2. PATHOGENS
Basic Information
Accession number
GCA_000153685.2
Release date
2013-09-11
Organism
Mycobacterium tuberculosis str. Haarlem
Species name
Mycobacterium tuberculosis
Assembly level
Complete Genome
Assembly name
ASM15368v2
Assembly submitter
Broad Institute
Assembly Type
haploid
Genome size
4.4 Mb
GC percent
65.5
Contig count
1
Collection date
-
Sample location
-
Host
-
Isolation source
-
Isolate type
-
Strain
Haarlem
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
CP001664.1_279 # 314630 # 315175 300.0 365.925 AAC(2')-Ic 100.0 ARO:3002525 protein homolog model aminoglycoside antibiotic antibiotic inactivation AAC(2') AAC(2')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in M. tuberculosis and Mycobacterium tuberculosis variant bovis.
CP001664.1_2156 # 2330518 # 2331441 500.0 619.772 blaC 100.0 ARO:3007182 protein homolog model cephalosporin; cephamycin; penam; penem antibiotic inactivation class A Mycobacterium tuberculosis bla beta-lactamase blaC is a broad-spectrum class A beta-lactamase coded in the chromosome of Mycobacterium tuberculosis. It has been shown to hydrolyze a large number of beta-lactam antibiotics and is a major obstacle in the treatment of tuberculosis with such drugs.
CP001664.1_2932 # 3148546 # 3150138 1000.0 1046.96 efpA 100.0 ARO:3003955 protein homolog model rifamycin antibiotic; isoniazid-like antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump efpA is an MFS transporter found in Mycobacterium tuberculosis.
CP001664.1_3477 # 3768059 # 3768610 350.0 363.999 mfpA 100.0 ARO:3003035 protein homolog model fluoroquinolone antibiotic antibiotic target protection quinolone resistance protein (qnr) mfpA is a qnr homolog and a pentapeptide repeat protein that confers resistance to fluoroquinolones in Mycolicibacterium smegmatis.
CP001664.1_700 # 764801 # 768319 2300.0 2395.54 Mycobacterium tuberculosis rpoB mutants conferring resistance to rifampicin 100.0 ARO:3003283 protein variant model D516G, H526T, L511R rifamycin antibiotic antibiotic target alteration; antibiotic target replacement rifamycin-resistant beta-subunit of RNA polymerase (rpoB) Point mutations that occurs in Mycobacterium tuberculosis rpoB resulting in resistance to rifampicin.
CP001664.1_1375 # 1475381 # 1476637 750.0 842.803 Mycobacterium tuberculosis intrinsic murA conferring resistance to fosfomycin 100.0 ARO:3003784 protein variant model C117D phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant murA transferase Mycobacterium tuberculosis murA confers intrinsic resistance to fosfomycin. The presence of an aspartic acid residue in place of the critical cysteine at position 117 that enables fosfomycin binding is believed to be responsible for this intrinsic resistance.
CP001664.1_1981 # 2153203 # 2155425 1400.0 1513.43 Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid 100.0 ARO:3003392 protein variant model A234G, A431V, G300W isoniazid-like antibiotic antibiotic target alteration isoniazid resistant katG katG is a catalase-peroxidase that catalyzes the activation of isoniazid. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. Mutations in katG results in inability to activate isoniazid. Over 280 different mutations have been documented in PubMed for katG, with mutations to Ser315 being the most prevalent.
