2. PATHOGENS
Basic Information
Accession number
GCA_000258825.1
Release date
2012-04-16
Organism
Helicobacter pylori
Species name
Helicobacter pylori
Assembly level
Contig
Assembly name
ASM25882v1
Assembly submitter
Microbiology Dept, University College Cork
Assembly Type
haploid
Genome size
1.6 Mb
GC percent
39.0
Contig count
215
Collection date
-
Sample location
-
Host
Homo sapiens
Isolation source
-
Isolate type
-
Strain
HP2RS
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
AIHW01000059.1_5 # 4982 # 6313 850.0 877.47 hp1181 100.0 ARO:3003964 protein homolog model fluoroquinolone antibiotic; tetracycline antibiotic; nitroimidazole antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump hp1181 is a translocase that is part of the MFS efflux pump family. It is found in H. pylori and has role in the active efflux of antibiotics.
AIHW01000106.1_2 # 560 # 1693 175.0 177.563 vanT gene in vanG cluster 32.98 ARO:3002972 protein homolog model glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanT Also known as vanTG, is a vanT variant found in the vanG gene cluster.
AIHW01000040.1_13 # 7636 # 9402 1000.0 1181.39 Helicobacter pylori pbp2 mutants conferring resistance to amoxicillin 98.3 ARO:3007058 protein variant model S494H, E572G cephalosporin; cephamycin; penam antibiotic target alteration Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics Point mutations in Helicobacter pylori pbp2 observed to confer resistance to amoxicillin.
AIHW01000109.1_9 # 5571 # 6203 400.0 438.728 Helicobacter pylori rdxA mutation conferring resistance to metronidazole 100.0 ARO:3007055 protein variant model C49T nitroimidazole antibiotic antibiotic target alteration Antibiotic resistant Helicobacter pylori nitroreductase The rdxA gene in Helicobacter pylori encodes an NADPH nitroreductase. Mutations in this gene are associated with metronidazole resistance.
AIHW01000160.1_9 # 8151 # 8804 420.0 455.292 Helicobacter pylori frxA mutation conferring resistance to metronidazole 100.0 ARO:3007059 protein variant model Y62D nitroimidazole antibiotic antibiotic target alteration Antibiotic resistant Helicobacter pylori nitroreductase FrxA encodes an NADH-flavin oxidoreductase in Helicobacter pylori. Mutations in this gene confer resistance to nitrofuran antibiotics and metronidazole.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
AIHW01000005.1_25 76.441 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
AIHW01000010.1_2 84.71 0.0 virB10/cagY VF0060 Type IV secretion system Effector delivery system VFC0086 (virB10/cagY) type IV secretion system protein Cag7/CagY, VirB10 homolog [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000010.1_3 99.533 6.38E-146 virB10/cagY VF0060 Type IV secretion system Effector delivery system VFC0086 (virB10/cagY) type IV secretion system protein Cag7/CagY, VirB10 homolog [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000010.1_4 100.0 7.21E-147 cagZ VF0060 Type IV secretion system Effector delivery system VFC0086 (cagZ) type IV secretion system protein Cag6/CagZ [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000010.1_5 100.0 0.0 virB11 VF0060 Type IV secretion system Effector delivery system VFC0086 (virB11) type IV secretion system ATPase, VirB11 homolog [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000010.1_6 100.0 0.0 virD4/cag5 VF0060 Type IV secretion system Effector delivery system VFC0086 (virD4/cag5) type IV secretion system protein Cag5, VirD4 homolog [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000011.1_1 100.0 0.0 virD4/cag5 VF0060 Type IV secretion system Effector delivery system VFC0086 (virD4/cag5) type IV secretion system protein Cag5, VirD4 homolog [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000011.1_2 100.0 4.14E-127 virB1/cag4 VF0060 Type IV secretion system Effector delivery system VFC0086 (virB1/cag4) type IV secretion system protein Cag4, VirB1 homolog [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000011.1_3 100.0 0.0 cag3 VF0060 Type IV secretion system Effector delivery system VFC0086 (cag3) type IV secretion system protein Cag3, component outer membrane subcomplex [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000011.1_4 100.0 6.69E-82 cag1 VF0060 Type IV secretion system Effector delivery system VFC0086 (cag1) type IV secretion system protein Cag1 [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000011.1_6 100.0 0.0 cds6 VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (cds6) L,D-carboxypeptidase [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000012.1_22 100.0 0.0 HP_RS02435 VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (HP_RS02435) neuraminyllactose-binding hemagglutinin [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000027.1_3 99.805 0.0 flaB VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flaB) flagellin B FlaB [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000029.1_1 100.0 0.0 tlpB VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (tlpB) membrane-bound chemoreceptor sensing pH and autoinducer-2 [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000029.1_5 99.852 0.0 tlpA VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (tlpA) membrane-bound chemoreceptor sensing arginine and bicarbonate [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000029.1_10 100.0 1.47E-100 futC2 VF0057 Lewis antigen Immune modulation VFC0258 (futC2) alpha-(1,2)-fucosyltransferase [Lewis antigen (VF0057) - Immune modulation (VFC0258)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000030.1_1 100.0 1.59E-104 futC1 VF0057 Lewis antigen Immune modulation VFC0258 (futC1) alpha-(1,2)-fucosyltransferase [Lewis antigen (VF0057) - Immune modulation (VFC0258)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000030.1_12 100.0 0.0 tlpC VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (tlpC) membrane-bound chemoreceptor [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000031.1_6 100.0 1.17E-176 ureA VF0050 Urease Stress survival VFC0282 (ureA) urease alpha subunit UreA [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000031.1_7 99.655 0.0 ureB VF0050 Urease Stress survival VFC0282 (ureB) urease beta subunit UreB, urea amidohydrolase [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000031.1_8 100.0 0.0 ureB VF0050 Urease Stress survival VFC0282 (ureB) urease beta subunit UreB, urea amidohydrolase [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000031.1_9 100.0 1.5E-140 ureI VF0050 Urease Stress survival VFC0282 (ureI) acid-activated urea channel protein [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000031.1_10 100.0 6.45E-125 ureE VF0050 Urease Stress survival VFC0282 (ureE) urease accessory protein (ureE), metallochaperone [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000031.1_11 99.597 0.0 ureF VF0050 Urease Stress survival VFC0282 (ureF) urease accessory protein (ureF) [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000031.1_12 100.0 5.91E-148 ureG VF0050 Urease Stress survival VFC0282 (ureG) urease accessory protein (ureG) [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000031.1_13 100.0 0.0 ureH VF0050 Urease Stress survival VFC0282 (ureH) urease accessory protein (ureH) [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000032.1_14 100.0 0.0 wbcJ VF0056 LPS Immune modulation VFC0258 (wbcJ) GDP fucose synthase [LPS (VF0056) - Immune modulation (VFC0258)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000032.1_15 100.0 0.0 rfbD VF0056 LPS Immune modulation VFC0258 (rfbD) GDP-D-mannose dehydratase [LPS (VF0056) - Immune modulation (VFC0258)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000032.1_16 100.0 0.0 rfbM VF0056 LPS Immune modulation VFC0258 (rfbM) mannose-6-phosphate isomerase [LPS (VF0056) - Immune modulation (VFC0258)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000033.1_2 65.714 0.0 babB/hopT VF0053 BabA Adherence VFC0001 Two alleles: babA2 gene encodes the complete adhesin, whereas babA1 is defective due to the presence of a 10 bp repeat motif which results in the elimination of the start codon and the lack of Leb antigen-binding activity; babA2-genopositive H. pylori usually coexists with other disease-related H. pylori virulence-factor genes, such as vacA s1 and cagA (babB/hopT) outer membrane protein adhesin [BabA (VF0053) - Adherence (VFC0001)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000033.1_6 100.0 0.0 cheV1 VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (cheV1) chemotaxis coupling protein CheV1 [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000033.1_16 63.0 1.15E-178 groEL VF0594 GroEL Adherence VFC0001 GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. (groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] Clostridium difficile
AIHW01000035.1_2 100.0 0.0 hopZ VF0054 HopZ Adherence VFC0001 Regulated by slipped-strand repair mechanism (CT dinucleotide repeats in signal-peptide coding region) (hopZ) outer membrane protein adhesin [HopZ (VF0054) - Adherence (VFC0001)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000036.1_1 100.0 0.0 hopZ VF0054 HopZ Adherence VFC0001 Regulated by slipped-strand repair mechanism (CT dinucleotide repeats in signal-peptide coding region) (hopZ) outer membrane protein adhesin [HopZ (VF0054) - Adherence (VFC0001)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000038.1_8 100.0 0.0 flgG_2 VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flgG_2) flagellar basal-body rod protein (flgG) [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000038.1_11 100.0 0.0 pdxA VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (pdxA) 4-hydroxythreonine-4-phosphate dehydrogenase [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000038.1_12 100.0 0.0 pdxJ VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (pdxJ) pyridoxine 5'-phosphate synthase [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000040.1_3 100.0 1.68E-63 flhB2 VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flhB2) ABC transporter, putative [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000040.1_19 100.0 6.73E-119 flgC VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flgC) flagellar basal-body rod protein FlgC [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000040.1_20 100.0 2.36E-77 fliE VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (fliE) flagellar hook-basal body complex protein FliE [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000044.1_12 100.0 4.09E-119 cheW VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (cheW) chemotaxis coupling protein CheW [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000044.1_13 100.0 0.0 cheA VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (cheA) histidine kinase CheA [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000044.1_14 100.0 0.0 cheV2 VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (cheV2) chemotaxis coupling protein CheV2 [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000044.1_32 100.0 0.0 hpaA2 VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (hpaA2) ahesin protein [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000045.1_6 73.128 1.08E-120 fliP VF0114 Flagella Motility VFC0204 Two different (approximately 59-kDa) flagellin subunits, FlaA and FlaB are subject to both antigenic variation and phase variation; The expression of FlaA and FlaB is controlled by different transcription factors, namely the alternative sigma28 (FlaA) and sigma54 (FlaB) transcription factors; post-translationally modified through O-linked glycosylation. The major modification are pseudaminic acid (Pse5Ac7Ac), a nine carbon sugar that is similar to sialic acid, and an acetamidino-substituted pseudaminic acid (PseAm). There are also minor amounts of a dihydroxyproprionyl form (Pse5Pr7Pr) and an O-acetylated form (Pse5Ac7Ac8OAc); the exact role of glycosylation is unknown. The modification appears to be important for flagellar assembly and may be required for recognition by the flagellar secretion/assembly apparatus (fliP) flagellar biosynthesis protein FliP [Flagella (VF0114) - Motility (VFC0204)] [Campylobacter jejuni subsp. jejuni NCTC 11168] Campylobacter jejuni
AIHW01000059.1_11 100.0 0.0 gluP VF0056 LPS Immune modulation VFC0258 (gluP) glucose/galactose transporter [LPS (VF0056) - Immune modulation (VFC0258)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000072.1_2 100.0 0.0 pflA VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (pflA) paralysed flagella protein (pflA) [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000078.1_1 100.0 0.0 babA/hopS VF0053 BabA Adherence VFC0001 Two alleles: babA2 gene encodes the complete adhesin, whereas babA1 is defective due to the presence of a 10 bp repeat motif which results in the elimination of the start codon and the lack of Leb antigen-binding activity; babA2-genopositive H. pylori usually coexists with other disease-related H. pylori virulence-factor genes, such as vacA s1 and cagA (babA/hopS) outer membrane protein adhesin [BabA (VF0053) - Adherence (VFC0001)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000079.1_2 100.0 0.0 flgG VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flgG) flagellar basal-body rod protein FlgG [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000082.1_3 100.0 2.2E-88 cheY VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (cheY) chemotaxis response regulator CheY [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000084.1_5 100.0 0.0 flhA VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flhA) flagellar biosynthesis protein [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000084.1_11 100.0 0.0 flhF VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flhF) flagellar biosynthesis protein [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000084.1_12 100.0 0.0 ylxH VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (ylxH) ATP-binding protein [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000084.1_14 100.0 0.0 fliA VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (fliA) flagellar biosynthesis sigma factor FliA [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000084.1_15 100.0 0.0 fliM VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (fliM) flagellar motor switch protein FliM [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000084.1_16 100.0 0.0 fliY VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (fliY) flagellar motor switch protein [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000089.1_1 78.302 9.51E-105 babA/hopS VF0053 BabA Adherence VFC0001 Two alleles: babA2 gene encodes the complete adhesin, whereas babA1 is defective due to the presence of a 10 bp repeat motif which results in the elimination of the start codon and the lack of Leb antigen-binding activity; babA2-genopositive H. pylori usually coexists with other disease-related H. pylori virulence-factor genes, such as vacA s1 and cagA (babA/hopS) outer membrane protein adhesin [BabA (VF0053) - Adherence (VFC0001)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000097.1_15 100.0 0.0 pseI VF0608 Flagellar glycosylation/Pse biosynthetic pathway Motility VFC0204 Flagellar glycosylation is common among a number of bacterial pathogens such as H. pylori and Campylobacter jejuni.;H. pylori flagellins are O-glycosylated on serines and threonines with an unusual nine-carbon sugar pseudaminic acid (Pse). (pseI) pseudaminic acid synthase [Flagellar glycosylation/Pse biosynthetic pathway (VF0608) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000097.1_20 100.0 0.0 fliR VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (fliR) flagellar biosynthetic protein FliR [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000098.1_2 100.0 0.0 rfaJ VF0056 LPS Immune modulation VFC0258 (rfaJ) alpha-1,6 Glc transferase [LPS (VF0056) - Immune modulation (VFC0258)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000099.1_7 100.0 1.53E-175 flgH VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flgH) flagellar L-ring protein precursor FlgH [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000099.1_8 100.0 1.79E-151 pseFG VF0608 Flagellar glycosylation/Pse biosynthetic pathway Motility VFC0204 Flagellar glycosylation is common among a number of bacterial pathogens such as H. pylori and Campylobacter jejuni.;H. pylori flagellins are O-glycosylated on serines and threonines with an unusual nine-carbon sugar pseudaminic acid (Pse). (pseFG) CMP-N-acetylneuraminic acid synthetase [Flagellar glycosylation/Pse biosynthetic pathway (VF0608) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000099.1_9 100.0 0.0 pseFG VF0608 Flagellar glycosylation/Pse biosynthetic pathway Motility VFC0204 Flagellar glycosylation is common among a number of bacterial pathogens such as H. pylori and Campylobacter jejuni.;H. pylori flagellins are O-glycosylated on serines and threonines with an unusual nine-carbon sugar pseudaminic acid (Pse). (pseFG) CMP-N-acetylneuraminic acid synthetase [Flagellar glycosylation/Pse biosynthetic pathway (VF0608) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000099.1_10 100.0 1.38E-130 pseH/flmH/flaG1 VF0608 Flagellar glycosylation/Pse biosynthetic pathway Motility VFC0204 Flagellar glycosylation is common among a number of bacterial pathogens such as H. pylori and Campylobacter jejuni.;H. pylori flagellins are O-glycosylated on serines and threonines with an unusual nine-carbon sugar pseudaminic acid (Pse). (pseH/flmH/flaG1) UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase; Pseudaminic acid biosynthesis protein H [Flagellar glycosylation/Pse biosynthetic pathway (VF0608) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000099.1_14 66.667 2.11E-6 flhG VF0114 Flagella Motility VFC0204 Two different (approximately 59-kDa) flagellin subunits, FlaA and FlaB are subject to both antigenic variation and phase variation; The expression of FlaA and FlaB is controlled by different transcription factors, namely the alternative sigma28 (FlaA) and sigma54 (FlaB) transcription factors; post-translationally modified through O-linked glycosylation. The major modification are pseudaminic acid (Pse5Ac7Ac), a nine carbon sugar that is similar to sialic acid, and an acetamidino-substituted pseudaminic acid (PseAm). There are also minor amounts of a dihydroxyproprionyl form (Pse5Pr7Pr) and an O-acetylated form (Pse5Ac7Ac8OAc); the exact role of glycosylation is unknown. The modification appears to be important for flagellar assembly and may be required for recognition by the flagellar secretion/assembly apparatus (flhG) ATP-binding protein [Flagella (VF0114) - Motility (VFC0204)] [Campylobacter jejuni subsp. jejuni NCTC 11168] Campylobacter jejuni
AIHW01000104.1_1 79.769 2.86E-99 babA/hopS VF0053 BabA Adherence VFC0001 Two alleles: babA2 gene encodes the complete adhesin, whereas babA1 is defective due to the presence of a 10 bp repeat motif which results in the elimination of the start codon and the lack of Leb antigen-binding activity; babA2-genopositive H. pylori usually coexists with other disease-related H. pylori virulence-factor genes, such as vacA s1 and cagA (babA/hopS) outer membrane protein adhesin [BabA (VF0053) - Adherence (VFC0001)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000109.1_13 100.0 0.0 HP_RS04690 VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (HP_RS04690) zinc ribbon domain-containing protein [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000110.1_1 100.0 0.0 futB VF0057 Lewis antigen Immune modulation VFC0258 (futB) fucosyltransferase [Lewis antigen (VF0057) - Immune modulation (VFC0258)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000114.1_1 63.636 9.82E-20 babA/hopS VF0053 BabA Adherence VFC0001 Two alleles: babA2 gene encodes the complete adhesin, whereas babA1 is defective due to the presence of a 10 bp repeat motif which results in the elimination of the start codon and the lack of Leb antigen-binding activity; babA2-genopositive H. pylori usually coexists with other disease-related H. pylori virulence-factor genes, such as vacA s1 and cagA (babA/hopS) outer membrane protein adhesin [BabA (VF0053) - Adherence (VFC0001)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000114.1_15 100.0 4.53E-104 napA VF0052 HP-NAP Immune modulation VFC0258 (napA) neutrophil activating protein NapA [HP-NAP (VF0052) - Immune modulation (VFC0258)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000114.1_16 100.0 0.0 flgS VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flgS) signal-transducing protein, histidine kinase [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000114.1_18 100.0 0.0 flgI VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flgI) flagellar P-ring protein precursor FlgI [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000114.1_27 100.0 1.08E-95 HP0256 VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (HP0256) involved in motility and cell envelope architecture [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000117.1_2 100.0 0.0 rfaC VF0056 LPS Immune modulation VFC0258 (rfaC) lipopolysaccharide heptosyltransferase-1 [LPS (VF0056) - Immune modulation (VFC0258)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000121.1_1 100.0 0.0 flgL VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flgL) flagellar hook-associated protein 3 FlgL [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000122.1_4 100.0 0.0 fliF VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (fliF) flagellar M-ring protein FliF [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000122.1_5 100.0 0.0 fliG VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (fliG) flagellar motor switch protein G [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000122.1_6 99.609 0.0 fliH VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (fliH) flagellar assembly protein H [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000122.1_12 100.0 0.0 gluE VF0056 LPS Immune modulation VFC0258 (gluE) UDP-glucose 4-epimerase [LPS (VF0056) - Immune modulation (VFC0258)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000122.1_17 100.0 0.0 pseC VF0608 Flagellar glycosylation/Pse biosynthetic pathway Motility VFC0204 Flagellar glycosylation is common among a number of bacterial pathogens such as H. pylori and Campylobacter jejuni.;H. pylori flagellins are O-glycosylated on serines and threonines with an unusual nine-carbon sugar pseudaminic acid (Pse). (pseC) flagellar modification protein, aminotransferase PseC [Flagellar glycosylation/Pse biosynthetic pathway (VF0608) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000127.1_2 100.0 0.0 flgK VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flgK) flagellar hook-associated protein 1 FlgK [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000127.1_5 100.0 3.27E-44 flgM VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flgM) negative regulator of flagellin synthesis [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000129.1_1 99.751 0.0 virB10/cagY VF0060 Type IV secretion system Effector delivery system VFC0086 (virB10/cagY) type IV secretion system protein Cag7/CagY, VirB10 homolog [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000141.1_15 100.0 8.02E-155 flgA VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flgA) flagellar basal body P-ring biosynthesis protein FlgA [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000141.1_17 100.0 7.09E-117 kdtB VF0056 LPS Immune modulation VFC0258 (kdtB) lipopolysaccharide core biosynthesis protein [LPS (VF0056) - Immune modulation (VFC0258)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000145.1_7 100.0 4.84E-149 HP_RS07240 VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (HP_RS07240) META domain-containing protein [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000150.1_4 100.0 0.0 HP_RS07005 VF0056 LPS Immune modulation VFC0258 (HP_RS07005) alpha-1,2/4 Glc transferase [LPS (VF0056) - Immune modulation (VFC0258)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000150.1_8 100.0 4.32E-57 fliQ VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (fliQ) flagellar biosynthesis protein [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000150.1_9 100.0 0.0 fliI VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (fliI) flagellum-specific ATP synthase FliI [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000151.1_1 100.0 3.41E-121 sabB/hopO VF0055 SabA Adherence VFC0001 (sabB/hopO) outer membrane protein adhesin [SabA (VF0055) - Adherence (VFC0001)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000154.1_11 100.0 0.0 flgE VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flgE) flagellar hook protein [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000154.1_12 100.0 0.0 flgD VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flgD) flagellar basal-body rod modification protein FlgD [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000156.1_2 99.825 0.0 babB/hopT VF0053 BabA Adherence VFC0001 Two alleles: babA2 gene encodes the complete adhesin, whereas babA1 is defective due to the presence of a 10 bp repeat motif which results in the elimination of the start codon and the lack of Leb antigen-binding activity; babA2-genopositive H. pylori usually coexists with other disease-related H. pylori virulence-factor genes, such as vacA s1 and cagA (babB/hopT) outer membrane protein adhesin [BabA (VF0053) - Adherence (VFC0001)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000159.1_1 100.0 2.99E-167 sabB/hopO VF0055 SabA Adherence VFC0001 (sabB/hopO) outer membrane protein adhesin [SabA (VF0055) - Adherence (VFC0001)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000160.1_13 100.0 0.0 oipA/hopH VF0266 OipA Immune modulation VFC0258 H. pylori-related gastritis is characterized by mucosal infiltration with neutrophils and mononuclear cells. The migration and activation of these cells is thought to be related to the local production of various proinflammatory cytokines, especially IL-8. The presence of a functional cag PAI is associated with increased IL-8 production. But it is not the sole H. pylori factor able to promote IL-8 secretion; regulated by slipped-strand repair mechanism (CT dinucleotide repeats in oipA gene) (oipA/hopH) outer inflammatory protein A, adhesin [OipA (VF0266) - Immune modulation (VFC0258)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000169.1_4 100.0 0.0 HP_RS03030 VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (HP_RS03030) chemotaxis protein [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000172.1_1 100.0 2.95E-178 sabB/hopO VF0055 SabA Adherence VFC0001 (sabB/hopO) outer membrane protein adhesin [SabA (VF0055) - Adherence (VFC0001)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000174.1_10 100.0 0.0 flaA VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flaA) flagellin A FlaA [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000174.1_13 100.0 1.45E-146 cheV3 VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (cheV3) chemotaxis coupling protein CheV3 [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000175.1_1 100.0 9.11E-161 cheV3 VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (cheV3) chemotaxis coupling protein CheV3 [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000179.1_5 100.0 1.41E-86 fliN VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (fliN) flagellar motor switch protein FliN [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_21 100.0 0.0 cagA VF0059 CagA Effector delivery system VFC0086 (cagA) cag T4SS translocated effector CagA [CagA (VF0059) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_23 100.0 6.51E-80 virB2/cagC VF0060 Type IV secretion system Effector delivery system VFC0086 (virB2/cagC) type IV secretion system protein Cag25/CagC, VirB2 homolog [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_24 100.0 1.14E-148 cagD VF0060 Type IV secretion system Effector delivery system VFC0086 (cagD) type IV secretion system protein Cag24/CagD [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_25 99.898 0.0 virB4/cagE VF0060 Type IV secretion system Effector delivery system VFC0086 (virB4/cagE) type IV secretion system protein Cag23/CagE, VirB4 homolog [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_26 99.627 0.0 cagF VF0060 Type IV secretion system Effector delivery system VFC0086 (cagF) type IV secretion system protein Cag22/CagF, chaperone-like protein for CagA [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_27 100.0 4.36E-103 cagG VF0060 Type IV secretion system Effector delivery system VFC0086 (cagG) type IV secretion system protein Cag21/CagG [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_28 99.73 0.0 cagH VF0060 Type IV secretion system Effector delivery system VFC0086 (cagH) type IV secretion system protein Cag20/CagH [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_29 100.0 0.0 cagI VF0060 Type IV secretion system Effector delivery system VFC0086 (cagI) type IV secretion system protein Cag19/CagI [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_30 100.0 9.04E-174 virB5/cagL VF0060 Type IV secretion system Effector delivery system VFC0086 (virB5/cagL) type IV secretion system protein Cag18/CagL, VirB5 homolog [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_31 100.0 0.0 cagN VF0060 Type IV secretion system Effector delivery system VFC0086 (cagN) type IV secretion system protein Cag17/CagN, membrane-associated protein [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_32 100.0 0.0 cagM VF0060 Type IV secretion system Effector delivery system VFC0086 (cagM) type IV secretion system protein Cag16/CagM, transmembrane channel protein [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_33 100.0 4.82E-66 cagQ VF0060 Type IV secretion system Effector delivery system VFC0086 (cagQ) type IV secretion system protein Cag14/CagQ [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_34 100.0 2.67E-139 cagS VF0060 Type IV secretion system Effector delivery system VFC0086 (cagS) type IV secretion system protein Cag13/CagS [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_36 100.0 0.0 virB7/cagT VF0060 Type IV secretion system Effector delivery system VFC0086 (virB7/cagT) type IV secretion system protein Cag12/CagT, VirB7 homolog [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_37 100.0 5.92E-160 cagU VF0060 Type IV secretion system Effector delivery system VFC0086 (cagU) type IV secretion system protein Cag11/CagU [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_38 99.603 0.0 virB8/cagV VF0060 Type IV secretion system Effector delivery system VFC0086 (virB8/cagV) type IV secretion system protein Cag10/CagV, VirB8 homolog [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_39 100.0 0.0 virB6/cagW VF0060 Type IV secretion system Effector delivery system VFC0086 (virB6/cagW) type IV secretion system protein Cag9/CagW, VirB6 homolog [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_40 100.0 0.0 virB9/cagX VF0060 Type IV secretion system Effector delivery system VFC0086 (virB9/cagX) type IV secretion system protein Cag8/CagX, VirB9 homolog [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000181.1_41 100.0 1.44E-11 virB10/cagY VF0060 Type IV secretion system Effector delivery system VFC0086 (virB10/cagY) type IV secretion system protein Cag7/CagY, VirB10 homolog [Type IV secretion system (VF0060) - Effector delivery system (VFC0086)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000184.1_9 100.0 4.24E-167 vacA VF0058 VacA Exotoxin VFC0235 VacA expression is determined by variation in the signal sequence (s1a, s1b, s1c, s2) and mid-region (m1, m2) of the vacA gene. s1-type signaling-sequence allele produce functional VacA toxin, whereas s2-type produce VacA with little cytotoxic activity. And s1/m1 strains are more toxic than s1/m2 strains (vacA) vacuolating cytotoxin [VacA (VF0058) - Exotoxin (VFC0235)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000185.1_1 100.0 0.0 vacA VF0058 VacA Exotoxin VFC0235 VacA expression is determined by variation in the signal sequence (s1a, s1b, s1c, s2) and mid-region (m1, m2) of the vacA gene. s1-type signaling-sequence allele produce functional VacA toxin, whereas s2-type produce VacA with little cytotoxic activity. And s1/m1 strains are more toxic than s1/m2 strains (vacA) vacuolating cytotoxin [VacA (VF0058) - Exotoxin (VFC0235)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000186.1_1 100.0 2.85E-13 vacA VF0058 VacA Exotoxin VFC0235 VacA expression is determined by variation in the signal sequence (s1a, s1b, s1c, s2) and mid-region (m1, m2) of the vacA gene. s1-type signaling-sequence allele produce functional VacA toxin, whereas s2-type produce VacA with little cytotoxic activity. And s1/m1 strains are more toxic than s1/m2 strains (vacA) vacuolating cytotoxin [VacA (VF0058) - Exotoxin (VFC0235)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000188.1_6 100.0 0.0 flgE_1 VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flgE_1) flagellar hook protein [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000189.1_1 100.0 1.53E-114 flgE_1 VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flgE_1) flagellar hook protein [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000189.1_4 100.0 0.0 lpxB VF0056 LPS Immune modulation VFC0258 (lpxB) lipid A disaccharide synthetase [LPS (VF0056) - Immune modulation (VFC0258)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000190.1_1 61.594 7.97E-53 hldE VF0326 LOS Immune modulation VFC0258 (hldE) bifunctional D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase [LOS (VF0326) - Immune modulation (VFC0258)] [Campylobacter jejuni subsp. jejuni NCTC 11168] Campylobacter jejuni
AIHW01000190.1_2 61.081 8.3E-75 gmhA VF0326 LOS Immune modulation VFC0258 (gmhA) phosphoheptose isomerase [LOS (VF0326) - Immune modulation (VFC0258)] [Campylobacter jejuni subsp. jejuni NCTC 11168] Campylobacter jejuni
AIHW01000193.1_6 100.0 0.0 pseB VF0608 Flagellar glycosylation/Pse biosynthetic pathway Motility VFC0204 Flagellar glycosylation is common among a number of bacterial pathogens such as H. pylori and Campylobacter jejuni.;H. pylori flagellins are O-glycosylated on serines and threonines with an unusual nine-carbon sugar pseudaminic acid (Pse). (pseB) UDP-N-acetylglucosamine 4,6-dehydratase [Flagellar glycosylation/Pse biosynthetic pathway (VF0608) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000194.1_5 100.0 0.0 HP_RS03480 VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (HP_RS03480) RNA polymerase factor sigma-54 [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000198.1_6 100.0 0.0 motB VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (motB) flagellar motor protein [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000198.1_7 100.0 6.2E-76 motA VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (motA) flagellar motor protein [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000199.1_1 100.0 4.2E-94 motA VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (motA) flagellar motor protein [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000201.1_3 100.0 9.6E-131 fliL VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (fliL) flagellar basal body protein FliL [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000202.1_14 65.789 2.2E-94 clpP VF0074 ClpP Stress survival VFC0282 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
AIHW01000205.1_3 100.0 0.0 flgR VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flgR) response regulator [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000209.1_8 100.0 0.0 flhB VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flhB) flagellar biosynthesis protein [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000211.1_5 100.0 1.37E-91 fliS VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (fliS) flagellar protein FliS [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000211.1_6 99.847 0.0 fliD VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (fliD) flagellar capping protein FliD [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000211.1_7 100.0 1.86E-84 flaG VF0051 Flagella Motility VFC0204 H. pylori typically produce 4-6 unipolar flagella, which are encased in a membranous sheath and capped by terminal bulbs (flaG) a negative regulator of flagellar assembly [Flagella (VF0051) - Motility (VFC0204)] [Helicobacter pylori 26695] Helicobacter pylori
AIHW01000215.1_1 100.0 0.0 sabA/hopP VF0055 SabA Adherence VFC0001 (sabA/hopP) outer membrane protein adhesin [SabA (VF0055) - Adherence (VFC0001)] [Helicobacter pylori 26695] Helicobacter pylori