| DS985201.1_1 |
100.0 |
4.02E-32 |
PE35 |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(PE35) PE family-related protein PE35 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985201.1_3 |
99.384 |
0.0 |
eccD1 |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(eccD1) ESX-1 type VII secretion system EccD1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985201.1_4 |
100.0 |
0.0 |
espJ |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(espJ) ESX-1 secretion associated protein EspJ [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985201.1_5 |
99.63 |
0.0 |
espK |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(espK) ESX-1 type VII secretion system EspK [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_117 |
100.0 |
9.1E-100 |
panD |
VF0319 |
PanC/PanD |
Nutritional/Metabolic factor |
VFC0272 |
|
(panD) aspartate 1-decarboxylase [PanC/PanD (VF0319) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_118 |
100.0 |
0.0 |
panC |
VF0319 |
PanC/PanD |
Nutritional/Metabolic factor |
VFC0272 |
|
(panC) pantothenate synthetase [PanC/PanD (VF0319) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_129 |
99.457 |
5.84E-134 |
espD |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(espD) ESX-1 type VII secretion system EspD [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_130 |
100.0 |
1.42E-73 |
espC |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(espC) ESX-1 type VII secretion system EspC [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_131 |
99.745 |
0.0 |
espA |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(espA) ESX-1 type VII secretion system EspA [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_134 |
90.426 |
1.13E-58 |
esxN |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_137 |
62.069 |
3.6E-26 |
PE18 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_166 |
60.256 |
2.63E-17 |
PE18 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_259 |
74.026 |
1.21E-29 |
PPE4 |
VF0521 |
ESX-3 |
Effector delivery system |
VFC0086 |
|
(PPE4) PPE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_319 |
100.0 |
0.0 |
embC |
VF0318 |
LAM |
Immune modulation |
VFC0258 |
A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) |
(embC) arabinosyltransferase C [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_329 |
100.0 |
0.0 |
fbpD |
VF0311 |
Antigen 85 |
Adherence |
VFC0001 |
Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp) |
(fbpD) MPT51/MPB51 antigen [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_330 |
100.0 |
0.0 |
fbpA |
VF0311 |
Antigen 85 |
Adherence |
VFC0001 |
Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp) |
(fbpA) Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_331 |
99.841 |
0.0 |
aftB |
VF0318 |
LAM |
Immune modulation |
VFC0258 |
A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) |
(aftB) terminal beta-(1->2)-arabinofuranosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_336 |
100.0 |
0.0 |
erp |
VF0312 |
Erp |
Others |
VFC0346 |
Surface-located protein;No homologue of Erp has been found in other bacterial species, making Erp a mycobacterial signature |
(erp) exported repetitive protein precursor Erp [Erp (VF0312) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_348 |
99.786 |
0.0 |
papA2 |
VF0803 |
Sulfolipid-1 biosynthesis and transport |
Immune modulation |
VFC0258 |
|
(papA2) trehalose-2-sulfate acyltransferase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_351 |
100.0 |
0.0 |
mmpL8 |
VF0803 |
Sulfolipid-1 biosynthesis and transport |
Immune modulation |
VFC0258 |
|
(mmpL8) integral membrane transport protein MmpL8 [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_352 |
100.0 |
0.0 |
papA1 |
VF0803 |
Sulfolipid-1 biosynthesis and transport |
Immune modulation |
VFC0258 |
|
(papA1) acyltransferase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_353 |
100.0 |
0.0 |
pks2 |
VF0803 |
Sulfolipid-1 biosynthesis and transport |
Immune modulation |
VFC0258 |
|
(pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_354 |
66.034 |
0.0 |
fadD28 |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_377 |
100.0 |
1.71E-154 |
sodA |
VF0304 |
SodA |
Stress survival |
VFC0282 |
|
(sodA) superoxide dismutase [SodA (VF0304) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_380 |
100.0 |
6.88E-98 |
espR |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(espR) ESX-1 transcriptional regulator EspR [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_395 |
100.0 |
0.0 |
espE |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(espE) ESX-1 secretion-associated protein EspE [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_396 |
100.0 |
3.55E-71 |
espF |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(espF) ESX-1 secretion-associated protein EspF [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_397 |
100.0 |
0.0 |
espG1 |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(espG1) ESX-1 secretion-associated protein EspG1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_398 |
100.0 |
2.46E-132 |
espH |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(espH) ESX-1 secretion-associated protein EspH [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_399 |
100.0 |
0.0 |
eccA1 |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(eccA1) ESX-1 type VII secretion system AAA+ ATPase EccA1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_400 |
100.0 |
0.0 |
eccB1 |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(eccB1) ESX-1 type VII secretion system protein EccB1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_401 |
100.0 |
0.0 |
eccCa1 |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(eccCa1) ESX-1 type VII secretion system FtsK/SpoIIIE family protein EccCa1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_402 |
100.0 |
0.0 |
eccCb1 |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(eccCb1) ESX-1 type VII secretion system FtsK/SpoIIIE family protein EccCb1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_403 |
100.0 |
1.44E-66 |
PE35 |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(PE35) PE family-related protein PE35 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_404 |
100.0 |
0.0 |
PPE68 |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(PPE68) PPE family protein [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_405 |
100.0 |
2.88E-68 |
esxB |
VF0310 |
ESAT-6/CFP-10 |
Effector delivery system |
VFC0086 |
Secreted protein; ESAT-6 and CFP-10 proteins are cotranscribed and form a tight 1:1 complex |
(esxB) 10 kDa culture filtrate antigen EsxB (CFP-10) [ESAT-6/CFP-10 (VF0310) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_406 |
100.0 |
1.09E-64 |
esxA |
VF0310 |
ESAT-6/CFP-10 |
Effector delivery system |
VFC0086 |
Secreted protein; ESAT-6 and CFP-10 proteins are cotranscribed and form a tight 1:1 complex |
(esxA) 6 kDa early secretory antigenic target EsxA (ESAT-6) [ESAT-6/CFP-10 (VF0310) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_407 |
96.774 |
0.0 |
espI |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(espI) ESX-1 secretion-associated protein EspI [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_409 |
99.782 |
0.0 |
eccD1 |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(eccD1) ESX-1 type VII secretion system EccD1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_411 |
90.634 |
1.1E-135 |
espK |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(espK) ESX-1 type VII secretion system EspK [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_412 |
100.0 |
6.08E-81 |
espL |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(espL) ESX-1 secretion associated protein EspL [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_413 |
100.0 |
0.0 |
espB |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(espB) ESX-1 type VII secretion system EspB [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_414 |
100.0 |
0.0 |
eccE1 |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(eccE1) ESX-1 type VII secretion system EccE1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_415 |
99.776 |
0.0 |
mycP1 |
VF0315 |
ESX-1 |
Effector delivery system |
VFC0086 |
The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. |
(mycP1) ESX-1 type VII secretion system subtilisin-like serine protease MycP1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_442 |
100.0 |
0.0 |
cpnT |
VF1197 |
CpnT |
Effector delivery system |
VFC0086 |
Secreted by ESX-5; CpnT is a two-domain protein in which the toxic activity resides in the C-terminus. |
(cpnT) NAD+ glycohydrolase [CpnT (VF1197) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_602 |
100.0 |
0.0 |
fbpC |
VF0311 |
Antigen 85 |
Adherence |
VFC0001 |
Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp) |
(fbpC) Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_720 |
99.929 |
0.0 |
aftD |
VF0318 |
LAM |
Immune modulation |
VFC0258 |
A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) |
(aftD) alpha-(1->3)-arabinofuranosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_774 |
99.842 |
0.0 |
eccA3 |
VF0521 |
ESX-3 |
Effector delivery system |
VFC0086 |
|
(eccA3) Type VII secretion system protein EccA3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_775 |
100.0 |
0.0 |
eccB3 |
VF0521 |
ESX-3 |
Effector delivery system |
VFC0086 |
|
(eccB3) Type VII secretion system protein EccB3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_776 |
99.925 |
0.0 |
eccC3 |
VF0521 |
ESX-3 |
Effector delivery system |
VFC0086 |
|
(eccC3) Type VII secretion system protein EccC3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_777 |
100.0 |
2.51E-63 |
PE5 |
VF0521 |
ESX-3 |
Effector delivery system |
VFC0086 |
|
(PE5) PE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_778 |
100.0 |
0.0 |
PPE4 |
VF0521 |
ESX-3 |
Effector delivery system |
VFC0086 |
|
(PPE4) PPE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_779 |
99.333 |
6.95E-102 |
PPE4 |
VF0521 |
ESX-3 |
Effector delivery system |
VFC0086 |
|
(PPE4) PPE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_780 |
100.0 |
8.84E-64 |
esxG |
VF1196 |
EsxG-EsxH |
Effector delivery system |
VFC0086 |
EsxG-EsxH heterodimer is secreted by ESX-3. |
(esxG) Type VII secretion system protein EsxG [EsxG-EsxH (VF1196) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_781 |
100.0 |
2.41E-66 |
esxH |
VF1196 |
EsxG-EsxH |
Effector delivery system |
VFC0086 |
EsxG-EsxH heterodimer is secreted by ESX-3. |
(esxH) Type VII secretion system protein ESXH (10 kDa antigen) (CFP-7) (protein TB10.4) [EsxG-EsxH (VF1196) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_782 |
100.0 |
0.0 |
espG3 |
VF0521 |
ESX-3 |
Effector delivery system |
VFC0086 |
|
(espG3) Type VII secretion system protein EspG3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_783 |
99.576 |
0.0 |
eccD3 |
VF0521 |
ESX-3 |
Effector delivery system |
VFC0086 |
|
(eccD3) Type IIV secretion system transmembrane protein EccD3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_784 |
100.0 |
0.0 |
mycP3 |
VF0521 |
ESX-3 |
Effector delivery system |
VFC0086 |
|
(mycP3) Type VII secretion system membrane-anchored mycosin MycP3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_785 |
99.698 |
0.0 |
eccE3 |
VF0521 |
ESX-3 |
Effector delivery system |
VFC0086 |
|
(eccE3) Type VII secretion system transmembrane protein EccE3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985200.1_788 |
100.0 |
0.0 |
stf0 |
VF0803 |
Sulfolipid-1 biosynthesis and transport |
Immune modulation |
VFC0258 |
|
(stf0) hypothetical protein [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985199.1_27 |
100.0 |
9.92E-74 |
whiB3 |
VF0288 |
WhiB3 |
Regulation |
VFC0301 |
Seven members of the WhiB family in M. tuberculosis H37Rv, homolog of the Streptomyces coelicolor whiB gene, a transcription factor whose function is required for sporulation process |
(whiB3) redox-responsive transcriptional regulator WhiB3 [WhiB3 (VF0288) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985199.1_89 |
65.517 |
1.01E-25 |
PE18 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985199.1_100 |
99.278 |
0.0 |
lipF |
VF0307 |
LipF |
Nutritional/Metabolic factor |
VFC0272 |
|
(lipF) Probable esterase/lipase LipF [LipF (VF0307) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985198.1_11 |
72.822 |
1.39E-158 |
pcaA |
VF0285 |
PcaA |
Others |
VFC0346 |
Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate |
(pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985197.1_50 |
81.373 |
4.39E-33 |
PE5 |
VF0521 |
ESX-3 |
Effector delivery system |
VFC0086 |
|
(PE5) PE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985197.1_164 |
100.0 |
0.0 |
devS |
VF0317 |
DevRS |
Regulation |
VFC0301 |
A two-component system consists of a histidine sensor kinase and a response regulator; phosphorylation-based signalling has been established for five of eleven systems in M. tuberculosis, RegX3-SenX3, TrcR-TrcS, MprA-MprB, PrrA-PrrB and DevR-DevS (DosR-DosS) |
(devS) two component sensor histidine kinase DevS [DevRS (VF0317) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985197.1_165 |
100.0 |
9.56E-155 |
devR/dosR |
VF0317 |
DevRS |
Regulation |
VFC0301 |
A two-component system consists of a histidine sensor kinase and a response regulator; phosphorylation-based signalling has been established for five of eleven systems in M. tuberculosis, RegX3-SenX3, TrcR-TrcS, MprA-MprB, PrrA-PrrB and DevR-DevS (DosR-DosS) |
(devR/dosR) two component transcriptional regulator DevR [DevRS (VF0317) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985197.1_270 |
100.0 |
4.28E-162 |
sigH |
VF0296 |
SigH |
Regulation |
VFC0301 |
Similar to the sigma R of Streptomyces species; sigma H activity is regulated at the posttranslational level by a cystein-containing anti-sigma factor RsrA, encoded by a gene in the sigH operon; the ability of RshA to inhibit SigH-dependent transcription is redox-dependent |
(sigH) ECF RNA polymerase sigma factor SigH [SigH (VF0296) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985197.1_335 |
100.0 |
0.0 |
sigF |
VF0294 |
SigF |
Regulation |
VFC0301 |
|
(sigF) RNA polymerase sigma factor SigF [SigF (VF0294) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985197.1_455 |
67.58 |
9.15E-110 |
pcaA |
VF0285 |
PcaA |
Others |
VFC0346 |
Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate |
(pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_97 |
100.0 |
0.0 |
tesA |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(tesA) thioesterase TesA [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_98 |
100.0 |
0.0 |
fadD26 |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(fadD26) fatty-acid--CoA ligase FadD26 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_99 |
99.68 |
0.0 |
ppsA |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(ppsA) phthiocerol synthesis polyketide synthase type I PpsA [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_100 |
100.0 |
0.0 |
ppsB |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(ppsB) phthiocerol synthesis polyketide synthase type I PpsB [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_101 |
100.0 |
0.0 |
ppsC |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(ppsC) phthiocerol synthesis polyketide synthase type I PpsC [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_102 |
98.632 |
0.0 |
ppsD |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(ppsD) phthiocerol synthesis polyketide synthase type I PpsD [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_103 |
100.0 |
0.0 |
ppsE |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(ppsE) phthiocerol synthesis polyketide synthase type I PpsE [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_104 |
100.0 |
0.0 |
ddrA |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(ddrA) daunorubicin ABC transporter ATP-binding protein DrrA [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_105 |
100.0 |
0.0 |
ddrB |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(ddrB) daunorubicin ABC transporter permease DrrB [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_106 |
100.0 |
0.0 |
drrC |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(drrC) daunorubicin ABC transporter permease DrrC [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_107 |
100.0 |
0.0 |
papA5 |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(papA5) phthiocerol/phthiodiolone dimycocerosyl transferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_108 |
99.905 |
0.0 |
mas |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(mas) multifunctional mycocerosic acid synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_109 |
100.0 |
0.0 |
fadD28 |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_110 |
99.891 |
0.0 |
mmpL7 |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(mmpL7) transmembrane transport protein MmpL7 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_113 |
100.0 |
4.35E-170 |
lppx |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(lppx) lipoprotein LppX [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_115 |
100.0 |
0.0 |
fadD22 |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(fadD22) p-hydroxybenzoyl--AMP ligase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_116 |
100.0 |
1.87E-148 |
Rv2949c |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(Rv2949c) chorismate pyruvate-lyase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_117 |
99.519 |
8.22E-148 |
fadD29 |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(fadD29) long-chain-fatty-acid--AMP ligase FadD29 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_118 |
100.0 |
0.0 |
fadD29 |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(fadD29) long-chain-fatty-acid--AMP ligase FadD29 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_119 |
100.0 |
0.0 |
Rv2951c |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(Rv2951c) phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_120 |
99.63 |
0.0 |
Rv2952 |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(Rv2952) phthiotriol/phenolphthiotriol dimycocerosates methyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_121 |
100.0 |
0.0 |
Rv2953 |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(Rv2953) trans-acting enoyl reductase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_122 |
100.0 |
0.0 |
Rv2954c |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(Rv2954c) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_123 |
100.0 |
0.0 |
Rv2955c |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(Rv2955c) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_125 |
100.0 |
0.0 |
Rv2958c |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(Rv2958c) PGL/p-HBAD biosynthesis glycosyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_126 |
99.592 |
0.0 |
Rv2959c |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(Rv2959c) rhamnosyl O-methyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985196.1_128 |
100.0 |
0.0 |
Rv2962c |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(Rv2962c) PGL/p-HBAD biosynthesis rhamnosyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985194.1_43 |
100.0 |
0.0 |
relA |
VF0287 |
RelA |
Regulation |
VFC0301 |
|
(relA) Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) [RelA (VF0287) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985194.1_180 |
100.0 |
6.78E-119 |
sigA/rpoV |
VF0257 |
SigA |
Regulation |
VFC0301 |
In M. tuberculosis, 13 sigma factor genes have been annotated in the genome, 9 of which belong to a special subfamily thought to direct extracytoplasmic functions and various other stress responses (temperature, oxidative stress, pH, and infection of macrophages); sigma A also known as RpoV, is the essential principal mycobacterial sigma factors, necessary for most mycobacterial housekeeping gene transcription; It was the first mycobacterial sigma factor to be associated with virulence |
(sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985194.1_187 |
62.857 |
7.43E-135 |
sigA/rpoV |
VF0257 |
SigA |
Regulation |
VFC0301 |
In M. tuberculosis, 13 sigma factor genes have been annotated in the genome, 9 of which belong to a special subfamily thought to direct extracytoplasmic functions and various other stress responses (temperature, oxidative stress, pH, and infection of macrophages); sigma A also known as RpoV, is the essential principal mycobacterial sigma factors, necessary for most mycobacterial housekeeping gene transcription; It was the first mycobacterial sigma factor to be associated with virulence |
(sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985194.1_188 |
100.0 |
1.59E-166 |
ideR |
VF0300 |
IdeR |
Regulation |
VFC0301 |
A DNA binding protein interacts with a conserved DNA sequence requires the binding of Fe2+ or related divalent cations |
(ideR) Iron-dependent repressor and activator IdeR [IdeR (VF0300) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985192.1_39 |
100.0 |
2.49E-146 |
ahpC |
VF0306 |
AhpC |
Stress survival |
VFC0282 |
|
(ahpC) alkyl hydroperoxide reductase subunit AhpC [AhpC (VF0306) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985192.1_41 |
100.0 |
1.15E-145 |
PPE41 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(PPE41) PPE family protein PPE41 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985192.1_59 |
67.542 |
0.0 |
Rv2953 |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(Rv2953) trans-acting enoyl reductase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985191.1_36 |
100.0 |
1.49E-104 |
hspX |
VF0301 |
HspX |
Stress survival |
VFC0282 |
|
(hspX) Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3) [HspX (VF0301) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985191.1_40 |
71.311 |
8.15E-114 |
devS |
VF0317 |
DevRS |
Regulation |
VFC0301 |
A two-component system consists of a histidine sensor kinase and a response regulator; phosphorylation-based signalling has been established for five of eleven systems in M. tuberculosis, RegX3-SenX3, TrcR-TrcS, MprA-MprB, PrrA-PrrB and DevR-DevS (DosR-DosS) |
(devS) two component sensor histidine kinase DevS [DevRS (VF0317) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985191.1_191 |
98.592 |
1.63E-49 |
mbtH |
VF0299 |
Mycobactin |
Nutritional/Metabolic factor |
VFC0272 |
Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. |
(mbtH) putative protein MbtH [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985191.1_192 |
100.0 |
0.0 |
mbtG |
VF0299 |
Mycobactin |
Nutritional/Metabolic factor |
VFC0272 |
Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. |
(mbtG) Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985191.1_193 |
99.932 |
0.0 |
mbtF |
VF0299 |
Mycobactin |
Nutritional/Metabolic factor |
VFC0272 |
Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. |
(mbtF) Peptide synthetase MbtF (peptide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985191.1_194 |
100.0 |
0.0 |
mbtE |
VF0299 |
Mycobactin |
Nutritional/Metabolic factor |
VFC0272 |
Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. |
(mbtE) Peptide synthetase MbtE (peptide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985191.1_195 |
99.153 |
3.07E-74 |
mbtD |
VF0299 |
Mycobactin |
Nutritional/Metabolic factor |
VFC0272 |
Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. |
(mbtD) Polyketide synthetase MbtD (polyketide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985191.1_196 |
99.534 |
0.0 |
mbtD |
VF0299 |
Mycobactin |
Nutritional/Metabolic factor |
VFC0272 |
Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. |
(mbtD) Polyketide synthetase MbtD (polyketide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985191.1_197 |
99.552 |
1.65E-148 |
mbtD |
VF0299 |
Mycobactin |
Nutritional/Metabolic factor |
VFC0272 |
Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. |
(mbtD) Polyketide synthetase MbtD (polyketide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985191.1_198 |
100.0 |
0.0 |
mbtC |
VF0299 |
Mycobactin |
Nutritional/Metabolic factor |
VFC0272 |
Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. |
(mbtC) Polyketide synthetase MbtC (polyketide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985191.1_199 |
99.929 |
0.0 |
mbtB |
VF0299 |
Mycobactin |
Nutritional/Metabolic factor |
VFC0272 |
Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. |
(mbtB) Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985191.1_200 |
100.0 |
0.0 |
mbtA |
VF0299 |
Mycobactin |
Nutritional/Metabolic factor |
VFC0272 |
Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. |
(mbtA) Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985191.1_201 |
100.0 |
0.0 |
mbtJ |
VF0299 |
Mycobactin |
Nutritional/Metabolic factor |
VFC0272 |
Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. |
(mbtJ) Putative acetyl hydrolase MbtJ [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985191.1_202 |
100.0 |
0.0 |
mbtI |
VF0299 |
Mycobactin |
Nutritional/Metabolic factor |
VFC0272 |
Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. |
(mbtI) Isochorismate synthase MbtI [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_67 |
62.025 |
6.94E-48 |
PPE4 |
VF0521 |
ESX-3 |
Effector delivery system |
VFC0086 |
|
(PPE4) PPE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_132 |
99.766 |
0.0 |
mptC |
VF0318 |
LAM |
Immune modulation |
VFC0258 |
A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) |
(mptC) alpha-(1-2)-phosphatidylinositol mannoside mannosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_301 |
93.617 |
7.23E-62 |
esxN |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_306 |
96.875 |
0.0 |
plcB |
VF0320 |
Phospholipase C |
Exotoxin |
VFC0235 |
Phospholipases can be divided into four groups depending on the position of the bond they hydrolyse on the phospholipid substrate: phospholipases A1, A2, C and D |
(plcB) membrane-associated phospholipase B [Phospholipase C (VF0320) - Exotoxin (VFC0235)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_307 |
100.0 |
0.0 |
plcC |
VF0320 |
Phospholipase C |
Exotoxin |
VFC0235 |
Phospholipases can be divided into four groups depending on the position of the bond they hydrolyse on the phospholipid substrate: phospholipases A1, A2, C and D |
(plcC) phospholipase C [Phospholipase C (VF0320) - Exotoxin (VFC0235)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_310 |
92.553 |
1.3E-60 |
esxN |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_344 |
99.865 |
0.0 |
katG |
VF0303 |
KatG |
Stress survival |
VFC0282 |
|
(katG) catalase-peroxidase [KatG (VF0303) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_370 |
100.0 |
0.0 |
fbpB |
VF0311 |
Antigen 85 |
Adherence |
VFC0001 |
Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp) |
(fbpB) Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_448 |
100.0 |
3.94E-171 |
mgtC |
VF0289 |
MgtC |
Nutritional/Metabolic factor |
VFC0272 |
Homology to MgtC of Salmonella enterica, which is essential for the survival of S.enterica within macrophages |
(mgtC) Possible Mg2+ transport P-type ATPase C MgtC [MgtC (VF0289) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_460 |
100.0 |
0.0 |
eccA5 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(eccA5) ESX-5 type VII secretion system AAA+ ATPase EccA5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_461 |
100.0 |
0.0 |
eccE5 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(eccE5) ESX-5 type VII secretion system EccE5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_462 |
100.0 |
0.0 |
mycP5 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(mycP5) ESX-5 type VII secretion system subtilisin-like serine protease MycP5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_463 |
100.0 |
0.0 |
eccD5 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(eccD5) ESX-5 type VII secretion system EccD5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_464 |
100.0 |
0.0 |
Rv1794 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(Rv1794) ESX-5 locus protein [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_465 |
100.0 |
1.0E-65 |
esxN |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_468 |
100.0 |
2.0E-62 |
PE19 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(PE19) PE family protein PE19 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_469 |
100.0 |
0.0 |
PPE27 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(PPE27) PPE family protein PPE27 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_470 |
99.746 |
0.0 |
PPE26 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(PPE26) PPE family protein PPE26 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_471 |
100.0 |
1.16E-62 |
PE18 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_472 |
95.068 |
0.0 |
