2. PATHOGENS
Basic Information
Accession number
GCA_000017745.1
Release date
2007-09-11
Organism
Escherichia coli O139:H28 str. E24377A
Species name
Escherichia coli
Assembly level
Complete Genome
Assembly name
ASM1774v1
Assembly submitter
TIGR
Assembly Type
haploid
Genome size
5.2 Mb
GC percent
50.5
Contig count
7
Collection date
-
Sample location
-
Host
-
Isolation source
-
Isolate type
-
Strain
E24377A
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
CP000800.1_73 # 86058 # 87002 500.0 648.662 leuO 99.04 ARO:3003843 protein homolog model nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump leuO, a LysR family transcription factor, exists in a wide variety of bacteria of the family Enterobacteriaceae and is involved in the regulation of as yet unidentified genes affecting the stress response and pathogenesis expression. LeuO is also an activator of the MdtNOP efflux pump.
CP000800.1_367 # 432809 # 433903 250.0 266.544 vanG 39.5 ARO:3002909 protein homolog model glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; Van ligase VanG is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis.
CP000800.1_448 # 516401 # 519550 1900.0 2138.23 acrB 100.0 ARO:3000216 protein homolog model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter.
CP000800.1_449 # 519573 # 520766 670.0 798.119 Escherichia coli acrA 100.0 ARO:3004043 protein homolog model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrA is a subunit of the AcrAB-TolC multidrug efflux system found in E. coli.
CP000800.1_646 # 742568 # 743245 400.0 449.129 kdpE 99.11 ARO:3003841 protein homolog model aminoglycoside antibiotic antibiotic efflux kdpDE kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding.
CP000800.1_736 # 836722 # 837054 190.0 218.009 Escherichia coli emrE 99.09 ARO:3004039 protein homolog model macrolide antibiotic antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump Member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation.
CP000800.1_833 # 933088 # 934320 700.0 781.941 Escherichia coli mdfA 96.34 ARO:3001328 protein homolog model tetracycline antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter.
CP000800.1_926 # 1032534 # 1034282 1000.0 1191.79 msbA 100.0 ARO:3003950 protein homolog model nitroimidazole antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A, a major component of the bacterial outer cell membrane, and is the only bacterial ABC transporter that is essential for cell viability.
CP000800.1_1078 # 1191728 # 1192954 700.0 806.979 mdtG 100.0 ARO:3001329 protein homolog model phosphonic acid antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump The MdtG protein, also named YceE, appears to be a member of the major facilitator superfamily of transporters, and it has been reported, when overexpressed, to increase fosfomycin and deoxycholate resistances. mdtG is a member of the marA-soxS-rob regulon.
CP000800.1_1090 # 1201585 # 1202793 750.0 801.201 mdtH 100.0 ARO:3001216 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug resistance protein MdtH.
CP000800.1_1283 # 1382571 # 1382984 240.0 276.944 H-NS 100.0 ARO:3000676 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; cephalosporin; cephamycin; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE, mdtE, and emrK as well as nearby genes of many RND-type multidrug exporters.
CP000800.1_1632 # 1734037 # 1734420 230.0 266.544 marA 100.0 ARO:3000263 protein homolog model fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux; reduced permeability to antibiotic resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF.
CP000800.1_1704 # 1798828 # 1799157 150.0 186.808 Klebsiella pneumoniae KpnF 84.4 ARO:3004583 protein homolog model macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic; disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump KpnF subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan.
CP000800.1_1705 # 1799144 # 1799509 150.0 182.57 Klebsiella pneumoniae KpnE 82.2 ARO:3004580 protein homolog model macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic; disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump KpnE subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan.
CP000800.1_2041 # 2141617 # 2141949 190.0 213.772 Escherichia coli emrE 97.27 ARO:3004039 protein homolog model macrolide antibiotic antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump Member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation.
CP000800.1_2199 # 2281109 # 2282275 700.0 791.571 ugd 98.97 ARO:3003577 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin.
CP000800.1_2246 # 2336532 # 2337899 725.0 826.239 mdtA 99.04 ARO:3000792 protein homolog model aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC.
CP000800.1_2247 # 2337899 # 2341021 1800.0 2078.91 mdtB 99.81 ARO:3000793 protein homolog model aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex.
CP000800.1_2248 # 2341022 # 2344099 1800.0 2063.11 mdtC 99.61 ARO:3000794 protein homolog model aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB, MdtC can form a homomultimer complex that results in a functioning efflux complex with a narrower drug specificity. mdtC corresponds to 3 loci in Pseudomonas aeruginosa PAO1 (gene name: muxC/muxB) and 3 loci in Pseudomonas aeruginosa LESB58.
CP000800.1_2250 # 2345512 # 2346915 850.0 942.569 baeS 98.93 ARO:3000829 protein homolog model aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity, BaeS is not necessary for overexpressed BaeR to confer resistance.
CP000800.1_2251 # 2346912 # 2347634 450.0 484.567 baeR 99.58 ARO:3000828 protein homolog model aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes.
CP000800.1_2387 # 2493321 # 2494964 1050.0 1107.43 YojI 99.82 ARO:3003952 protein homolog model peptide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI.
CP000800.1_2420 # 2541928 # 2542896 550.0 666.766 PmrF 99.69 ARO:3003578 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58.
CP000800.1_2423 # 2545765 # 2547417 400.0 733.021 ArnT 63.7 ARO:3005053 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase ArnT is involved in Cell Wall Biosynthesis, specifically 4-amino-4-deoxy-L-arabinose (Ara4N). It confers resistance to peptide antibiotics.
CP000800.1_2517 # 2644147 # 2645685 900.0 1023.08 emrY 100.0 ARO:3000254 protein homolog model tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB.
CP000800.1_2518 # 2645685 # 2646848 600.0 712.22 emrK 99.15 ARO:3000206 protein homolog model tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC, it mediates multidrug efflux.
CP000800.1_2519 # 2647264 # 2647878 390.0 417.157 evgA 100.0 ARO:3000832 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump EvgA, when phosphorylated, is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner, it can be phosphorylated in the absence of EvgS when overexpressed.
CP000800.1_2520 # 2647883 # 2651476 2300.0 2473.74 evgS 99.5 ARO:3000833 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump EvgS is a sensor protein that phosphorylates the regulatory protein EvgA. evgS corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58.
CP000800.1_2600 # 2737425 # 2740538 1900.0 2119.35 acrD 99.61 ARO:3000491 protein homolog model aminoglycoside antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrD is an aminoglycoside efflux pump expressed in E. coli. Its expression can be induced by indole, and is regulated by baeRS and cpxAR.
CP000800.1_2824 # 2971399 # 2971929 280.0 358.607 emrR 99.43 ARO:3000516 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression.
CP000800.1_2825 # 2972056 # 2973228 675.0 791.186 emrA 99.74 ARO:3000027 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump EmrA is a membrane fusion protein, providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli, a Gram-negative bacterium.
CP000800.1_2826 # 2973245 # 2974783 900.0 1029.24 emrB 100.0 ARO:3000074 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP), nalidixic acid, and thioloactomycin.
CP000800.1_2831 # 2979455 # 2979640 100.0 109.383 rsmA 85.25 ARO:3005069 protein homolog model fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump rsmA is a gene that regulates virulence of Pseudomonas aeruginosa. However, its negative effect on MexEF-OprN overexpression has been noted to confer resistance to various antibiotics. It's Escherichia coli homolog is csrA.
CP000800.1_3332 # 3509138 # 3510619 900.0 994.186 TolC 100.0 ARO:3000237 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex.
CP000800.1_3352 # 3532976 # 3533797 500.0 543.117 bacA 99.63 ARO:3002986 protein homolog model peptide antibiotic antibiotic target alteration undecaprenyl pyrophosphate related proteins The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin.
CP000800.1_3548 # 3742607 # 3743269 380.0 457.988 AcrS 100.0 ARO:3000656 protein homolog model fluoroquinolone antibiotic; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux.
CP000800.1_3549 # 3743668 # 3744825 675.0 785.793 AcrE 100.0 ARO:3000499 protein homolog model fluoroquinolone antibiotic; cephalosporin; cephamycin; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrE is a membrane fusion protein, similar to AcrA.
CP000800.1_3550 # 3744837 # 3747941 1900.0 2091.23 AcrF 99.52 ARO:3000502 protein homolog model fluoroquinolone antibiotic; cephalosporin; cephamycin; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrF is a inner membrane transporter, similar to AcrB.
CP000800.1_3624 # 3800827 # 3801459 400.0 432.95 CRP 99.05 ARO:3000518 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump CRP is a global regulator that represses MdtEF multidrug efflux pump expression.
CP000800.1_3781 # 3971043 # 3972200 675.0 778.859 mdtE 100.0 ARO:3000795 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA.
CP000800.1_3782 # 3972225 # 3975338 1850.0 2102.79 mdtF 99.81 ARO:3000796 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtF is the multidrug inner membrane transporter for the MdtEF-TolC efflux complex.
CP000800.1_3785 # 3976797 # 3977621 450.0 560.836 gadX 98.54 ARO:3000508 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance.
CP000800.1_4187 # 4431275 # 4432648 890.0 926.391 cpxA 100.0 ARO:3000830 protein homolog model aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR, which promotes efflux complex expression.
CP000800.1_4358 # 4638082 # 4639548 875.0 978.393 mdtP 98.16 ARO:3003550 protein homolog model nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
CP000800.1_4359 # 4639545 # 4641596 1300.0 1393.25 mdtO 99.41 ARO:3003549 protein homolog model nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
CP000800.1_4360 # 4641596 # 4642627 600.0 682.559 mdtN 99.42 ARO:3003548 protein homolog model nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
CP000800.1_4386 # 4665347 # 4666990 1000.0 1131.32 eptA 99.63 ARO:3003576 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine, resulting in a less negative cell membrane and decreased binding of polymyxin B.
CP000800.1_4425 # 4710491 # 4711624 725.0 772.311 EC-13 99.2 ARO:3006874 protein homolog model cephalosporin antibiotic inactivation EC beta-lactamase EC-13 is a EC beta-lactamase.
CP000800.1_4634 # 4924191 # 4925423 700.0 796.964 mdtM 97.32 ARO:3001214 protein homolog model fluoroquinolone antibiotic; lincosamide antibiotic; nucleoside antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug resistance protein MdtM.
CP000798.1_5 # 3372 # 4208 500.0 568.155 APH(6)-Id 99.64 ARO:3002660 protein homolog model aminoglycoside antibiotic antibiotic inactivation APH(6) APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids, integrative conjugative elements and chromosomal genomic islands in K. pneumoniae, Salmonella spp., E. coli, Shigella flexneri, Providencia alcalifaciens, Pseudomonas spp., V. cholerae, Edwardsiella tarda, Pasteurella multocida and Aeromonas bestiarum.
CP000798.1_6 # 4208 # 5011 500.0 541.191 APH(3'')-Ib 99.63 ARO:3002639 protein homolog model aminoglycoside antibiotic antibiotic inactivation APH(3'') APH(3'')-Ib is an aminoglycoside phosphotransferase encoded by plasmids, transposons, integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp.
CP000798.1_7 # 5072 # 5887 500.0 528.865 sul2 100.0 ARO:3000412 protein homolog model sulfonamide antibiotic antibiotic target replacement sulfonamide resistant sul Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria, usually found on small plasmids.
CP000800.1_80 # 93103 # 94869 500.0 595.89 Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics 53.11 ARO:3004446 protein variant model D350N, S357N cephalosporin; cephamycin; penam antibiotic target alteration Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics PBP3 is a penicillin-binding protein and beta-lactam resistance enzyme encoded by the ftsI gene in Haemophilus influenzae. Mutations in ftsI confer resistance to beta-lactam antibiotics.
CP000800.1_2409 # 2529931 # 2531289 850.0 919.842 Escherichia coli GlpT with mutation conferring resistance to fosfomycin 99.78 ARO:3003889 protein variant model E448K phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant GlpT Point mutations to the active importer GlpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria.
CP000800.1_3605 # 3784852 # 3786036 700.0 797.734 Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin 99.75 ARO:3003369 protein variant model R234F elfamycin antibiotic antibiotic target alteration elfamycin resistant EF-Tu Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin.
CP000800.1_4255 # 4512970 # 4514154 700.0 794.653 Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin 99.49 ARO:3003369 protein variant model R234F elfamycin antibiotic antibiotic target alteration elfamycin resistant EF-Tu Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin.
CP000800.1_450 # 520908 # 521555 375.0 446.047 Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime 100.0 ARO:3003807 protein overexpression model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. The mutations associated with this model are specific to E. coli.
CP000800.1_1631 # 1733583 # 1734017 210.0 289.656 Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline 98.61 ARO:3003378 protein overexpression model Y137H, G103S fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB.
