| CP002003.1_196 |
100.0 |
2.75E-178 |
prfA |
VF0062 |
PrfA |
Regulation |
VFC0301 |
Belongs to CAP (for catabolite gene activator protein) /FNR family; dimeric protein that binds to its DNA target sequences in dimeric form; natural isolates have been shown to carry a mutation changing Gly145 to Ser, the substitution renders PrfA protein has greater binding affinity for the specific target DNA sequence, also increases the capacity of the PrfA-RNA polymerase complex to initiate transcription |
(prfA) listeriolysin positive regulatory protein [PrfA (VF0062) - Regulation (VFC0301)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_197 |
100.0 |
0.0 |
plcA |
VF0063 |
PlcA |
Exotoxin |
VFC0235 |
33-kDa, highly specific for PI, with a pH optimum between 5.5 and 6.5; able to hydrolyze glycosyl PI(GPI)-anchored eukaryotic membrane proteins |
(plcA) phosphatidylinositol-specific phospholipase c [PlcA (VF0063) - Exotoxin (VFC0235)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_198 |
100.0 |
0.0 |
hly |
VF0064 |
LLO |
Exotoxin |
VFC0235 |
Active at low optimum pH (5.5) and the narrow pH range, so although Listeriolysin O (LLO) is produced by bacteria in both the cytosol (pH 7.0) and the vacuole, LLO activity is restricted to the vacuole compartment; belongs to the family of cholesterol-dependent, pore-forming toxins(CDTX)(such as streptolysin O (SLO), pneumolysin, perfringolysin) or cholesterol-binding 'thiol-activated' family, means inhibition by oxidation or thiol-reacting compounds and reactivation by thiol-reducing agents, LLO and ivanolysin (the homolog of LLO in L.ivanovii) are the only members produced by an intracellular bacteria |
(hly) listeriolysin O precursor [LLO (VF0064) - Exotoxin (VFC0235)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_199 |
100.0 |
0.0 |
mpl |
VF0065 |
Mpl |
Exoenzyme |
VFC0251 |
|
(mpl) Zinc metalloproteinase precursor [Mpl (VF0065) - Exoenzyme (VFC0251)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_200 |
100.0 |
0.0 |
actA |
VF0066 |
ActA |
Motility |
VFC0204 |
|
(actA) actin-assembly inducing protein precursor [ActA (VF0066) - Motility (VFC0204)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_201 |
100.0 |
0.0 |
plcB |
VF0067 |
PlcB |
Exotoxin |
VFC0235 |
Secreted as an inactive propeptide, activated on cleavage by the Mpl; active between pH 5.0 and 8.0; also called lecithinase, zinc-dependent enzyme |
(plcB) phospholipase C [PlcB (VF0067) - Exotoxin (VFC0235)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_228 |
100.0 |
0.0 |
clpC |
VF0072 |
ClpC |
Stress survival |
VFC0282 |
27-kDa stress protein belongs to the Hsp100/Clp family; Regulation of Clp protease expression is mediated by CtsR, the product of the first gene in the ClpC operon |
(clpC) endopeptidase Clp ATP-binding chain C [ClpC (VF0072) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_317 |
100.0 |
0.0 |
vip |
VF0443 |
Vip |
Invasion |
VFC0083 |
A LPXTG protein anchored to the peptidoglycan by SrtA |
(vip) surface adhesin Vip [Vip (VF0443) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_407 |
100.0 |
0.0 |
inlF |
VF0447 |
InlF |
Adherence |
VFC0001 |
An example of a virulence factor whose function may be only significant under specific host cell conditions or during infection of specific host species |
(inlF) internalin F [InlF (VF0447) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_413 |
100.0 |
0.0 |
pdgA |
VF0442 |
PgdA |
Immune modulation |
VFC0258 |
|
(pdgA) Peptidoglycan N-deacetylase [PgdA (VF0442) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_431 |
100.0 |
0.0 |
inlA |
VF0069 |
InlA |
Invasion |
VFC0083 |
|
(inlA) Internalin A [InlA (VF0069) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_432 |
100.0 |
0.0 |
inlB |
VF0070 |
InlB |
Invasion |
VFC0083 |
|
(inlB) Internalin B [InlB (VF0070) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_436 |
100.0 |
1.24E-147 |
lntA |
VF0440 |
LntA |
Immune modulation |
VFC0258 |
|
(lntA) listeria nuclear targeted protein A [LntA (VF0440) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_581 |
99.587 |
0.0 |
iap/cwhA |
VF0068 |
P60 |
Invasion |
VFC0083 |
Encoded by the iap (for invasion-associated protein) gene; not regulated by PrfA |
(iap/cwhA) P60 extracellular protein, invasion associated protein Iap [P60 (VF0068) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_839 |
100.0 |
0.0 |
hpt |
VF0264 |
Hpt |
Nutritional/Metabolic factor |
VFC0272 |
"Belongs to the organophosphate:inorganic phosphate antiporter (OPA) family, of the major facilitator superfamily of permease.; Hpt is the first virulence factor to be identified as specifically involved in the replication phase of a facultative intracellular pathogen. It could be termed ""metabolic"" virulence factor and represent an example of the concept in the biology of host-pathogen interaction: adaptation to parasitic life often involves the mimicry of eukaryotic host functions by microbial virulence factors.; Expression of the Hpt permease is tightly cotrolled by the PrfA." |
(hpt) hexose phosphate transport protein [Hpt (VF0264) - Nutritional/Metabolic factor (VFC0272)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_932 |
100.0 |
0.0 |
lplA1 |
VF0347 |
LplA1 |
Nutritional/Metabolic factor |
VFC0272 |
|
(lplA1) lipoate protein ligase [LplA1 (VF0347) - Nutritional/Metabolic factor (VFC0272)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_999 |
100.0 |
0.0 |
clpE |
VF0073 |
ClpE |
Stress survival |
VFC0282 |
Belongs to HSP-100/Clp family |
(clpE) ATP-dependent protease [ClpE (VF0073) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_1079 |
100.0 |
0.0 |
aut |
VF0348 |
Auto |
Invasion |
VFC0083 |
A surface protein in L. monocytogenes but absent in L. innocua; the aut gene is expressed independently of PrfA |
(aut) autolysin [Auto (VF0348) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_1081 |
64.505 |
2.55E-137 |
hasC |
VF0244 |
Hyaluronic acid capsule |
Immune modulation |
VFC0258 |
|
(hasC) UTP--glucose-1-phosphate uridylyltransferase HasC [Hyaluronic acid capsule (VF0244) - Immune modulation (VFC0258)] [Streptococcus pyogenes M1 GAS] |
Streptococcus pyogenes |
| CP002003.1_1084 |
63.793 |
3.29E-138 |
wbtL |
VF0542 |
LPS |
Immune modulation |
VFC0258 |
The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion |
(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| CP002003.1_1344 |
100.0 |
0.0 |
inlK |
VF0439 |
InlK |
Immune modulation |
VFC0258 |
|
(inlK) internalin K [InlK (VF0439) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_1345 |
100.0 |
0.0 |
oatA |
VF0441 |
OatA |
Immune modulation |
VFC0258 |
|
(oatA) peptidoglycan O-acetyltransferase [OatA (VF0441) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_1370 |
63.084 |
1.78E-100 |
cpsA/uppS |
VF0361 |
Capsule |
Immune modulation |
VFC0258 |
The biosynthesis of capsular polysaccharides by E. faecalis is encoded by the csp operon, which includes 11 open reading frames (cpsA to cpsK). However, only 7 open reading frames in the cps operon are essential for capsule production (cpsC, cpsD, cpsE, cpsG, cpsI, cpsJ, and cpsK); Previous genetic evidence demonstrated that E. faecalis isolates can be classified in 1 of 3 capsule operon polymorphisms. CPS 1 presents only cpsA and cpsB. CPS 2 presents all 11 genes in the cps operon. CPS 5 presents all genes except for cpsF. Furthermore, CPS 2 and 5 express the capsular polysaccharide, whereas CPS 1 does not. |
(cpsA/uppS) undecaprenyl diphosphate synthase [Capsule (VF0361) - Immune modulation (VFC0258)] [Enterococcus faecalis V583] |
Enterococcus faecalis |
| CP002003.1_1433 |
75.427 |
0.0 |
gndA |
VF0560 |
Capsule |
Immune modulation |
VFC0258 |
The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. |
(gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| CP002003.1_1692 |
100.0 |
0.0 |
lap |
VF0444 |
Lap |
Adherence |
VFC0001 |
Originally named surface protein p104, is a 104 kDa adhesion protein, present in every Listeria spp. except L. grayi |
(lap) Listeria adhesion protein Lap [Lap (VF0444) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_1726 |
100.0 |
0.0 |
lapB |
VF0446 |
LapB |
Adherence |
VFC0001 |
A sortase SrtA-anchored LPXTG protein |
(lapB) Listeria adhesion protein LapB [LapB (VF0446) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_1847 |
99.662 |
0.0 |
inlC |
VF0438 |
InlC |
Immune modulation |
VFC0258 |
|
(inlC) internalin C [InlC (VF0438) - Immune modulation (VFC0258)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_1868 |
63.514 |
2.93E-25 |
acpXL |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| CP002003.1_1891 |
100.0 |
0.0 |
fbpA |
VF0349 |
FbpA |
Adherence |
VFC0001 |
A 570 aa polypeptide with strong homologies to the fibronectin binding proteins PavA of S. pneumoniae, Fbp54 of S. pyogenes and FbpA of S. gordonii; a substrate for the SecA2 pathway |
(fbpA) fibronectin-binding protein [FbpA (VF0349) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_1906 |
100.0 |
3.1E-110 |
lspA |
VF0351 |
Lsp |
Post-translational modification |
VFC0315 |
|
(lspA) signal peptidase II [Lsp (VF0351) - Post-translational modification (VFC0315)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_1910 |
100.0 |
0.0 |
lpeA |
VF0346 |
LpeA |
Invasion |
VFC0083 |
Membrane protein homologous to a Streptococcus pneumoniae adherence factor PsaA, but LpeA is not involved in adhesion; the only listerial lipoprotein known to date to be involved in invasion |
(lpeA) lipoprotein promoting cell invasion [LpeA (VF0346) - Invasion (VFC0083)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_1922 |
62.222 |
1.31E-54 |
msrA/B(pilB |
VF0456 |
MsrAB |
Stress survival |
VFC0282 |
Methionine sulfoxide reductases (Msr) are enzymes that catalyze the reduction of free and protein-bound methionine sulfoxide (MetSO) back to Met. Two structurally unrelated classes of Msrs have been described so far. MsrAs are stereo specific toward the S isomer on the sulfur of the sulfoxide function, whereas MsrBs are specific toward the R isomer |
(msrA/B(pilB)) trifunctional thioredoxin/methionine sulfoxide reductase A/B protein [MsrAB (VF0456) - Stress survival (VFC0282)] [Neisseria meningitidis MC58] |
Neisseria meningitidis |
| CP002003.1_2090 |
65.296 |
1.25E-169 |
inlP |
VF0577 |
InlP |
Adherence |
VFC0001 |
Of the 25 known members of the L. monocytogenes internalin family, InlC and InlP are two of only four internalin family members that are thought to be secreted in a soluble form rather than anchored to the bacteria cell surface. |
(inlP) internalin P [InlP (VF0577) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_2130 |
100.0 |
0.0 |
bsh |
VF0350 |
BSH |
Stress survival |
VFC0282 |
The bsh gene is positively regulated by the central listerial virulence regulator PrfA in vivo |
(bsh) bile salt hydrolase [BSH (VF0350) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_2131 |
72.624 |
0.0 |
groEL |
VF0594 |
GroEL |
Adherence |
VFC0001 |
GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. |
(groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] |
Clostridium difficile |
| CP002003.1_2248 |
100.0 |
0.0 |
hbp2 |
VF0263 |
SvpA |
Nutritional/Metabolic factor |
VFC0272 |
The transcription of svpA gene is not controlled by PrfA; HupDCG system of haem transport with cooperating proteins Hbp1 (SvpA) and Hbp2 |
(hbp2) hypothetical protein [SvpA (VF0263) - Nutritional/Metabolic factor (VFC0272)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_2249 |
100.0 |
1.26E-151 |
hbp1/svpA |
VF0263 |
SvpA |
Nutritional/Metabolic factor |
VFC0272 |
The transcription of svpA gene is not controlled by PrfA; HupDCG system of haem transport with cooperating proteins Hbp1 (SvpA) and Hbp2 |
(hbp1/svpA) Haemoglobin binding protein 1 [SvpA (VF0263) - Nutritional/Metabolic factor (VFC0272)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_2282 |
100.0 |
0.0 |
prsA2 |
VF0449 |
PrsA2 |
Post-translational modification |
VFC0315 |
A conserved post-translocation chaperone and a peptidyl prolyl cis-trans isomerase (PPIase) contributing to LLO folding and pore-forming ability and to the activity of the broad-range PC-PLC |
(prsA2) post translocation chaperone PrsA2 [PrsA2 (VF0449) - Post-translational modification (VFC0315)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_2527 |
100.0 |
2.52E-146 |
clpP |
VF0074 |
ClpP |
Stress survival |
VFC0282 |
21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes |
(clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_2529 |
100.0 |
0.0 |
inlP |
VF0577 |
InlP |
Adherence |
VFC0001 |
Of the 25 known members of the L. monocytogenes internalin family, InlC and InlP are two of only four internalin family members that are thought to be secreted in a soluble form rather than anchored to the bacteria cell surface. |
(inlP) internalin P [InlP (VF0577) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_2612 |
100.0 |
1.83E-102 |
gtcA |
VF0607 |
GtcA |
Post-translational modification |
VFC0315 |
|
(gtcA) wall teichoic acid glycosylation protein GtcA [GtcA (VF0607) - Post-translational modification (VFC0315)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_2623 |
99.891 |
0.0 |
ami |
VF0071 |
Ami |
Adherence |
VFC0001 |
|
(ami) autolysin amidase, adhesin [Ami (VF0071) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| CP002003.1_2719 |
74.3 |
0.0 |
tufA |
VF0460 |
EF-Tu |
Adherence |
VFC0001 |
|
(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| CP002003.1_2903 |
100.0 |
0.0 |
inlJ |
VF0445 |
InlJ |
Adherence |
VFC0001 |
|
(inlJ) internalin J [InlJ (VF0445) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |