2. PATHOGENS
Basic Information
Accession number
GCA_000152105.1
Release date
2010-10-19
Organism
Mycobacterium tuberculosis SUMu001
Species name
Mycobacterium tuberculosis
Assembly level
Scaffold
Assembly name
ASM15210v1
Assembly submitter
Broad Institute
Assembly Type
haploid
Genome size
4.4 Mb
GC percent
65.5
Contig count
182
Collection date
-
Sample location
-
Host
-
Isolation source
-
Isolate type
-
Strain
SUMu001
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
GL503107.1_176 # 209734 # 210279 300.0 365.925 AAC(2')-Ic 100.0 ARO:3002525 protein homolog model aminoglycoside antibiotic antibiotic inactivation AAC(2') AAC(2')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in M. tuberculosis and Mycobacterium tuberculosis variant bovis.
GL503146.1_139 # 126722 # 127645 500.0 619.772 blaC 100.0 ARO:3007182 protein homolog model cephalosporin; cephamycin; penam; penem antibiotic inactivation class A Mycobacterium tuberculosis bla beta-lactamase blaC is a broad-spectrum class A beta-lactamase coded in the chromosome of Mycobacterium tuberculosis. It has been shown to hydrolyze a large number of beta-lactam antibiotics and is a major obstacle in the treatment of tuberculosis with such drugs.
GL503160.1_33 # 30847 # 32439 1000.0 1046.96 efpA 100.0 ARO:3003955 protein homolog model rifamycin antibiotic; isoniazid-like antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump efpA is an MFS transporter found in Mycobacterium tuberculosis.
GL503177.1_20 # 30591 # 31142 350.0 363.999 mfpA 100.0 ARO:3003035 protein homolog model fluoroquinolone antibiotic antibiotic target protection quinolone resistance protein (qnr) mfpA is a qnr homolog and a pentapeptide repeat protein that confers resistance to fluoroquinolones in Mycolicibacterium smegmatis.
GL503115.1_95 # 84502 # 88020 2300.0 2395.54 Mycobacterium tuberculosis rpoB mutants conferring resistance to rifampicin 100.0 ARO:3003283 protein variant model D516G, H526T, L511R rifamycin antibiotic antibiotic target alteration; antibiotic target replacement rifamycin-resistant beta-subunit of RNA polymerase (rpoB) Point mutations that occurs in Mycobacterium tuberculosis rpoB resulting in resistance to rifampicin.
GL503131.1_4 # 2737 # 3993 750.0 842.803 Mycobacterium tuberculosis intrinsic murA conferring resistance to fosfomycin 100.0 ARO:3003784 protein variant model C117D phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant murA transferase Mycobacterium tuberculosis murA confers intrinsic resistance to fosfomycin. The presence of an aspartic acid residue in place of the critical cysteine at position 117 that enables fosfomycin binding is believed to be responsible for this intrinsic resistance.
GL503144.1_142 # 146197 # 148419 1400.0 1513.43 Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid 100.0 ARO:3003392 protein variant model A234G, A431V, G300W isoniazid-like antibiotic antibiotic target alteration isoniazid resistant katG katG is a catalase-peroxidase that catalyzes the activation of isoniazid. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. Mutations in katG results in inability to activate isoniazid. Over 280 different mutations have been documented in PubMed for katG, with mutations to Ser315 being the most prevalent.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
GL503107.1_38 100.0 0.0 fbpC VF0311 Antigen 85 Adherence VFC0001 Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp) (fbpC) Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503107.1_150 100.0 0.0 aftD VF0318 LAM Immune modulation VFC0258 A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) (aftD) alpha-(1->3)-arabinofuranosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503112.1_5 100.0 0.0 eccA3 VF0521 ESX-3 Effector delivery system VFC0086 (eccA3) Type VII secretion system protein EccA3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503112.1_6 100.0 0.0 eccB3 VF0521 ESX-3 Effector delivery system VFC0086 (eccB3) Type VII secretion system protein EccB3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503112.1_7 99.925 0.0 eccC3 VF0521 ESX-3 Effector delivery system VFC0086 (eccC3) Type VII secretion system protein EccC3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503112.1_8 100.0 2.51E-63 PE5 VF0521 ESX-3 Effector delivery system VFC0086 (PE5) PE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503112.1_9 100.0 0.0 PPE4 VF0521 ESX-3 Effector delivery system VFC0086 (PPE4) PPE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503112.1_10 100.0 8.84E-64 esxG VF1196 EsxG-EsxH Effector delivery system VFC0086 EsxG-EsxH heterodimer is secreted by ESX-3. (esxG) Type VII secretion system protein EsxG [EsxG-EsxH (VF1196) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503112.1_11 100.0 2.41E-66 esxH VF1196 EsxG-EsxH Effector delivery system VFC0086 EsxG-EsxH heterodimer is secreted by ESX-3. (esxH) Type VII secretion system protein ESXH (10 kDa antigen) (CFP-7) (protein TB10.4) [EsxG-EsxH (VF1196) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503112.1_12 100.0 0.0 espG3 VF0521 ESX-3 Effector delivery system VFC0086 (espG3) Type VII secretion system protein EspG3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503112.1_13 100.0 0.0 eccD3 VF0521 ESX-3 Effector delivery system VFC0086 (eccD3) Type IIV secretion system transmembrane protein EccD3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503112.1_14 100.0 0.0 mycP3 VF0521 ESX-3 Effector delivery system VFC0086 (mycP3) Type VII secretion system membrane-anchored mycosin MycP3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503112.1_15 99.698 0.0 eccE3 VF0521 ESX-3 Effector delivery system VFC0086 (eccE3) Type VII secretion system transmembrane protein EccE3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503112.1_18 100.0 0.0 stf0 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (stf0) hypothetical protein [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503113.1_19 100.0 7.04E-90 hspR VF0297 HspR Regulation VFC0301 (hspR) heat shock protein transcriptional repressor HspR [HspR (VF0297) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503113.1_99 100.0 1.03E-174 sodC VF0305 SodC Stress survival VFC0282 (sodC) superoxide dismutase [SodC (VF0305) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503113.1_107 64.272 0.0 groEL VF0594 GroEL Adherence VFC0001 GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. (groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] Clostridium difficile
GL503113.1_135 100.0 0.0 icl VF0253 Isocitrate lyase Others VFC0346 (icl) Isocitrate lyase Icl (isocitrase) (isocitratase) [Isocitrate lyase (VF0253) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503113.1_138 100.0 0.0 pcaA VF0285 PcaA Others VFC0346 Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate (pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503113.1_144 100.0 4.37E-137 hbhA VF0313 HbhA Adherence VFC0001 Surface-located protein (hbhA) iron-regulated heparin binding hemagglutinin hbhA (adhesin) [HbhA (VF0313) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503115.1_70 100.0 0.0 mmaA4 VF0314 MmaA4 Others VFC0346 (mmaA4) hydroxymycolate synthase MmaA4 [MmaA4 (VF0314) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503115.1_71 64.26 1.33E-136 pcaA VF0285 PcaA Others VFC0346 Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate (pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503115.1_72 72.474 5.4E-153 pcaA VF0285 PcaA Others VFC0346 Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate (pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503115.1_114 71.788 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
GL503116.1_13 99.552 4.08E-163 phoP VF0286 PhoP Regulation VFC0301 Similar to the PhoP response regulator of S. enteric serovar Typhimurium that senses Mg2+ starvation and controls the expression of virulence genes (phoP) Possible two component system response transcriptional positive regulator PhoP [PhoP (VF0286) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503116.1_14 99.794 0.0 phoR VF0286 PhoP Regulation VFC0301 Similar to the PhoP response regulator of S. enteric serovar Typhimurium that senses Mg2+ starvation and controls the expression of virulence genes (phoR) Possible two component system response sensor kinase membrane associated PhoR [PhoP (VF0286) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503120.1_155 99.561 5.99E-163 mprA VF0298 MprAB Regulation VFC0301 MprB, sensor kinase, can undergo autophosphorylation. MprA, transcriptional factor, can accept phosphate from MprB or from small phosphodonors including acetyl phosphate (mprA) two-component response regulator MrpA [MprAB (VF0298) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503120.1_156 100.0 0.0 mprB VF0298 MprAB Regulation VFC0301 MprB, sensor kinase, can undergo autophosphorylation. MprA, transcriptional factor, can accept phosphate from MprB or from small phosphodonors including acetyl phosphate (mprB) two component histidine-protein kinase/phosphatase MprB [MprAB (VF0298) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503120.1_216 91.667 9.02E-36 esxN VF0402 ESX-5 Effector delivery system VFC0086 (esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503122.1_1 92.553 1.15E-60 esxN VF0402 ESX-5 Effector delivery system VFC0086 (esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503127.1_1 91.86 1.7E-53 esxN VF0402 ESX-5 Effector delivery system VFC0086 (esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503129.1_15 100.0 0.0 narG VF0302 Nitrate reductase Nutritional/Metabolic factor VFC0272 NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein (narG) nitrate reductase subunit alpha [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503129.1_16 100.0 0.0 narH VF0302 Nitrate reductase Nutritional/Metabolic factor VFC0272 NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein (narH) nitrate reductase subunit beta [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503129.1_17 99.502 6.76E-145 narJ VF0302 Nitrate reductase Nutritional/Metabolic factor VFC0272 NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein (narJ) nitrate reductase subunit delta [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503129.1_18 100.0 0.0 narI VF0302 Nitrate reductase Nutritional/Metabolic factor VFC0272 NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein (narI) nitrate reductase subunit gamma [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503129.1_35 65.128 0.0 pks2 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503129.1_39 62.003 0.0 fadD28 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503129.1_49 68.966 2.2E-29 PE18 VF0402 ESX-5 Effector delivery system VFC0086 (PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503129.1_74 100.0 1.29E-158 sigE VF0295 SigE Regulation VFC0301 SigE activity is downregulated by an anti-sigma factor, RseA, that is encoded by a gene Rv1222, adjacent to sigE (sigE) ECF RNA polymerase sigma factor SigE [SigE (VF0295) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503131.1_37 100.0 1.05E-54 mbtL VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtL) Acyl carrier protein (ACP) MbtL [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503131.1_38 100.0 0.0 mbtM VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtM) Probable fatty acyl-AMP ligase MbtM [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503131.1_39 100.0 0.0 mbtN VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtN) Acyl-CoA dehydrogenase MbtN [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503131.1_40 100.0 3.18E-157 mbtK VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtK) Lysine N-acetyltransferase MbtK [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503132.1_16 68.041 2.09E-24 PE5 VF0521 ESX-3 Effector delivery system VFC0086 (PE5) PE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503134.1_66 68.724 1.52E-120 Rv2956 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2956) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503134.1_74 64.014 0.0 fadD28 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503134.1_79 67.161 0.0 pks2 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503134.1_80 74.413 0.0 pks2 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503134.1_82 65.641 0.0 fadD28 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503135.1_49 100.0 0.0 capA VF0318 LAM Immune modulation VFC0258 A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) (capA) mannosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503135.1_69 99.801 0.0 PE_PGRS30 VF0316 PE/PE-PGRS Immune modulation VFC0258 PE family members are characterized by highly conserved N-terminal Pro-Glu motif, PE-PGRS proteins have tandem repetitions of Gly-Gly-Ala or Gly-Gly-Asn termed the PGRS domain (polymorphic GC-rich repetitive sequence) near C-terminal; PE family members have been found in all the sequenced Mycobacterium genomes, although their number is highly variable (PE_PGRS30) PE-PGRS family protein PE_PGRS30 [PE/PE-PGRS (VF0316) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503135.1_82 60.592 5.6E-154 pks1 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (pks1) polyketide synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503135.1_181 71.624 0.0 plcA VF0320 Phospholipase C Exotoxin VFC0235 Phospholipases can be divided into four groups depending on the position of the bond they hydrolyse on the phospholipid substrate: phospholipases A1, A2, C and D (plcA) membrane-associated phospholipase A [Phospholipase C (VF0320) - Exotoxin (VFC0235)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503142.1_1 100.0 1.12E-116 PPE25 VF0402 ESX-5 Effector delivery system VFC0086 (PPE25) PPE family protein PPE25 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503143.1_2 93.617 7.23E-62 esxN VF0402 ESX-5 Effector delivery system VFC0086 (esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_7 100.0 0.0 eccB5 VF0402 ESX-5 Effector delivery system VFC0086 (eccB5) ESX-5 type VII secretion system protein EccB5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_8 100.0 0.0 eccC5 VF0402 ESX-5 Effector delivery system VFC0086 (eccC5) ESX-5 type VII secretion system FtsK/SpoIIIE family protein EccC5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_9 100.0 0.0 cyp143 VF0402 ESX-5 Effector delivery system VFC0086 (cyp143) cytochrome P450 Cyp143 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_10 100.0 1.24E-45 Rv1786 VF0402 ESX-5 Effector delivery system VFC0086 (Rv1786) ferredoxin [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_12 100.0 6.55E-152 PPE25 VF0402 ESX-5 Effector delivery system VFC0086 (PPE25) PPE family protein PPE25 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_13 100.0 1.16E-62 PE18 VF0402 ESX-5 Effector delivery system VFC0086 (PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_14 100.0 0.0 PPE26 VF0402 ESX-5 Effector delivery system VFC0086 (PPE26) PPE family protein PPE26 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_16 100.0 0.0 PPE27 VF0402 ESX-5 Effector delivery system VFC0086 (PPE27) PPE family protein PPE27 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_17 100.0 2.0E-62 PE19 VF0402 ESX-5 Effector delivery system VFC0086 (PE19) PE family protein PE19 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_19 91.86 1.47E-54 esxN VF0402 ESX-5 Effector delivery system VFC0086 (esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_22 100.0 1.0E-65 esxN VF0402 ESX-5 Effector delivery system VFC0086 (esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_23 100.0 0.0 Rv1794 VF0402 ESX-5 Effector delivery system VFC0086 (Rv1794) ESX-5 locus protein [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_24 100.0 0.0 eccD5 VF0402 ESX-5 Effector delivery system VFC0086 (eccD5) ESX-5 type VII secretion system EccD5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_25 100.0 0.0 mycP5 VF0402 ESX-5 Effector delivery system VFC0086 (mycP5) ESX-5 type VII secretion system subtilisin-like serine protease MycP5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_26 100.0 0.0 eccE5 VF0402 ESX-5 Effector delivery system VFC0086 (eccE5) ESX-5 type VII secretion system EccE5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_27 100.0 0.0 eccA5 VF0402 ESX-5 Effector delivery system VFC0086 (eccA5) ESX-5 type VII secretion system AAA+ ATPase EccA5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_40 100.0 3.94E-171 mgtC VF0289 MgtC Nutritional/Metabolic factor VFC0272 Homology to MgtC of Salmonella enterica, which is essential for the survival of S.enterica within macrophages (mgtC) Possible Mg2+ transport P-type ATPase C MgtC [MgtC (VF0289) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_116 100.0 0.0 fbpB VF0311 Antigen 85 Adherence VFC0001 Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp) (fbpB) Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503144.1_142 100.0 0.0 katG VF0303 KatG Stress survival VFC0282 (katG) catalase-peroxidase [KatG (VF0303) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503146.1_92 62.5 0.0 devS VF0317 DevRS Regulation VFC0301 A two-component system consists of a histidine sensor kinase and a response regulator; phosphorylation-based signalling has been established for five of eleven systems in M. tuberculosis, RegX3-SenX3, TrcR-TrcS, MprA-MprB, PrrA-PrrB and DevR-DevS (DosR-DosS) (devS) two component sensor histidine kinase DevS [DevRS (VF0317) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503146.1_96 100.0 1.49E-104 hspX VF0301 HspX Stress survival VFC0282 (hspX) Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3) [HspX (VF0301) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503146.1_119 67.227 6.13E-172 pks15 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (pks15) polyketide synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503147.1_1 60.984 3.09E-110 pks1 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (pks1) polyketide synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503148.1_1 71.0 1.96E-85 pks1 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (pks1) polyketide synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503151.1_81 100.0 0.0 mptC VF0318 LAM Immune modulation VFC0258 A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) (mptC) alpha-(1-2)-phosphatidylinositol mannoside mannosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503151.1_255 97.872 4.89E-64 esxN VF0402 ESX-5 Effector delivery system VFC0086 (esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503151.1_259 100.0 0.0 plcC VF0320 Phospholipase C Exotoxin VFC0235 Phospholipases can be divided into four groups