CP000800.1_4339 # 4616144 # 4616467 200.0 220.32 Escherichia coli soxS with mutation conferring antibiotic resistance 100.0 ARO:3003511 protein overexpression model fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux; reduced permeability to antibiotic ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability.
CP000800.1_4340 # 4616553 # 4617017 300.0 313.538 Escherichia coli soxR with mutation conferring antibiotic resistance 100.0 ARO:3003381 protein overexpression model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
CP000800.1_21 91.136 0.0 espX1 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espX1) Type III secretion system effector EspX1 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP000800.1_92 77.303 0.0 lpxC VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxC) UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP000800.1_173 65.385 8.0E-161 lpxD VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxD) UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP000800.1_175 67.557 1.62E-132 lpxA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxA) UDP-N-acetylglucosamine acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP000800.1_176 63.542 1.28E-177 lpxB VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxB) lipid-A-disaccharide synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP000800.1_193 67.528 1.16E-127 IlpA VF0513 IlpA Adherence VFC0001 (IlpA) immunogenic lipoprotein A [IlpA (VF0513) - Adherence (VFC0001)] [Vibrio vulnificus YJ016] Vibrio vulnificus
CP000800.1_210 100.0 1.24E-120 hcp1/tssD1 VF0579 T6SS Effector delivery system VFC0086 (hcp1/tssD1) type VI secretion system protein, Hcp family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_211 98.889 0.0 tssA VF0579 T6SS Effector delivery system VFC0086 (tssA) Type VI secretion system protein TssA [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_213 99.574 0.0 tssA VF0579 T6SS Effector delivery system VFC0086 (tssA) Type VI secretion system protein TssA [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_215 64.159 0.0 clpB VF0480 T6SS Effector delivery system VFC0086 (clpB) type VI secretion system ATPase ClpV1 [T6SS (VF0480) - Effector delivery system (VFC0086)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966] Aeromonas hydrophila
CP000800.1_216 99.605 0.0 tssL VF0579 T6SS Effector delivery system VFC0086 (tssL) Type VI secretion system protein TssL [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_218 98.851 3.74E-128 tssJ VF0579 T6SS Effector delivery system VFC0086 (tssJ) Type VI secretion system protein TssJ [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_219 98.826 0.0 fha VF0579 T6SS Effector delivery system VFC0086 (fha) Type VI secretion system protein Fha [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_220 98.333 0.0 tssG VF0579 T6SS Effector delivery system VFC0086 (tssG) Type VI secretion system protein TssG [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_221 99.513 0.0 tssF VF0579 T6SS Effector delivery system VFC0086 (tssF) Type VI secretion system protein TssF [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_223 73.131 0.0 vipB VF0480 T6SS Effector delivery system VFC0086 (vipB) Type VI secretion system contractile sheath large subunit TssC/VipB [T6SS (VF0480) - Effector delivery system (VFC0086)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966] Aeromonas hydrophila
CP000800.1_225 100.0 1.91E-120 tssB VF0579 T6SS Effector delivery system VFC0086 (tssB) Type VI secretion system protein TssB [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_226 99.419 6.02E-131 hcp2/tssD2 VF0579 T6SS Effector delivery system VFC0086 (hcp2/tssD2) Type VI secretion system protein, Hcp family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_227 98.036 0.0 vgrG/tssI VF0579 T6SS Effector delivery system VFC0086 (vgrG/tssI) type VI secretion system effector VgrG [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_228 82.213 0.0 rhs/PAAR VF0579 T6SS Effector delivery system VFC0086 (rhs/PAAR) Type VI secretion system protein, PAAR family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_235 74.479 8.28E-108 gmhA/lpcA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (gmhA/lpcA) phosphoheptose isomerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP000800.1_278 98.305 9.29E-177 yagV/ecpE VF0404 ECP Adherence VFC0001 (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP000800.1_279 98.537 0.0 yagW/ecpD VF0404 ECP Adherence VFC0001 (yagW/ecpD) polymerized tip adhesin of ECP fibers [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP000800.1_280 99.524 0.0 yagX/ecpC VF0404 ECP Adherence VFC0001 (yagX/ecpC) E. coli common pilus usher EcpC [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP000800.1_281 98.649 5.27E-165 yagY/ecpB VF0404 ECP Adherence VFC0001 (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP000800.1_282 99.487 3.18E-138 yagZ/ecpA VF0404 ECP Adherence VFC0001 (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP000800.1_283 97.778 7.89E-131 ykgK/ecpR VF0404 ECP Adherence VFC0001 (ykgK/ecpR) regulator protein EcpR [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP000800.1_287 91.166 0.0 fdeC VF0506 FdeC Adherence VFC0001 (fdeC) adhesin FdeC [FdeC (VF0506) - Adherence (VFC0001)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
CP000800.1_424 66.495 8.54E-98 clpP VF0074 ClpP Stress survival VFC0282 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
CP000800.1_448 91.516 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_449 84.887 0.0 acrA VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrA) acriflavine resistance protein A [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_483 73.91 0.0 rhs/PAAR VF0579 T6SS Effector delivery system VFC0086 (rhs/PAAR) Type VI secretion system protein, PAAR family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_489 73.77 2.72E-173 allS VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allS) DNA-binding transcriptional activator AllS [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_490 74.375 9.6E-92 allA VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allA) ureidoglycolate hydrolase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_491 86.194 1.18E-176 allR VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allR) DNA-binding transcriptional repressor AllR [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_496 91.17 0.0 allB VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allB) allantoinase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_500 80.929 0.0 allC VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allC) allantoate amidohydrolase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_501 83.381 0.0 allD VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allD) ureidoglycolate dehydrogenase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_514 64.865 2.07E-83 fimA VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimA) type-1 fimbrial protein subunit A [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP000800.1_515 61.572 4.98E-105 fimC VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimC) chaperone protein FimC [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP000800.1_516 71.25 0.0 fimD VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimD) usher protein FimD [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP000800.1_517 70.659 4.06E-177 fimH VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimH) type I fimbriae minor fimbrial subunit FimH, adhesin [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP000800.1_519 71.905 1.85E-112 fimZ VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimZ) DNA-binding response regulator [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP000800.1_531 93.006 0.0 vgrG/tssI VF0579 T6SS Effector delivery system VFC0086 (vgrG/tssI) type VI secretion system effector VgrG [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_534 98.913 0.0 ibeB VF0237 Ibes Invasion VFC0083 IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC [Ibes (VF0237) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
CP000800.1_546 94.66 9.9E-147 entD VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entD) phosphopantetheinyl transferase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_547 99.598 0.0 fepA VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepA) ferrienterobactin outer membrane transporter [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_548 96.25 0.0 fes VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fes) enterobactin/ferric enterobactin esterase [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_550 96.21 0.0 entF VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entF) enterobactin synthase multienzyme complex component, ATP-dependent [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_551 93.899 0.0 fepE VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepE) LPS O-antigen length regulator [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_552 99.259 0.0 fepC VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_553 97.879 0.0 fepG VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepG) iron-enterobactin ABC transporter permease [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_554 99.401 0.0 fepD VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepD) ferrienterobactin ABC transporter permease [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_555 99.519 0.0 entS VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entS) enterobactin exporter, iron-regulated [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_556 99.686 0.0 fepB VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_557 99.233 0.0 entC VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entC) isochorismate synthase 1 [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_558 98.881 0.0 entE VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entE) 2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_559 99.298 0.0 entB VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entB) isochorismatase [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_560 97.984 1.2E-180 entA VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entA) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase EntA [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_637 99.315 1.76E-107 fur VF0113 Fur Regulation VFC0301 (fur) ferric iron uptake transcriptional regulator [Fur (VF0113) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP000800.1_652 68.894 0.0 rhs/PAAR VF0579 T6SS Effector delivery system VFC0086 (rhs/PAAR) Type VI secretion system protein, PAAR family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_926 66.782 0.0 msbA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (msbA) lipid transporter ATP-binding/permease [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP000800.1_930 70.281 1.63E-127 nueA VF0473 Polar flagella Motility VFC0204 Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments (nueA) NeuA protein [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119] Aeromonas hydrophila
CP000800.1_985 95.714 0.0 ompA VF0236 OmpA Invasion VFC0083 Major outer membrane protein in E. coli, homologous to Neisseria Opa proteins which have been shown to be involved in invasion of eukaryotic cells (ompA) outer membrane protein A [OmpA (VF0236) - Invasion (VFC0083)] [Escherichia coli O18:K1:H7 str. RS218] Escherichia coli (NMEC)
CP000800.1_1011 72.414 0.0 KP1_RS17340 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17340) polysaccharide export protein [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_1063 99.639 0.0 cgsG VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (cgsG) curli production assembly/transport protein CsgG [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
CP000800.1_1064 99.275 1.6E-99 cgsF VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (cgsF) curli production assembly/transport protein CsgF [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
CP000800.1_1065 100.0 5.13E-95 cgsE VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (cgsE) curli production assembly/transport protein CsgE [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
CP000800.1_1066 100.0 9.54E-163 cgsD VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (cgsD) transcriptional regulator CsgD [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
CP000800.1_1067 100.0 1.13E-106 csgB VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (csgB) curlin minor subunit CsgB [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
CP000800.1_1068 97.368 2.19E-101 csgA VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (csgA) curlin major subunit CsgA [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
CP000800.1_1069 98.182 2.91E-75 csgC VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (csgC) curli assembly protein CsgC [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
CP000800.1_1096 62.626 1.86E-34 flgM VF0394 Flagella Motility VFC0204 (flgM) negative regulator of flagellin synthesis [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_1098 71.533 1.67E-73 flgB VF0394 Flagella Motility VFC0204 (flgB) flagellar basal-body rod protein FlgB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_1099 83.582 7.9E-82 flgC VF0394 Flagella Motility VFC0204 (flgC) flagellar basal-body rod protein FlgC [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_1100 74.752 4.11E-103 flgD VF0394 Flagella Motility VFC0204 (flgD) flagellar basal-body rod modification protein FlgD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_1101 63.484 0.0 flgE VF0394 Flagella Motility VFC0204 (flgE) flagellar hook protein FlgE [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_1102 66.135 5.94E-120 flgF VF0394 Flagella Motility VFC0204 (flgF) flagellar basal-body rod protein FlgF [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_1103 86.923 7.79E-170 flgG VF0394 Flagella Motility VFC0204 (flgG) flagellar basal-body rod protein FlgG [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_1104 81.193 3.69E-122 flgH VF0394 Flagella Motility VFC0204 (flgH) flagellar L-ring protein precursor FlgH [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_1105 78.356 0.0 flgI VF0394 Flagella Motility VFC0204 (flgI) flagellar P-ring protein precursor FlgI [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_1106 60.458 1.46E-129 flgJ VF0394 Flagella Motility VFC0204 (flgJ) <beta>-N-acetylglucosaminidase [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_1117 77.459 7.98E-140 flmH VF0473 Polar flagella Motility VFC0204 Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments (flmH) short chain dehydrogenase/reductase family oxidoreductase [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119] Aeromonas hydrophila
CP000800.1_1118 61.538 1.93E-27 acpXL VF0367 LPS Immune modulation VFC0258 Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. (acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] Brucella melitensis
CP000800.1_1197 85.421 0.0 phoQ VF0111 PhoPQ Regulation VFC0301 (phoQ) sensor protein PhoQ [PhoPQ (VF0111) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP000800.1_1198 93.722 1.14E-157 phoP VF0111 PhoPQ Regulation VFC0301 (phoP) response regulator in two-component regulatory system with PhoQ [PhoPQ (VF0111) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP000800.1_1262 81.625 1.99E-178 kdsA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP000800.1_1282 73.958 2.16E-159 galU VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (galU) glucosephosphate uridylyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP000800.1_1537 88.64 0.0 vgrG/tssI VF0579 T6SS Effector delivery system VFC0086 (vgrG/tssI) type VI secretion system effector VgrG [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_1538 73.196 0.0 rhs/PAAR VF0579 T6SS Effector delivery system VFC0086 (rhs/PAAR) Type VI secretion system protein, PAAR family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_1552 90.883 0.0 espR1 VF1111 TTSS secreted effectors Effector delivery system VFC0086 (espR1) Type III secretion system effector espR1 [TTSS secreted effectors (VF1111) - Effector delivery system (VFC0086)] [Escherichia coli O55:H7 str. CB9615] Escherichia coli (EPEC)
CP000800.1_1596 63.333 1.44E-67 focC VF0224 F1C fimbriae Adherence VFC0001 A nonhemagglutinating adherence factor and is expressed by approximately 14% of the E. coli known to cause urinary tract infections and 7% of E. coli fecal isolates; genetically homologous to S fimbriae, but differ in their receptor specificity (focC) F1C periplasmic chaperone [F1C fimbriae (VF0224) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_1762 67.539 7.96E-100 sodB VF0169 SodB Stress survival VFC0282 (sodB) superoxide dismutase [SodB (VF0169) - Stress survival (VFC0282)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
CP000800.1_1825 94.879 0.0 espL1 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espL1) Type III secretion system effector espL1 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP000800.1_1826 90.708 1.69E-146 espL1 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espL1) Type III secretion system effector espL1 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP000800.1_1990 85.362 0.0 flhA VF0394 Flagella Motility VFC0204 (flhA) flagellar biosynthesis protein FlhA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_1991 65.172 1.35E-178 flhB VF0394 Flagella Motility VFC0204 (flhB) flagellar biosynthetic protein FlhB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_1992 77.67 1.61E-108 cheZ VF0394 Flagella Motility VFC0204 (cheZ) chemotaxis regulator CheZ [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_1993 91.473 1.1E-84 cheY VF0394 Flagella Motility VFC0204 (cheY) chemotaxis regulatory protein CheY [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_1994 85.96 0.0 cheB VF0394 Flagella Motility VFC0204 (cheB) chemotaxis-specific methylesterase CheB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_1995 72.101 2.79E-146 cheR VF0394 Flagella Motility VFC0204 (cheR) chemotaxis methyltransferase CheR [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_1998 85.093 3.74E-98 cheW VF0394 Flagella Motility VFC0204 (cheW) purine-binding chemotaxis protein CheW [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_1999 73.521 0.0 cheA VF0394 Flagella Motility VFC0204 (cheA) chemotaxis protein CheA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_2000 68.987 9.25E-153 motB VF0394 Flagella Motility VFC0204 (motB) flagellar motor protein MotB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_2001 81.017 0.0 motA VF0394 Flagella Motility VFC0204 (motA) flagellar motor protein MotA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_2002 82.902 5.06E-117 flhC VF0394 Flagella Motility VFC0204 (flhC) flagellar biosynthesis transcription activator FlhC [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_2003 72.414 5.04E-52 flhD VF0394 Flagella Motility VFC0204 (flhD) flagellar transcriptional activator FlhD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_2027 83.613 4.37E-145 fliA VF0394 Flagella Motility VFC0204 (fliA) flagellar biosynthesis sigma factor [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_2043 63.375 0.0 fliF VF0394 Flagella Motility VFC0204 (fliF) flagellar M-ring protein FliF [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_2044 83.587 0.0 fliG VF0394 Flagella Motility VFC0204 (fliG) flagellar motor switch protein G [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_2046 83.48 0.0 fliI VF0394 Flagella Motility VFC0204 (fliI) flagellum-specific ATP synthase FliI [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_2050 84.384 0.0 fliM VF0394 Flagella Motility VFC0204 (fliM) flagellar motor switch protein FliM [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_2051 74.638 1.47E-69 fliN VF0394 Flagella Motility VFC0204 (fliN) flagellar motor switch protein FliN [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_2053 80.972 6.93E-141 fliP VF0394 Flagella Motility VFC0204 (fliP) flagellar biosynthetic protein FliP [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_2054 77.528 1.94E-37 fliQ VF0394 Flagella Motility VFC0204 (fliQ) flagellar biosynthetic protein FliQ [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_2055 68.605 2.97E-108 fliR VF0394 Flagella Motility VFC0204 (fliR) flagellar biosynthetic protein FliR [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000800.1_2056 67.633 3.45E-102 rcsA VF0571 RcsAB Regulation VFC0301 (rcsA) transcriptional activator for ctr capsule biosynthesis [RcsAB (VF0571) - Regulation (VFC0301)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_2199 82.732 0.0 ugd VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (ugd) UDP-glucose 6-dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_2200 95.085 0.0 gndA VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_2204 62.537 4.0E-159 tviC VF0101 Vi antigen Immune modulation VFC0258 Vi is abbreviation for virulence; the viaB locus is within Salmonella pathogenicity island SPI-7, which also encodes SopE and a type IVB pilus; The viaB locus encodes genes involved in regulation (tviA), Vi biosynthesis (tviBCDE), export, and retention of the Vi on the bacterial cell surface (vexABCDE); A viaB locus is absent from S. Paratyphi A, and most gastroenteritis-causing serovars including S. Typhimurium (tviC) Vi polysaccharide biosynthesis protein, UDP-GlcNAcA 4-epimerase TviC [Vi antigen (VF0101) - Immune modulation (VFC0258)] [Salmonella enterica subsp. enterica serovar Typhi str. CT18] Salmonella enterica (serovar typhi)
CP000800.1_2205 66.038 0.0 tviB VF0465 Capsule Immune modulation VFC0258 A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. (tviB) Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB [Capsule (VF0465) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
CP000800.1_2209 62.722 8.77E-75 rfbC VF0171 LPS Immune modulation VFC0258 (rfbC) dTDP-4-dehydrorhamnose 3,5-epimerase [LPS (VF0171) - Immune modulation (VFC0258)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
CP000800.1_2210 64.138 2.68E-141 wbtL VF0542 LPS Immune modulation VFC0258 The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion (wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
CP000800.1_2212 62.865 3.76E-161 rffG VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rffG) dTDP-glucose 46-dehydratase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP000800.1_2214 89.189 0.0 galF VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (galF) GalU regulator GalF [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_2219 64.454 0.0 wcaJ VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (wcaJ) undecaprenyl-phosphate glucose phosphotransferase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_2220 75.824 0.0 rfbK1 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (rfbK1) O9 family phosphomannomutase RfbK1 [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_2221 61.441 0.0 KP1_RS17280 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17280) mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_2222 61.916 0.0 KP1_RS17295 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17295) glycosyltransferase WbuB [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_2224 77.987 0.0 KP1_RS17305 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17305) GDP-L-fucose synthase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_2225 88.919 0.0 gmd VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gmd) GDP-mannose 4,6-dehydratase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_2234 64.908 0.0 KP1_RS17340 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17340) polysaccharide export protein [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_2393 96.759 1.41E-152 rcsB VF0571 RcsAB Regulation VFC0301 (rcsB) transcriptional regulator RcsB [RcsAB (VF0571) - Regulation (VFC0301)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_2600 64.833 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_2715 65.969 5.37E-91 algU VF0091 Alginate Biofilm VFC0271 Alginate production is frequently referred to as mucoidy because colonies producing alginate have a wet glistening (mucoid) appearance, which is very different from that of colonies not producing alginate; most of the alginate biosynthetic genes are clustered in the algD operon; Alginate production is highly regulated. Regulatory genes are located in two areas far removed from the biosynthetic genes, with one exception algC (algU) alginate biosynthesis protein AlgZ/FimS [Alginate (VF0091) - Biofilm (VFC0271)] [Pseudomonas aeruginosa PAO1] Pseudomonas aeruginosa
CP000800.1_2827 73.099 4.94E-96 luxS VF0406 AI-2 Biofilm VFC0271 AI-2 is produced and detected by a wide variety of bacteria and is presumed to facilitate interspecies communications. (luxS) S-ribosylhomocysteinase [AI-2 (VF0406) - Biofilm (VFC0271)] [Vibrio cholerae O1 biovar El Tor str. N16961] Vibrio cholerae
CP000800.1_2831 76.667 1.4E-30 csrA VF0261 CsrA Regulation VFC0301 Belongs to a highly conserved family of global regulators that typically control stationary phase traits post-transcriptionally (csrA) carbon storage regulator CsrA [CsrA (VF0261) - Regulation (VFC0301)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
CP000800.1_2896 99.394 0.0 rpoS VF0112 RpoS Regulation VFC0301 (rpoS) RNA polymerase sigma factor RpoS [RpoS (VF0112) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP000800.1_2970 73.006 1.74E-88 vipA/tssB VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (vipA/tssB) type VI secretion system contractile sheath small subunit VipA [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_2971 77.821 0.0 vipB/tssC VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (vipB/tssC) type VI secretion system contractile sheath large subunit VipB [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_2975 84.663 8.47E-105 hcp/tssD VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (hcp/tssD) type VI secretion system protein, Hcp family [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_2976 72.81 0.0 clpV/tssH VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (clpV/tssH) type VI secretion system ATPase TssH [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_2977 60.241 0.0 vgrG/tssI VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (vgrG/tssI) type VI secretion system tip protein VgrG [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_3038 68.605 1.08E-39 spaQ VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (spaQ) type III secretion system minor export apparatus protein SpaQ [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP000800.1_3039 69.058 2.89E-97 spaP VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (spaP) type III secretion system minor export apparatus protein SpaP [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP000800.1_3256 94.643 0.0 gspL VF0333 T2SS Effector delivery system VFC0086 T2SS encoded by genes of the general secretion pathway (gsp) is widely distributed in Gram-negative bacteria. The known E.coli T2SS, responsible for chitinase secretion, encoded by the yhe genes at 74.5 min of the MG1655 chromosome is absent in all four sequenced Shigella genomes; A novel set of gsp genes are located on the S. dysenteriae Sd197 and S. boydii Sb227 chromosomes. The Sb227 T2SS is likely to be inactive due to a frameshift in gspC and a nonsense mutation in gspD. Those genes show significant similarity to those from ETEC and Vibrio cholerae responsible for secreting the E.coli heat labile toxin (Ltx) and cholera toxin (Ctx), respectively. While Shiga toxin has an overall similar structure to Ctx and Ltx. (gspL) general secretion pathway protein L [T2SS (VF0333) - Effector delivery system (VFC0086)] [Shigella dysenteriae Sd197] Shigella dysenteriae
CP000800.1_3257 98.154 0.0 gspK VF0333 T2SS Effector delivery system VFC0086 T2SS encoded by genes of the general secretion pathway (gsp) is widely distributed in Gram-negative bacteria. The known E.coli T2SS, responsible for chitinase secretion, encoded by the yhe genes at 74.5 min of the MG1655 chromosome is absent in all four sequenced Shigella genomes; A novel set of gsp genes are located on the S. dysenteriae Sd197 and S. boydii Sb227 chromosomes. The Sb227 T2SS is likely to be inactive due to a frameshift in gspC and a nonsense mutation in gspD. Those genes show significant similarity to those from ETEC and Vibrio cholerae responsible for secreting the E.coli heat labile toxin (Ltx) and cholera toxin (Ctx), respectively. While Shiga toxin has an overall similar structure to Ctx and Ltx. (gspK) general secretion pathway protein K [T2SS (VF0333) - Effector delivery system (VFC0086)] [Shigella dysenteriae Sd197] Shigella dysenteriae
CP000800.1_3258 98.492 3.16E-145 gspJ VF0333 T2SS Effector delivery system VFC0086 T2SS encoded by genes of the general secretion pathway (gsp) is widely distributed in Gram-negative bacteria. The known E.coli T2SS, responsible for chitinase secretion, encoded by the yhe genes at 74.5 min of the MG1655 chromosome is absent in all four sequenced Shigella genomes; A novel set of gsp genes are located on the S. dysenteriae Sd197 and S. boydii Sb227 chromosomes. The Sb227 T2SS is likely to be inactive due to a frameshift in gspC and a nonsense mutation in gspD. Those genes show significant similarity to those from ETEC and Vibrio cholerae responsible for secreting the E.coli heat labile toxin (Ltx) and cholera toxin (Ctx), respectively. While Shiga toxin has an overall similar structure to Ctx and Ltx. (gspJ) general secretion pathway protein J [T2SS (VF0333) - Effector delivery system (VFC0086)] [Shigella dysenteriae Sd197] Shigella dysenteriae
CP000800.1_3259 93.496 3.33E-74 gspI VF0333 T2SS Effector delivery system VFC0086 T2SS encoded by genes of the general secretion pathway (gsp) is widely distributed in Gram-negative bacteria. The known E.coli T2SS, responsible for chitinase secretion, encoded by the yhe genes at 74.5 min of the MG1655 chromosome is absent in all four sequenced Shigella genomes; A novel set of gsp genes are located on the S. dysenteriae Sd197 and S. boydii Sb227 chromosomes. The Sb227 T2SS is likely to be inactive due to a frameshift in gspC and a nonsense mutation in gspD. Those genes show significant similarity to those from ETEC and Vibrio cholerae responsible for secreting the E.coli heat labile toxin (Ltx) and cholera toxin (Ctx), respectively. While Shiga toxin has an overall similar structure to Ctx and Ltx. (gspI) general secretion pathway protein I [T2SS (VF0333) - Effector delivery system (VFC0086)] [Shigella dysenteriae Sd197] Shigella dysenteriae
CP000800.1_3260 95.455 1.66E-123 gspH VF0333 T2SS Effector delivery system VFC0086 T2SS encoded by genes of the general secretion pathway (gsp) is widely distributed in Gram-negative bacteria. The known E.coli T2SS, responsible for chitinase secretion, encoded by the yhe genes at 74.5 min of the MG1655 chromosome is absent in all four sequenced Shigella genomes; A novel set of gsp genes are located on the S. dysenteriae Sd197 and S. boydii Sb227 chromosomes. The Sb227 T2SS is likely to be inactive due to a frameshift in gspC and a nonsense mutation in gspD. Those genes show significant similarity to those from ETEC and Vibrio cholerae responsible for secreting the E.coli heat labile toxin (Ltx) and cholera toxin (Ctx), respectively. While Shiga toxin has an overall similar structure to Ctx and Ltx. (gspH) general secretion pathway protein H [T2SS (VF0333) - Effector delivery system (VFC0086)] [Shigella dysenteriae Sd197] Shigella dysenteriae
CP000800.1_3261 98.675 3.33E-109 gspG VF0333 T2SS Effector delivery system VFC0086 T2SS encoded by genes of the general secretion pathway (gsp) is widely distributed in Gram-negative bacteria. The known E.coli T2SS, responsible for chitinase secretion, encoded by the yhe genes at 74.5 min of the MG1655 chromosome is absent in all four sequenced Shigella genomes; A novel set of gsp genes are located on the S. dysenteriae Sd197 and S. boydii Sb227 chromosomes. The Sb227 T2SS is likely to be inactive due to a frameshift in gspC and a nonsense mutation in gspD. Those genes show significant similarity to those from ETEC and Vibrio cholerae responsible for secreting the E.coli heat labile toxin (Ltx) and cholera toxin (Ctx), respectively. While Shiga toxin has an overall similar structure to Ctx and Ltx. (gspG) general secretion pathway protein G [T2SS (VF0333) - Effector delivery system (VFC0086)] [Shigella dysenteriae Sd197] Shigella dysenteriae
CP000800.1_3262 97.243 0.0 gspF VF0333 T2SS Effector delivery system VFC0086 T2SS encoded by genes of the general secretion pathway (gsp) is widely distributed in Gram-negative bacteria. The known E.coli T2SS, responsible for chitinase secretion, encoded by the yhe genes at 74.5 min of the MG1655 chromosome is absent in all four sequenced Shigella genomes; A novel set of gsp genes are located on the S. dysenteriae Sd197 and S. boydii Sb227 chromosomes. The Sb227 T2SS is likely to be inactive due to a frameshift in gspC and a nonsense mutation in gspD. Those genes show significant similarity to those from ETEC and Vibrio cholerae responsible for secreting the E.coli heat labile toxin (Ltx) and cholera toxin (Ctx), respectively. While Shiga toxin has an overall similar structure to Ctx and Ltx. (gspF) general secretion pathway protein F [T2SS (VF0333) - Effector delivery system (VFC0086)] [Shigella dysenteriae Sd197] Shigella dysenteriae
CP000800.1_3263 97.988 0.0 gspE VF0333 T2SS Effector delivery system VFC0086 T2SS encoded by genes of the general secretion pathway (gsp) is widely distributed in Gram-negative bacteria. The known E.coli T2SS, responsible for chitinase secretion, encoded by the yhe genes at 74.5 min of the MG1655 chromosome is absent in all four sequenced Shigella genomes; A novel set of gsp genes are located on the S. dysenteriae Sd197 and S. boydii Sb227 chromosomes. The Sb227 T2SS is likely to be inactive due to a frameshift in gspC and a nonsense mutation in gspD. Those genes show significant similarity to those from ETEC and Vibrio cholerae responsible for secreting the E.coli heat labile toxin (Ltx) and cholera toxin (Ctx), respectively. While Shiga toxin has an overall similar structure to Ctx and Ltx. (gspE) general secretion pathway protein E [T2SS (VF0333) - Effector delivery system (VFC0086)] [Shigella dysenteriae Sd197] Shigella dysenteriae
CP000800.1_3264 98.98 0.0 gspD VF0333 T2SS Effector delivery system VFC0086 T2SS encoded by genes of the general secretion pathway (gsp) is widely distributed in Gram-negative bacteria. The known E.coli T2SS, responsible for chitinase secretion, encoded by the yhe genes at 74.5 min of the MG1655 chromosome is absent in all four sequenced Shigella genomes; A novel set of gsp genes are located on the S. dysenteriae Sd197 and S. boydii Sb227 chromosomes. The Sb227 T2SS is likely to be inactive due to a frameshift in gspC and a nonsense mutation in gspD. Those genes show significant similarity to those from ETEC and Vibrio cholerae responsible for secreting the E.coli heat labile toxin (Ltx) and cholera toxin (Ctx), respectively. While Shiga toxin has an overall similar structure to Ctx and Ltx. (gspD) general secretion pathway protein D [T2SS (VF0333) - Effector delivery system (VFC0086)] [Shigella dysenteriae Sd197] Shigella dysenteriae
CP000800.1_3265 93.75 0.0 gspC VF0333 T2SS Effector delivery system VFC0086 T2SS encoded by genes of the general secretion pathway (gsp) is widely distributed in Gram-negative bacteria. The known E.coli T2SS, responsible for chitinase secretion, encoded by the yhe genes at 74.5 min of the MG1655 chromosome is absent in all four sequenced Shigella genomes; A novel set of gsp genes are located on the S. dysenteriae Sd197 and S. boydii Sb227 chromosomes. The Sb227 T2SS is likely to be inactive due to a frameshift in gspC and a nonsense mutation in gspD. Those genes show significant similarity to those from ETEC and Vibrio cholerae responsible for secreting the E.coli heat labile toxin (Ltx) and cholera toxin (Ctx), respectively. While Shiga toxin has an overall similar structure to Ctx and Ltx. (gspC) general secretion pathway protein C [T2SS (VF0333) - Effector delivery system (VFC0086)] [Shigella dysenteriae Sd197] Shigella dysenteriae
CP000800.1_3347 71.03 0.0 rfaE VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaE) ADP-heptose synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP000800.1_3387 100.0 0.0 cfaD/cfaE VF0213 Adhesive fimbriae Adherence VFC0001 Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT (cfaD/cfaE) minor pilin and initiator [Adhesive fimbriae (VF0213) - Adherence (VFC0001)] [Escherichia coli E24377A] Escherichia coli (ETEC)
CP000800.1_3388 100.0 0.0 cfaC VF0213 Adhesive fimbriae Adherence VFC0001 Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT (cfaC) colonisation factor antigen c, usher [Adhesive fimbriae (VF0213) - Adherence (VFC0001)] [Escherichia coli E24377A] Escherichia coli (ETEC)
CP000800.1_3389 100.0 2.91E-119 cfaB VF0213 Adhesive fimbriae Adherence VFC0001 Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT (cfaB) colonization factor antigen 1 [Adhesive fimbriae (VF0213) - Adherence (VFC0001)] [Escherichia coli E24377A] Escherichia coli (ETEC)
CP000800.1_3390 100.0 3.7E-178 cfaA VF0213 Adhesive fimbriae Adherence VFC0001 Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT (cfaA) colonisation factor antigen a, chaperone [Adhesive fimbriae (VF0213) - Adherence (VFC0001)] [Escherichia coli E24377A] Escherichia coli (ETEC)
CP000800.1_3549 68.267 0.0 acrA VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrA) acriflavine resistance protein A [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_3550 77.996 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_3605 80.153 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
CP000800.1_3624 66.337 3.79E-99 vfr VF0082 Type IV pili Adherence VFC0001 PilA, B, C, D, E, F, M, N, O, P, Q, T, U, V, W, X, Y1, Y2, Z, and fimT, U, V are involved in the biogenesis and mechanical function of pili, pilG, H, I, K, chpA, B, C, D, E, pilS, R, fimS, rpoN, algR, algU, and vfr are involved in transcriptional regulation and chemosensory pathways that control the expression or activity of the twitching motility of the pili (vfr) cAMP-regulatory protein [Type IV pili (VF0082) - Adherence (VFC0001)] [Pseudomonas aeruginosa PAO1] Pseudomonas aeruginosa
CP000800.1_3652 63.964 5.49E-101 rpe VF0543 Capsule Immune modulation VFC0258 Group 4 capsule; high molecular weight (HMW) O-antigen capsule (rpe) ribulose-phosphate 3-epimerase [Capsule (VF0543) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
CP000800.1_3782 71.022 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP000800.1_3868 69.078 0.0 rhs/PAAR VF0579 T6SS Effector delivery system VFC0086 (rhs/PAAR) Type VI secretion system protein, PAAR family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_3898 78.247 0.0 rfaD VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaD) ADP-L-glycero-D-mannoheptose-6-epimerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP000800.1_3899 63.506 4.74E-158 rfaF VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaF) ADP-heptose-LPS heptosyltransferase II [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP000800.1_4061 66.369 3.89E-172 rffG VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rffG) dTDP-glucose 46-dehydratase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP000800.1_4062 67.01 7.32E-144 wbtL VF0542 LPS Immune modulation VFC0258 The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion (wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
CP000800.1_4071 95.652 9.08E-18 aslA VF0238 AslA Invasion VFC0083 Homology to aslA of E. coli K12; based on its protein sequence, AslA is predicted to be a member of the arylsulfatase family of enzymes that contains highly conserved sulfatase motifs, but E. coli AslA failed to exhibit in vitro arylsulfatase activity (aslA) putative arylsulfatase [AslA (VF0238) - Invasion (VFC0083)] [Escherichia coli O18:K1:H7 str. RS218] Escherichia coli (NMEC)
CP000800.1_4213 67.436 0.0 rhs/PAAR VF0579 T6SS Effector delivery system VFC0086 (rhs/PAAR) Type VI secretion system protein, PAAR family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
CP000800.1_4235 98.614 0.0 ibeC VF0237 Ibes Invasion VFC0083 IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. (ibeC) phosphoethanolamine transferase CptA [Ibes (VF0237) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
CP000800.1_4255 79.898 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
CP000800.1_4287 62.295 0.0 icl VF0253 Isocitrate lyase Others VFC0346 (icl) Isocitrate lyase Icl (isocitrase) (isocitratase) [Isocitrate lyase (VF0253) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP000800.1_4289 82.7 0.0 espL4 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espL4) Type III secretion system effector EspL4 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP000800.1_4314 80.328 1.84E-26 espX4 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espX4) Type III secretion system effector EspX4 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP000800.1_4315 87.5 0.0 espX4 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espX4) Type III secretion system effector EspX4 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP000800.1_4343 92.558 0.0 espX5 VF1111 TTSS secreted effectors Effector delivery system VFC0086 (espX5) Type III secretion system effector EspX5 [TTSS secreted effectors (VF1111) - Effector delivery system (VFC0086)] [Escherichia coli O55:H7 str. CB9615] Escherichia coli (EPEC)
CP000800.1_4384 85.915 0.0 pmrB VF1355 PmrAB Regulation VFC0301 (pmrB) sensory kinase PmrB [PmrAB (VF1355) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP000800.1_4385 90.991 1.08E-150 pmrA VF1355 PmrAB Regulation VFC0301 (pmrA) response regulator PmrA [PmrAB (VF1355) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP000800.1_4415 75.568 0.0 htpB VF0159 Hsp60 Adherence VFC0001 (htpB) Hsp60, 60K heat shock protein HtpB [Hsp60 (VF0159) - Adherence (VFC0001)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
CP000800.1_4612 99.301 0.0 fimD VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_4613 98.864 3.16E-129 fimF VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimF) FimF protein precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_4614 97.006 4.0E-118 fimG VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimG) FimG protein precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_4615 98.0 0.0 fimH VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimH) FimH protein precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP000800.1_4641 69.3 0.0 cheD VF0394 Flagella Motility VFC0204 (cheD) methyl-accepting chemotaxis protein CheD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP000795.1_1 98.023 0.0 etpA VF0437 EtpA Adherence VFC0001 (etpA) Two-partner secreted adhesin EtpA [EtpA (VF0437) - Adherence (VFC0001)] [Escherichia coli O78:H11:K80 str. H10407] Escherichia coli (ETEC)
CP000795.1_19 99.541 3.52E-165 eltA VF0210 Heat-labile toxin (LT) Exotoxin VFC0235 Secreted to the extracellular milieu by a type II secretion system; LT-I is plasmid-encoded; LT-II only produced by strains isolated from animals (eltA) heat-labile enterotoxin A prepeptide (from human) [Heat-labile toxin (LT) (VF0210) - Exotoxin (VFC0235)] [Escherichia coli O78:H11:K80 str. H10407] Escherichia coli (ETEC)
CP000795.1_20 98.387 1.13E-89 eltB VF0210 Heat-labile toxin (LT) Exotoxin VFC0235 Secreted to the extracellular milieu by a type II secretion system; LT-I is plasmid-encoded; LT-II only produced by strains isolated from animals (eltB) enterotoxin subunit B (from human) [Heat-labile toxin (LT) (VF0210) - Exotoxin (VFC0235)] [Escherichia coli O78:H11:K80 str. H10407] Escherichia coli (ETEC)
CP000795.1_92 98.662 0.0 etpB VF0437 EtpA Adherence VFC0001 (etpB) two-partner secretion transporter EtpB [EtpA (VF0437) - Adherence (VFC0001)] [Escherichia coli O78:H11:K80 str. H10407] Escherichia coli (ETEC)
CP000795.1_93 95.349 0.0 etpA VF0437 EtpA Adherence VFC0001 (etpA) Two-partner secreted adhesin EtpA [EtpA (VF0437) - Adherence (VFC0001)] [Escherichia coli O78:H11:K80 str. H10407] Escherichia coli (ETEC)