PPE25 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(PPE25) PPE family protein PPE25 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_473 |
100.0 |
1.24E-45 |
Rv1786 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(Rv1786) ferredoxin [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_474 |
99.746 |
0.0 |
cyp143 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(cyp143) cytochrome P450 Cyp143 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_475 |
100.0 |
0.0 |
eccC5 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(eccC5) ESX-5 type VII secretion system FtsK/SpoIIIE family protein EccC5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_476 |
100.0 |
0.0 |
eccB5 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(eccB5) ESX-5 type VII secretion system protein EccB5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_594 |
60.592 |
5.6E-154 |
pks1 |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(pks1) polyketide synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985189.1_627 |
100.0 |
0.0 |
capA |
VF0318 |
LAM |
Immune modulation |
VFC0258 |
A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM) |
(capA) mannosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985187.1_68 |
68.724 |
1.52E-120 |
Rv2956 |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(Rv2956) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985187.1_76 |
64.014 |
0.0 |
fadD28 |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985187.1_83 |
68.354 |
0.0 |
pks2 |
VF0803 |
Sulfolipid-1 biosynthesis and transport |
Immune modulation |
VFC0258 |
|
(pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985187.1_84 |
72.964 |
0.0 |
pks2 |
VF0803 |
Sulfolipid-1 biosynthesis and transport |
Immune modulation |
VFC0258 |
|
(pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985187.1_86 |
65.641 |
0.0 |
fadD28 |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985185.1_32 |
100.0 |
1.05E-54 |
mbtL |
VF0299 |
Mycobactin |
Nutritional/Metabolic factor |
VFC0272 |
Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. |
(mbtL) Acyl carrier protein (ACP) MbtL [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985185.1_33 |
100.0 |
0.0 |
mbtM |
VF0299 |
Mycobactin |
Nutritional/Metabolic factor |
VFC0272 |
Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. |
(mbtM) Probable fatty acyl-AMP ligase MbtM [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985185.1_34 |
100.0 |
0.0 |
mbtN |
VF0299 |
Mycobactin |
Nutritional/Metabolic factor |
VFC0272 |
Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. |
(mbtN) Acyl-CoA dehydrogenase MbtN [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985185.1_35 |
100.0 |
3.18E-157 |
mbtK |
VF0299 |
Mycobactin |
Nutritional/Metabolic factor |
VFC0272 |
Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium. |
(mbtK) Lysine N-acetyltransferase MbtK [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985184.1_5 |
99.561 |
5.99E-163 |
mprA |
VF0298 |
MprAB |
Regulation |
VFC0301 |
MprB, sensor kinase, can undergo autophosphorylation. MprA, transcriptional factor, can accept phosphate from MprB or from small phosphodonors including acetyl phosphate |
(mprA) two-component response regulator MrpA [MprAB (VF0298) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985184.1_6 |
99.802 |
0.0 |
mprB |
VF0298 |
MprAB |
Regulation |
VFC0301 |
MprB, sensor kinase, can undergo autophosphorylation. MprA, transcriptional factor, can accept phosphate from MprB or from small phosphodonors including acetyl phosphate |
(mprB) two component histidine-protein kinase/phosphatase MprB [MprAB (VF0298) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985184.1_66 |
91.489 |
1.15E-59 |
esxN |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985184.1_205 |
100.0 |
0.0 |
narG |
VF0302 |
Nitrate reductase |
Nutritional/Metabolic factor |
VFC0272 |
NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein |
(narG) nitrate reductase subunit alpha [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985184.1_206 |
100.0 |
0.0 |
narH |
VF0302 |
Nitrate reductase |
Nutritional/Metabolic factor |
VFC0272 |
NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein |
(narH) nitrate reductase subunit beta [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985184.1_207 |
99.502 |
6.76E-145 |
narJ |
VF0302 |
Nitrate reductase |
Nutritional/Metabolic factor |
VFC0272 |
NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein |
(narJ) nitrate reductase subunit delta [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985184.1_208 |
100.0 |
0.0 |
narI |
VF0302 |
Nitrate reductase |
Nutritional/Metabolic factor |
VFC0272 |
NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein |
(narI) nitrate reductase subunit gamma [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985184.1_226 |
68.204 |
0.0 |
pks2 |
VF0803 |
Sulfolipid-1 biosynthesis and transport |
Immune modulation |
VFC0258 |
|
(pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985184.1_227 |
63.558 |
0.0 |
pks2 |
VF0803 |
Sulfolipid-1 biosynthesis and transport |
Immune modulation |
VFC0258 |
|
(pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985184.1_228 |
63.357 |
1.79E-173 |
pks2 |
VF0803 |
Sulfolipid-1 biosynthesis and transport |
Immune modulation |
VFC0258 |
|
(pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985184.1_232 |
62.003 |
0.0 |
fadD28 |
VF0309 |
PDIM |
Immune modulation |
VFC0258 |
Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM |
(fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985184.1_242 |
68.966 |
2.2E-29 |
PE18 |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985184.1_245 |
92.553 |
1.3E-60 |
esxN |
VF0402 |
ESX-5 |
Effector delivery system |
VFC0086 |
|
(esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985184.1_269 |
100.0 |
0.0 |
sigE |
VF0295 |
SigE |
Regulation |
VFC0301 |
SigE activity is downregulated by an anti-sigma factor, RseA, that is encoded by a gene Rv1222, adjacent to sigE |
(sigE) ECF RNA polymerase sigma factor SigE [SigE (VF0295) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985183.1_6 |
100.0 |
0.0 |
mprB |
VF0298 |
MprAB |
Regulation |
VFC0301 |
MprB, sensor kinase, can undergo autophosphorylation. MprA, transcriptional factor, can accept phosphate from MprB or from small phosphodonors including acetyl phosphate |
(mprB) two component histidine-protein kinase/phosphatase MprB [MprAB (VF0298) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985182.1_40 |
71.091 |
3.82E-170 |
tufA |
VF0460 |
EF-Tu |
Adherence |
VFC0001 |
|
(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| DS985182.1_118 |
99.552 |
4.08E-163 |
phoP |
VF0286 |
PhoP |
Regulation |
VFC0301 |
Similar to the PhoP response regulator of S. enteric serovar Typhimurium that senses Mg2+ starvation and controls the expression of virulence genes |
(phoP) Possible two component system response transcriptional positive regulator PhoP [PhoP (VF0286) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985182.1_119 |
99.588 |
0.0 |
phoR |
VF0286 |
PhoP |
Regulation |
VFC0301 |
Similar to the PhoP response regulator of S. enteric serovar Typhimurium that senses Mg2+ starvation and controls the expression of virulence genes |
(phoR) Possible two component system response sensor kinase membrane associated PhoR [PhoP (VF0286) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985182.1_359 |
98.901 |
6.99E-58 |
mprA |
VF0298 |
MprAB |
Regulation |
VFC0301 |
MprB, sensor kinase, can undergo autophosphorylation. MprA, transcriptional factor, can accept phosphate from MprB or from small phosphodonors including acetyl phosphate |
(mprA) two-component response regulator MrpA [MprAB (VF0298) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985181.1_185 |
100.0 |
0.0 |
mmaA4 |
VF0314 |
MmaA4 |
Others |
VFC0346 |
|
(mmaA4) hydroxymycolate synthase MmaA4 [MmaA4 (VF0314) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985181.1_186 |
64.26 |
1.33E-136 |
pcaA |
VF0285 |
PcaA |
Others |
VFC0346 |
Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate |
(pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985181.1_187 |
72.125 |
2.22E-152 |
pcaA |
VF0285 |
PcaA |
Others |
VFC0346 |
Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate |
(pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985180.1_19 |
100.0 |
7.04E-90 |
hspR |
VF0297 |
HspR |
Regulation |
VFC0301 |
|
(hspR) heat shock protein transcriptional repressor HspR [HspR (VF0297) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985180.1_103 |
100.0 |
1.03E-174 |
sodC |
VF0305 |
SodC |
Stress survival |
VFC0282 |
|
(sodC) superoxide dismutase [SodC (VF0305) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985180.1_111 |
64.272 |
0.0 |
groEL |
VF0594 |
GroEL |
Adherence |
VFC0001 |
GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. |
(groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] |
Clostridium difficile |
| DS985180.1_140 |
100.0 |
0.0 |
icl |
VF0253 |
Isocitrate lyase |
Others |
VFC0346 |
|
(icl) Isocitrate lyase Icl (isocitrase) (isocitratase) [Isocitrate lyase (VF0253) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985180.1_143 |
100.0 |
0.0 |
pcaA |
VF0285 |
PcaA |
Others |
VFC0346 |
Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate |
(pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| DS985180.1_149 |
100.0 |
4.37E-137 |
hbhA |
VF0313 |
HbhA |
Adherence |
VFC0001 |
Surface-located protein |
(hbhA) iron-regulated heparin binding hemagglutinin hbhA (adhesin) [HbhA (VF0313) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |