病原微生物综合分析云平台

Basic Information

Accession number

GCA_000162135.1

Release date

2009-11-06

Organism

Bacteroides fragilis

Species name

Bacteroides fragilis

Assembly level

Scaffold

Assembly name

ASM16213v1

Assembly submitter

Broad Institute

Assembly Type

haploid

Genome size

5.2 Mb

GC percent

43.0

Contig count

Collection date

Sample location

Host

Homo sapiens

Isolation source

Isolate type

Strain

2_1_16

Isolate

ARG List

ORF_ID	Pass_Bitscore	Best_Hit_Bitscore	Best_Hit_ARO	Best_Identities	ARO	Model_type	Drug class	Resistance mechanism	AMR gene family	Description
GG705212.1_124 # 147952 # 149877	300.0	1281.54	tet(Q)	96.41	ARO:3000191	protein homolog model	tetracycline antibiotic	antibiotic target protection	tetracycline-resistant ribosomal protection protein	Tet(Q) is a ribosomal protection protein. Its gene is associated with a conjugative transposon and has been found in both Gram-positive and Gram-negative bacteria.
GG705211.1_331 # 424172 # 427351	750.0	768.074	adeF	42.53	ARO:3000777	protein homolog model	fluoroquinolone antibiotic; tetracycline antibiotic	antibiotic efflux	resistance-nodulation-cell division (RND) antibiotic efflux pump	AdeF is the membrane fusion protein of the multidrug efflux complex AdeFGH.
GG705210.1_819 # 1050569 # 1053064	175.0	193.356	vanT gene in vanG cluster	33.15	ARO:3002972	protein homolog model	glycopeptide antibiotic	antibiotic target alteration	glycopeptide resistance gene cluster; vanT	Also known as vanTG, is a vanT variant found in the vanG gene cluster.
GG705209.1_251 # 308798 # 309700	600.0	626.32	cepA	100.0	ARO:3003559	protein homolog model	cephalosporin	antibiotic inactivation	CepA beta-lactamase	A beta-lactamase found in Bacteroides fragilis producing either low or high levels of the endogenous cephalosporinase activity.
GG705209.1_1564 # 1742949 # 1746071	750.0	802.357	adeF	44.22	ARO:3000777	protein homolog model	fluoroquinolone antibiotic; tetracycline antibiotic	antibiotic efflux	resistance-nodulation-cell division (RND) antibiotic efflux pump	AdeF is the membrane fusion protein of the multidrug efflux complex AdeFGH.

VF List

Query_id	%Identity	E-value	Related genes	VF ID	Virulence factor	VFcategory	VFcategoryID	Characteristics	Description	Strain
GG705213.1_270	71.066	0.0	tufA	VF0460	EF-Tu	Adherence	VFC0001		(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4]	Francisella tularensis
GG705212.1_199	63.699	2.59E-139	wbtL	VF0542	LPS	Immune modulation	VFC0258	The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion	(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4]	Francisella tularensis
GG705212.1_257	62.284	1.08E-133	wbtL	VF0542	LPS	Immune modulation	VFC0258	The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion	(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4]	Francisella tularensis
GG705212.1_443	62.329	1.35E-134	wbtL	VF0542	LPS	Immune modulation	VFC0258	The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion	(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4]	Francisella tularensis
GG705211.1_51	60.681	0.0	htpB	VF0159	Hsp60	Adherence	VFC0001		(htpB) Hsp60, 60K heat shock protein HtpB [Hsp60 (VF0159) - Adherence (VFC0001)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]	Legionella pneumophila
GG705210.1_223	64.0	1.83E-28	acpXL	VF0367	LPS	Immune modulation	VFC0258	Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella.	(acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M]	Brucella melitensis
GG705209.1_247	73.013	0.0	katA	VF0454	KatA	Stress survival	VFC0282		(katA) catalase [KatA (VF0454) - Stress survival (VFC0282)] [Neisseria meningitidis MC58]	Neisseria meningitidis
GG705209.1_374	62.585	1.74E-136	wbtL	VF0542	LPS	Immune modulation	VFC0258	The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion	(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4]	Francisella tularensis
GG705209.1_457	64.041	4.57E-140	wbtL	VF0542	LPS	Immune modulation	VFC0258	The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion	(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4]	Francisella tularensis
GG705209.1_738	67.236	2.46E-174	gmd	VF0367	LPS	Immune modulation	VFC0258	Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella.	(gmd) GDP-mannose 4,6-dehydratase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M]	Brucella melitensis
GG705209.1_745	63.356	9.95E-139	wbtL	VF0542	LPS	Immune modulation	VFC0258	The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion	(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4]	Francisella tularensis
GG705209.1_749	64.286	4.39E-163	cap8E	VF0003	Capsule	Immune modulation	VFC0258	Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans	(cap8E) type 8 capsular polysaccharide synthesis protein Cap8E [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2]	Staphylococcus aureus
GG705209.1_1761	63.356	3.9E-138	wbtL	VF0542	LPS	Immune modulation	VFC0258	The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion	(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4]	Francisella tularensis