modulation (VFC0258)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
CP000003.1_1826 99.342 0.0 hasC VF0244 Hyaluronic acid capsule Immune modulation VFC0258 (hasC) UTP--glucose-1-phosphate uridylyltransferase HasC [Hyaluronic acid capsule (VF0244) - Immune modulation (VFC0258)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes