2. PATHOGENS
Basic Information
Accession number
GCA_000168455.1
Release date
2008-09-03
Organism
Listeria monocytogenes FSL J2-003
Species name
Listeria monocytogenes
Assembly level
Contig
Assembly name
ASM16845v1
Assembly submitter
Broad Institute
Assembly Type
haploid
Genome size
2.7 Mb
GC percent
38.0
Contig count
795
Collection date
-
Sample location
-
Host
-
Isolation source
-
Isolate type
-
Strain
FSL J2-003
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
AARM02000402.1_1 # 2 # 298 100.0 107.071 FosI 46.94 ARO:3007370 protein homolog model phosphonic acid antibiotic antibiotic inactivation fosfomycin thiol transferase FosI is a fosfomycin resistance gene.
AARM02000163.1_7 # 3048 # 4154 175.0 203.756 vanT gene in vanG cluster 35.15 ARO:3002972 protein homolog model glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanT Also known as vanTG, is a vanT variant found in the vanG gene cluster.
AARM02000080.1_7 # 2692 # 5289 1650.0 1752.26 Listeria monocytogenes mprF 100.0 ARO:3003770 protein homolog model peptide antibiotic antibiotic target alteration defensin resistant mprF MprF is a integral membrane protein that modifies the negatively-charged phosphatidylglycerol on the membrane surface. This confers resistance to cationic peptides that disrupt the cell membrane, including defensins.
AARM02000019.1_6 # 2199 # 3023 50.0 107.842 vanY gene in vanM cluster 43.33 ARO:3002961 protein homolog model glycopeptide antibiotic antibiotic target alteration vanY; glycopeptide resistance gene cluster Also known as vanYM, is a vanY variant found in the vanM gene cluster.
AARM02000002.1_5 # 2867 # 4267 900.0 907.516 norB 100.0 ARO:3000421 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump NorB is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 30% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. It is regulated by mgrA, also known as NorR.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
AARM02000741.1_1 100.0 1.84E-146 lapB VF0446 LapB Adherence VFC0001 A sortase SrtA-anchored LPXTG protein (lapB) Listeria adhesion protein LapB [LapB (VF0446) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000725.1_1 100.0 1.17E-154 clpE VF0073 ClpE Stress survival VFC0282 Belongs to HSP-100/Clp family (clpE) ATP-dependent protease [ClpE (VF0073) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000703.1_1 88.144 2.01E-122 lntA VF0440 LntA Immune modulation VFC0258 (lntA) listeria nuclear targeted protein A [LntA (VF0440) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000701.1_2 99.49 1.04E-137 hly VF0064 LLO Exotoxin VFC0235 Active at low optimum pH (5.5) and the narrow pH range, so although Listeriolysin O (LLO) is produced by bacteria in both the cytosol (pH 7.0) and the vacuole, LLO activity is restricted to the vacuole compartment; belongs to the family of cholesterol-dependent, pore-forming toxins(CDTX)(such as streptolysin O (SLO), pneumolysin, perfringolysin) or cholesterol-binding 'thiol-activated' family, means inhibition by oxidation or thiol-reacting compounds and reactivation by thiol-reducing agents, LLO and ivanolysin (the homolog of LLO in L.ivanovii) are the only members produced by an intracellular bacteria (hly) listeriolysin O precursor [LLO (VF0064) - Exotoxin (VFC0235)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000692.1_2 100.0 2.81E-122 clpP VF0074 ClpP Stress survival VFC0282 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000691.1_2 69.912 4.21E-54 iap/cwhA VF0068 P60 Invasion VFC0083 Encoded by the iap (for invasion-associated protein) gene; not regulated by PrfA (iap/cwhA) P60 extracellular protein, invasion associated protein Iap [P60 (VF0068) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000675.1_1 99.687 0.0 lapB VF0446 LapB Adherence VFC0001 A sortase SrtA-anchored LPXTG protein (lapB) Listeria adhesion protein LapB [LapB (VF0446) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000666.1_1 61.017 8.55E-97 inlA VF0069 InlA Invasion VFC0083 (inlA) Internalin A [InlA (VF0069) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000658.1_1 100.0 2.28E-16 pdgA VF0442 PgdA Immune modulation VFC0258 (pdgA) Peptidoglycan N-deacetylase [PgdA (VF0442) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000633.1_1 99.164 0.0 ami VF0071 Ami Adherence VFC0001 (ami) autolysin amidase, adhesin [Ami (VF0071) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000630.1_1 73.714 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
AARM02000628.1_1 88.983 1.99E-66 lapB VF0446 LapB Adherence VFC0001 A sortase SrtA-anchored LPXTG protein (lapB) Listeria adhesion protein LapB [LapB (VF0446) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000628.1_2 96.403 2.19E-84 lapB VF0446 LapB Adherence VFC0001 A sortase SrtA-anchored LPXTG protein (lapB) Listeria adhesion protein LapB [LapB (VF0446) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000628.1_3 96.078 1.86E-57 lapB VF0446 LapB Adherence VFC0001 A sortase SrtA-anchored LPXTG protein (lapB) Listeria adhesion protein LapB [LapB (VF0446) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000623.1_1 100.0 1.62E-127 hbp1/svpA VF0263 SvpA Nutritional/Metabolic factor VFC0272 The transcription of svpA gene is not controlled by PrfA; HupDCG system of haem transport with cooperating proteins Hbp1 (SvpA) and Hbp2 (hbp1/svpA) Haemoglobin binding protein 1 [SvpA (VF0263) - Nutritional/Metabolic factor (VFC0272)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000620.1_1 60.87 9.05E-13 cpsE VF0361 Capsule Immune modulation VFC0258 The biosynthesis of capsular polysaccharides by E. faecalis is encoded by the csp operon, which includes 11 open reading frames (cpsA to cpsK). However, only 7 open reading frames in the cps operon are essential for capsule production (cpsC, cpsD, cpsE, cpsG, cpsI, cpsJ, and cpsK); Previous genetic evidence demonstrated that E. faecalis isolates can be classified in 1 of 3 capsule operon polymorphisms. CPS 1 presents only cpsA and cpsB. CPS 2 presents all 11 genes in the cps operon. CPS 5 presents all genes except for cpsF. Furthermore, CPS 2 and 5 express the capsular polysaccharide, whereas CPS 1 does not. (cpsE) glycosyl transferase, group 2 family protein [Capsule (VF0361) - Immune modulation (VFC0258)] [Enterococcus faecalis V583] Enterococcus faecalis
AARM02000575.1_1 99.544 0.0 clpE VF0073 ClpE Stress survival VFC0282 Belongs to HSP-100/Clp family (clpE) ATP-dependent protease [ClpE (VF0073) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000572.1_1 99.569 2.0E-163 clpC VF0072 ClpC Stress survival VFC0282 27-kDa stress protein belongs to the Hsp100/Clp family; Regulation of Clp protease expression is mediated by CtsR, the product of the first gene in the ClpC operon (clpC) endopeptidase Clp ATP-binding chain C [ClpC (VF0072) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000555.1_2 100.0 7.57E-106 lspA VF0351 Lsp Post-translational modification VFC0315 (lspA) signal peptidase II [Lsp (VF0351) - Post-translational modification (VFC0315)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000535.1_2 100.0 1.72E-29 iap/cwhA VF0068 P60 Invasion VFC0083 Encoded by the iap (for invasion-associated protein) gene; not regulated by PrfA (iap/cwhA) P60 extracellular protein, invasion associated protein Iap [P60 (VF0068) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000490.1_1 70.523 1.47E-176 groEL VF0594 GroEL Adherence VFC0001 GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. (groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] Clostridium difficile
AARM02000490.1_3 76.667 3.09E-27 groEL VF0594 GroEL Adherence VFC0001 GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. (groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] Clostridium difficile
AARM02000486.1_1 98.473 7.96E-91 mpl VF0065 Mpl Exoenzyme VFC0251 (mpl) Zinc metalloproteinase precursor [Mpl (VF0065) - Exoenzyme (VFC0251)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000486.1_2 96.212 2.05E-88 mpl VF0065 Mpl Exoenzyme VFC0251 (mpl) Zinc metalloproteinase precursor [Mpl (VF0065) - Exoenzyme (VFC0251)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000486.1_3 100.0 7.47E-144 hly VF0064 LLO Exotoxin VFC0235 Active at low optimum pH (5.5) and the narrow pH range, so although Listeriolysin O (LLO) is produced by bacteria in both the cytosol (pH 7.0) and the vacuole, LLO activity is restricted to the vacuole compartment; belongs to the family of cholesterol-dependent, pore-forming toxins(CDTX)(such as streptolysin O (SLO), pneumolysin, perfringolysin) or cholesterol-binding 'thiol-activated' family, means inhibition by oxidation or thiol-reacting compounds and reactivation by thiol-reducing agents, LLO and ivanolysin (the homolog of LLO in L.ivanovii) are the only members produced by an intracellular bacteria (hly) listeriolysin O precursor [LLO (VF0064) - Exotoxin (VFC0235)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000481.1_1 93.939 1.92E-111 lapB VF0446 LapB Adherence VFC0001 A sortase SrtA-anchored LPXTG protein (lapB) Listeria adhesion protein LapB [LapB (VF0446) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000481.1_2 98.391 0.0 lapB VF0446 LapB Adherence VFC0001 A sortase SrtA-anchored LPXTG protein (lapB) Listeria adhesion protein LapB [LapB (VF0446) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000442.1_3 63.514 2.93E-25 acpXL VF0367 LPS Immune modulation VFC0258 Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. (acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] Brucella melitensis
AARM02000431.1_2 97.744 1.01E-87 inlP VF0577 InlP Adherence VFC0001 Of the 25 known members of the L. monocytogenes internalin family, InlC and InlP are two of only four internalin family members that are thought to be secreted in a soluble form rather than anchored to the bacteria cell surface. (inlP) internalin P [InlP (VF0577) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000304.1_5 100.0 0.0 bsh VF0350 BSH Stress survival VFC0282 The bsh gene is positively regulated by the central listerial virulence regulator PrfA in vivo (bsh) bile salt hydrolase [BSH (VF0350) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000302.1_2 99.412 2.27E-120 aut VF0348 Auto Invasion VFC0083 A surface protein in L. monocytogenes but absent in L. innocua; the aut gene is expressed independently of PrfA (aut) autolysin [Auto (VF0348) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000302.1_3 100.0 0.0 aut VF0348 Auto Invasion VFC0083 A surface protein in L. monocytogenes but absent in L. innocua; the aut gene is expressed independently of PrfA (aut) autolysin [Auto (VF0348) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000302.1_4 100.0 3.64E-53 aut VF0348 Auto Invasion VFC0083 A surface protein in L. monocytogenes but absent in L. innocua; the aut gene is expressed independently of PrfA (aut) autolysin [Auto (VF0348) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000290.1_7 77.193 5.9E-30 cpsA/uppS VF0361 Capsule Immune modulation VFC0258 The biosynthesis of capsular polysaccharides by E. faecalis is encoded by the csp operon, which includes 11 open reading frames (cpsA to cpsK). However, only 7 open reading frames in the cps operon are essential for capsule production (cpsC, cpsD, cpsE, cpsG, cpsI, cpsJ, and cpsK); Previous genetic evidence demonstrated that E. faecalis isolates can be classified in 1 of 3 capsule operon polymorphisms. CPS 1 presents only cpsA and cpsB. CPS 2 presents all 11 genes in the cps operon. CPS 5 presents all genes except for cpsF. Furthermore, CPS 2 and 5 express the capsular polysaccharide, whereas CPS 1 does not. (cpsA/uppS) undecaprenyl diphosphate synthase [Capsule (VF0361) - Immune modulation (VFC0258)] [Enterococcus faecalis V583] Enterococcus faecalis
AARM02000283.1_2 97.297 0.0 inlC VF0438 InlC Immune modulation VFC0258 (inlC) internalin C [InlC (VF0438) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000268.1_3 99.379 1.02E-113 inlB VF0070 InlB Invasion VFC0083 (inlB) Internalin B [InlB (VF0070) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000268.1_4 98.987 0.0 inlB VF0070 InlB Invasion VFC0083 (inlB) Internalin B [InlB (VF0070) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000246.1_7 100.0 2.88E-40 lapB VF0446 LapB Adherence VFC0001 A sortase SrtA-anchored LPXTG protein (lapB) Listeria adhesion protein LapB [LapB (VF0446) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000220.1_1 100.0 0.0 clpC VF0072 ClpC Stress survival VFC0282 27-kDa stress protein belongs to the Hsp100/Clp family; Regulation of Clp protease expression is mediated by CtsR, the product of the first gene in the ClpC operon (clpC) endopeptidase Clp ATP-binding chain C [ClpC (VF0072) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000191.1_4 99.698 0.0 lplA1 VF0347 LplA1 Nutritional/Metabolic factor VFC0272 (lplA1) lipoate protein ligase [LplA1 (VF0347) - Nutritional/Metabolic factor (VFC0272)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000182.1_1 60.625 1.64E-61 carB VF0558 Pyrimidine biosynthesis Nutritional/Metabolic factor VFC0272 CarB, CarA, and PyrB encode the large and small subunits of carbamoylphosphate synthetase and aspartate carbamoyl transferase, respectively. These enzymes catalyze the first two steps in the pyrimidine nucleotide biosynthetic pathway in many bacteria, including Francisella, and are required for the virulence of several pathogens, including Salmonella and E. coli (carB) carbamoyl phosphate synthase large subunit [Pyrimidine biosynthesis (VF0558) - Nutritional/Metabolic factor (VFC0272)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
AARM02000167.1_3 94.366 2.83E-41 oatA VF0441 OatA Immune modulation VFC0258 (oatA) peptidoglycan O-acetyltransferase [OatA (VF0441) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000167.1_4 99.813 0.0 oatA VF0441 OatA Immune modulation VFC0258 (oatA) peptidoglycan O-acetyltransferase [OatA (VF0441) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000167.1_5 99.247 0.0 inlK VF0439 InlK Immune modulation VFC0258 (inlK) internalin K [InlK (VF0439) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000134.1_8 61.966 1.07E-102 prsA2 VF0449 PrsA2 Post-translational modification VFC0315 A conserved post-translocation chaperone and a peptidyl prolyl cis-trans isomerase (PPIase) contributing to LLO folding and pore-forming ability and to the activity of the broad-range PC-PLC (prsA2) post translocation chaperone PrsA2 [PrsA2 (VF0449) - Post-translational modification (VFC0315)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000130.1_2 60.87 1.07E-28 inlK VF0439 InlK Immune modulation VFC0258 (inlK) internalin K [InlK (VF0439) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000121.1_2 96.955 0.0 inlF VF0447 InlF Adherence VFC0001 An example of a virulence factor whose function may be only significant under specific host cell conditions or during infection of specific host species (inlF) internalin F [InlF (VF0447) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000097.1_1 100.0 2.25E-139 inlP VF0577 InlP Adherence VFC0001 Of the 25 known members of the L. monocytogenes internalin family, InlC and InlP are two of only four internalin family members that are thought to be secreted in a soluble form rather than anchored to the bacteria cell surface. (inlP) internalin P [InlP (VF0577) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000090.1_11 100.0 0.0 pdgA VF0442 PgdA Immune modulation VFC0258 (pdgA) Peptidoglycan N-deacetylase [PgdA (VF0442) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000090.1_12 97.368 7.09E-19 pdgA VF0442 PgdA Immune modulation VFC0258 (pdgA) Peptidoglycan N-deacetylase [PgdA (VF0442) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000082.1_7 98.962 0.0 plcB VF0067 PlcB Exotoxin VFC0235 Secreted as an inactive propeptide, activated on cleavage by the Mpl; active between pH 5.0 and 8.0; also called lecithinase, zinc-dependent enzyme (plcB) phospholipase C [PlcB (VF0067) - Exotoxin (VFC0235)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000082.1_8 96.584 0.0 actA VF0066 ActA Motility VFC0204 (actA) actin-assembly inducing protein precursor [ActA (VF0066) - Motility (VFC0204)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000082.1_9 87.755 4.47E-24 actA VF0066 ActA Motility VFC0204 (actA) actin-assembly inducing protein precursor [ActA (VF0066) - Motility (VFC0204)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000082.1_10 96.528 1.74E-95 actA VF0066 ActA Motility VFC0204 (actA) actin-assembly inducing protein precursor [ActA (VF0066) - Motility (VFC0204)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000082.1_11 99.375 7.7E-116 mpl VF0065 Mpl Exoenzyme VFC0251 (mpl) Zinc metalloproteinase precursor [Mpl (VF0065) - Exoenzyme (VFC0251)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000075.1_1 65.052 6.35E-137 hasC VF0244 Hyaluronic acid capsule Immune modulation VFC0258 (hasC) UTP--glucose-1-phosphate uridylyltransferase HasC [Hyaluronic acid capsule (VF0244) - Immune modulation (VFC0258)] [Streptococcus pyogenes M1 GAS] Streptococcus pyogenes
AARM02000075.1_6 63.793 3.29E-138 wbtL VF0542 LPS Immune modulation VFC0258 The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion (wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
AARM02000061.1_5 98.361 0.0 hpt VF0264 Hpt Nutritional/Metabolic factor VFC0272 "Belongs to the organophosphate:inorganic phosphate antiporter (OPA) family, of the major facilitator superfamily of permease.; Hpt is the first virulence factor to be identified as specifically involved in the replication phase of a facultative intracellular pathogen. It could be termed ""metabolic"" virulence factor and represent an example of the concept in the biology of host-pathogen interaction: adaptation to parasitic life often involves the mimicry of eukaryotic host functions by microbial virulence factors.; Expression of the Hpt permease is tightly cotrolled by the PrfA." (hpt) hexose phosphate transport protein [Hpt (VF0264) - Nutritional/Metabolic factor (VFC0272)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000059.1_7 76.221 6.61E-171 gndA VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
AARM02000057.1_3 99.659 0.0 prsA2 VF0449 PrsA2 Post-translational modification VFC0315 A conserved post-translocation chaperone and a peptidyl prolyl cis-trans isomerase (PPIase) contributing to LLO folding and pore-forming ability and to the activity of the broad-range PC-PLC (prsA2) post translocation chaperone PrsA2 [PrsA2 (VF0449) - Post-translational modification (VFC0315)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000054.1_8 100.0 2.75E-178 prfA VF0062 PrfA Regulation VFC0301 Belongs to CAP (for catabolite gene activator protein) /FNR family; dimeric protein that binds to its DNA target sequences in dimeric form; natural isolates have been shown to carry a mutation changing Gly145 to Ser, the substitution renders PrfA protein has greater binding affinity for the specific target DNA sequence, also increases the capacity of the PrfA-RNA polymerase complex to initiate transcription (prfA) listeriolysin positive regulatory protein [PrfA (VF0062) - Regulation (VFC0301)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000054.1_9 96.541 0.0 plcA VF0063 PlcA Exotoxin VFC0235 33-kDa, highly specific for PI, with a pH optimum between 5.5 and 6.5; able to hydrolyze glycosyl PI(GPI)-anchored eukaryotic membrane proteins (plcA) phosphatidylinositol-specific phospholipase c [PlcA (VF0063) - Exotoxin (VFC0235)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000047.1_8 98.795 2.9E-53 fbpA VF0349 FbpA Adherence VFC0001 A 570 aa polypeptide with strong homologies to the fibronectin binding proteins PavA of S. pneumoniae, Fbp54 of S. pyogenes and FbpA of S. gordonii; a substrate for the SecA2 pathway (fbpA) fibronectin-binding protein [FbpA (VF0349) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000047.1_9 99.773 0.0 fbpA VF0349 FbpA Adherence VFC0001 A 570 aa polypeptide with strong homologies to the fibronectin binding proteins PavA of S. pneumoniae, Fbp54 of S. pyogenes and FbpA of S. gordonii; a substrate for the SecA2 pathway (fbpA) fibronectin-binding protein [FbpA (VF0349) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000030.1_3 99.885 0.0 lap VF0444 Lap Adherence VFC0001 Originally named surface protein p104, is a 104 kDa adhesion protein, present in every Listeria spp. except L. grayi (lap) Listeria adhesion protein Lap [Lap (VF0444) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000026.1_1 98.26 0.0 inlA VF0069 InlA Invasion VFC0083 (inlA) Internalin A [InlA (VF0069) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000019.1_1 67.442 6.85E-18 msrA/B(pilB VF0456 MsrAB Stress survival VFC0282 Methionine sulfoxide reductases (Msr) are enzymes that catalyze the reduction of free and protein-bound methionine sulfoxide (MetSO) back to Met. Two structurally unrelated classes of Msrs have been described so far. MsrAs are stereo specific toward the S isomer on the sulfur of the sulfoxide function, whereas MsrBs are specific toward the R isomer (msrA/B(pilB)) trifunctional thioredoxin/methionine sulfoxide reductase A/B protein [MsrAB (VF0456) - Stress survival (VFC0282)] [Neisseria meningitidis MC58] Neisseria meningitidis
AARM02000019.1_15 99.355 0.0 lpeA VF0346 LpeA Invasion VFC0083 Membrane protein homologous to a Streptococcus pneumoniae adherence factor PsaA, but LpeA is not involved in adhesion; the only listerial lipoprotein known to date to be involved in invasion (lpeA) lipoprotein promoting cell invasion [LpeA (VF0346) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000018.1_4 100.0 1.83E-102 gtcA VF0607 GtcA Post-translational modification VFC0315 (gtcA) wall teichoic acid glycosylation protein GtcA [GtcA (VF0607) - Post-translational modification (VFC0315)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000018.1_13 99.32 0.0 ami VF0071 Ami Adherence VFC0001 (ami) autolysin amidase, adhesin [Ami (VF0071) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000005.1_10 84.982 9.27E-160 vip VF0443 Vip Invasion VFC0083 A LPXTG protein anchored to the peptidoglycan by SrtA (vip) surface adhesin Vip [Vip (VF0443) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000002.1_8 99.53 0.0 inlJ VF0445 InlJ Adherence VFC0001 (inlJ) internalin J [InlJ (VF0445) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000001.1_34 100.0 0.0 hbp2 VF0263 SvpA Nutritional/Metabolic factor VFC0272 The transcription of svpA gene is not controlled by PrfA; HupDCG system of haem transport with cooperating proteins Hbp1 (SvpA) and Hbp2 (hbp2) hypothetical protein [SvpA (VF0263) - Nutritional/Metabolic factor (VFC0272)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AARM02000001.1_35 100.0 8.03E-22 hbp1/svpA VF0263 SvpA Nutritional/Metabolic factor VFC0272 The transcription of svpA gene is not controlled by PrfA; HupDCG system of haem transport with cooperating proteins Hbp1 (SvpA) and Hbp2 (hbp1/svpA) Haemoglobin binding protein 1 [SvpA (VF0263) - Nutritional/Metabolic factor (VFC0272)] [Listeria monocytogenes EGD-e] Listeria monocytogenes