2. PATHOGENS
Basic Information
Accession number
GCA_000022245.1
Release date
2009-12-24
Organism
Shigella flexneri 2002017
Species name
Shigella flexneri
Assembly level
Complete Genome
Assembly name
ASM2224v1
Assembly submitter
Chinese Center for Disease Control and Prevention
Assembly Type
haploid
Genome size
4.9 Mb
GC percent
50.5
Contig count
6
Collection date
-
Sample location
-
Host
-
Isolation source
-
Isolate type
-
Strain
2002017
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
CP001383.1_71 # 81694 # 82638 500.0 648.662 leuO 99.04 ARO:3003843 protein homolog model nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump leuO, a LysR family transcription factor, exists in a wide variety of bacteria of the family Enterobacteriaceae and is involved in the regulation of as yet unidentified genes affecting the stress response and pathogenesis expression. LeuO is also an activator of the MdtNOP efflux pump.
CP001383.1_234 # 254563 # 255657 250.0 266.544 vanG 39.5 ARO:3002909 protein homolog model glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; Van ligase VanG is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis.
CP001383.1_444 # 435649 # 438798 1900.0 2133.61 acrB 99.81 ARO:3000216 protein homolog model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter.
CP001383.1_445 # 438821 # 440014 670.0 793.112 Escherichia coli acrA 99.5 ARO:3004043 protein homolog model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrA is a subunit of the AcrAB-TolC multidrug efflux system found in E. coli.
CP001383.1_862 # 842831 # 844057 700.0 775.778 Escherichia coli mdfA 96.1 ARO:3001328 protein homolog model tetracycline antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter.
CP001383.1_987 # 960096 # 961844 1000.0 1190.25 msbA 99.83 ARO:3003950 protein homolog model nitroimidazole antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A, a major component of the bacterial outer cell membrane, and is the only bacterial ABC transporter that is essential for cell viability.
CP001383.1_1136 # 1106058 # 1107263 700.0 785.023 tet(B) 99.25 ARO:3000166 protein homolog model tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Tet(B) is a tetracycline efflux protein expressed in many Gram-negative bacteria. It confers resistance to tetracycline, doxycycline, and minocycline, but not tigecycline.
CP001383.1_1139 # 1109184 # 1109963 450.0 519.62 ANT(3'')-IIa 99.61 ARO:3004089 protein homolog model aminoglycoside antibiotic antibiotic inactivation ANT(3'') ANT(3'')-IIa is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms.
CP001383.1_1140 # 1110088 # 1110963 500.0 564.688 OXA-1 100.0 ARO:3001396 protein homolog model carbapenem; cephalosporin; penam antibiotic inactivation OXA beta-lactamase OXA-1 is a beta-lactamase found in E. coli.
CP001383.1_1146 # 1116994 # 1117653 400.0 465.692 catI 100.0 ARO:3002683 protein homolog model phenicol antibiotic antibiotic inactivation chloramphenicol acetyltransferase (CAT) catA1 (formerly in CARD as catI) is a chromosome and transposon-encoded variant of the cat gene found in Escherichia coli and Acinetobacter baumannii.
CP001383.1_1150 # 1119452 # 1120657 700.0 785.023 tet(B) 99.25 ARO:3000166 protein homolog model tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Tet(B) is a tetracycline efflux protein expressed in many Gram-negative bacteria. It confers resistance to tetracycline, doxycycline, and minocycline, but not tigecycline.
CP001383.1_1221 # 1169311 # 1170519 750.0 799.275 mdtH 99.75 ARO:3001216 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug resistance protein MdtH.
CP001383.1_1404 # 1341366 # 1341779 240.0 276.944 H-NS 100.0 ARO:3000676 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; cephalosporin; cephamycin; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE, mdtE, and emrK as well as nearby genes of many RND-type multidrug exporters.
CP001383.1_1763 # 1651047 # 1651430 230.0 266.544 marA 100.0 ARO:3000263 protein homolog model fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux; reduced permeability to antibiotic resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF.
CP001383.1_1826 # 1702727 # 1703056 150.0 184.882 Klebsiella pneumoniae KpnF 83.49 ARO:3004583 protein homolog model macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic; disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump KpnF subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan.
CP001383.1_1827 # 1703043 # 1703408 150.0 182.57 Klebsiella pneumoniae KpnE 82.2 ARO:3004580 protein homolog model macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic; disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump KpnE subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan.
CP001383.1_2225 # 2067594 # 2067926 190.0 216.083 Escherichia coli emrE 98.18 ARO:3004039 protein homolog model macrolide antibiotic antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump Member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation.
CP001383.1_2387 # 2207408 # 2210473 1800.0 2045.01 mdtC 99.12 ARO:3000794 protein homolog model aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB, MdtC can form a homomultimer complex that results in a functioning efflux complex with a narrower drug specificity. mdtC corresponds to 3 loci in Pseudomonas aeruginosa PAO1 (gene name: muxC/muxB) and 3 loci in Pseudomonas aeruginosa LESB58.
CP001383.1_2389 # 2211886 # 2213289 850.0 946.036 baeS 99.36 ARO:3000829 protein homolog model aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity, BaeS is not necessary for overexpressed BaeR to confer resistance.
CP001383.1_2390 # 2213286 # 2214008 450.0 483.411 baeR 99.17 ARO:3000828 protein homolog model aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes.
CP001383.1_2550 # 2367315 # 2368958 1050.0 1100.5 YojI 99.27 ARO:3003952 protein homolog model peptide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI.
CP001383.1_2591 # 2418758 # 2419726 550.0 667.152 PmrF 99.69 ARO:3003578 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58.
CP001383.1_2594 # 2422594 # 2424246 400.0 736.873 ArnT 63.7 ARO:3005053 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase ArnT is involved in Cell Wall Biosynthesis, specifically 4-amino-4-deoxy-L-arabinose (Ara4N). It confers resistance to peptide antibiotics.
CP001383.1_2694 # 2521343 # 2522881 900.0 1018.45 emrY 99.41 ARO:3000254 protein homolog model tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB.
CP001383.1_2695 # 2522881 # 2524044 600.0 709.138 emrK 98.58 ARO:3000206 protein homolog model tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC, it mediates multidrug efflux.
CP001383.1_2696 # 2524460 # 2525074 390.0 417.157 evgA 100.0 ARO:3000832 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump EvgA, when phosphorylated, is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner, it can be phosphorylated in the absence of EvgS when overexpressed.
CP001383.1_2697 # 2525079 # 2528672 2300.0 2474.89 evgS 99.42 ARO:3000833 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump EvgS is a sensor protein that phosphorylates the regulatory protein EvgA. evgS corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58.
CP001383.1_2780 # 2613291 # 2616404 1900.0 2119.35 acrD 99.61 ARO:3000491 protein homolog model aminoglycoside antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrD is an aminoglycoside efflux pump expressed in E. coli. Its expression can be induced by indole, and is regulated by baeRS and cpxAR.
CP001383.1_2990 # 2823550 # 2824080 280.0 360.147 emrR 99.43 ARO:3000516 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression.
CP001383.1_2993 # 2825396 # 2826934 900.0 1018.84 emrB 99.22 ARO:3000074 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP), nalidixic acid, and thioloactomycin.
CP001383.1_2998 # 2831060 # 2831245 100.0 109.383 rsmA 85.25 ARO:3005069 protein homolog model fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump rsmA is a gene that regulates virulence of Pseudomonas aeruginosa. However, its negative effect on MexEF-OprN overexpression has been noted to confer resistance to various antibiotics. It's Escherichia coli homolog is csrA.
CP001383.1_3391 # 3230014 # 3230835 500.0 543.117 bacA 99.63 ARO:3002986 protein homolog model peptide antibiotic antibiotic target alteration undecaprenyl pyrophosphate related proteins The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin.
CP001383.1_3677 # 3491345 # 3491977 400.0 434.491 CRP 99.52 ARO:3000518 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump CRP is a global regulator that represses MdtEF multidrug efflux pump expression.
CP001383.1_3903 # 3729535 # 3730359 450.0 559.296 gadX 98.18 ARO:3000508 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance.
CP001383.1_3904 # 3730727 # 3731455 470.0 473.011 gadW 94.63 ARO:3003838 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump GadW is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance. GadW inhibits GadX-dependent activation. GadW clearly represses gadX and, in situations where GadX is missing, activates gadA and gadBC.
CP001383.1_4122 # 3946993 # 3947466 300.0 321.627 dfrA1 99.36 ARO:3002854 protein homolog model diaminopyrimidine antibiotic antibiotic target replacement trimethoprim resistant dihydrofolate reductase dfr dfrA1 is an integron-encoded dihydrofolate reductase.
CP001383.1_4123 # 3947561 # 3948085 300.0 365.925 SAT-2 100.0 ARO:3002895 protein homolog model nucleoside antibiotic antibiotic inactivation streptothricin acetyltransferase (SAT) SAT-2 is a plasmid-mediated streptothricin acetyltransferase, which confers resistance to streptothricin, a nucleoside antibiotic. Originally described from an E. coli plasmid sequence by Heim et al., 1989.
CP001383.1_4124 # 3948143 # 3948931 450.0 522.316 ANT(3'')-IIa 99.62 ARO:3004089 protein homolog model aminoglycoside antibiotic antibiotic inactivation ANT(3'') ANT(3'')-IIa is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms.
CP001383.1_4323 # 4158259 # 4159632 890.0 924.465 cpxA 99.78 ARO:3000830 protein homolog model aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR, which promotes efflux complex expression.
CP001383.1_4458 # 4313675 # 4315318 1000.0 1130.55 eptA 99.27 ARO:3003576 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine, resulting in a less negative cell membrane and decreased binding of polymyxin B.
CP001383.1_4496 # 4350860 # 4352326 875.0 975.311 mdtP 97.95 ARO:3003550 protein homolog model nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
CP001383.1_4498 # 4354297 # 4355328 600.0 683.715 mdtN 99.42 ARO:3003548 protein homolog model nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
CP001383.1_4666 # 4525907 # 4527040 700.0 755.362 Escherichia coli ampC beta-lactamase 98.14 ARO:3004290 protein homolog model cephalosporin; penam antibiotic inactivation ampC-type beta-lactamase A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics.
CP001386.1_5 # 3303 # 4139 500.0 568.155 APH(6)-Id 99.64 ARO:3002660 protein homolog model aminoglycoside antibiotic antibiotic inactivation APH(6) APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids, integrative conjugative elements and chromosomal genomic islands in K. pneumoniae, Salmonella spp., E. coli, Shigella flexneri, Providencia alcalifaciens, Pseudomonas spp., V. cholerae, Edwardsiella tarda, Pasteurella multocida and Aeromonas bestiarum.
CP001386.1_6 # 4139 # 4942 500.0 541.191 APH(3'')-Ib 99.63 ARO:3002639 protein homolog model aminoglycoside antibiotic antibiotic inactivation APH(3'') APH(3'')-Ib is an aminoglycoside phosphotransferase encoded by plasmids, transposons, integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp.
CP001386.1_7 # 5003 # 5818 500.0 528.865 sul2 100.0 ARO:3000412 protein homolog model sulfonamide antibiotic antibiotic target replacement sulfonamide resistant sul Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria, usually found on small plasmids.
CP001383.1_79 # 89516 # 91282 500.0 595.89 Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics 53.11 ARO:3004446 protein variant model D350N, S357N cephalosporin; cephamycin; penam antibiotic target alteration Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics PBP3 is a penicillin-binding protein and beta-lactam resistance enzyme encoded by the ftsI gene in Haemophilus influenzae. Mutations in ftsI confer resistance to beta-lactam antibiotics.
CP001383.1_2568 # 2391190 # 2393817 1500.0 1763.43 Escherichia coli gyrA conferring resistance to fluoroquinolones 99.77 ARO:3003294 protein variant model S83L fluoroquinolone antibiotic antibiotic target alteration fluoroquinolone resistant gyrA Point mutation of Escherichia coli gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance.
CP001383.1_2580 # 2406727 # 2408085 850.0 918.302 Escherichia coli GlpT with mutation conferring resistance to fosfomycin 99.56 ARO:3003889 protein variant model E448K phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant GlpT Point mutations to the active importer GlpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria.
CP001383.1_3356 # 3196752 # 3199010 1400.0 1536.55 Escherichia coli parC conferring resistance to fluoroquinolones 99.87 ARO:3003308 protein variant model S80I fluoroquinolone antibiotic antibiotic target alteration fluoroquinolone resistant parC Point mutation in Escherichia coli parC resulting in fluoroquinolone resistance.
CP001383.1_3658 # 3475438 # 3476622 700.0 797.734 Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin 99.75 ARO:3003369 protein variant model R234F elfamycin antibiotic antibiotic target alteration elfamycin resistant EF-Tu Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin.
CP001383.1_4393 # 4235356 # 4236540 700.0 795.808 Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin 99.75 ARO:3003369 protein variant model R234F elfamycin antibiotic antibiotic target alteration elfamycin resistant EF-Tu Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin.
CP001383.1_446 # 440156 # 440803 375.0 446.047 Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime 100.0 ARO:3003807 protein overexpression model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. The mutations associated with this model are specific to E. coli.
CP001383.1_1137 # 1107345 # 1107968 400.0 427.172 tetR 100.0 ARO:3003479 protein overexpression model tetracycline antibiotic antibiotic target alteration; antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites. Mutations arise within tetR results in lower affinity for tetracyclin.
CP001383.1_1149 # 1118747 # 1119370 400.0 427.172 tetR 100.0 ARO:3003479 protein overexpression model tetracycline antibiotic antibiotic target alteration; antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites. Mutations arise within tetR results in lower affinity for tetracyclin.
CP001383.1_1764 # 1651450 # 1651884 210.0 289.656 Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline 98.61 ARO:3003378 protein overexpression model Y137H, G103S fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB.
CP001383.1_4475 # 4328761 # 4329084 200.0 217.238 Escherichia coli soxS with mutation conferring antibiotic resistance 99.07 ARO:3003511 protein overexpression model fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux; reduced permeability to antibiotic ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability.
CP001383.1_4476 # 4329170 # 4329634 300.0 313.538 Escherichia coli soxR with mutation conferring antibiotic resistance 100.0 ARO:3003381 protein overexpression model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
CP001383.1_91 77.303 0.0 lpxC VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxC) UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP001383.1_170 65.089 1.35E-160 lpxD VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxD) UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP001383.1_172 67.557 1.62E-132 lpxA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxA) UDP-N-acetylglucosamine acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP001383.1_173 63.281 6.64E-176 lpxB VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxB) lipid-A-disaccharide synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP001383.1_189 67.528 1.16E-127 IlpA VF0513 IlpA Adherence VFC0001 (IlpA) immunogenic lipoprotein A [IlpA (VF0513) - Adherence (VFC0001)] [Vibrio vulnificus YJ016] Vibrio vulnificus
CP001383.1_204 71.795 4.07E-168 STM0266 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
CP001383.1_205 78.218 3.4E-55 STM0267 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
CP001383.1_206 91.547 0.0 STM0268 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
CP001383.1_207 78.049 2.14E-92 STM0269 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
CP001383.1_208 70.0 5.09E-110 STM0270 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
CP001383.1_210 61.29 3.98E-39 STM0271 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
CP001383.1_268 84.332 0.0 vgrG VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
CP001383.1_269 75.0 2.06E-31 STM0290 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
CP001383.1_270 85.827 9.62E-55 tre<sup>Tu</sup> VF1195 SCI T6SS secreted effectors Effector delivery system VFC0086 (tre<up>Tu</up>) Rhs polymorphic toxin, ADP-ribosyltransferase, type VI ribosyltransferase effector targeting EF-Tu [SCI T6SS secreted effectors (VF1195) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP001383.1_271 68.613 0.0 tre<sup>Tu</sup> VF1195 SCI T6SS secreted effectors Effector delivery system VFC0086 (tre<up>Tu</up>) Rhs polymorphic toxin, ADP-ribosyltransferase, type VI ribosyltransferase effector targeting EF-Tu [SCI T6SS secreted effectors (VF1195) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP001383.1_272 78.498 1.02E-155 tre<sup>Tu</sup> VF1195 SCI T6SS secreted effectors Effector delivery system VFC0086 (tre<up>Tu</up>) Rhs polymorphic toxin, ADP-ribosyltransferase, type VI ribosyltransferase effector targeting EF-Tu [SCI T6SS secreted effectors (VF1195) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP001383.1_277 74.479 8.28E-108 gmhA/lpcA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (gmhA/lpcA) phosphoheptose isomerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP001383.1_353 96.026 0.0 gtrB VF0124 LPS Immune modulation VFC0258 Composed of the O-antigen, core polysaccharides and lipid A; the genes involved in the biosynthesis of the basic O-antigen are located in the rfb/rfc loci; O-antigen modification is associated with temperate bacteriophages. Four different serotype-converting phages have been found: SfII, Sf6, SfV and SfX, which are involved in conversion of a serotype Y stain to serotypes 2a, 3b, 5a and X, respectively (gtrB) bactoprenol glucosyl transferase [LPS (VF0124) - Immune modulation (VFC0258)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001383.1_418 66.495 8.54E-98 clpP VF0074 ClpP Stress survival VFC0282 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
CP001383.1_444 91.325 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_445 84.635 0.0 acrA VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrA) acriflavine resistance protein A [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_480 73.267 1.7E-170 allS VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allS) DNA-binding transcriptional activator AllS [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_481 73.75 9.39E-91 allA VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allA) ureidoglycolate hydrolase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_482 85.821 8.99E-176 allR VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allR) DNA-binding transcriptional repressor AllR [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_489 80.535 0.0 allC VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allC) allantoate amidohydrolase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_500 64.865 4.65E-83 fimA VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimA) type-1 fimbrial protein subunit A [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP001383.1_501 61.135 1.65E-103 fimC VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimC) chaperone protein FimC [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP001383.1_504 76.056 1.3E-35 fimZ VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimZ) DNA-binding response regulator [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP001383.1_513 98.261 0.0 ibeB VF0237 Ibes Invasion VFC0083 IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC [Ibes (VF0237) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
CP001383.1_536 94.66 3.13E-147 entD VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entD) phosphopantetheinyl transferase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_537 99.464 0.0 fepA VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepA) ferrienterobactin outer membrane transporter [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_538 96.0 0.0 fes VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fes) enterobactin/ferric enterobactin esterase [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_540 95.143 0.0 entF VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entF) enterobactin synthase multienzyme complex component, ATP-dependent [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_542 90.698 8.6E-84 fepE VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepE) LPS O-antigen length regulator [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_543 94.69 6.26E-158 fepE VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepE) LPS O-antigen length regulator [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_544 98.889 0.0 fepC VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_545 96.667 0.0 fepG VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepG) iron-enterobactin ABC transporter permease [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_546 99.401 0.0 fepD VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepD) ferrienterobactin ABC transporter permease [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_547 97.115 0.0 entS VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entS) enterobactin exporter, iron-regulated [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_548 99.371 0.0 fepB VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_549 100.0 5.36E-64 entC VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entC) isochorismate synthase 1 [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_550 98.462 0.0 entC VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entC) isochorismate synthase 1 [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_551 97.761 0.0 entE VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entE) 2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_552 99.649 0.0 entB VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entB) isochorismatase [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_553 97.177 6.0E-180 entA VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entA) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase EntA [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_664 99.315 1.76E-107 fur VF0113 Fur Regulation VFC0301 (fur) ferric iron uptake transcriptional regulator [Fur (VF0113) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP001383.1_783 100.0 0.0 ipaH0722 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH0722) type III secretion system effector IpaH0722, E3 ubiquitin ligase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001383.1_958 99.502 0.0 ipaH VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH) invasion plasmid antigen IpaH [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001383.1_987 66.955 0.0 msbA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (msbA) lipid transporter ATP-binding/permease [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP001383.1_991 69.076 4.95E-125 nueA VF0473 Polar flagella Motility VFC0204 Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments (nueA) NeuA protein [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119] Aeromonas hydrophila
CP001383.1_1036 94.857 0.0 ompA VF0236 OmpA Invasion VFC0083 Major outer membrane protein in E. coli, homologous to Neisseria Opa proteins which have been shown to be involved in invasion of eukaryotic cells (ompA) outer membrane protein A [OmpA (VF0236) - Invasion (VFC0083)] [Escherichia coli O18:K1:H7 str. RS218] Escherichia coli (NMEC)
CP001383.1_1064 72.414 0.0 KP1_RS17340 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17340) polysaccharide export protein [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_1174 100.0 3.62E-83 cgsG VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (cgsG) curli production assembly/transport protein CsgG [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
CP001383.1_1175 78.182 1.21E-56 cgsG VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (cgsG) curli production assembly/transport protein CsgG [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
CP001383.1_1176 99.275 1.6E-99 cgsF VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (cgsF) curli production assembly/transport protein CsgF [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
CP001383.1_1177 98.45 8.36E-93 cgsE VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (cgsE) curli production assembly/transport protein CsgE [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
CP001383.1_1178 100.0 9.54E-163 cgsD VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (cgsD) transcriptional regulator CsgD [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
CP001383.1_1179 99.338 5.9E-106 csgB VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (csgB) curlin minor subunit CsgB [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
CP001383.1_1183 97.391 1.05E-76 csgA VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (csgA) curlin major subunit CsgA [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
CP001383.1_1227 62.626 1.86E-34 flgM VF0394 Flagella Motility VFC0204 (flgM) negative regulator of flagellin synthesis [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_1229 71.533 1.67E-73 flgB VF0394 Flagella Motility VFC0204 (flgB) flagellar basal-body rod protein FlgB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_1231 90.476 1.97E-22 flgC VF0394 Flagella Motility VFC0204 (flgC) flagellar basal-body rod protein FlgC [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_1232 75.622 1.12E-104 flgD VF0394 Flagella Motility VFC0204 (flgD) flagellar basal-body rod modification protein FlgD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_1234 63.291 1.24E-68 flgF VF0394 Flagella Motility VFC0204 (flgF) flagellar basal-body rod protein FlgF [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_1235 86.538 4.81E-169 flgG VF0394 Flagella Motility VFC0204 (flgG) flagellar basal-body rod protein FlgG [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_1236 81.193 3.69E-122 flgH VF0394 Flagella Motility VFC0204 (flgH) flagellar L-ring protein precursor FlgH [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_1237 78.356 0.0 flgI VF0394 Flagella Motility VFC0204 (flgI) flagellar P-ring protein precursor FlgI [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_1239 63.436 1.02E-93 flgK VF0394 Flagella Motility VFC0204 (flgK) flagellar hook-associated protein 1 FlgK [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_1241 67.407 5.1E-63 flgL VF0394 Flagella Motility VFC0204 (flgL) flagellar hook-associated protein 3 FlgL [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_1251 77.459 7.98E-140 flmH VF0473 Polar flagella Motility VFC0204 Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments (flmH) short chain dehydrogenase/reductase family oxidoreductase [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119] Aeromonas hydrophila
CP001383.1_1252 61.538 1.93E-27 acpXL VF0367 LPS Immune modulation VFC0258 Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. (acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] Brucella melitensis
CP001383.1_1307 85.216 0.0 phoQ VF0111 PhoPQ Regulation VFC0301 (phoQ) sensor protein PhoQ [PhoPQ (VF0111) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP001383.1_1308 93.722 1.14E-157 phoP VF0111 PhoPQ Regulation VFC0301 (phoP) response regulator in two-component regulatory system with PhoQ [PhoPQ (VF0111) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP001383.1_1383 81.625 1.99E-178 kdsA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP001383.1_1403 73.958 2.16E-159 galU VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (galU) glucosephosphate uridylyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP001383.1_1569 99.825 0.0 ipaH VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH) invasion plasmid antigen IpaH [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001383.1_1701 97.203 6.63E-97 espL1 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espL1) Type III secretion system effector espL1 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP001383.1_1702 91.525 2.54E-71 espL1 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espL1) Type III secretion system effector espL1 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP001383.1_1895 67.539 7.96E-100 sodB VF0169 SodB Stress survival VFC0282 (sodB) superoxide dismutase [SodB (VF0169) - Stress survival (VFC0282)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
CP001383.1_1968 90.789 9.01E-46 espR1 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espR1) Type III secretion system effector espR1 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP001383.1_1973 62.162 1.93E-140 narH VF0302 Nitrate reductase Nutritional/Metabolic factor VFC0272 NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein (narH) nitrate reductase subunit beta [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001383.1_2113 99.828 0.0 ipaH VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH) invasion plasmid antigen IpaH [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001383.1_2162 81.004 0.0 flhA VF0394 Flagella Motility VFC0204 (flhA) flagellar biosynthesis protein FlhA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2163 93.782 4.72E-115 flhA VF0394 Flagella Motility VFC0204 (flhA) flagellar biosynthesis protein FlhA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2164 64.305 3.52E-169 flhB VF0394 Flagella Motility VFC0204 (flhB) flagellar biosynthetic protein FlhB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2171 76.699 2.62E-106 cheZ VF0394 Flagella Motility VFC0204 (cheZ) chemotaxis regulator CheZ [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2172 91.473 1.1E-84 cheY VF0394 Flagella Motility VFC0204 (cheY) chemotaxis regulatory protein CheY [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2173 86.246 0.0 cheB VF0394 Flagella Motility VFC0204 (cheB) chemotaxis-specific methylesterase CheB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2174 72.101 3.95E-145 cheR VF0394 Flagella Motility VFC0204 (cheR) chemotaxis methyltransferase CheR [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2177 85.093 3.74E-98 cheW VF0394 Flagella Motility VFC0204 (cheW) purine-binding chemotaxis protein CheW [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2178 73.225 0.0 cheA VF0394 Flagella Motility VFC0204 (cheA) chemotaxis protein CheA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2179 68.671 2.92E-151 motB VF0394 Flagella Motility VFC0204 (motB) flagellar motor protein MotB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2180 80.678 1.72E-179 motA VF0394 Flagella Motility VFC0204 (motA) flagellar motor protein MotA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2181 82.902 5.06E-117 flhC VF0394 Flagella Motility VFC0204 (flhC) flagellar biosynthesis transcription activator FlhC [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2182 66.667 4.12E-21 flhD VF0394 Flagella Motility VFC0204 (flhD) flagellar transcriptional activator FlhD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2207 77.848 1.41E-85 fliA VF0394 Flagella Motility VFC0204 (fliA) flagellar biosynthesis sigma factor [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2208 95.833 1.15E-45 fliA VF0394 Flagella Motility VFC0204 (fliA) flagellar biosynthesis sigma factor [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2227 75.403 5.23E-129 fliF VF0394 Flagella Motility VFC0204 (fliF) flagellar M-ring protein FliF [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2229 83.283 0.0 fliG VF0394 Flagella Motility VFC0204 (fliG) flagellar motor switch protein G [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2231 83.48 0.0 fliI VF0394 Flagella Motility VFC0204 (fliI) flagellum-specific ATP synthase FliI [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2232 63.636 1.31E-43 fliJ VF0394 Flagella Motility VFC0204 (fliJ) flagellar protein FliJ [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2235 84.384 0.0 fliM VF0394 Flagella Motility VFC0204 (fliM) flagellar motor switch protein FliM [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2236 74.638 2.28E-69 fliN VF0394 Flagella Motility VFC0204 (fliN) flagellar motor switch protein FliN [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2239 85.366 1.7E-73 fliP VF0394 Flagella Motility VFC0204 (fliP) flagellar biosynthetic protein FliP [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2240 77.528 1.94E-37 fliQ VF0394 Flagella Motility VFC0204 (fliQ) flagellar biosynthetic protein FliQ [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2241 68.217 2.46E-106 fliR VF0394 Flagella Motility VFC0204 (fliR) flagellar biosynthetic protein FliR [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001383.1_2242 67.633 2.11E-102 rcsA VF0571 RcsAB Regulation VFC0301 (rcsA) transcriptional activator for ctr capsule biosynthesis [RcsAB (VF0571) - Regulation (VFC0301)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_2271 74.081 0.0 ipaH VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH) invasion plasmid antigen IpaH [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001383.1_2342 85.714 9.77E-52 ugd VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (ugd) UDP-glucose 6-dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_2343 80.836 1.7E-176 ugd VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (ugd) UDP-glucose 6-dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_2344 94.872 0.0 gndA VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_2355 64.483 1.17E-142 wbtL VF0542 LPS Immune modulation VFC0258 The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion (wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
CP001383.1_2357 61.808 5.02E-160 rffG VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rffG) dTDP-glucose 46-dehydratase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP001383.1_2358 89.189 0.0 galF VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (galF) GalU regulator GalF [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_2363 64.454 0.0 wcaJ VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (wcaJ) undecaprenyl-phosphate glucose phosphotransferase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_2364 75.824 0.0 rfbK1 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (rfbK1) O9 family phosphomannomutase RfbK1 [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_2365 61.441 0.0 KP1_RS17280 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17280) mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_2366 61.916 0.0 KP1_RS17295 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17295) glycosyltransferase WbuB [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_2368 77.987 0.0 KP1_RS17305 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17305) GDP-L-fucose synthase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_2369 88.919 0.0 gmd VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gmd) GDP-mannose 4,6-dehydratase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_2379 64.644 0.0 KP1_RS17340 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17340) polysaccharide export protein [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_2450 74.081 0.0 ipaH VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH) invasion plasmid antigen IpaH [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001383.1_2556 96.759 1.41E-152 rcsB VF0571 RcsAB Regulation VFC0301 (rcsB) transcriptional regulator RcsB [RcsAB (VF0571) - Regulation (VFC0301)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_2780 64.637 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_2885 99.668 0.0 ipaH VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH) invasion plasmid antigen IpaH [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001383.1_2910 65.969 5.37E-91 algU VF0091 Alginate Biofilm VFC0271 Alginate production is frequently referred to as mucoidy because colonies producing alginate have a wet glistening (mucoid) appearance, which is very different from that of colonies not producing alginate; most of the alginate biosynthetic genes are clustered in the algD operon; Alginate production is highly regulated. Regulatory genes are located in two areas far removed from the biosynthetic genes, with one exception algC (algU) alginate biosynthesis protein AlgZ/FimS [Alginate (VF0091) - Biofilm (VFC0271)] [Pseudomonas aeruginosa PAO1] Pseudomonas aeruginosa
CP001383.1_2994 73.099 6.29E-96 luxS VF0406 AI-2 Biofilm VFC0271 AI-2 is produced and detected by a wide variety of bacteria and is presumed to facilitate interspecies communications. (luxS) S-ribosylhomocysteinase [AI-2 (VF0406) - Biofilm (VFC0271)] [Vibrio cholerae O1 biovar El Tor str. N16961] Vibrio cholerae
CP001383.1_2998 76.667 1.4E-30 csrA VF0261 CsrA Regulation VFC0301 Belongs to a highly conserved family of global regulators that typically control stationary phase traits post-transcriptionally (csrA) carbon storage regulator CsrA [CsrA (VF0261) - Regulation (VFC0301)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
CP001383.1_3047 99.091 0.0 rpoS VF0112 RpoS Regulation VFC0301 (rpoS) RNA polymerase sigma factor RpoS [RpoS (VF0112) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP001383.1_3261 100.0 0.0 sigA VF0119 SigA Exoenzyme VFC0251 Belongs to the SPATEs (serine protease autotransporters of Enterobacteriaceae) subfamily, cytotoxic SPATE;carried on the she pathogenicity island of Shigella flexneri 2a (sigA) serine protease, autotransporter SigA [SigA (VF0119) - Exoenzyme (VFC0251)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001383.1_3267 100.0 0.0 pic VF0120 Pic Exoenzyme VFC0251 Produced by Shigella flexneri, EAEC and UPEC; belongs to the SPATEs (serine protease autotransporters of Enterobacteriaceae) subfamily, noncytotoxic (class 2) SPATE; the pic gene overlaps two other virulence genes, set1A and set1B (pic) serine protease, autotransporter Pic [Pic (VF0120) - Exoenzyme (VFC0251)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001383.1_3386 70.815 0.0 rfaE VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaE) ADP-heptose synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP001383.1_3434 99.724 0.0 cfaD/cfaE VF0213 Adhesive fimbriae Adherence VFC0001 Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT (cfaD/cfaE) minor pilin and initiator [Adhesive fimbriae (VF0213) - Adherence (VFC0001)] [Escherichia coli E24377A] Escherichia coli (ETEC)
CP001383.1_3435 99.142 0.0 cfaC VF0213 Adhesive fimbriae Adherence VFC0001 Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT (cfaC) colonisation factor antigen c, usher [Adhesive fimbriae (VF0213) - Adherence (VFC0001)] [Escherichia coli E24377A] Escherichia coli (ETEC)
CP001383.1_3658 80.153 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
CP001383.1_3677 66.832 1.28E-99 vfr VF0082 Type IV pili Adherence VFC0001 PilA, B, C, D, E, F, M, N, O, P, Q, T, U, V, W, X, Y1, Y2, Z, and fimT, U, V are involved in the biogenesis and mechanical function of pili, pilG, H, I, K, chpA, B, C, D, E, pilS, R, fimS, rpoN, algR, algU, and vfr are involved in transcriptional regulation and chemosensory pathways that control the expression or activity of the twitching motility of the pili (vfr) cAMP-regulatory protein [Type IV pili (VF0082) - Adherence (VFC0001)] [Pseudomonas aeruginosa PAO1] Pseudomonas aeruginosa
CP001383.1_3706 63.964 5.49E-101 rpe VF0543 Capsule Immune modulation VFC0258 Group 4 capsule; high molecular weight (HMW) O-antigen capsule (rpe) ribulose-phosphate 3-epimerase [Capsule (VF0543) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
CP001383.1_3906 73.379 9.01E-154 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_3907 69.496 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP001383.1_3970 78.571 0.0 rfaD VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaD) ADP-L-glycero-D-mannoheptose-6-epimerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP001383.1_3971 63.506 4.74E-158 rfaF VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaF) ADP-heptose-LPS heptosyltransferase II [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP001383.1_4027 100.0 0.0 iucA VF0123 Aerobactin Nutritional/Metabolic factor VFC0272 A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae (iucA) aerobactin synthesis protein IucA [Aerobactin (VF0123) - Nutritional/Metabolic factor (VFC0272)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001383.1_4028 100.0 0.0 iucB VF0123 Aerobactin Nutritional/Metabolic factor VFC0272 A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae (iucB) aerobactin synthesis protein IucB [Aerobactin (VF0123) - Nutritional/Metabolic factor (VFC0272)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001383.1_4029 100.0 0.0 iucC VF0123 Aerobactin Nutritional/Metabolic factor VFC0272 A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae (iucC) aerobactin synthesis protein IucC [Aerobactin (VF0123) - Nutritional/Metabolic factor (VFC0272)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001383.1_4030 100.0 0.0 iucD VF0123 Aerobactin Nutritional/Metabolic factor VFC0272 A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae (iucD) aerobactin synthesis protein IucC, lysine 6-monooxygenase [Aerobactin (VF0123) - Nutritional/Metabolic factor (VFC0272)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001383.1_4031 100.0 0.0 iutA VF0123 Aerobactin Nutritional/Metabolic factor VFC0272 A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae (iutA) aerobactin receptor IutA [Aerobactin (VF0123) - Nutritional/Metabolic factor (VFC0272)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001383.1_4032 97.51 1.26E-160 sat VF0231 Sat Effector delivery system VFC0086 Belongs to SPATE (serine protease autotransporters to Enterobacteriaceae) proteins (eight known SPATE proteins: Sat of UPEC, Pet of EAEC, EspC of EPEC, Pic of EAEC and Shigella, SigA of Shigella, SepA of Shigella, Tsh of avian E. coli, and EspP of EHEC); reside within PAI II of E. coli CFT073 (sat) Aecreted auto transpoter toxin [Sat (VF0231) - Effector delivery system (VFC0086)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_4112 98.742 0.0 sat VF0231 Sat Effector delivery system VFC0086 Belongs to SPATE (serine protease autotransporters to Enterobacteriaceae) proteins (eight known SPATE proteins: Sat of UPEC, Pet of EAEC, EspC of EPEC, Pic of EAEC and Shigella, SigA of Shigella, SepA of Shigella, Tsh of avian E. coli, and EspP of EHEC); reside within PAI II of E. coli CFT073 (sat) Aecreted auto transpoter toxin [Sat (VF0231) - Effector delivery system (VFC0086)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_4113 98.78 0.0 sat VF0231 Sat Effector delivery system VFC0086 Belongs to SPATE (serine protease autotransporters to Enterobacteriaceae) proteins (eight known SPATE proteins: Sat of UPEC, Pet of EAEC, EspC of EPEC, Pic of EAEC and Shigella, SigA of Shigella, SepA of Shigella, Tsh of avian E. coli, and EspP of EHEC); reside within PAI II of E. coli CFT073 (sat) Aecreted auto transpoter toxin [Sat (VF0231) - Effector delivery system (VFC0086)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_4189 66.667 6.11E-173 rffG VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rffG) dTDP-glucose 46-dehydratase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
CP001383.1_4190 67.01 7.32E-144 wbtL VF0542 LPS Immune modulation VFC0258 The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion (wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
CP001383.1_4370 98.614 0.0 ibeC VF0237 Ibes Invasion VFC0083 IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. (ibeC) phosphoethanolamine transferase CptA [Ibes (VF0237) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
CP001383.1_4393 80.153 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
CP001383.1_4426 62.061 0.0 icl VF0253 Isocitrate lyase Others VFC0346 (icl) Isocitrate lyase Icl (isocitrase) (isocitratase) [Isocitrate lyase (VF0253) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001383.1_4429 96.61 3.03E-78 espL4 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espL4) Type III secretion system effector EspL4 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP001383.1_4430 96.989 0.0 espL4 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espL4) Type III secretion system effector EspL4 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP001383.1_4431 92.0 8.27E-96 espL4 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espL4) Type III secretion system effector EspL4 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP001383.1_4459 90.991 2.75E-150 pmrA VF1355 PmrAB Regulation VFC0301 (pmrA) response regulator PmrA [PmrAB (VF1355) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP001383.1_4460 86.197 0.0 pmrB VF1355 PmrAB Regulation VFC0301 (pmrB) sensory kinase PmrB [PmrAB (VF1355) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
CP001383.1_4479 92.791 0.0 espX5 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espX5) Type III secretion system effector EspX5 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP001383.1_4522 87.037 4.91E-170 espX4 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espX4) Type III secretion system effector EspX4 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP001383.1_4523 83.936 1.58E-151 espX4 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espX4) Type III secretion system effector EspX4 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
CP001383.1_4559 98.333 0.0 fimH VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimH) FimH protein precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_4560 95.098 5.66E-68 fimG VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimG) FimG protein precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_4561 98.295 5.3E-128 fimF VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimF) FimF protein precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_4562 99.482 0.0 fimD VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_4564 96.0 1.07E-138 fimD VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_4565 98.755 3.5E-179 fimC VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimC) Chaperone protein fimC precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_4566 96.97 4.73E-121 fimI VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimI) Fimbrin-like protein fimI precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_4567 90.11 2.52E-103 fimA VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimA) Type-1 fimbrial protein, A chain precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_4568 100.0 7.59E-149 fimE VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimE) Type 1 fimbriae Regulatory protein fimE [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_4569 96.894 4.22E-117 fimB VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
CP001383.1_4656 75.568 0.0 htpB VF0159 Hsp60 Adherence VFC0001 (htpB) Hsp60, 60K heat shock protein HtpB [Hsp60 (VF0159) - Adherence (VFC0001)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
CP001383.1_4747 68.873 0.0 cheD VF0394 Flagella Motility VFC0204 (cheD) methyl-accepting chemotaxis protein CheD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
CP001384.1_2 100.0 0.0 ospB VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospB) type III secretion system effector OspB [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_5 99.733 0.0 ospC4 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospC4) type III secretion system effector OspC4 [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_6 94.118 1.93E-16 ospC2 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospC2) type III secretion system effector OspC2 [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_11 100.0 0.0 ospD2 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospD2) type III secretion system effector OspD2 [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_12 100.0 0.0 ospF VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospF) type III secretion system effector OspF, phosphothreonine lyase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_24 100.0 2.14E-166 ospD1 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospD1) type III secretion system effector OspD1 [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_27 100.0 4.19E-139 ipgB2 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipgB2) type III secretion system effector IpgB2, guanine nucleotide exchange factor (GEF) [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_46 100.0 9.47E-170 virF VF0979 VirF Regulation VFC0301 A DNA-binding protein belonging to the AraC family of transcriptional regulators; located on the large virulence plasmid, is expressed only within the host, mainly in response to the temperature transition occurring when the bacterium transits from the outer environment to the intestinal milieu (virF) transcriptional activator VirF [VirF (VF0979) - Regulation (VFC0301)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_47 100.0 8.08E-63 ospE2 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospE2) type III secretion system effector OspE2 [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_50 98.224 0.0 ipaH2.5 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH2.5) type III secretion system effector ipaH2.5, E3 ubiquitin ligase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_58 100.0 0.0 ospC2 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospC2) type III secretion system effector OspC2 [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_71 100.0 0.0 ipaH7.8 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH7.8) type III secretion system effector ipaH7.8, E3 ubiquitin ligase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_72 100.0 0.0 ipaH4.5 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH4.5) type III secretion system effector ipaH4.5, E3 ubiquitin ligase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_86 99.823 0.0 ospD3/senA VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospD3/senA) type III secretion system effector OspD3 [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_88 100.0 0.0 ospC1 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospC1) type III secretion system effector OspC1 [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_110 95.868 0.0 ospC3 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospC3) type III secretion system effector OspC3, ADP-riboxanase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_118 100.0 1.59E-150 ipaJ VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaJ) type III secretion system effector IpaJ, cysteine protease [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_119 100.0 0.0 virB VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (virB) transcriptional activator VirB [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_121 100.0 0.0 ipaA VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaA) type III secretion system effector IpaA, vinculin binding protein [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_122 100.0 0.0 ipaD VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (ipaD) type III secretion system hydrophilic translocator, needle tip protein IpaD [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_123 99.725 0.0 ipaC VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (ipaC) type III secretion system hydrophilic translocator, pore protein IpaC [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_124 100.0 0.0 ipaB VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (ipaB) type III secretion system hydrophilic translocator, pore protein IpaB [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_125 100.0 4.56E-114 ipgC VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (ipgC) type III secretion system chaperone for IpaB and IpaC [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_126 99.519 9.37E-154 ipgB1 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipgB1) type III secretion system effector IpgB1, guanine nucleotide exchange factor (GEF) [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_127 100.0 1.74E-92 ipgA VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (ipgA) type III secretion system chaperone for IcsB [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_128 100.0 0.0 icsB VF0978 TTSS secreted effectors Effector delivery system VFC0086 (icsB) type III secretion system effector IcsB, fatty acyltransferase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_129 99.814 0.0 ipgD VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipgD) type III secretion system effector IpgD, phosphoinositide 4-phosphatase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_130 100.0 1.54E-84 ipgE VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (ipgE) type III secretion system chaperone for IpgD [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_131 100.0 7.49E-114 ipgF VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (ipgF) type III secretion system protein IpgF [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_132 100.0 0.0 mxiG VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiG) type III secretion system outer MS ring protein MixG [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_133 100.0 1.04E-57 mxiH VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiH) type III secretion system needle filament protein MxiH [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_134 100.0 1.67E-66 mxiI VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiI) type III secretion system inner rod protein MxiI [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_135 100.0 1.91E-179 mxiJ VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiJ) type III secretion system inner MS ring protein MxiJ [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_136 100.0 9.77E-130 mxiK VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiK) type III secretion system accessory cytosolic protein MxiK [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_137 100.0 1.73E-167 mxiN VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiN) type III secretion system stator MxiN [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_138 100.0 3.37E-96 mxiL VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiL) type III secretion system protein MxiL [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_139 100.0 1.88E-101 mxiM VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiM) type III secretion system pilotin MxiM [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_140 100.0 7.47E-158 mxiE VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiE) type III secretion system regulatory protein MxiE [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_141 100.0 0.0 mxiD VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiD) type III secretion system secretin MxiD [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_142 100.0 0.0 mxiC VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiC) type III secretion system gatekeeper MxiD [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_143 100.0 0.0 mxiA VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiA) type III secretion system major export apparatus protein MxiA [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_144 100.0 8.99E-96 spa15 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa15) type III secretion system chaparone [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_145 100.0 0.0 spa47 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa47) type III secretion system ATPase spa47 [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_146 100.0 7.87E-78 spa13 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa13) type III secretion system stalk protein Spa13 [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_147 100.0 0.0 spa32 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa32) type III secretion system needle length regulator Spa32 [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_148 99.597 0.0 spa33 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa33) type III secretion system C ring protein Spa33 [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_149 100.0 3.04E-158 spa24 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa24) type III secretion system minor export apparatus protein Spa24 [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_150 100.0 1.84E-56 spa9 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa9) type III secretion system minor export apparatus protein Spa9 [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_151 100.0 0.0 spa29 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa29) type III secretion system minor export apparatus protein Spa29 [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_152 100.0 0.0 spa40 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa40) type III secretion system export apparatus switch protein Spa40 [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_174 100.0 0.0 virA VF0978 TTSS secreted effectors Effector delivery system VFC0086 (virA) type III secretion system effector VirA, GTPase-activating protein (GAP) [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_175 100.0 0.0 icsA/virG VF0121 IcsA (VirG) Motility VFC0204 (icsA/virG) autotransporter, actin tail assembly protein IcsA/VirG [IcsA (VirG) (VF0121) - Motility (VFC0204)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_203 99.528 6.29E-162 ospI VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospI) type III secretion system effector OspI, glutamine deamidase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_220 99.633 0.0 ipaH9.8 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH9.8) type III secretion system effector ipaH9.8, E3 ubiquitin ligase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_224 100.0 2.81E-146 ospG VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospG) type III secretion system effector OspG, protein kinase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_255 100.0 0.0 ipaH1.4 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH1.4) type III secretion system effector ipaH1.4, E3 ubiquitin ligase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_256 100.0 1.16E-62 ospE1 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospE1) type III secretion system effector OspE1 [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001384.1_265 97.312 1.49E-135 ospZ VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospZ) type III secretion system effector cysteine methyltransferase OspZ [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella boydii CDC 3083-94] Shigella flexneri
CP001384.1_267 100.0 0.0 icsP/sopA VF0122 IcsP (SopA) Exoenzyme VFC0251 (icsP/sopA) outer membrane protease of the OmpP family, involved in cleavage of surface exposed IcsA [IcsP (SopA) (VF0122) - Exoenzyme (VFC0251)] [Shigella flexneri 2a str. 301] Shigella flexneri
CP001388.1_3 61.685 1.66E-174 fepE VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepE) LPS O-antigen length regulator [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)