CP001664.1_3925 # 4236702 # 4239986 2000.0 2172.51 Mycobacterium tuberculosis embC mutant conferring resistance to ethambutol 99.91 ARO:3003327 protein variant model V981L polyamine antibiotic antibiotic target alteration ethambutol resistant embC Point mutations in Mycobacterium tuberculosis embC that result in lower affinity between ethambutol and EmbC, resulting in resistance.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
CP001664.1_140 100.0 0.0 fbpC VF0311 Antigen 85 Adherence VFC0001 Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp) (fbpC) Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_253 99.929 0.0 aftD VF0318 LAM Immune modulation VFC0258 A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) (aftD) alpha-(1->3)-arabinofuranosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_301 100.0 0.0 eccA3 VF0521 ESX-3 Effector delivery system VFC0086 (eccA3) Type VII secretion system protein EccA3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_302 100.0 0.0 eccB3 VF0521 ESX-3 Effector delivery system VFC0086 (eccB3) Type VII secretion system protein EccB3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_303 99.925 0.0 eccC3 VF0521 ESX-3 Effector delivery system VFC0086 (eccC3) Type VII secretion system protein EccC3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_304 100.0 2.51E-63 PE5 VF0521 ESX-3 Effector delivery system VFC0086 (PE5) PE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_305 100.0 0.0 PPE4 VF0521 ESX-3 Effector delivery system VFC0086 (PPE4) PPE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_306 100.0 8.84E-64 esxG VF1196 EsxG-EsxH Effector delivery system VFC0086 EsxG-EsxH heterodimer is secreted by ESX-3. (esxG) Type VII secretion system protein EsxG [EsxG-EsxH (VF1196) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_307 100.0 2.41E-66 esxH VF1196 EsxG-EsxH Effector delivery system VFC0086 EsxG-EsxH heterodimer is secreted by ESX-3. (esxH) Type VII secretion system protein ESXH (10 kDa antigen) (CFP-7) (protein TB10.4) [EsxG-EsxH (VF1196) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_308 100.0 0.0 espG3 VF0521 ESX-3 Effector delivery system VFC0086 (espG3) Type VII secretion system protein EspG3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_309 100.0 0.0 eccD3 VF0521 ESX-3 Effector delivery system VFC0086 (eccD3) Type IIV secretion system transmembrane protein EccD3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_310 100.0 0.0 mycP3 VF0521 ESX-3 Effector delivery system VFC0086 (mycP3) Type VII secretion system membrane-anchored mycosin MycP3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_311 99.698 0.0 eccE3 VF0521 ESX-3 Effector delivery system VFC0086 (eccE3) Type VII secretion system transmembrane protein EccE3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_314 100.0 0.0 stf0 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (stf0) hypothetical protein [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_371 100.0 7.04E-90 hspR VF0297 HspR Regulation VFC0301 (hspR) heat shock protein transcriptional repressor HspR [HspR (VF0297) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_452 100.0 1.03E-174 sodC VF0305 SodC Stress survival VFC0282 (sodC) superoxide dismutase [SodC (VF0305) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_460 64.272 0.0 groEL VF0594 GroEL Adherence VFC0001 GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. (groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] Clostridium difficile
CP001664.1_488 100.0 0.0 icl VF0253 Isocitrate lyase Others VFC0346 (icl) Isocitrate lyase Icl (isocitrase) (isocitratase) [Isocitrate lyase (VF0253) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_491 100.0 0.0 pcaA VF0285 PcaA Others VFC0346 Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate (pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_497 100.0 4.37E-137 hbhA VF0313 HbhA Adherence VFC0001 Surface-located protein (hbhA) iron-regulated heparin binding hemagglutinin hbhA (adhesin) [HbhA (VF0313) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_675 100.0 0.0 mmaA4 VF0314 MmaA4 Others VFC0346 (mmaA4) hydroxymycolate synthase MmaA4 [MmaA4 (VF0314) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_676 64.26 1.33E-136 pcaA VF0285 PcaA Others VFC0346 Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate (pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_677 72.474 5.4E-153 pcaA VF0285 PcaA Others VFC0346 Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate (pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_719 71.788 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
CP001664.1_793 99.583 5.41E-176 phoP VF0286 PhoP Regulation VFC0301 Similar to the PhoP response regulator of S. enteric serovar Typhimurium that senses Mg2+ starvation and controls the expression of virulence genes (phoP) Possible two component system response transcriptional positive regulator PhoP [PhoP (VF0286) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_794 99.794 0.0 phoR VF0286 PhoP Regulation VFC0301 Similar to the PhoP response regulator of S. enteric serovar Typhimurium that senses Mg2+ starvation and controls the expression of virulence genes (phoR) Possible two component system response sensor kinase membrane associated PhoR [PhoP (VF0286) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1025 99.561 5.99E-163 mprA VF0298 MprAB Regulation VFC0301 MprB, sensor kinase, can undergo autophosphorylation. MprA, transcriptional factor, can accept phosphate from MprB or from small phosphodonors including acetyl phosphate (mprA) two-component response regulator MrpA [MprAB (VF0298) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1026 100.0 0.0 mprB VF0298 MprAB Regulation VFC0301 MprB, sensor kinase, can undergo autophosphorylation. MprA, transcriptional factor, can accept phosphate from MprB or from small phosphodonors including acetyl phosphate (mprB) two component histidine-protein kinase/phosphatase MprB [MprAB (VF0298) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1084 92.553 1.15E-60 esxN VF0402 ESX-5 Effector delivery system VFC0086 (esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1219 100.0 0.0 narG VF0302 Nitrate reductase Nutritional/Metabolic factor VFC0272 NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein (narG) nitrate reductase subunit alpha [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1220 99.821 0.0 narH VF0302 Nitrate reductase Nutritional/Metabolic factor VFC0272 NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein (narH) nitrate reductase subunit beta [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1221 99.502 6.76E-145 narJ VF0302 Nitrate reductase Nutritional/Metabolic factor VFC0272 NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein (narJ) nitrate reductase subunit delta [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1222 100.0 0.0 narI VF0302 Nitrate reductase Nutritional/Metabolic factor VFC0272 NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein (narI) nitrate reductase subunit gamma [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1239 65.128 0.0 pks2 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1243 62.003 0.0 fadD28 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1253 68.966 2.2E-29 PE18 VF0402 ESX-5 Effector delivery system VFC0086 (PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1256 92.553 1.3E-60 esxN VF0402 ESX-5 Effector delivery system VFC0086 (esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1280 100.0 1.29E-158 sigE VF0295 SigE Regulation VFC0301 SigE activity is downregulated by an anti-sigma factor, RseA, that is encoded by a gene Rv1222, adjacent to sigE (sigE) ECF RNA polymerase sigma factor SigE [SigE (VF0295) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1406 100.0 1.05E-54 mbtL VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtL) Acyl carrier protein (ACP) MbtL [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1407 100.0 0.0 mbtM VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtM) Probable fatty acyl-AMP ligase MbtM [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1408 100.0 0.0 mbtN VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtN) Acyl-CoA dehydrogenase MbtN [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1409 100.0 3.18E-157 mbtK VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtK) Lysine N-acetyltransferase MbtK [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1447 67.01 1.28E-23 PE5 VF0521 ESX-3 Effector delivery system VFC0086 (PE5) PE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1583 68.724 1.52E-120 Rv2956 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2956) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1591 63.841 0.0 fadD28 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1600 69.976 0.0 pks2 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1602 65.641 0.0 fadD28 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1693 100.0 0.0 capA VF0318 LAM Immune modulation VFC0258 A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) (capA) mannosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1711 99.901 0.0 PE_PGRS30 VF0316 PE/PE-PGRS Immune modulation VFC0258 PE family members are characterized by highly conserved N-terminal Pro-Glu motif, PE-PGRS proteins have tandem repetitions of Gly-Gly-Ala or Gly-Gly-Asn termed the PGRS domain (polymorphic GC-rich repetitive sequence) near C-terminal; PE family members have been found in all the sequenced Mycobacterium genomes, although their number is highly variable (PE_PGRS30) PE-PGRS family protein PE_PGRS30 [PE/PE-PGRS (VF0316) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1723 60.592 5.6E-154 pks1 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (pks1) polyketide synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1824 71.624 0.0 plcA VF0320 Phospholipase C Exotoxin VFC0235 Phospholipases can be divided into four groups depending on the position of the bond they hydrolyse on the phospholipid substrate: phospholipases A1, A2, C and D (plcA) membrane-associated phospholipase A [Phospholipase C (VF0320) - Exotoxin (VFC0235)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1852 100.0 0.0 eccB5 VF0402 ESX-5 Effector delivery system VFC0086 (eccB5) ESX-5 type VII secretion system protein EccB5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1853 100.0 0.0 eccC5 VF0402 ESX-5 Effector delivery system VFC0086 (eccC5) ESX-5 type VII secretion system FtsK/SpoIIIE family protein EccC5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1854 100.0 0.0 cyp143 VF0402 ESX-5 Effector delivery system VFC0086 (cyp143) cytochrome P450 Cyp143 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1855 100.0 1.24E-45 Rv1786 VF0402 ESX-5 Effector delivery system VFC0086 (Rv1786) ferredoxin [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1856 99.452 0.0 PPE25 VF0402 ESX-5 Effector delivery system VFC0086 (PPE25) PPE family protein PPE25 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1857 98.99 9.73E-62 PE18 VF0402 ESX-5 Effector delivery system VFC0086 (PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1858 99.491 0.0 PPE26 VF0402 ESX-5 Effector delivery system VFC0086 (PPE26) PPE family protein PPE26 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1859 100.0 0.0 PPE27 VF0402 ESX-5 Effector delivery system VFC0086 (PPE27) PPE family protein PPE27 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1860 100.0 2.0E-62 PE19 VF0402 ESX-5 Effector delivery system VFC0086 (PE19) PE family protein PE19 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1863 100.0 1.0E-65 esxN VF0402 ESX-5 Effector delivery system VFC0086 (esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1864 100.0 0.0 Rv1794 VF0402 ESX-5 Effector delivery system VFC0086 (Rv1794) ESX-5 locus protein [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1865 100.0 0.0 eccD5 VF0402 ESX-5 Effector delivery system VFC0086 (eccD5) ESX-5 type VII secretion system EccD5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1866 100.0 0.0 mycP5 VF0402 ESX-5 Effector delivery system VFC0086 (mycP5) ESX-5 type VII secretion system subtilisin-like serine protease MycP5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1867 100.0 0.0 eccE5 VF0402 ESX-5 Effector delivery system VFC0086 (eccE5) ESX-5 type VII secretion system EccE5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1868 100.0 0.0 eccA5 VF0402 ESX-5 Effector delivery system VFC0086 (eccA5) ESX-5 type VII secretion system AAA+ ATPase EccA5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1881 99.573 2.57E-170 mgtC VF0289 MgtC Nutritional/Metabolic factor VFC0272 Homology to MgtC of Salmonella enterica, which is essential for the survival of S.enterica within macrophages (mgtC) Possible Mg2+ transport P-type ATPase C MgtC [MgtC (VF0289) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1956 100.0 0.0 fbpB VF0311 Antigen 85 Adherence VFC0001 Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp) (fbpB) Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_1981 100.0 0.0 katG VF0303 KatG Stress survival VFC0282 (katG) catalase-peroxidase [KatG (VF0303) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2115 62.5 0.0 devS VF0317 DevRS Regulation VFC0301 A two-component system consists of a histidine sensor kinase and a response regulator; phosphorylation-based signalling has been established for five of eleven systems in M. tuberculosis, RegX3-SenX3, TrcR-TrcS, MprA-MprB, PrrA-PrrB and DevR-DevS (DosR-DosS) (devS) two component sensor histidine kinase DevS [DevRS (VF0317) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2119 100.0 1.49E-104 hspX VF0301 HspX Stress survival VFC0282 (hspX) Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3) [HspX (VF0301) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2269 100.0 0.0 mptC VF0318 LAM Immune modulation VFC0258 A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) (mptC) alpha-(1-2)-phosphatidylinositol mannoside mannosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2435 97.872 4.89E-64 esxN VF0402 ESX-5 Effector delivery system VFC0086 (esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2438 100.0 0.0 plcC VF0320 Phospholipase C Exotoxin VFC0235 Phospholipases can be divided into four groups depending on the position of the bond they hydrolyse on the phospholipid substrate: phospholipases A1, A2, C and D (plcC) phospholipase C [Phospholipase C (VF0320) - Exotoxin (VFC0235)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2439 100.0 0.0 plcB VF0320 Phospholipase C Exotoxin VFC0235 Phospholipases can be divided into four groups depending on the position of the bond they hydrolyse on the phospholipid substrate: phospholipases A1, A2, C and D (plcB) membrane-associated phospholipase B [Phospholipase C (VF0320) - Exotoxin (VFC0235)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2440 100.0 0.0 plcA VF0320 Phospholipase C Exotoxin VFC0235 Phospholipases can be divided into four groups depending on the position of the bond they hydrolyse on the phospholipid substrate: phospholipases A1, A2, C and D (plcA) membrane-associated phospholipase A [Phospholipase C (VF0320) - Exotoxin (VFC0235)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2467 98.592 1.63E-49 mbtH VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtH) putative protein MbtH [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2468 100.0 0.0 mbtG VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtG) Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2469 99.932 0.0 mbtF VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtF) Peptide synthetase MbtF (peptide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2470 100.0 0.0 mbtE VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtE) Peptide synthetase MbtE (peptide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2471 100.0 0.0 mbtD VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtD) Polyketide synthetase MbtD (polyketide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2472 100.0 0.0 mbtC VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtC) Polyketide synthetase MbtC (polyketide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2473 100.0 0.0 mbtB VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtB) Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2474 100.0 0.0 mbtA VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtA) Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2475 100.0 0.0 mbtJ VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtJ) Putative acetyl hydrolase MbtJ [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2476 100.0 0.0 mbtI VF0299 Mycobactin Nutritional/Metabolic factor VFC0272 Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. (mbtI) Isochorismate synthase MbtI [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2520 100.0 2.49E-146 ahpC VF0306 AhpC Stress survival VFC0282 (ahpC) alkyl hydroperoxide reductase subunit AhpC [AhpC (VF0306) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2522 100.0 1.15E-145 PPE41 VF0402 ESX-5 Effector delivery system VFC0086 (PPE41) PPE family protein PPE41 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2540 67.542 0.0 Rv2953 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2953) trans-acting enoyl reductase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2671 100.0 0.0 relA VF0287 RelA Regulation VFC0301 (relA) Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) [RelA (VF0287) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2789 100.0 0.0 sigA/rpoV VF0257 SigA Regulation VFC0301 In M. tuberculosis, 13 sigma factor genes have been annotated in the genome, 9 of which belong to a special subfamily thought to direct extracytoplasmic functions and various other stress responses (temperature, oxidative stress, pH, and infection of macrophages); sigma A also known as RpoV, is the essential principal mycobacterial sigma factors, necessary for most mycobacterial housekeeping gene transcription; It was the first mycobacterial sigma factor to be associated with virulence (sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2796 62.857 7.43E-135 sigA/rpoV VF0257 SigA Regulation VFC0301 In M. tuberculosis, 13 sigma factor genes have been annotated in the genome, 9 of which belong to a special subfamily thought to direct extracytoplasmic functions and various other stress responses (temperature, oxidative stress, pH, and infection of macrophages); sigma A also known as RpoV, is the essential principal mycobacterial sigma factors, necessary for most mycobacterial housekeeping gene transcription; It was the first mycobacterial sigma factor to be associated with virulence (sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_2797 100.0 1.59E-166 ideR VF0300 IdeR Regulation VFC0301 A DNA binding protein interacts with a conserved DNA sequence requires the binding of Fe2+ or related divalent cations (ideR) Iron-dependent repressor and activator IdeR [IdeR (VF0300) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3020 100.0 0.0 tesA VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (tesA) thioesterase TesA [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3021 100.0 0.0 fadD26 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD26) fatty-acid--CoA ligase FadD26 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3022 99.733 0.0 ppsA VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ppsA) phthiocerol synthesis polyketide synthase type I PpsA [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3023 100.0 0.0 ppsB VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ppsB) phthiocerol synthesis polyketide synthase type I PpsB [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3024 99.954 0.0 ppsC VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ppsC) phthiocerol synthesis polyketide synthase type I PpsC [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3025 100.0 0.0 ppsD VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ppsD) phthiocerol synthesis polyketide synthase type I PpsD [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3026 100.0 0.0 ppsE VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ppsE) phthiocerol synthesis polyketide synthase type I PpsE [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3027 100.0 0.0 ddrA VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ddrA) daunorubicin ABC transporter ATP-binding protein DrrA [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3028 100.0 0.0 ddrB VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (ddrB) daunorubicin ABC transporter permease DrrB [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3029 100.0 0.0 drrC VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (drrC) daunorubicin ABC transporter permease DrrC [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3030 100.0 0.0 papA5 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (papA5) phthiocerol/phthiodiolone dimycocerosyl transferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3031 100.0 0.0 mas VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (mas) multifunctional mycocerosic acid synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3032 100.0 0.0 fadD28 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3033 100.0 0.0 mmpL7 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (mmpL7) transmembrane transport protein MmpL7 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3036 100.0 4.35E-170 lppx VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (lppx) lipoprotein LppX [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3037 100.0 0.0 pks1 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (pks1) polyketide synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3038 99.796 0.0 pks15 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (pks15) polyketide synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3039 100.0 0.0 fadD22 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD22) p-hydroxybenzoyl--AMP ligase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3040 100.0 1.87E-148 Rv2949c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2949c) chorismate pyruvate-lyase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3041 100.0 0.0 fadD29 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD29) long-chain-fatty-acid--AMP ligase FadD29 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3042 100.0 0.0 Rv2951c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2951c) phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3043 100.0 0.0 Rv2952 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2952) phthiotriol/phenolphthiotriol dimycocerosates methyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3044 100.0 0.0 Rv2953 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2953) trans-acting enoyl reductase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3045 100.0 0.0 Rv2954c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2954c) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3046 100.0 0.0 Rv2955c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2955c) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3047 100.0 0.0 Rv2956 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2956) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3048 100.0 0.0 Rv2957 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2957) PGL/p-HBAD biosynthesis glycosyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3049 100.0 0.0 Rv2958c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2958c) PGL/p-HBAD biosynthesis glycosyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3050 100.0 0.0 Rv2959c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2959c) rhamnosyl O-methyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3052 100.0 0.0 Rv2962c VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (Rv2962c) PGL/p-HBAD biosynthesis rhamnosyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3113 80.392 3.98E-32 PE5 VF0521 ESX-3 Effector delivery system VFC0086 (PE5) PE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3227 100.0 0.0 devS VF0317 DevRS Regulation VFC0301 A two-component system consists of a histidine sensor kinase and a response regulator; phosphorylation-based signalling has been established for five of eleven systems in M. tuberculosis, RegX3-SenX3, TrcR-TrcS, MprA-MprB, PrrA-PrrB and DevR-DevS (DosR-DosS) (devS) two component sensor histidine kinase DevS [DevRS (VF0317) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3228 100.0 9.56E-155 devR/dosR VF0317 DevRS Regulation VFC0301 A two-component system consists of a histidine sensor kinase and a response regulator; phosphorylation-based signalling has been established for five of eleven systems in M. tuberculosis, RegX3-SenX3, TrcR-TrcS, MprA-MprB, PrrA-PrrB and DevR-DevS (DosR-DosS) (devR/dosR) two component transcriptional regulator DevR [DevRS (VF0317) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3327 100.0 4.28E-162 sigH VF0296 SigH Regulation VFC0301 Similar to the sigma R of Streptomyces species; sigma H activity is regulated at the posttranslational level by a cystein-containing anti-sigma factor RsrA, encoded by a gene in the sigH operon; the ability of RshA to inhibit SigH-dependent transcription is redox-dependent (sigH) ECF RNA polymerase sigma factor SigH [SigH (VF0296) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3392 100.0 9.74E-175 sigF VF0294 SigF Regulation VFC0301 (sigF) RNA polymerase sigma factor SigF [SigF (VF0294) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3510 72.822 1.39E-158 pcaA VF0285 PcaA Others VFC0346 Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate (pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3536 99.02 6.48E-73 whiB3 VF0288 WhiB3 Regulation VFC0301 Seven members of the WhiB family in M. tuberculosis H37Rv, homolog of the Streptomyces coelicolor whiB gene, a transcription factor whose function is required for sporulation process (whiB3) redox-responsive transcriptional regulator WhiB3 [WhiB3 (VF0288) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3604 65.517 1.01E-25 PE18 VF0402 ESX-5 Effector delivery system VFC0086 (PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3614 99.639 0.0 lipF VF0307 LipF Nutritional/Metabolic factor VFC0272 (lipF) Probable esterase/lipase LipF [LipF (VF0307) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3730 100.0 9.1E-100 panD VF0319 PanC/PanD Nutritional/Metabolic factor VFC0272 (panD) aspartate 1-decarboxylase [PanC/PanD (VF0319) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3731 100.0 0.0 panC VF0319 PanC/PanD Nutritional/Metabolic factor VFC0272 (panC) pantothenate synthetase [PanC/PanD (VF0319) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3740 99.457 5.84E-134 espD VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espD) ESX-1 type VII secretion system EspD [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3741 100.0 1.42E-73 espC VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espC) ESX-1 type VII secretion system EspC [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3742 99.745 0.0 espA VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espA) ESX-1 type VII secretion system EspA [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3745 90.426 1.13E-58 esxN VF0402 ESX-5 Effector delivery system VFC0086 (esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3748 62.069 3.6E-26 PE18 VF0402 ESX-5 Effector delivery system VFC0086 (PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3775 60.256 2.63E-17 PE18 VF0402 ESX-5 Effector delivery system VFC0086 (PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3868 74.026 1.21E-29 PPE4 VF0521 ESX-3 Effector delivery system VFC0086 (PPE4) PPE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3925 99.909 0.0 embC VF0318 LAM Immune modulation VFC0258 A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) (embC) arabinosyltransferase C [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3935 100.0 0.0 fbpD VF0311 Antigen 85 Adherence VFC0001 Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp) (fbpD) MPT51/MPB51 antigen [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3936 100.0 0.0 fbpA VF0311 Antigen 85 Adherence VFC0001 Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp) (fbpA) Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3937 100.0 0.0 aftB VF0318 LAM Immune modulation VFC0258 A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) (aftB) terminal beta-(1->2)-arabinofuranosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3942 100.0 0.0 erp VF0312 Erp Others VFC0346 Surface-located protein;No homologue of Erp has been found in other bacterial species, making Erp a mycobacterial signature (erp) exported repetitive protein precursor Erp [Erp (VF0312) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3953 100.0 0.0 papA2 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (papA2) trehalose-2-sulfate acyltransferase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3956 100.0 0.0 mmpL8 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (mmpL8) integral membrane transport protein MmpL8 [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3957 100.0 0.0 papA1 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (papA1) acyltransferase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3958 100.0 0.0 pks2 VF0803 Sulfolipid-1 biosynthesis and transport Immune modulation VFC0258 (pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3959 66.207 0.0 fadD28 VF0309 PDIM Immune modulation VFC0258 Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM (fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3984 100.0 1.71E-154 sodA VF0304 SodA Stress survival VFC0282 (sodA) superoxide dismutase [SodA (VF0304) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_3987 100.0 6.88E-98 espR VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espR) ESX-1 transcriptional regulator EspR [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4002 100.0 0.0 espE VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espE) ESX-1 secretion-associated protein EspE [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4003 100.0 3.55E-71 espF VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espF) ESX-1 secretion-associated protein EspF [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4004 100.0 0.0 espG1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espG1) ESX-1 secretion-associated protein EspG1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4005 100.0 2.46E-132 espH VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espH) ESX-1 secretion-associated protein EspH [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4006 100.0 0.0 eccA1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (eccA1) ESX-1 type VII secretion system AAA+ ATPase EccA1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4007 100.0 0.0 eccB1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (eccB1) ESX-1 type VII secretion system protein EccB1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4008 99.866 0.0 eccCa1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (eccCa1) ESX-1 type VII secretion system FtsK/SpoIIIE family protein EccCa1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4009 100.0 0.0 eccCb1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (eccCb1) ESX-1 type VII secretion system FtsK/SpoIIIE family protein EccCb1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4010 100.0 1.44E-66 PE35 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (PE35) PE family-related protein PE35 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4011 99.728 0.0 PPE68 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (PPE68) PPE family protein [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4012 99.0 9.85E-68 esxB VF0310 ESAT-6/CFP-10 Effector delivery system VFC0086 Secreted protein; ESAT-6 and CFP-10 proteins are cotranscribed and form a tight 1:1 complex (esxB) 10 kDa culture filtrate antigen EsxB (CFP-10) [ESAT-6/CFP-10 (VF0310) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4013 100.0 1.09E-64 esxA VF0310 ESAT-6/CFP-10 Effector delivery system VFC0086 Secreted protein; ESAT-6 and CFP-10 proteins are cotranscribed and form a tight 1:1 complex (esxA) 6 kDa early secretory antigenic target EsxA (ESAT-6) [ESAT-6/CFP-10 (VF0310) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4015 99.675 0.0 espI VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espI) ESX-1 secretion-associated protein EspI [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4016 99.795 0.0 eccD1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (eccD1) ESX-1 type VII secretion system EccD1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4017 99.643 0.0 espJ VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espJ) ESX-1 secretion associated protein EspJ [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4018 98.111 0.0 espK VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espK) ESX-1 type VII secretion system EspK [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4019 100.0 6.08E-81 espL VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espL) ESX-1 secretion associated protein EspL [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4020 100.0 0.0 espB VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (espB) ESX-1 type VII secretion system EspB [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4021 99.784 0.0 eccE1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (eccE1) ESX-1 type VII secretion system EccE1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4022 99.776 0.0 mycP1 VF0315 ESX-1 Effector delivery system VFC0086 The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. (mycP1) ESX-1 type VII secretion system subtilisin-like serine protease MycP1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP001664.1_4046 100.0 0.0 cpnT VF1197 CpnT Effector delivery system VFC0086 Secreted by ESX-5; CpnT is a two-domain protein in which the toxic activity resides in the C-terminus. (cpnT) NAD+ glycohydrolase [CpnT (VF1197) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis