病原微生物综合分析云平台

Basic Information

Accession number

GCA_000218345.1

Release date

2011-06-15

Organism

Bacteroides fragilis

Species name

Bacteroides fragilis

Assembly level

Scaffold

Assembly name

Bacteroides_sp_2_1_56FAA_V1

Assembly submitter

Broad Institute

Assembly Type

haploid

Genome size

5.6 Mb

GC percent

43.5

Contig count

Collection date

Sample location

Host

Homo sapiens

Isolation source

gastrointestinal tract

Isolate type

Strain

2_1_56FAA

Isolate

ARG List

ORF_ID	Pass_Bitscore	Best_Hit_Bitscore	Best_Hit_ARO	Best_Identities	ARO	Model_type	Drug class	Resistance mechanism	AMR gene family	Description
GL945043.1_911 # 1145875 # 1148370	175.0	193.741	vanT gene in vanG cluster	33.15	ARO:3002972	protein homolog model	glycopeptide antibiotic	antibiotic target alteration	glycopeptide resistance gene cluster; vanT	Also known as vanTG, is a vanT variant found in the vanG gene cluster.
GL945043.1_1360 # 1655844 # 1656746	600.0	622.083	cepA	99.0	ARO:3003559	protein homolog model	cephalosporin	antibiotic inactivation	CepA beta-lactamase	A beta-lactamase found in Bacteroides fragilis producing either low or high levels of the endogenous cephalosporinase activity.
GL945044.1_880 # 951061 # 952986	300.0	1278.85	tet(Q)	96.1	ARO:3000191	protein homolog model	tetracycline antibiotic	antibiotic target protection	tetracycline-resistant ribosomal protection protein	Tet(Q) is a ribosomal protection protein. Its gene is associated with a conjugative transposon and has been found in both Gram-positive and Gram-negative bacteria.
GL945044.1_883 # 957563 # 958363	500.0	536.569	ErmF	99.62	ARO:3000498	protein homolog model	macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic	antibiotic target alteration	Erm 23S ribosomal RNA methyltransferase	ErmF confers the MLSb phenotype.
GL945048.1_50 # 58940 # 62119	750.0	768.074	adeF	42.53	ARO:3000777	protein homolog model	fluoroquinolone antibiotic; tetracycline antibiotic	antibiotic efflux	resistance-nodulation-cell division (RND) antibiotic efflux pump	AdeF is the membrane fusion protein of the multidrug efflux complex AdeFGH.

VF List

Query_id	%Identity	E-value	Related genes	VF ID	Virulence factor	VFcategory	VFcategoryID	Characteristics	Description	Strain
GL945043.1_219	64.0	1.83E-28	acpXL	VF0367	LPS	Immune modulation	VFC0258	Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella.	(acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M]	Brucella melitensis
GL945043.1_836	75.0	0.0	wbtF	VF0542	LPS	Immune modulation	VFC0258	The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion	(wbtF) NAD dependent epimerase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4]	Francisella tularensis
GL945043.1_838	69.653	0.0	cps4J	VF0144	Capsule	Immune modulation	VFC0258	Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages	(cps4J) capsular polysaccharide biosynthesis protein Cps4J [Capsule (VF0144) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4]	Streptococcus pneumoniae
GL945043.1_839	63.119	0.0	cps4K	VF0144	Capsule	Immune modulation	VFC0258	Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages	(cps4K) capsular polysaccharide biosynthesis protein Cps4K [Capsule (VF0144) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4]	Streptococcus pneumoniae
GL945043.1_840	81.186	0.0	cps4L	VF0144	Capsule	Immune modulation	VFC0258	Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages	(cps4L) capsular polysaccharide biosynthesis protein Cps4L [Capsule (VF0144) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4]	Streptococcus pneumoniae
GL945043.1_1110	81.395	1.7E-19	cps4J	VF0144	Capsule	Immune modulation	VFC0258	Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages	(cps4J) capsular polysaccharide biosynthesis protein Cps4J [Capsule (VF0144) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4]	Streptococcus pneumoniae
GL945043.1_1111	60.959	1.32E-135	cap8E	VF0003	Capsule	Immune modulation	VFC0258	Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans	(cap8E) type 8 capsular polysaccharide synthesis protein Cap8E [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2]	Staphylococcus aureus
GL945043.1_1356	73.222	0.0	katA	VF0454	KatA	Stress survival	VFC0282		(katA) catalase [KatA (VF0454) - Stress survival (VFC0282)] [Neisseria meningitidis MC58]	Neisseria meningitidis
GL945043.1_1918	67.236	2.46E-174	gmd	VF0367	LPS	Immune modulation	VFC0258	Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella.	(gmd) GDP-mannose 4,6-dehydratase [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M]	Brucella melitensis
GL945044.1_10	63.356	4.67E-140	wbtL	VF0542	LPS	Immune modulation	VFC0258	The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion	(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4]	Francisella tularensis
GL945045.1_62	63.699	1.01E-138	wbtL	VF0542	LPS	Immune modulation	VFC0258	The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion	(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4]	Francisella tularensis
GL945045.1_268	62.284	1.08E-133	wbtL	VF0542	LPS	Immune modulation	VFC0258	The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion	(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4]	Francisella tularensis
GL945045.1_326	65.882	1.38E-126	wbtL	VF0542	LPS	Immune modulation	VFC0258	The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion	(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4]	Francisella tularensis
GL945046.1_382	60.827	0.0	htpB	VF0159	Hsp60	Adherence	VFC0001		(htpB) Hsp60, 60K heat shock protein HtpB [Hsp60 (VF0159) - Adherence (VFC0001)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]	Legionella pneumophila
GL945047.1_72	71.066	0.0	tufA	VF0460	EF-Tu	Adherence	VFC0001		(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4]	Francisella tularensis