depending on the position of the bond they hydrolyse on the phospholipid substrate: phospholipases A1, A2, C and D (plcC) phospholipase C [Phospholipase C (VF0320) - Exotoxin (VFC0235)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503151.1_260 100.0 0.0 plcB VF0320 Phospholipase C Exotoxin VFC0235 Phospholipases can be divided into four groups depending on the position of the bond they hydrolyse on the phospholipid substrate: phospholipases A1, A2, C and D (plcB) membrane-associated phospholipase B [Phospholipase C (VF0320) - Exotoxin (VFC0235)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503151.1_261 100.0 0.0 plcA VF0320 Phospholipase C Exotoxin VFC0235 Phospholipases can be divided into four groups depending on the position of the bond they hydrolyse on the phospholipid substrate: phospholipases A1, A2, C and D (plcA) membrane-associated phospholipase A [Phospholipase C (VF0320) - Exotoxin (VFC0235)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503153.1_22 98.592 1.63E-49 mbtH VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtH) putative protein MbtH [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503153.1_23 100.0 0.0 mbtG VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtG) Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503153.1_24 100.0 0.0 mbtF VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtF) Peptide synthetase MbtF (peptide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503153.1_25 99.763 0.0 mbtE VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtE) Peptide synthetase MbtE (peptide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503153.1_26 100.0 0.0 mbtE VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtE) Peptide synthetase MbtE (peptide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503153.1_27 100.0 0.0 mbtD VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtD) Polyketide synthetase MbtD (polyketide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503153.1_28 100.0 0.0 mbtC VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtC) Polyketide synthetase MbtC (polyketide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503153.1_29 100.0 0.0 mbtB VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtB) Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503153.1_30 100.0 0.0 mbtA VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtA) Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503153.1_31 100.0 0.0 mbtJ VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtJ) Putative acetyl hydrolase MbtJ [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503153.1_32 100.0 0.0 mbtI VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtI) Isochorismate synthase MbtI [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503153.1_77 100.0 2.49E-146 ahpC VF0306 AhpC Stress survival VFC0282 (ahpC) alkyl hydroperoxide reductase subunit AhpC [AhpC (VF0306) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503153.1_79 100.0 1.15E-145 PPE41 VF0402 ESX-5 Effector delivery system VFC0086 (PPE41) PPE family protein PPE41 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503153.1_97 67.542 0.0 Rv2953 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2953) trans-acting enoyl reductase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503155.1_96 100.0 0.0 relA VF0287 RelA Regulation VFC0301 (relA) Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) [RelA (VF0287) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503157.1_54 100.0 0.0 sigA/rpoV VF0257 SigA Regulation VFC0301 In M. tuberculosis, 13 sigma factor genes have been annotated in the genome, 9 of which belong to a special subfamily thought to direct extracytoplasmic functions and various other stress responses (temperature, oxidative stress, pH, and infection of macrophages); sigma A also known as RpoV, is the essential principal mycobacterial sigma factors, necessary for most mycobacterial housekeeping gene transcription; It was the first mycobacterial sigma factor to be associated with virulence (sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503157.1_61 62.857 7.43E-135 sigA/rpoV VF0257 SigA Regulation VFC0301 In M. tuberculosis, 13 sigma factor genes have been annotated in the genome, 9 of which belong to a special subfamily thought to direct extracytoplasmic functions and various other stress responses (temperature, oxidative stress, pH, and infection of macrophages); sigma A also known as RpoV, is the essential principal mycobacterial sigma factors, necessary for most mycobacterial housekeeping gene transcription; It was the first mycobacterial sigma factor to be associated with virulence (sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503157.1_62 100.0 1.59E-166 ideR VF0300 IdeR Regulation VFC0301 A DNA binding protein interacts with a conserved DNA sequence requires the binding of Fe2+ or related divalent cations (ideR) Iron-dependent repressor and activator IdeR [IdeR (VF0300) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_120 100.0 0.0 tesA VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (tesA) thioesterase TesA [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_121 100.0 0.0 fadD26 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD26) fatty-acid--CoA ligase FadD26 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_122 100.0 3.87E-135 fadD26 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD26) fatty-acid--CoA ligase FadD26 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_123 99.947 0.0 ppsA VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ppsA) phthiocerol synthesis polyketide synthase type I PpsA [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_124 100.0 0.0 ppsB VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ppsB) phthiocerol synthesis polyketide synthase type I PpsB [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_125 97.403 0.0 ppsC VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ppsC) phthiocerol synthesis polyketide synthase type I PpsC [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_126 99.921 0.0 ppsC VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ppsC) phthiocerol synthesis polyketide synthase type I PpsC [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_127 100.0 0.0 ppsD VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ppsD) phthiocerol synthesis polyketide synthase type I PpsD [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_128 100.0 0.0 ppsE VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ppsE) phthiocerol synthesis polyketide synthase type I PpsE [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_129 100.0 0.0 ddrA VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ddrA) daunorubicin ABC transporter ATP-binding protein DrrA [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_130 100.0 0.0 ddrB VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ddrB) daunorubicin ABC transporter permease DrrB [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_131 100.0 0.0 drrC VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (drrC) daunorubicin ABC transporter permease DrrC [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_132 100.0 0.0 papA5 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (papA5) phthiocerol/phthiodiolone dimycocerosyl transferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_133 100.0 0.0 mas VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (mas) multifunctional mycocerosic acid synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_134 100.0 0.0 fadD28 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_135 100.0 0.0 mmpL7 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (mmpL7) transmembrane transport protein MmpL7 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_138 100.0 4.35E-170 lppx VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (lppx) lipoprotein LppX [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_139 100.0 0.0 pks1 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (pks1) polyketide synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_140 99.796 0.0 pks15 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (pks15) polyketide synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_141 100.0 0.0 fadD22 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD22) p-hydroxybenzoyl--AMP ligase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_142 100.0 1.87E-148 Rv2949c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2949c) chorismate pyruvate-lyase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_143 100.0 0.0 fadD29 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD29) long-chain-fatty-acid--AMP ligase FadD29 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_144 100.0 0.0 Rv2951c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2951c) phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_145 100.0 0.0 Rv2952 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2952) phthiotriol/phenolphthiotriol dimycocerosates methyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_146 100.0 0.0 Rv2953 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2953) trans-acting enoyl reductase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_147 100.0 0.0 Rv2954c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2954c) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_148 100.0 0.0 Rv2955c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2955c) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_149 100.0 0.0 Rv2956 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2956) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_150 100.0 0.0 Rv2957 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2957) PGL/p-HBAD biosynthesis glycosyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_152 100.0 0.0 Rv2958c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2958c) PGL/p-HBAD biosynthesis glycosyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_153 100.0 0.0 Rv2959c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2959c) rhamnosyl O-methyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503160.1_155 100.0 0.0 Rv2962c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2962c) PGL/p-HBAD biosynthesis rhamnosyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503162.1_1 73.571 1.01E-48 PPE4 VF0521 ESX-3 Effector delivery system VFC0086 (PPE4) PPE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503162.1_4 84.375 8.56E-57 esxH VF1196 EsxG-EsxH Effector delivery system VFC0086 EsxG-EsxH heterodimer is secreted by ESX-3. (esxH) Type VII secretion system protein ESXH (10 kDa antigen) (CFP-7) (protein TB10.4) [EsxG-EsxH (VF1196) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503162.1_5 90.722 2.43E-46 esxG VF1196 EsxG-EsxH Effector delivery system VFC0086 EsxG-EsxH heterodimer is secreted by ESX-3. (esxG) Type VII secretion system protein EsxG [EsxG-EsxH (VF1196) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503164.1_2 80.392 3.98E-32 PE5 VF0521 ESX-3 Effector delivery system VFC0086 (PE5) PE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503168.1_13 100.0 0.0 devS VF0317 DevRS Regulation VFC0301 A two-component system consists of a histidine sensor kinase and a response regulator; phosphorylation-based signalling has been established for five of eleven systems in M. tuberculosis, RegX3-SenX3, TrcR-TrcS, MprA-MprB, PrrA-PrrB and DevR-DevS (DosR-DosS) (devS) two component sensor histidine kinase DevS [DevRS (VF0317) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503168.1_14 100.0 9.56E-155 devR/dosR VF0317 DevRS Regulation VFC0301 A two-component system consists of a histidine sensor kinase and a response regulator; phosphorylation-based signalling has been established for five of eleven systems in M. tuberculosis, RegX3-SenX3, TrcR-TrcS, MprA-MprB, PrrA-PrrB and DevR-DevS (DosR-DosS) (devR/dosR) two component transcriptional regulator DevR [DevRS (VF0317) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503169.1_49 100.0 4.28E-162 sigH VF0296 SigH Regulation VFC0301 Similar to the sigma R of Streptomyces species; sigma H activity is regulated at the posttranslational level by a cystein-containing anti-sigma factor RsrA, encoded by a gene in the sigH operon; the ability of RshA to inhibit SigH-dependent transcription is redox-dependent (sigH) ECF RNA polymerase sigma factor SigH [SigH (VF0296) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503169.1_114 100.0 9.74E-175 sigF VF0294 SigF Regulation VFC0301 (sigF) RNA polymerase sigma factor SigF [SigF (VF0294) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503177.1_54 72.822 1.39E-158 pcaA VF0285 PcaA Others VFC0346 Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate (pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503177.1_83 100.0 9.92E-74 whiB3 VF0288 WhiB3 Regulation VFC0301 Seven members of the WhiB family in M. tuberculosis H37Rv, homolog of the Streptomyces coelicolor whiB gene, a transcription factor whose function is required for sporulation process (whiB3) redox-responsive transcriptional regulator WhiB3 [WhiB3 (VF0288) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503181.1_3 65.517 1.01E-25 PE18 VF0402 ESX-5 Effector delivery system VFC0086 (PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503181.1_14 99.639 0.0 lipF VF0307 LipF Nutritional/Metabolic factor VFC0272 (lipF) Probable esterase/lipase LipF [LipF (VF0307) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503184.1_93 100.0 9.1E-100 panD VF0319 PanC/PanD Nutritional/Metabolic factor VFC0272 (panD) aspartate 1-decarboxylase [PanC/PanD (VF0319) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503184.1_94 100.0 0.0 panC VF0319 PanC/PanD Nutritional/Metabolic factor VFC0272 (panC) pantothenate synthetase [PanC/PanD (VF0319) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503184.1_104 100.0 6.11E-119 espD VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espD) ESX-1 type VII secretion system EspD [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503184.1_105 100.0 1.42E-73 espC VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espC) ESX-1 type VII secretion system EspC [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503184.1_106 100.0 0.0 espA VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espA) ESX-1 type VII secretion system EspA [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503184.1_109 92.553 1.15E-60 esxN VF0402 ESX-5 Effector delivery system VFC0086 (esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503184.1_113 62.069 3.6E-26 PE18 VF0402 ESX-5 Effector delivery system VFC0086 (PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503184.1_141 60.256 2.63E-17 PE18 VF0402 ESX-5 Effector delivery system VFC0086 (PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503184.1_234 74.026 1.21E-29 PPE4 VF0521 ESX-3 Effector delivery system VFC0086 (PPE4) PPE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503184.1_291 99.909 0.0 embC VF0318 LAM Immune modulation VFC0258 A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) (embC) arabinosyltransferase C [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_6 100.0 0.0 fbpD VF0311 Antigen 85 Adherence VFC0001 Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp) (fbpD) MPT51/MPB51 antigen [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_7 100.0 0.0 fbpA VF0311 Antigen 85 Adherence VFC0001 Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp) (fbpA) Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_8 100.0 0.0 aftB VF0318 LAM Immune modulation VFC0258 A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) (aftB) terminal beta-(1->2)-arabinofuranosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_13 100.0 0.0 erp VF0312 Erp Others VFC0346 Surface-located protein;No homologue of Erp has been found in other bacterial species, making Erp a mycobacterial signature (erp) exported repetitive protein precursor Erp [Erp (VF0312) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_25 100.0 0.0 papA2 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (papA2) trehalose-2-sulfate acyltransferase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_28 100.0 0.0 mmpL8 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (mmpL8) integral membrane transport protein MmpL8 [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_29 100.0 0.0 papA1 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (papA1) acyltransferase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_30 100.0 0.0 pks2 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_31 100.0 1.54E-130 pks2 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_32 66.207 0.0 fadD28 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_57 100.0 1.71E-154 sodA VF0304 SodA Stress survival VFC0282 (sodA) superoxide dismutase [SodA (VF0304) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_60 100.0 6.88E-98 espR VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espR) ESX-1 transcriptional regulator EspR [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_75 100.0 0.0 espE VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espE) ESX-1 secretion-associated protein EspE [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_76 100.0 3.55E-71 espF VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espF) ESX-1 secretion-associated protein EspF [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_77 100.0 0.0 espG1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espG1) ESX-1 secretion-associated protein EspG1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_78 100.0 2.46E-132 espH VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espH) ESX-1 secretion-associated protein EspH [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_79 100.0 0.0 eccA1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (eccA1) ESX-1 type VII secretion system AAA+ ATPase EccA1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_80 100.0 0.0 eccB1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (eccB1) ESX-1 type VII secretion system protein EccB1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_81 100.0 0.0 eccCa1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (eccCa1) ESX-1 type VII secretion system FtsK/SpoIIIE family protein EccCa1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_83 100.0 0.0 eccCb1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (eccCb1) ESX-1 type VII secretion system FtsK/SpoIIIE family protein EccCb1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_84 100.0 2.0E-67 PE35 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (PE35) PE family-related protein PE35 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_85 100.0 0.0 PPE68 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (PPE68) PPE family protein [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_86 100.0 2.88E-68 esxB VF0310 ESAT-6/CFP-10 Effector delivery system VFC0086 Secreted protein; ESAT-6 and CFP-10 proteins are cotranscribed and form a tight 1:1 complex (esxB) 10 kDa culture filtrate antigen EsxB (CFP-10) [ESAT-6/CFP-10 (VF0310) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_87 100.0 1.09E-64 esxA VF0310 ESAT-6/CFP-10 Effector delivery system VFC0086 Secreted protein; ESAT-6 and CFP-10 proteins are cotranscribed and form a tight 1:1 complex (esxA) 6 kDa early secretory antigenic target EsxA (ESAT-6) [ESAT-6/CFP-10 (VF0310) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_89 99.675 0.0 espI VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espI) ESX-1 secretion-associated protein EspI [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_90 99.795 0.0 eccD1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (eccD1) ESX-1 type VII secretion system EccD1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_91 100.0 0.0 espJ VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espJ) ESX-1 secretion associated protein EspJ [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_92 100.0 0.0 espK VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espK) ESX-1 type VII secretion system EspK [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_93 92.282 0.0 espK VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espK) ESX-1 type VII secretion system EspK [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_94 100.0 6.08E-81 espL VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espL) ESX-1 secretion associated protein EspL [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_95 100.0 0.0 espB VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espB) ESX-1 type VII secretion system EspB [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_96 100.0 0.0 eccE1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (eccE1) ESX-1 type VII secretion system EccE1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_97 99.776 0.0 mycP1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (mycP1) ESX-1 type VII secretion system subtilisin-like serine protease MycP1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
GL503185.1_119 100.0 0.0 cpnT VF1197 CpnT Effector delivery system VFC0086 Secreted by ESX-5; CpnT is a two-domain protein in which the toxic activity resides in the C-terminus. (cpnT) NAD+ glycohydrolase [CpnT (VF1197) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis