| CP000921.1_103 |
98.246 |
0.0 |
pavB/pfbB |
VF0524 |
PavB |
Adherence |
VFC0001 |
|
(pavB/pfbB) cell wall surface anchor family protein, Plasminogen- and Fibronectin-binding protein B [PavB (VF0524) - Adherence (VFC0001)] [Streptococcus pneumoniae R6] |
Streptococcus pneumoniae |
| CP000921.1_152 |
88.322 |
0.0 |
pspA |
VF0152 |
PspA |
Immune modulation |
VFC0258 |
Surface protein: choline binding protein |
(pspA) surface protein A [PspA (VF0152) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_351 |
98.5 |
0.0 |
hysA |
VF0146 |
Hyaluronidase |
Exoenzyme |
VFC0251 |
Surface protein: LPXTG-anchored proteins |
(hysA) hyaluronidase [Hyaluronidase (VF0146) - Exoenzyme (VFC0251)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_378 |
94.595 |
0.0 |
cps4A |
VF0144 |
Capsule |
Immune modulation |
VFC0258 |
Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages |
(cps4A) capsular polysaccharide biosynthesis protein Cps4A [Capsule (VF0144) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_379 |
86.831 |
9.88E-162 |
cps4B |
VF0144 |
Capsule |
Immune modulation |
VFC0258 |
Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages |
(cps4B) capsular polysaccharide biosynthesis protein Cps4B [Capsule (VF0144) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_380 |
86.522 |
1.91E-145 |
cpsC |
VF0144 |
Capsule |
Immune modulation |
VFC0258 |
Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages |
(cpsC) capsular polysaccharide biosynthesis protein CpsC [Capsule (VF0144) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_381 |
93.392 |
1.08E-158 |
cps4D |
VF0144 |
Capsule |
Immune modulation |
VFC0258 |
Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages |
(cps4D) capsular polysaccharide biosynthesis protein Cps4D [Capsule (VF0144) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_388 |
65.84 |
0.0 |
cps4I |
VF0144 |
Capsule |
Immune modulation |
VFC0258 |
Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages |
(cps4I) capsular polysaccharide biosynthesis protein Cps4I [Capsule (VF0144) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_389 |
64.828 |
1.58E-141 |
wbtL |
VF0542 |
LPS |
Immune modulation |
VFC0258 |
The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion |
(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| CP000921.1_393 |
72.603 |
1.98E-30 |
cpsI |
VF0361 |
Capsule |
Immune modulation |
VFC0258 |
The biosynthesis of capsular polysaccharides by E. faecalis is encoded by the csp operon, which includes 11 open reading frames (cpsA to cpsK). However, only 7 open reading frames in the cps operon are essential for capsule production (cpsC, cpsD, cpsE, cpsG, cpsI, cpsJ, and cpsK); Previous genetic evidence demonstrated that E. faecalis isolates can be classified in 1 of 3 capsule operon polymorphisms. CPS 1 presents only cpsA and cpsB. CPS 2 presents all 11 genes in the cps operon. CPS 5 presents all genes except for cpsF. Furthermore, CPS 2 and 5 express the capsular polysaccharide, whereas CPS 1 does not. |
(cpsI) UDP-galactopyranose mutase [Capsule (VF0361) - Immune modulation (VFC0258)] [Enterococcus faecalis V583] |
Enterococcus faecalis |
| CP000921.1_403 |
70.551 |
0.0 |
gndA |
VF0560 |
Capsule |
Immune modulation |
VFC0258 |
The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. |
(gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| CP000921.1_475 |
98.533 |
0.0 |
rrgA |
VF0529 |
RlrA islet |
Adherence |
VFC0001 |
Pili are encoded by the rlrA pathogenicity islet, which carries genes for three pilin proteins (the major pilin RrgB and two minor pilins, RrgA and RrgC, RrgA is the tip adhesin) as well as three sortases |
(rrgA) cell wall surface anchor family protein, pilus tip adhesin RrgA [RlrA islet (VF0529) - Adherence (VFC0001)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_476 |
99.85 |
0.0 |
rrgB |
VF0529 |
RlrA islet |
Adherence |
VFC0001 |
Pili are encoded by the rlrA pathogenicity islet, which carries genes for three pilin proteins (the major pilin RrgB and two minor pilins, RrgA and RrgC, RrgA is the tip adhesin) as well as three sortases |
(rrgB) cell wall surface anchor family protein, major pilin RrgB [RlrA islet (VF0529) - Adherence (VFC0001)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_477 |
97.201 |
0.0 |
rrgC |
VF0529 |
RlrA islet |
Adherence |
VFC0001 |
Pili are encoded by the rlrA pathogenicity islet, which carries genes for three pilin proteins (the major pilin RrgB and two minor pilins, RrgA and RrgC, RrgA is the tip adhesin) as well as three sortases |
(rrgC) cell wall surface anchor family protein, minor pili RrgC [RlrA islet (VF0529) - Adherence (VFC0001)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_478 |
97.643 |
0.0 |
srtC-1/srtB |
VF0529 |
RlrA islet |
Adherence |
VFC0001 |
Pili are encoded by the rlrA pathogenicity islet, which carries genes for three pilin proteins (the major pilin RrgB and two minor pilins, RrgA and RrgC, RrgA is the tip adhesin) as well as three sortases |
(srtC-1/srtB) sortase [RlrA islet (VF0529) - Adherence (VFC0001)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_479 |
98.113 |
0.0 |
srtC-2/srtC |
VF0529 |
RlrA islet |
Adherence |
VFC0001 |
Pili are encoded by the rlrA pathogenicity islet, which carries genes for three pilin proteins (the major pilin RrgB and two minor pilins, RrgA and RrgC, RrgA is the tip adhesin) as well as three sortases |
(srtC-2/srtC) sortase [RlrA islet (VF0529) - Adherence (VFC0001)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_480 |
100.0 |
0.0 |
srtC-3/srtD |
VF0529 |
RlrA islet |
Adherence |
VFC0001 |
Pili are encoded by the rlrA pathogenicity islet, which carries genes for three pilin proteins (the major pilin RrgB and two minor pilins, RrgA and RrgC, RrgA is the tip adhesin) as well as three sortases |
(srtC-3/srtD) sortase [RlrA islet (VF0529) - Adherence (VFC0001)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_723 |
63.918 |
1.79E-92 |
clpP |
VF0074 |
ClpP |
Stress survival |
VFC0282 |
21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes |
(clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP000921.1_1005 |
100.0 |
3.33E-134 |
sipA |
VF0530 |
PI-2 |
Adherence |
VFC0001 |
The type PI-2 streptococcal pilus presents in a number of invasive pneumococcal serotypes and consists of repeated units of a single protein, PitB, whose covalent association is catalyzed by cognate sortase SrtG-1 and partner protein SipA. |
(sipA) signal peptidase I [PI-2 (VF0530) - Adherence (VFC0001)] [Streptococcus pneumoniae Taiwan19F-14] |
Streptococcus pneumoniae |
| CP000921.1_1006 |
100.0 |
0.0 |
pitB |
VF0530 |
PI-2 |
Adherence |
VFC0001 |
The type PI-2 streptococcal pilus presents in a number of invasive pneumococcal serotypes and consists of repeated units of a single protein, PitB, whose covalent association is catalyzed by cognate sortase SrtG-1 and partner protein SipA. |
(pitB) major pilin PitB [PI-2 (VF0530) - Adherence (VFC0001)] [Streptococcus pneumoniae Taiwan19F-14] |
Streptococcus pneumoniae |
| CP000921.1_1007 |
100.0 |
0.0 |
srtG1 |
VF0530 |
PI-2 |
Adherence |
VFC0001 |
The type PI-2 streptococcal pilus presents in a number of invasive pneumococcal serotypes and consists of repeated units of a single protein, PitB, whose covalent association is catalyzed by cognate sortase SrtG-1 and partner protein SipA. |
(srtG1) sortase, SrtB family [PI-2 (VF0530) - Adherence (VFC0001)] [Streptococcus pneumoniae Taiwan19F-14] |
Streptococcus pneumoniae |
| CP000921.1_1008 |
60.335 |
2.01E-78 |
srtG1 |
VF0530 |
PI-2 |
Adherence |
VFC0001 |
The type PI-2 streptococcal pilus presents in a number of invasive pneumococcal serotypes and consists of repeated units of a single protein, PitB, whose covalent association is catalyzed by cognate sortase SrtG-1 and partner protein SipA. |
(srtG1) sortase, SrtB family [PI-2 (VF0530) - Adherence (VFC0001)] [Streptococcus pneumoniae Taiwan19F-14] |
Streptococcus pneumoniae |
| CP000921.1_1125 |
92.373 |
0.0 |
iga |
VF0147 |
IgA1 protease |
Immune modulation |
VFC0258 |
Two more zinc metalloproteinase ZmpB and ZmpC may also contribute to virulence |
(iga) G5 domain-containing protein [IgA1 protease (VF0147) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_1144 |
63.279 |
4.5E-139 |
lmb |
VF0275 |
Lmb |
Adherence |
VFC0001 |
Lmb is an extracellular protein that was first identified in S. agalactiae. Homologs of this protein were reported in S. pyogenes and S. pneumonia and termed Lbp and AdcAII, respectively |
(lmb) laminin-binding surface protein [Lmb (VF0275) - Adherence (VFC0001)] [Streptococcus agalactiae NEM316] |
Streptococcus agalactiae |
| CP000921.1_1180 |
99.274 |
0.0 |
pavA |
VF0283 |
PavA |
Adherence |
VFC0001 |
PavA was the first Fibronectin-binding protein identified in S. pneumoniae and shares about 70% sequence identity with the Fibronectin-binding proteins FBP54 of S. pyogenes and FbpA of S. gordonii |
(pavA) Fibronectin-binding protein-like protein A [PavA (VF0283) - Adherence (VFC0001)] [Streptococcus pneumoniae R6] |
Streptococcus pneumoniae |
| CP000921.1_1210 |
96.81 |
0.0 |
pce/cbpE |
VF0145 |
CBPs |
Adherence |
VFC0001 |
Surface protein: choline-binding |
(pce/cbpE) choline binding protein E [CBPs (VF0145) - Adherence (VFC0001)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_1357 |
69.697 |
0.0 |
tufA |
VF0460 |
EF-Tu |
Adherence |
VFC0001 |
|
(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| CP000921.1_1508 |
99.676 |
0.0 |
psaA |
VF0151 |
PsaA |
Nutritional/Metabolic factor |
VFC0272 |
Surface protein: lipid-attached; AdcABC is another ABC transporter for Zn2+ uptake |
(psaA) manganese ABC transporter, manganese-binding adhesion liprotein [PsaA (VF0151) - Nutritional/Metabolic factor (VFC0272)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_1542 |
99.426 |
0.0 |
nanB |
VF0148 |
Neuraminidase |
Exoenzyme |
VFC0251 |
Surface protein: LPXTG-anchored; two forms of the pneumococcal neuraminidase enzymes, NanA and NanB. The activity of NanB is approximately 100 times lower than that of NanA. NanA but not NanB contains a LPXTG motif in C-terminal, the sequence similarity between the two enzymes is only 20%; maximum activity: NanA at ~pH5, NanB at ~pH7 |
(nanB) neuraminidase B [Neuraminidase (VF0148) - Exoenzyme (VFC0251)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_1662 |
60.714 |
1.26E-151 |
galE |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(galE) UDP-glucose 4-epimerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| CP000921.1_1666 |
85.257 |
0.0 |
pfbA |
VF0525 |
PfbA |
Adherence |
VFC0001 |
|
(pfbA) cell wall surface anchor family protein, Plasminogen- and Fibronectin-binding protein A [PfbA (VF0525) - Adherence (VFC0001)] [Streptococcus pneumoniae R6] |
Streptococcus pneumoniae |
| CP000921.1_1739 |
69.143 |
0.0 |
groEL |
VF0594 |
GroEL |
Adherence |
VFC0001 |
GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. |
(groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] |
Clostridium difficile |
| CP000921.1_1754 |
100.0 |
0.0 |
ply |
VF0149 |
Pneumolysin |
Exotoxin |
VFC0235 |
Shares amino acid homology with similar hemolysins such as SLO, LLO, but pneumolysin is a cytoplasmic protein rather than a secreted protein |
(ply) pneumolysin [Pneumolysin (VF0149) - Exotoxin (VFC0235)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_1776 |
99.686 |
0.0 |
lytA |
VF0143 |
Autolysin |
Exoenzyme |
VFC0251 |
Surface protein: choline-binding proteins anchored to the cell surface by a non-covalent interaction of a repeat region at the C-terminal with the phosphorylcholine of the cell wall; Attachment of the enzyme to the choline of the S. pneumoniae cell wall teichoic acid is essential for the lytic activity of the enzyme; two other cell wall hydrolases, LytB and LytC have recently been described, but their roles in virulence have not been assessed. LytB plays a role in pneumococcal daughter cell separation. LytC has a lysozyme-like activity |
(lytA) autolysin (N-acetylmuramoyl-L-alanine amidase) [Autolysin (VF0143) - Exoenzyme (VFC0251)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_1939 |
86.007 |
0.0 |
hasC |
VF0244 |
Hyaluronic acid capsule |
Immune modulation |
VFC0258 |
|
(hasC) UTP--glucose-1-phosphate uridylyltransferase HasC [Hyaluronic acid capsule (VF0244) - Immune modulation (VFC0258)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| CP000921.1_2037 |
71.605 |
0.0 |
cbpA/pspC |
VF0150 |
CbpA/PspC |
Adherence |
VFC0001 |
Also known as PspC, SpsA, Hic (factor H-binding inhibitor of complement); surface protein: choline-binding protein |
(cbpA/pspC) choline binding protein A [CbpA/PspC (VF0150) - Adherence (VFC0001)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |
| CP000921.1_2047 |
98.661 |
0.0 |
cbpD |
VF0143 |
Autolysin |
Exoenzyme |
VFC0251 |
Surface protein: choline-binding proteins anchored to the cell surface by a non-covalent interaction of a repeat region at the C-terminal with the phosphorylcholine of the cell wall; Attachment of the enzyme to the choline of the S. pneumoniae cell wall teichoic acid is essential for the lytic activity of the enzyme; two other cell wall hydrolases, LytB and LytC have recently been described, but their roles in virulence have not been assessed. LytB plays a role in pneumococcal daughter cell separation. LytC has a lysozyme-like activity |
(cbpD) choline binding protein D [Autolysin (VF0143) - Exoenzyme (VFC0251)] [Streptococcus pneumoniae TIGR4] |
Streptococcus pneumoniae |