病原微生物综合分析云平台

Basic Information

Accession number

GCA_000155225.1

Release date

2008-06-06

Organism

Mycobacterium tuberculosis EAS054

Species name

Mycobacterium tuberculosis

Assembly level

Scaffold

Assembly name

ASM15522v1

Assembly submitter

Broad Institute

Assembly Type

haploid

Genome size

4.4 Mb

GC percent

65.5

Contig count

125

Collection date

Sample location

Host

Isolation source

Isolate type

Strain

EAS054

Isolate

ARG List

ORF_ID	Pass_Bitscore	Best_Hit_Bitscore	Best_Hit_ARO	Best_Identities	ARO	Model_type	SNPs_in_Best_Hit_ARO	Drug class	Resistance mechanism	AMR gene family	Description
DS985169.1_722 # 780475 # 781020	300.0	365.925	AAC(2')-Ic	100.0	ARO:3002525	protein homolog model		aminoglycoside antibiotic	antibiotic inactivation	AAC(2')	AAC(2')-Ic is a chromosomal-encoded aminoglycoside acetyltransferase in M. tuberculosis and Mycobacterium tuberculosis variant bovis.
DS985167.1_300 # 279813 # 281405	1000.0	1046.96	efpA	100.0	ARO:3003955	protein homolog model		rifamycin antibiotic; isoniazid-like antibiotic	antibiotic efflux	major facilitator superfamily (MFS) antibiotic efflux pump	efpA is an MFS transporter found in Mycobacterium tuberculosis.
DS985167.1_866 # 901967 # 902518	350.0	363.999	mfpA	100.0	ARO:3003035	protein homolog model		fluoroquinolone antibiotic	antibiotic target protection	quinolone resistance protein (qnr)	mfpA is a qnr homolog and a pentapeptide repeat protein that confers resistance to fluoroquinolones in Mycolicibacterium smegmatis.
DS985165.1_1362 # 1415141 # 1416064	500.0	619.772	blaC	100.0	ARO:3007182	protein homolog model		cephalosporin; cephamycin; penam; penem	antibiotic inactivation	class A Mycobacterium tuberculosis bla beta-lactamase	blaC is a broad-spectrum class A beta-lactamase coded in the chromosome of Mycobacterium tuberculosis. It has been shown to hydrolyze a large number of beta-lactam antibiotics and is a major obstacle in the treatment of tuberculosis with such drugs.
DS985169.1_290 # 296553 # 299837	2000.0	2160.96	Mycobacterium tuberculosis embA mutant conferring resistance to ethambutol	99.73	ARO:3003453	protein variant model	P913S	polyamine antibiotic	antibiotic target alteration	ethambutol resistant embA	Specific mutations that occurs on Mycobacterium tuberculosis embA leading to the lowered affinity of ethambutol to embA.
DS985169.1_291 # 299834 # 303130	2000.0	2187.92	Mycobacterium tuberculosis embB mutant conferring resistance to ethambutol	99.91	ARO:3003326	protein variant model	E378A	polyamine antibiotic	antibiotic target alteration	ethambutol resistant embB	Point mutations that occur within Mycobacterium tuberculosis embB gene resulting in resistance to ethambutol.
DS985165.1_485 # 496199 # 497365	700.0	787.719	Mycobacterium tuberculosis embR mutant conferring resistance to ethambutol	99.74	ARO:3003455	protein variant model	C110Y	polyamine antibiotic	antibiotic target alteration	ethambutol resistant embR	Point mutation in the M.tuberculosis embR results in increased resistance to ethambutol.
DS985165.1_537 # 550436 # 551692	750.0	842.803	Mycobacterium tuberculosis intrinsic murA conferring resistance to fosfomycin	100.0	ARO:3003784	protein variant model	C117D	phosphonic acid antibiotic	antibiotic target alteration	antibiotic-resistant murA transferase	Mycobacterium tuberculosis murA confers intrinsic resistance to fosfomycin. The presence of an aspartic acid residue in place of the critical cysteine at position 117 that enables fosfomycin binding is believed to be responsible for this intrinsic resistance.
DS985165.1_1177 # 1238953 # 1241175	1400.0	1510.35	Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid	99.86	ARO:3003392	protein variant model	R463L, A234G, A431V, G300W	isoniazid-like antibiotic	antibiotic target alteration	isoniazid resistant katG	katG is a catalase-peroxidase that catalyzes the activation of isoniazid. Isoniazid inhibits mycolic acid synthesis, which prevents cell wall synthesis in mycobacteria. Mutations in katG results in inability to activate isoniazid. Over 280 different mutations have been documented in PubMed for katG, with mutations to Ser315 being the most prevalent.
DS985164.1_421 # 428398 # 431916	2300.0	2395.54	Mycobacterium tuberculosis rpoB mutants conferring resistance to rifampicin	100.0	ARO:3003283	protein variant model	D516G, H526T, L511R	rifamycin antibiotic	antibiotic target alteration; antibiotic target replacement	rifamycin-resistant beta-subunit of RNA polymerase (rpoB)	Point mutations that occurs in Mycobacterium tuberculosis rpoB resulting in resistance to rifampicin.

VF List

Query_id	%Identity	E-value	Related genes	VF ID	Virulence factor	VFcategory	VFcategoryID	Characteristics	Description	Strain
DS985169.1_90	100.0	9.1E-100	panD	VF0319	PanC/PanD	Nutritional/Metabolic factor	VFC0272		(panD) aspartate 1-decarboxylase [PanC/PanD (VF0319) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_91	100.0	0.0	panC	VF0319	PanC/PanD	Nutritional/Metabolic factor	VFC0272		(panC) pantothenate synthetase [PanC/PanD (VF0319) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_101	99.457	5.84E-134	espD	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(espD) ESX-1 type VII secretion system EspD [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_102	100.0	1.42E-73	espC	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(espC) ESX-1 type VII secretion system EspC [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_103	99.745	0.0	espA	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(espA) ESX-1 type VII secretion system EspA [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_106	90.426	1.13E-58	esxN	VF0402	ESX-5	Effector delivery system	VFC0086		(esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_109	62.069	3.6E-26	PE18	VF0402	ESX-5	Effector delivery system	VFC0086		(PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_137	60.256	2.63E-17	PE18	VF0402	ESX-5	Effector delivery system	VFC0086		(PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_289	98.254	0.0	embC	VF0318	LAM	Immune modulation	VFC0258	A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM)	(embC) arabinosyltransferase C [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_300	100.0	0.0	fbpD	VF0311	Antigen 85	Adherence	VFC0001	Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp)	(fbpD) MPT51/MPB51 antigen [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_301	100.0	0.0	fbpA	VF0311	Antigen 85	Adherence	VFC0001	Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp)	(fbpA) Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_302	100.0	0.0	aftB	VF0318	LAM	Immune modulation	VFC0258	A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM)	(aftB) terminal beta-(1->2)-arabinofuranosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_307	100.0	0.0	erp	VF0312	Erp	Others	VFC0346	Surface-located protein;No homologue of Erp has been found in other bacterial species, making Erp a mycobacterial signature	(erp) exported repetitive protein precursor Erp [Erp (VF0312) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_319	99.786	0.0	papA2	VF0803	Sulfolipid-1 biosynthesis and transport	Immune modulation	VFC0258		(papA2) trehalose-2-sulfate acyltransferase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_322	99.725	0.0	mmpL8	VF0803	Sulfolipid-1 biosynthesis and transport	Immune modulation	VFC0258		(mmpL8) integral membrane transport protein MmpL8 [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_323	100.0	0.0	papA1	VF0803	Sulfolipid-1 biosynthesis and transport	Immune modulation	VFC0258		(papA1) acyltransferase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_324	99.952	0.0	pks2	VF0803	Sulfolipid-1 biosynthesis and transport	Immune modulation	VFC0258		(pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_325	66.207	0.0	fadD28	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_349	100.0	1.71E-154	sodA	VF0304	SodA	Stress survival	VFC0282		(sodA) superoxide dismutase [SodA (VF0304) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_352	100.0	6.88E-98	espR	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(espR) ESX-1 transcriptional regulator EspR [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_367	96.172	0.0	espE	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(espE) ESX-1 secretion-associated protein EspE [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_368	100.0	3.55E-71	espF	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(espF) ESX-1 secretion-associated protein EspF [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_369	100.0	0.0	espG1	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(espG1) ESX-1 secretion-associated protein EspG1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_370	100.0	2.46E-132	espH	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(espH) ESX-1 secretion-associated protein EspH [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_371	99.825	0.0	eccA1	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(eccA1) ESX-1 type VII secretion system AAA+ ATPase EccA1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_372	100.0	0.0	eccB1	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(eccB1) ESX-1 type VII secretion system protein EccB1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_373	100.0	0.0	eccCa1	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(eccCa1) ESX-1 type VII secretion system FtsK/SpoIIIE family protein EccCa1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_374	100.0	0.0	eccCb1	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(eccCb1) ESX-1 type VII secretion system FtsK/SpoIIIE family protein EccCb1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_375	100.0	1.44E-66	PE35	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(PE35) PE family-related protein PE35 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_376	99.728	0.0	PPE68	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(PPE68) PPE family protein [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_377	100.0	2.88E-68	esxB	VF0310	ESAT-6/CFP-10	Effector delivery system	VFC0086	Secreted protein; ESAT-6 and CFP-10 proteins are cotranscribed and form a tight 1:1 complex	(esxB) 10 kDa culture filtrate antigen EsxB (CFP-10) [ESAT-6/CFP-10 (VF0310) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_378	100.0	1.09E-64	esxA	VF0310	ESAT-6/CFP-10	Effector delivery system	VFC0086	Secreted protein; ESAT-6 and CFP-10 proteins are cotranscribed and form a tight 1:1 complex	(esxA) 6 kDa early secretory antigenic target EsxA (ESAT-6) [ESAT-6/CFP-10 (VF0310) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_380	99.675	0.0	espI	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(espI) ESX-1 secretion-associated protein EspI [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_381	99.795	0.0	eccD1	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(eccD1) ESX-1 type VII secretion system EccD1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_382	100.0	1.9E-33	espJ	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(espJ) ESX-1 secretion associated protein EspJ [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_383	100.0	3.53E-142	espJ	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(espJ) ESX-1 secretion associated protein EspJ [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_384	97.715	0.0	espK	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(espK) ESX-1 type VII secretion system EspK [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_385	100.0	6.08E-81	espL	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(espL) ESX-1 secretion associated protein EspL [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_386	99.528	2.94E-146	espB	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(espB) ESX-1 type VII secretion system EspB [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_387	100.0	6.97E-177	espB	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(espB) ESX-1 type VII secretion system EspB [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_388	100.0	1.35E-22	eccE1	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(eccE1) ESX-1 type VII secretion system EccE1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_389	97.744	5.59E-90	eccE1	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(eccE1) ESX-1 type VII secretion system EccE1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_390	95.238	1.54E-65	eccE1	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(eccE1) ESX-1 type VII secretion system EccE1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_391	99.776	0.0	mycP1	VF0315	ESX-1	Effector delivery system	VFC0086	The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species.; All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion.	(mycP1) ESX-1 type VII secretion system subtilisin-like serine protease MycP1 [ESX-1 (VF0315) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_415	99.855	0.0	cpnT	VF1197	CpnT	Effector delivery system	VFC0086	Secreted by ESX-5; CpnT is a two-domain protein in which the toxic activity resides in the C-terminus.	(cpnT) NAD+ glycohydrolase [CpnT (VF1197) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_416	99.18	5.92E-54	cpnT	VF1197	CpnT	Effector delivery system	VFC0086	Secreted by ESX-5; CpnT is a two-domain protein in which the toxic activity resides in the C-terminus.	(cpnT) NAD+ glycohydrolase [CpnT (VF1197) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_577	100.0	0.0	fbpC	VF0311	Antigen 85	Adherence	VFC0001	Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp)	(fbpC) Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985169.1_693	99.929	0.0	aftD	VF0318	LAM	Immune modulation	VFC0258	A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM)	(aftD) alpha-(1->3)-arabinofuranosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_47	100.0	0.0	relA	VF0287	RelA	Regulation	VFC0301		(relA) Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) [RelA (VF0287) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_152	100.0	6.78E-119	sigA/rpoV	VF0257	SigA	Regulation	VFC0301	In M. tuberculosis, 13 sigma factor genes have been annotated in the genome, 9 of which belong to a special subfamily thought to direct extracytoplasmic functions and various other stress responses (temperature, oxidative stress, pH, and infection of macrophages); sigma A also known as RpoV, is the essential principal mycobacterial sigma factors, necessary for most mycobacterial housekeeping gene transcription; It was the first mycobacterial sigma factor to be associated with virulence	(sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_159	62.857	7.43E-135	sigA/rpoV	VF0257	SigA	Regulation	VFC0301	In M. tuberculosis, 13 sigma factor genes have been annotated in the genome, 9 of which belong to a special subfamily thought to direct extracytoplasmic functions and various other stress responses (temperature, oxidative stress, pH, and infection of macrophages); sigma A also known as RpoV, is the essential principal mycobacterial sigma factors, necessary for most mycobacterial housekeeping gene transcription; It was the first mycobacterial sigma factor to be associated with virulence	(sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_160	100.0	1.59E-166	ideR	VF0300	IdeR	Regulation	VFC0301	A DNA binding protein interacts with a conserved DNA sequence requires the binding of Fe2+ or related divalent cations	(ideR) Iron-dependent repressor and activator IdeR [IdeR (VF0300) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_390	100.0	0.0	tesA	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(tesA) thioesterase TesA [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_391	99.828	0.0	fadD26	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(fadD26) fatty-acid--CoA ligase FadD26 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_392	99.622	0.0	ppsA	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(ppsA) phthiocerol synthesis polyketide synthase type I PpsA [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_393	100.0	0.0	ppsA	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(ppsA) phthiocerol synthesis polyketide synthase type I PpsA [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_394	99.935	0.0	ppsB	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(ppsB) phthiocerol synthesis polyketide synthase type I PpsB [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_395	100.0	0.0	ppsC	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(ppsC) phthiocerol synthesis polyketide synthase type I PpsC [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_396	99.836	0.0	ppsD	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(ppsD) phthiocerol synthesis polyketide synthase type I PpsD [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_397	99.933	0.0	ppsE	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(ppsE) phthiocerol synthesis polyketide synthase type I PpsE [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_398	99.698	0.0	ddrA	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(ddrA) daunorubicin ABC transporter ATP-binding protein DrrA [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_399	100.0	0.0	ddrB	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(ddrB) daunorubicin ABC transporter permease DrrB [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_400	100.0	0.0	drrC	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(drrC) daunorubicin ABC transporter permease DrrC [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_401	100.0	0.0	papA5	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(papA5) phthiocerol/phthiodiolone dimycocerosyl transferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_402	99.953	0.0	mas	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(mas) multifunctional mycocerosic acid synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_403	100.0	0.0	fadD28	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_404	100.0	0.0	mmpL7	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(mmpL7) transmembrane transport protein MmpL7 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_408	100.0	4.35E-170	lppx	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(lppx) lipoprotein LppX [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_410	99.932	0.0	pks1	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(pks1) polyketide synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_412	99.858	0.0	fadD22	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(fadD22) p-hydroxybenzoyl--AMP ligase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_413	100.0	1.87E-148	Rv2949c	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(Rv2949c) chorismate pyruvate-lyase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_414	100.0	0.0	fadD29	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(fadD29) long-chain-fatty-acid--AMP ligase FadD29 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_415	100.0	0.0	Rv2951c	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(Rv2951c) phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_416	100.0	0.0	Rv2952	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(Rv2952) phthiotriol/phenolphthiotriol dimycocerosates methyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_417	99.043	0.0	Rv2953	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(Rv2953) trans-acting enoyl reductase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_418	100.0	0.0	Rv2954c	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(Rv2954c) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_419	100.0	0.0	Rv2955c	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(Rv2955c) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_420	100.0	3.27E-90	Rv2956	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(Rv2956) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_421	100.0	0.0	Rv2957	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(Rv2957) PGL/p-HBAD biosynthesis glycosyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_423	100.0	0.0	Rv2958c	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(Rv2958c) PGL/p-HBAD biosynthesis glycosyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_424	100.0	0.0	Rv2959c	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(Rv2959c) rhamnosyl O-methyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_426	99.351	4.46E-104	Rv2962c	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(Rv2962c) PGL/p-HBAD biosynthesis rhamnosyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_427	100.0	0.0	Rv2962c	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(Rv2962c) PGL/p-HBAD biosynthesis rhamnosyltransferase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_603	99.827	0.0	devS	VF0317	DevRS	Regulation	VFC0301	A two-component system consists of a histidine sensor kinase and a response regulator; phosphorylation-based signalling has been established for five of eleven systems in M. tuberculosis, RegX3-SenX3, TrcR-TrcS, MprA-MprB, PrrA-PrrB and DevR-DevS (DosR-DosS)	(devS) two component sensor histidine kinase DevS [DevRS (VF0317) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_604	100.0	9.56E-155	devR/dosR	VF0317	DevRS	Regulation	VFC0301	A two-component system consists of a histidine sensor kinase and a response regulator; phosphorylation-based signalling has been established for five of eleven systems in M. tuberculosis, RegX3-SenX3, TrcR-TrcS, MprA-MprB, PrrA-PrrB and DevR-DevS (DosR-DosS)	(devR/dosR) two component transcriptional regulator DevR [DevRS (VF0317) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_708	100.0	4.28E-162	sigH	VF0296	SigH	Regulation	VFC0301	Similar to the sigma R of Streptomyces species; sigma H activity is regulated at the posttranslational level by a cystein-containing anti-sigma factor RsrA, encoded by a gene in the sigH operon; the ability of RshA to inhibit SigH-dependent transcription is redox-dependent	(sigH) ECF RNA polymerase sigma factor SigH [SigH (VF0296) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_775	99.583	2.56E-174	sigF	VF0294	SigF	Regulation	VFC0301		(sigF) RNA polymerase sigma factor SigF [SigF (VF0294) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_902	72.822	8.33E-159	pcaA	VF0285	PcaA	Others	VFC0346	Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate	(pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_930	100.0	9.92E-74	whiB3	VF0288	WhiB3	Regulation	VFC0301	Seven members of the WhiB family in M. tuberculosis H37Rv, homolog of the Streptomyces coelicolor whiB gene, a transcription factor whose function is required for sporulation process	(whiB3) redox-responsive transcriptional regulator WhiB3 [WhiB3 (VF0288) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_993	65.517	1.01E-25	PE18	VF0402	ESX-5	Effector delivery system	VFC0086		(PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985167.1_1003	99.278	0.0	lipF	VF0307	LipF	Nutritional/Metabolic factor	VFC0272		(lipF) Probable esterase/lipase LipF [LipF (VF0307) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_166	99.123	4.46E-162	mprA	VF0298	MprAB	Regulation	VFC0301	MprB, sensor kinase, can undergo autophosphorylation. MprA, transcriptional factor, can accept phosphate from MprB or from small phosphodonors including acetyl phosphate	(mprA) two-component response regulator MrpA [MprAB (VF0298) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_167	99.469	0.0	mprB	VF0298	MprAB	Regulation	VFC0301	MprB, sensor kinase, can undergo autophosphorylation. MprA, transcriptional factor, can accept phosphate from MprB or from small phosphodonors including acetyl phosphate	(mprB) two component histidine-protein kinase/phosphatase MprB [MprAB (VF0298) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_229	91.489	1.15E-59	esxN	VF0402	ESX-5	Effector delivery system	VFC0086		(esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_282	60.0	1.5E-19	PE18	VF0402	ESX-5	Effector delivery system	VFC0086		(PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_370	100.0	0.0	narG	VF0302	Nitrate reductase	Nutritional/Metabolic factor	VFC0272	NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein	(narG) nitrate reductase subunit alpha [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_371	100.0	0.0	narH	VF0302	Nitrate reductase	Nutritional/Metabolic factor	VFC0272	NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein	(narH) nitrate reductase subunit beta [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_372	99.502	6.76E-145	narJ	VF0302	Nitrate reductase	Nutritional/Metabolic factor	VFC0272	NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein	(narJ) nitrate reductase subunit delta [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_373	100.0	0.0	narI	VF0302	Nitrate reductase	Nutritional/Metabolic factor	VFC0272	NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein	(narI) nitrate reductase subunit gamma [Nitrate reductase (VF0302) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_391	65.033	0.0	pks2	VF0803	Sulfolipid-1 biosynthesis and transport	Immune modulation	VFC0258		(pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_395	62.003	0.0	fadD28	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_406	68.966	2.2E-29	PE18	VF0402	ESX-5	Effector delivery system	VFC0086		(PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_409	91.489	9.57E-60	esxN	VF0402	ESX-5	Effector delivery system	VFC0086		(esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_435	100.0	1.29E-158	sigE	VF0295	SigE	Regulation	VFC0301	SigE activity is downregulated by an anti-sigma factor, RseA, that is encoded by a gene Rv1222, adjacent to sigE	(sigE) ECF RNA polymerase sigma factor SigE [SigE (VF0295) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_572	100.0	1.05E-54	mbtL	VF0299	Mycobactin	Nutritional/Metabolic factor	VFC0272	Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium.	(mbtL) Acyl carrier protein (ACP) MbtL [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_573	100.0	0.0	mbtM	VF0299	Mycobactin	Nutritional/Metabolic factor	VFC0272	Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium.	(mbtM) Probable fatty acyl-AMP ligase MbtM [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_574	100.0	0.0	mbtN	VF0299	Mycobactin	Nutritional/Metabolic factor	VFC0272	Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium.	(mbtN) Acyl-CoA dehydrogenase MbtN [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_575	100.0	3.18E-157	mbtK	VF0299	Mycobactin	Nutritional/Metabolic factor	VFC0272	Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium.	(mbtK) Lysine N-acetyltransferase MbtK [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_614	68.041	2.09E-24	PE5	VF0521	ESX-3	Effector delivery system	VFC0086		(PE5) PE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_757	68.724	1.52E-120	Rv2956	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(Rv2956) hypothetical protein [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_765	64.014	0.0	fadD28	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_771	69.289	0.0	pks2	VF0803	Sulfolipid-1 biosynthesis and transport	Immune modulation	VFC0258		(pks2) phthioceranic/hydroxyphthioceranic acid synthase [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_776	65.641	0.0	fadD28	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(fadD28) long-chain-fatty-acid--AMP ligase FadD28 [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_885	100.0	0.0	capA	VF0318	LAM	Immune modulation	VFC0258	A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM)	(capA) mannosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_903	95.411	0.0	PE_PGRS30	VF0316	PE/PE-PGRS	Immune modulation	VFC0258	PE family members are characterized by highly conserved N-terminal Pro-Glu motif, PE-PGRS proteins have tandem repetitions of Gly-Gly-Ala or Gly-Gly-Asn termed the PGRS domain (polymorphic GC-rich repetitive sequence) near C-terminal; PE family members have been found in all the sequenced Mycobacterium genomes, although their number is highly variable	(PE_PGRS30) PE-PGRS family protein PE_PGRS30 [PE/PE-PGRS (VF0316) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_917	69.849	2.25E-83	pks1	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(pks1) polyketide synthase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1017	71.624	0.0	plcA	VF0320	Phospholipase C	Exotoxin	VFC0235	Phospholipases can be divided into four groups depending on the position of the bond they hydrolyse on the phospholipid substrate: phospholipases A1, A2, C and D	(plcA) membrane-associated phospholipase A [Phospholipase C (VF0320) - Exotoxin (VFC0235)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1047	100.0	0.0	eccB5	VF0402	ESX-5	Effector delivery system	VFC0086		(eccB5) ESX-5 type VII secretion system protein EccB5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1048	99.928	0.0	eccC5	VF0402	ESX-5	Effector delivery system	VFC0086		(eccC5) ESX-5 type VII secretion system FtsK/SpoIIIE family protein EccC5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1049	100.0	0.0	cyp143	VF0402	ESX-5	Effector delivery system	VFC0086		(cyp143) cytochrome P450 Cyp143 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1050	100.0	1.24E-45	Rv1786	VF0402	ESX-5	Effector delivery system	VFC0086		(Rv1786) ferredoxin [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1051	99.726	0.0	PPE25	VF0402	ESX-5	Effector delivery system	VFC0086		(PPE25) PPE family protein PPE25 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1052	100.0	1.16E-62	PE18	VF0402	ESX-5	Effector delivery system	VFC0086		(PE18) PE family protein PE18 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1053	100.0	0.0	PPE26	VF0402	ESX-5	Effector delivery system	VFC0086		(PPE26) PPE family protein PPE26 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1054	100.0	0.0	PPE27	VF0402	ESX-5	Effector delivery system	VFC0086		(PPE27) PPE family protein PPE27 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1055	100.0	2.0E-62	PE19	VF0402	ESX-5	Effector delivery system	VFC0086		(PE19) PE family protein PE19 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1057	100.0	1.0E-65	esxN	VF0402	ESX-5	Effector delivery system	VFC0086		(esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1058	100.0	0.0	Rv1794	VF0402	ESX-5	Effector delivery system	VFC0086		(Rv1794) ESX-5 locus protein [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1059	100.0	0.0	eccD5	VF0402	ESX-5	Effector delivery system	VFC0086		(eccD5) ESX-5 type VII secretion system EccD5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1060	100.0	0.0	mycP5	VF0402	ESX-5	Effector delivery system	VFC0086		(mycP5) ESX-5 type VII secretion system subtilisin-like serine protease MycP5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1061	99.754	0.0	eccE5	VF0402	ESX-5	Effector delivery system	VFC0086		(eccE5) ESX-5 type VII secretion system EccE5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1062	100.0	0.0	eccA5	VF0402	ESX-5	Effector delivery system	VFC0086		(eccA5) ESX-5 type VII secretion system AAA+ ATPase EccA5 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1074	100.0	3.94E-171	mgtC	VF0289	MgtC	Nutritional/Metabolic factor	VFC0272	Homology to MgtC of Salmonella enterica, which is essential for the survival of S.enterica within macrophages	(mgtC) Possible Mg2+ transport P-type ATPase C MgtC [MgtC (VF0289) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1150	100.0	0.0	fbpB	VF0311	Antigen 85	Adherence	VFC0001	Three homologous proteins: antigen 85A, 85B and 85C, also known as fibronectin-binding protein (Fbp)	(fbpB) Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) [Antigen 85 (VF0311) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1177	99.865	0.0	katG	VF0303	KatG	Stress survival	VFC0282		(katG) catalase-peroxidase [KatG (VF0303) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1318	62.5	0.0	devS	VF0317	DevRS	Regulation	VFC0301	A two-component system consists of a histidine sensor kinase and a response regulator; phosphorylation-based signalling has been established for five of eleven systems in M. tuberculosis, RegX3-SenX3, TrcR-TrcS, MprA-MprB, PrrA-PrrB and DevR-DevS (DosR-DosS)	(devS) two component sensor histidine kinase DevS [DevRS (VF0317) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1322	100.0	1.49E-104	hspX	VF0301	HspX	Stress survival	VFC0282		(hspX) Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3) [HspX (VF0301) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1480	100.0	0.0	mptC	VF0318	LAM	Immune modulation	VFC0258	A prominent component of the mycobacterial cell envelope, a phosphatidylinositol-anchored lipoglycan composed of a mannan core with oligoarabinosyl-containing side-chains with diverse biological activities; three major structural classes: ManLAM (mannose capping arabinan termini), AraLAM (lacks mannosylation in arabinan termini), PILAM (phospho-myo-inositol-capped LAM)	(mptC) alpha-(1-2)-phosphatidylinositol mannoside mannosyltransferase [LAM (VF0318) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1652	100.0	1.0E-65	esxN	VF0402	ESX-5	Effector delivery system	VFC0086		(esxN) ESX-5 type VII secretion system EsxA (ESAT-6) homolog [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1655	100.0	0.0	plcC	VF0320	Phospholipase C	Exotoxin	VFC0235	Phospholipases can be divided into four groups depending on the position of the bond they hydrolyse on the phospholipid substrate: phospholipases A1, A2, C and D	(plcC) phospholipase C [Phospholipase C (VF0320) - Exotoxin (VFC0235)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1656	100.0	0.0	plcB	VF0320	Phospholipase C	Exotoxin	VFC0235	Phospholipases can be divided into four groups depending on the position of the bond they hydrolyse on the phospholipid substrate: phospholipases A1, A2, C and D	(plcB) membrane-associated phospholipase B [Phospholipase C (VF0320) - Exotoxin (VFC0235)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1657	100.0	0.0	plcA	VF0320	Phospholipase C	Exotoxin	VFC0235	Phospholipases can be divided into four groups depending on the position of the bond they hydrolyse on the phospholipid substrate: phospholipases A1, A2, C and D	(plcA) membrane-associated phospholipase A [Phospholipase C (VF0320) - Exotoxin (VFC0235)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1682	98.592	1.63E-49	mbtH	VF0299	Mycobactin	Nutritional/Metabolic factor	VFC0272	Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium.	(mbtH) putative protein MbtH [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1683	100.0	0.0	mbtG	VF0299	Mycobactin	Nutritional/Metabolic factor	VFC0272	Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium.	(mbtG) Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1684	99.932	0.0	mbtF	VF0299	Mycobactin	Nutritional/Metabolic factor	VFC0272	Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium.	(mbtF) Peptide synthetase MbtF (peptide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1685	100.0	0.0	mbtE	VF0299	Mycobactin	Nutritional/Metabolic factor	VFC0272	Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium.	(mbtE) Peptide synthetase MbtE (peptide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1686	100.0	0.0	mbtD	VF0299	Mycobactin	Nutritional/Metabolic factor	VFC0272	Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium.	(mbtD) Polyketide synthetase MbtD (polyketide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1687	100.0	0.0	mbtC	VF0299	Mycobactin	Nutritional/Metabolic factor	VFC0272	Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium.	(mbtC) Polyketide synthetase MbtC (polyketide synthase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1688	100.0	0.0	mbtB	VF0299	Mycobactin	Nutritional/Metabolic factor	VFC0272	Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium.	(mbtB) Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1689	100.0	0.0	mbtA	VF0299	Mycobactin	Nutritional/Metabolic factor	VFC0272	Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium.	(mbtA) Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1690	100.0	0.0	mbtJ	VF0299	Mycobactin	Nutritional/Metabolic factor	VFC0272	Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium.	(mbtJ) Putative acetyl hydrolase MbtJ [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1691	100.0	0.0	mbtI	VF0299	Mycobactin	Nutritional/Metabolic factor	VFC0272	Mycobacteria produce two classes of siderophores, mycobactins and the exochelins. Pathogenic mycobacteria solely produce mycobactins, whereas saprophytic mycobacteria such as M. smegmatis and Mycobacterium neoarum produce both mycobactins and exochelins; Mycobactins are salicylate containing siderophores, and exochelins are peptidic molecules; Mycobactins are found in two forms that differ in the length of an alkyl substitution and hence in polarity and solubility. The less polar form remains cell associated (mycobactin), whereas the more polar one (carboxymycobactin) is secreted into the medium.	(mbtI) Isochorismate synthase MbtI [Mycobactin (VF0299) - Nutritional/Metabolic factor (VFC0272)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1736	100.0	2.49E-146	ahpC	VF0306	AhpC	Stress survival	VFC0282		(ahpC) alkyl hydroperoxide reductase subunit AhpC [AhpC (VF0306) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1738	100.0	1.15E-145	PPE41	VF0402	ESX-5	Effector delivery system	VFC0086		(PPE41) PPE family protein PPE41 [ESX-5 (VF0402) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985165.1_1756	67.542	0.0	Rv2953	VF0309	PDIM	Immune modulation	VFC0258	Major lipid, also referred as ball of wax; mas (mycocerosic acid synthase catalyzing the synthesis of long-chain, multiply methylated branched fatty acid, called mycocerosic acid), fadD26 and fadD28 (long-chain fatty acyl-AMP ligases) are essential for the biosynthesis of PDIM; drrC and mmpL7 gene are necessary for the proper localization of PDIM	(Rv2953) trans-acting enoyl reductase [PDIM (VF0309) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_7	99.842	0.0	eccA3	VF0521	ESX-3	Effector delivery system	VFC0086		(eccA3) Type VII secretion system protein EccA3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_8	100.0	0.0	eccB3	VF0521	ESX-3	Effector delivery system	VFC0086		(eccB3) Type VII secretion system protein EccB3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_9	99.454	0.0	eccC3	VF0521	ESX-3	Effector delivery system	VFC0086		(eccC3) Type VII secretion system protein EccC3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_10	100.0	2.51E-63	PE5	VF0521	ESX-3	Effector delivery system	VFC0086		(PE5) PE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_11	99.805	0.0	PPE4	VF0521	ESX-3	Effector delivery system	VFC0086		(PPE4) PPE family protein [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_12	100.0	8.84E-64	esxG	VF1196	EsxG-EsxH	Effector delivery system	VFC0086	EsxG-EsxH heterodimer is secreted by ESX-3.	(esxG) Type VII secretion system protein EsxG [EsxG-EsxH (VF1196) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_13	100.0	2.41E-66	esxH	VF1196	EsxG-EsxH	Effector delivery system	VFC0086	EsxG-EsxH heterodimer is secreted by ESX-3.	(esxH) Type VII secretion system protein ESXH (10 kDa antigen) (CFP-7) (protein TB10.4) [EsxG-EsxH (VF1196) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_14	100.0	0.0	espG3	VF0521	ESX-3	Effector delivery system	VFC0086		(espG3) Type VII secretion system protein EspG3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_15	100.0	0.0	eccD3	VF0521	ESX-3	Effector delivery system	VFC0086		(eccD3) Type IIV secretion system transmembrane protein EccD3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_16	100.0	0.0	mycP3	VF0521	ESX-3	Effector delivery system	VFC0086		(mycP3) Type VII secretion system membrane-anchored mycosin MycP3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_17	99.303	0.0	eccE3	VF0521	ESX-3	Effector delivery system	VFC0086		(eccE3) Type VII secretion system transmembrane protein EccE3 [ESX-3 (VF0521) - Effector delivery system (VFC0086)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_20	100.0	0.0	stf0	VF0803	Sulfolipid-1 biosynthesis and transport	Immune modulation	VFC0258		(stf0) hypothetical protein [Sulfolipid-1 biosynthesis and transport (VF0803) - Immune modulation (VFC0258)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_80	100.0	7.04E-90	hspR	VF0297	HspR	Regulation	VFC0301		(hspR) heat shock protein transcriptional repressor HspR [HspR (VF0297) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_158	100.0	1.03E-174	sodC	VF0305	SodC	Stress survival	VFC0282		(sodC) superoxide dismutase [SodC (VF0305) - Stress survival (VFC0282)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_167	64.272	0.0	groEL	VF0594	GroEL	Adherence	VFC0001	GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues.	(groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630]	Clostridium difficile
DS985164.1_196	100.0	0.0	icl	VF0253	Isocitrate lyase	Others	VFC0346		(icl) Isocitrate lyase Icl (isocitrase) (isocitratase) [Isocitrate lyase (VF0253) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_199	100.0	0.0	pcaA	VF0285	PcaA	Others	VFC0346	Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate	(pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_205	100.0	4.37E-137	hbhA	VF0313	HbhA	Adherence	VFC0001	Surface-located protein	(hbhA) iron-regulated heparin binding hemagglutinin hbhA (adhesin) [HbhA (VF0313) - Adherence (VFC0001)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_394	100.0	0.0	mmaA4	VF0314	MmaA4	Others	VFC0346		(mmaA4) hydroxymycolate synthase MmaA4 [MmaA4 (VF0314) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_395	64.26	1.33E-136	pcaA	VF0285	PcaA	Others	VFC0346	Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate	(pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_396	72.474	5.4E-153	pcaA	VF0285	PcaA	Others	VFC0346	Mycolic acids are characteristic alpha-branched beta-hydroxy fatty acids of the genus Mycobacterium and related taxa such as Corynebacterium and Nocardia; In pathogenic mycobacteria, but not in nonpathogenic species, mycolic acids are modified with cyclopropyl groups at relatively conserved positions in the meromycolate chain. cma2 is a mycolic acid proximal trans-cyclopropane synthase, mmaA2 is essential for the distal cyclopropane modification of the alpha-mycolate	(pcaA) cyclopropane mycolic acid synthase [PcaA (VF0285) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_440	71.788	0.0	tufA	VF0460	EF-Tu	Adherence	VFC0001		(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4]	Francisella tularensis
DS985164.1_518	100.0	0.0	phoP	VF0286	PhoP	Regulation	VFC0301	Similar to the PhoP response regulator of S. enteric serovar Typhimurium that senses Mg2+ starvation and controls the expression of virulence genes	(phoP) Possible two component system response transcriptional positive regulator PhoP [PhoP (VF0286) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis
DS985164.1_519	99.794	0.0	phoR	VF0286	PhoP	Regulation	VFC0301	Similar to the PhoP response regulator of S. enteric serovar Typhimurium that senses Mg2+ starvation and controls the expression of virulence genes	(phoR) Possible two component system response sensor kinase membrane associated PhoR [PhoP (VF0286) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv]	Mycobacterium tuberculosis

Host	Gene count
Homo sapiens	3
environmental samples	3