2. PATHOGENS
Basic Information
Accession number
GCA_000283715.1
Release date
2012-01-31
Organism
Shigella sonnei 53G
Species name
Shigella sonnei
Assembly level
Complete Genome
Assembly name
ASM28371v1
Assembly submitter
Wellcome Trust Sanger Insititute
Assembly Type
haploid
Genome size
5.2 Mb
GC percent
50.5
Contig count
5
Collection date
-
Sample location
-
Host
-
Isolation source
-
Isolate type
-
Strain
-
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
HE616528.1_83 # 90880 # 91824 500.0 648.662 leuO 99.04 ARO:3003843 protein homolog model nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump leuO, a LysR family transcription factor, exists in a wide variety of bacteria of the family Enterobacteriaceae and is involved in the regulation of as yet unidentified genes affecting the stress response and pathogenesis expression. LeuO is also an activator of the MdtNOP efflux pump.
HE616528.1_364 # 391636 # 392730 250.0 266.544 vanG 39.5 ARO:3002909 protein homolog model glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; Van ligase VanG is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis.
HE616528.1_456 # 480316 # 483465 1900.0 2136.69 acrB 99.9 ARO:3000216 protein homolog model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter.
HE616528.1_457 # 483488 # 484681 670.0 796.964 Escherichia coli acrA 99.75 ARO:3004043 protein homolog model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrA is a subunit of the AcrAB-TolC multidrug efflux system found in E. coli.
HE616528.1_651 # 689941 # 690618 400.0 449.514 kdpE 99.11 ARO:3003841 protein homolog model aminoglycoside antibiotic antibiotic efflux kdpDE kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding.
HE616528.1_940 # 983576 # 985324 1000.0 1188.71 msbA 99.66 ARO:3003950 protein homolog model nitroimidazole antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A, a major component of the bacterial outer cell membrane, and is the only bacterial ABC transporter that is essential for cell viability.
HE616528.1_1104 # 1149977 # 1151185 750.0 793.497 mdtH 99.25 ARO:3001216 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug resistance protein MdtH.
HE616528.1_1740 # 1726395 # 1726778 230.0 266.544 marA 100.0 ARO:3000263 protein homolog model fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux; reduced permeability to antibiotic resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF.
HE616528.1_1792 # 1770205 # 1770534 150.0 186.808 Klebsiella pneumoniae KpnF 84.4 ARO:3004583 protein homolog model macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic; disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump KpnF subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan.
HE616528.1_1793 # 1770521 # 1770886 150.0 182.57 Klebsiella pneumoniae KpnE 82.2 ARO:3004580 protein homolog model macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic; disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump KpnE subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan.
HE616528.1_2181 # 2136615 # 2137028 240.0 276.944 H-NS 100.0 ARO:3000676 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; cephalosporin; cephamycin; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump H-NS is a histone-like protein involved in global gene regulation in Gram-negative bacteria. It is a repressor of the membrane fusion protein genes acrE, mdtE, and emrK as well as nearby genes of many RND-type multidrug exporters.
HE616528.1_2237 # 2187915 # 2188247 190.0 216.083 Escherichia coli emrE 98.18 ARO:3004039 protein homolog model macrolide antibiotic antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump Member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation.
HE616528.1_2342 # 2281178 # 2282344 700.0 788.104 ugd 98.97 ARO:3003577 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin.
HE616528.1_2369 # 2316164 # 2317405 725.0 818.15 mdtA 98.55 ARO:3000792 protein homolog model aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtA is the membrane fusion protein of the multidrug efflux complex mdtABC.
HE616528.1_2370 # 2317405 # 2320527 1800.0 2070.82 mdtB 99.33 ARO:3000793 protein homolog model aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex.
HE616528.1_2371 # 2320528 # 2323605 1800.0 2065.04 mdtC 99.71 ARO:3000794 protein homolog model aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB, MdtC can form a homomultimer complex that results in a functioning efflux complex with a narrower drug specificity. mdtC corresponds to 3 loci in Pseudomonas aeruginosa PAO1 (gene name: muxC/muxB) and 3 loci in Pseudomonas aeruginosa LESB58.
HE616528.1_2373 # 2325018 # 2326421 850.0 942.184 baeS 98.93 ARO:3000829 protein homolog model aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump BaeS is a sensor kinase in the BaeSR regulatory system. While it phosphorylates BaeR to increase its activity, BaeS is not necessary for overexpressed BaeR to confer resistance.
HE616528.1_2374 # 2326418 # 2327140 450.0 486.493 baeR 100.0 ARO:3000828 protein homolog model aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes.
HE616528.1_2521 # 2472045 # 2473688 1050.0 1104.74 YojI 99.27 ARO:3003952 protein homolog model peptide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump YojI mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. YojI is capable of pumping out microcin molecules. The outer membrane protein TolC in addition to YojI is required for export of microcin J25 out of the cell. Microcin J25 is thus the first known substrate for YojI.
HE616528.1_2569 # 2532787 # 2533755 550.0 667.537 PmrF 100.0 ARO:3003578 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58.
HE616528.1_2572 # 2536624 # 2538276 400.0 736.487 ArnT 64.07 ARO:3005053 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase ArnT is involved in Cell Wall Biosynthesis, specifically 4-amino-4-deoxy-L-arabinose (Ara4N). It confers resistance to peptide antibiotics.
HE616528.1_2733 # 2684621 # 2686159 900.0 1023.08 emrY 100.0 ARO:3000254 protein homolog model tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump emrY is a multidrug transport that moves substrates across the inner membrane of the Gram-negative E. coli. It is a homolog of emrB.
HE616528.1_2734 # 2686159 # 2687322 600.0 715.301 emrK 99.43 ARO:3000206 protein homolog model tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump emrK is a membrane fusion protein that is a homolog of EmrA. Together with the inner membrane transporter EmrY and the outer membrane channel TolC, it mediates multidrug efflux.
HE616528.1_2735 # 2687738 # 2688352 390.0 414.075 evgA 99.51 ARO:3000832 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump EvgA, when phosphorylated, is a positive regulator for efflux protein complexes emrKY and mdtEF. While usually phosphorylated in a EvgS dependent manner, it can be phosphorylated in the absence of EvgS when overexpressed.
HE616528.1_2736 # 2688357 # 2691950 2300.0 2441.0 evgS 98.08 ARO:3000833 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump EvgS is a sensor protein that phosphorylates the regulatory protein EvgA. evgS corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58.
HE616528.1_2823 # 2780967 # 2784080 1900.0 2122.82 acrD 99.81 ARO:3000491 protein homolog model aminoglycoside antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrD is an aminoglycoside efflux pump expressed in E. coli. Its expression can be induced by indole, and is regulated by baeRS and cpxAR.
HE616528.1_3167 # 3105323 # 3105853 280.0 361.303 emrR 100.0 ARO:3000516 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression.
HE616528.1_3168 # 3105980 # 3107152 675.0 787.719 emrA 99.49 ARO:3000027 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump EmrA is a membrane fusion protein, providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli, a Gram-negative bacterium.
HE616528.1_3169 # 3107169 # 3108707 900.0 1029.24 emrB 100.0 ARO:3000074 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP), nalidixic acid, and thioloactomycin.
HE616528.1_3174 # 3113240 # 3113425 100.0 109.383 rsmA 85.25 ARO:3005069 protein homolog model fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump rsmA is a gene that regulates virulence of Pseudomonas aeruginosa. However, its negative effect on MexEF-OprN overexpression has been noted to confer resistance to various antibiotics. It's Escherichia coli homolog is csrA.
HE616528.1_3541 # 3485631 # 3487112 900.0 994.186 TolC 100.0 ARO:3000237 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump TolC is a protein subunit of many multidrug efflux complexes in Gram negative bacteria. It is an outer membrane efflux protein and is constitutively open. Regulation of efflux activity is often at its periplasmic entrance by other components of the efflux complex.
HE616528.1_3562 # 3510624 # 3511445 500.0 540.421 bacA 99.27 ARO:3002986 protein homolog model peptide antibiotic antibiotic target alteration undecaprenyl pyrophosphate related proteins The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin.
HE616528.1_3761 # 3718789 # 3719451 380.0 453.366 AcrS 99.09 ARO:3000656 protein homolog model fluoroquinolone antibiotic; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrS is a repressor of the AcrAB efflux complex and is associated with the expression of AcrEF. AcrS is believed to regulate a switch between AcrAB and AcrEF efflux.
HE616528.1_3762 # 3719850 # 3721007 675.0 781.556 AcrE 99.48 ARO:3000499 protein homolog model fluoroquinolone antibiotic; cephalosporin; cephamycin; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrE is a membrane fusion protein, similar to AcrA.
HE616528.1_3764 # 3721200 # 3724124 1900.0 1965.66 AcrF 99.28 ARO:3000502 protein homolog model fluoroquinolone antibiotic; cephalosporin; cephamycin; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrF is a inner membrane transporter, similar to AcrB.
HE616528.1_3844 # 3781944 # 3782576 400.0 433.335 CRP 99.05 ARO:3000518 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump CRP is a global regulator that represses MdtEF multidrug efflux pump expression.
HE616528.1_4020 # 3963270 # 3964427 675.0 776.548 mdtE 99.74 ARO:3000795 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtE is the membrane fusion protein of the MdtEF multidrug efflux complex. It shares 70% sequence similarity with AcrA.
HE616528.1_4021 # 3964452 # 3967565 1850.0 2102.79 mdtF 99.81 ARO:3000796 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtF is the multidrug inner membrane transporter for the MdtEF-TolC efflux complex.
HE616528.1_4024 # 3969024 # 3969848 450.0 560.836 gadX 98.54 ARO:3000508 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump GadX is an AraC-family regulator that promotes mdtEF expression to confer multidrug resistance.
HE616528.1_4471 # 4439207 # 4440580 890.0 926.391 cpxA 100.0 ARO:3000830 protein homolog model aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR, which promotes efflux complex expression.
HE616528.1_4706 # 4683386 # 4685437 1300.0 1378.62 mdtO 98.39 ARO:3003549 protein homolog model nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
HE616528.1_4707 # 4685437 # 4686468 600.0 685.641 mdtN 99.71 ARO:3003548 protein homolog model nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug resistance efflux pump. Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
HE616528.1_4734 # 4709175 # 4710818 1000.0 1127.85 eptA 99.09 ARO:3003576 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase PmrC mediates the modification of Lipid A by the addition of 4-amino-4-deoxy-L-arabinose (L-Ara4N) and phosphoethanolamine, resulting in a less negative cell membrane and decreased binding of polymyxin B.
HE616528.1_4787 # 4760455 # 4761588 700.0 761.14 Escherichia coli ampC beta-lactamase 98.41 ARO:3004290 protein homolog model cephalosporin; penam antibiotic inactivation ampC-type beta-lactamase A class C ampC beta-lactamase (cephalosporinase) enzyme described in Escherichia coli shown clinically to confer resistance to penicillin-like and cephalosporin-class antibiotics.
HE616528.1_92 # 98702 # 100468 500.0 593.578 Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics 52.93 ARO:3004446 protein variant model D350N, S357N cephalosporin; cephamycin; penam antibiotic target alteration Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics PBP3 is a penicillin-binding protein and beta-lactam resistance enzyme encoded by the ftsI gene in Haemophilus influenzae. Mutations in ftsI confer resistance to beta-lactam antibiotics.
HE616528.1_2555 # 2516927 # 2518285 850.0 919.842 Escherichia coli GlpT with mutation conferring resistance to fosfomycin 99.78 ARO:3003889 protein variant model E448K phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant GlpT Point mutations to the active importer GlpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria.
HE616528.1_3825 # 3765969 # 3767153 700.0 797.734 Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin 99.75 ARO:3003369 protein variant model R234F elfamycin antibiotic antibiotic target alteration elfamycin resistant EF-Tu Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin.
HE616528.1_4583 # 4550547 # 4551731 700.0 795.808 Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin 99.75 ARO:3003369 protein variant model R234F elfamycin antibiotic antibiotic target alteration elfamycin resistant EF-Tu Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin.
HE616528.1_458 # 484823 # 485470 375.0 446.047 Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime 100.0 ARO:3003807 protein overexpression model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. The mutations associated with this model are specific to E. coli.
HE616528.1_1739 # 1725941 # 1726375 210.0 289.656 Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline 98.61 ARO:3003378 protein overexpression model Y137H, G103S fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB.
HE616528.1_4680 # 4656993 # 4657316 200.0 220.32 Escherichia coli soxS with mutation conferring antibiotic resistance 100.0 ARO:3003511 protein overexpression model fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux; reduced permeability to antibiotic ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
HE616528.1_27 90.661 7.75E-172 espX1 VF1111 TTSS secreted effectors Effector delivery system VFC0086 (espX1) Type III secretion system effector EspX1 [TTSS secreted effectors (VF1111) - Effector delivery system (VFC0086)] [Escherichia coli O55:H7 str. CB9615] Escherichia coli (EPEC)
HE616528.1_104 77.303 0.0 lpxC VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxC) UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
HE616528.1_195 65.089 1.35E-160 lpxD VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxD) UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
HE616528.1_197 67.557 1.62E-132 lpxA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxA) UDP-N-acetylglucosamine acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
HE616528.1_198 63.542 1.28E-177 lpxB VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxB) lipid-A-disaccharide synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
HE616528.1_215 67.528 1.16E-127 IlpA VF0513 IlpA Adherence VFC0001 (IlpA) immunogenic lipoprotein A [IlpA (VF0513) - Adherence (VFC0001)] [Vibrio vulnificus YJ016] Vibrio vulnificus
HE616528.1_233 100.0 1.24E-120 hcp1/tssD1 VF0579 T6SS Effector delivery system VFC0086 (hcp1/tssD1) type VI secretion system protein, Hcp family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_234 99.778 0.0 tssA VF0579 T6SS Effector delivery system VFC0086 (tssA) Type VI secretion system protein TssA [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_237 99.362 0.0 tssA VF0579 T6SS Effector delivery system VFC0086 (tssA) Type VI secretion system protein TssA [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_239 63.547 0.0 clpB VF0480 T6SS Effector delivery system VFC0086 (clpB) type VI secretion system ATPase ClpV1 [T6SS (VF0480) - Effector delivery system (VFC0086)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966] Aeromonas hydrophila
HE616528.1_240 100.0 0.0 tssL VF0579 T6SS Effector delivery system VFC0086 (tssL) Type VI secretion system protein TssL [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_242 100.0 6.95E-130 tssJ VF0579 T6SS Effector delivery system VFC0086 (tssJ) Type VI secretion system protein TssJ [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_243 100.0 0.0 fha VF0579 T6SS Effector delivery system VFC0086 (fha) Type VI secretion system protein Fha [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_244 100.0 0.0 tssG VF0579 T6SS Effector delivery system VFC0086 (tssG) Type VI secretion system protein TssG [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_245 100.0 0.0 tssF VF0579 T6SS Effector delivery system VFC0086 (tssF) Type VI secretion system protein TssF [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_247 82.873 6.79E-113 vipB VF0480 T6SS Effector delivery system VFC0086 (vipB) Type VI secretion system contractile sheath large subunit TssC/VipB [T6SS (VF0480) - Effector delivery system (VFC0086)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966] Aeromonas hydrophila
HE616528.1_248 65.878 9.97E-146 vipB VF0480 T6SS Effector delivery system VFC0086 (vipB) Type VI secretion system contractile sheath large subunit TssC/VipB [T6SS (VF0480) - Effector delivery system (VFC0086)] [Aeromonas hydrophila subsp. hydrophila ATCC 7966] Aeromonas hydrophila
HE616528.1_250 100.0 1.91E-120 tssB VF0579 T6SS Effector delivery system VFC0086 (tssB) Type VI secretion system protein TssB [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_251 100.0 8.44E-132 hcp2/tssD2 VF0579 T6SS Effector delivery system VFC0086 (hcp2/tssD2) Type VI secretion system protein, Hcp family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_252 99.813 0.0 vgrG/tssI VF0579 T6SS Effector delivery system VFC0086 (vgrG/tssI) type VI secretion system effector VgrG [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_255 99.379 9.2E-112 vgrG/tssI VF0579 T6SS Effector delivery system VFC0086 (vgrG/tssI) type VI secretion system effector VgrG [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_256 99.715 0.0 rhs/PAAR VF0579 T6SS Effector delivery system VFC0086 (rhs/PAAR) Type VI secretion system protein, PAAR family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_268 74.479 8.28E-108 gmhA/lpcA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (gmhA/lpcA) phosphoheptose isomerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
HE616528.1_428 66.495 8.54E-98 clpP VF0074 ClpP Stress survival VFC0282 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
HE616528.1_456 91.42 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_457 84.635 0.0 acrA VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrA) acriflavine resistance protein A [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_494 70.283 3.69E-113 allS VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allS) DNA-binding transcriptional activator AllS [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_495 80.435 2.08E-50 allS VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allS) DNA-binding transcriptional activator AllS [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_510 91.803 0.0 allB VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allB) allantoinase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_514 75.0 5.34E-34 fimD VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimD) usher protein FimD [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
HE616528.1_515 71.954 0.0 fimD VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimD) usher protein FimD [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
HE616528.1_516 70.958 2.5E-176 fimH VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimH) type I fimbriae minor fimbrial subunit FimH, adhesin [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
HE616528.1_518 70.619 3.65E-100 fimZ VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimZ) DNA-binding response regulator [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
HE616528.1_528 92.25 0.0 vgrG/tssI VF0579 T6SS Effector delivery system VFC0086 (vgrG/tssI) type VI secretion system effector VgrG [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_531 98.261 0.0 ibeB VF0237 Ibes Invasion VFC0083 IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC [Ibes (VF0237) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
HE616528.1_543 94.66 5.26E-147 entD VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entD) phosphopantetheinyl transferase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_544 99.196 0.0 fepA VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepA) ferrienterobactin outer membrane transporter [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_545 95.5 0.0 fes VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fes) enterobactin/ferric enterobactin esterase [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_547 96.674 0.0 entF VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entF) enterobactin synthase multienzyme complex component, ATP-dependent [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_548 93.369 0.0 fepE VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepE) LPS O-antigen length regulator [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_549 98.889 0.0 fepC VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_550 97.576 0.0 fepG VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepG) iron-enterobactin ABC transporter permease [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_551 99.401 0.0 fepD VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepD) ferrienterobactin ABC transporter permease [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_552 99.519 0.0 entS VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entS) enterobactin exporter, iron-regulated [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_553 98.428 0.0 fepB VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_554 98.721 0.0 entC VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entC) isochorismate synthase 1 [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_555 98.507 0.0 entE VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entE) 2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_556 98.596 0.0 entB VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entB) isochorismatase [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_557 97.984 1.51E-180 entA VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entA) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase EntA [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_641 99.315 1.76E-107 fur VF0113 Fur Regulation VFC0301 (fur) ferric iron uptake transcriptional regulator [Fur (VF0113) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
HE616528.1_657 69.512 7.46E-109 rhs/PAAR VF0579 T6SS Effector delivery system VFC0086 (rhs/PAAR) Type VI secretion system protein, PAAR family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_660 68.591 0.0 rhs/PAAR VF0579 T6SS Effector delivery system VFC0086 (rhs/PAAR) Type VI secretion system protein, PAAR family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_780 100.0 0.0 ipaH0722 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH0722) type III secretion system effector IpaH0722, E3 ubiquitin ligase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616528.1_940 66.955 0.0 msbA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (msbA) lipid transporter ATP-binding/permease [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
HE616528.1_944 69.478 7.45E-126 nueA VF0473 Polar flagella Motility VFC0204 Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments (nueA) NeuA protein [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119] Aeromonas hydrophila
HE616528.1_988 99.133 0.0 ompA VF0236 OmpA Invasion VFC0083 Major outer membrane protein in E. coli, homologous to Neisseria Opa proteins which have been shown to be involved in invasion of eukaryotic cells (ompA) outer membrane protein A [OmpA (VF0236) - Invasion (VFC0083)] [Escherichia coli O18:K1:H7 str. RS218] Escherichia coli (NMEC)
HE616528.1_1018 72.414 0.0 KP1_RS17340 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17340) polysaccharide export protein [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_1065 99.278 0.0 cgsG VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (cgsG) curli production assembly/transport protein CsgG [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
HE616528.1_1066 99.275 1.6E-99 cgsF VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (cgsF) curli production assembly/transport protein CsgF [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
HE616528.1_1067 100.0 5.13E-95 cgsE VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (cgsE) curli production assembly/transport protein CsgE [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
HE616528.1_1068 100.0 6.93E-117 cgsD VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (cgsD) transcriptional regulator CsgD [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
HE616528.1_1070 99.338 5.32E-106 csgB VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (csgB) curlin minor subunit CsgB [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
HE616528.1_1071 96.711 1.6E-100 csgA VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (csgA) curlin major subunit CsgA [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
HE616528.1_1074 97.273 3.7E-75 csgC VF1138 Curli fibers Adherence VFC0001 Many commensal E. coli strains and the commonly studied lab strains express curli at temperatures of <30°C. In contrast, pathogenic E. coli strains like UPECs, EAECs including the 2012 German outbreak strain and S. Typhimurium, have been shown to express curli at 37°C (csgC) curli assembly protein CsgC [Curli fibers (VF1138) - Adherence (VFC0001)] [Escherichia coli O25b:H4-ST131] Escherichia coli (UPEC)
HE616528.1_1110 62.626 5.83E-35 flgM VF0394 Flagella Motility VFC0204 (flgM) negative regulator of flagellin synthesis [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1112 71.533 1.67E-73 flgB VF0394 Flagella Motility VFC0204 (flgB) flagellar basal-body rod protein FlgB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1113 82.836 5.95E-81 flgC VF0394 Flagella Motility VFC0204 (flgC) flagellar basal-body rod protein FlgC [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1114 75.248 8.45E-105 flgD VF0394 Flagella Motility VFC0204 (flgD) flagellar basal-body rod modification protein FlgD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1115 63.484 0.0 flgE VF0394 Flagella Motility VFC0204 (flgE) flagellar hook protein FlgE [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1116 62.658 3.07E-67 flgF VF0394 Flagella Motility VFC0204 (flgF) flagellar basal-body rod protein FlgF [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1117 86.957 8.21E-86 flgG VF0394 Flagella Motility VFC0204 (flgG) flagellar basal-body rod protein FlgG [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1118 81.6 1.49E-69 flgG VF0394 Flagella Motility VFC0204 (flgG) flagellar basal-body rod protein FlgG [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1119 81.193 3.69E-122 flgH VF0394 Flagella Motility VFC0204 (flgH) flagellar L-ring protein precursor FlgH [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1120 78.082 0.0 flgI VF0394 Flagella Motility VFC0204 (flgI) flagellar P-ring protein precursor FlgI [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1121 60.458 1.46E-129 flgJ VF0394 Flagella Motility VFC0204 (flgJ) <beta>-N-acetylglucosaminidase [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1123 60.429 1.29E-141 flgL VF0394 Flagella Motility VFC0204 (flgL) flagellar hook-associated protein 3 FlgL [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1132 77.459 7.98E-140 flmH VF0473 Polar flagella Motility VFC0204 Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments (flmH) short chain dehydrogenase/reductase family oxidoreductase [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119] Aeromonas hydrophila
HE616528.1_1133 61.538 1.93E-27 acpXL VF0367 LPS Immune modulation VFC0258 Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. (acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] Brucella melitensis
HE616528.1_1166 85.421 0.0 phoQ VF0111 PhoPQ Regulation VFC0301 (phoQ) sensor protein PhoQ [PhoPQ (VF0111) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
HE616528.1_1167 93.722 1.14E-157 phoP VF0111 PhoPQ Regulation VFC0301 (phoP) response regulator in two-component regulatory system with PhoQ [PhoPQ (VF0111) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
HE616528.1_1213 83.613 4.37E-145 fliA VF0394 Flagella Motility VFC0204 (fliA) flagellar biosynthesis sigma factor [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1242 72.414 5.04E-52 flhD VF0394 Flagella Motility VFC0204 (flhD) flagellar transcriptional activator FlhD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1243 82.902 5.06E-117 flhC VF0394 Flagella Motility VFC0204 (flhC) flagellar biosynthesis transcription activator FlhC [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1244 80.678 1.72E-179 motA VF0394 Flagella Motility VFC0204 (motA) flagellar motor protein MotA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1245 68.671 2.17E-152 motB VF0394 Flagella Motility VFC0204 (motB) flagellar motor protein MotB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1246 73.373 0.0 cheA VF0394 Flagella Motility VFC0204 (cheA) chemotaxis protein CheA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1247 85.093 3.74E-98 cheW VF0394 Flagella Motility VFC0204 (cheW) purine-binding chemotaxis protein CheW [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1250 72.464 8.27E-147 cheR VF0394 Flagella Motility VFC0204 (cheR) chemotaxis methyltransferase CheR [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1251 86.246 0.0 cheB VF0394 Flagella Motility VFC0204 (cheB) chemotaxis-specific methylesterase CheB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1252 91.473 1.1E-84 cheY VF0394 Flagella Motility VFC0204 (cheY) chemotaxis regulatory protein CheY [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1253 76.699 1.17E-106 cheZ VF0394 Flagella Motility VFC0204 (cheZ) chemotaxis regulator CheZ [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1257 65.595 1.86E-143 flhB VF0394 Flagella Motility VFC0204 (flhB) flagellar biosynthetic protein FlhB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1258 85.362 0.0 flhA VF0394 Flagella Motility VFC0204 (flhA) flagellar biosynthesis protein FlhA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_1296 100.0 0.0 ipaH VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH) invasion plasmid antigen IpaH [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616528.1_1349 98.774 0.0 ipaH VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH) invasion plasmid antigen IpaH [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616528.1_1532 96.903 2.44E-158 espL1 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espL1) Type III secretion system effector espL1 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
HE616528.1_1533 96.226 0.0 espL1 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espL1) Type III secretion system effector espL1 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
HE616528.1_1653 67.539 7.96E-100 sodB VF0169 SodB Stress survival VFC0282 (sodB) superoxide dismutase [SodB (VF0169) - Stress survival (VFC0282)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
HE616528.1_1714 64.407 5.0E-72 fimD VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_1724 63.333 9.96E-9 misL VF0397 MisL Adherence VFC0001 MisL is located within Salmonella Pathogenicity Island SPI-3 (misL) putative autotransporter [MisL (VF0397) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
HE616528.1_1857 90.985 0.0 rhs/PAAR VF0579 T6SS Effector delivery system VFC0086 (rhs/PAAR) Type VI secretion system protein, PAAR family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_1861 80.0 1.75E-82 rhs/PAAR VF0579 T6SS Effector delivery system VFC0086 (rhs/PAAR) Type VI secretion system protein, PAAR family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_1862 90.603 0.0 vgrG/tssI VF0579 T6SS Effector delivery system VFC0086 (vgrG/tssI) type VI secretion system effector VgrG [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_2182 73.958 2.16E-159 galU VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (galU) glucosephosphate uridylyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
HE616528.1_2203 81.272 2.98E-177 kdsA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
HE616528.1_2221 60.484 1.55E-48 fliS VF0394 Flagella Motility VFC0204 (fliS) flagellar protein FliS [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_2239 63.196 0.0 fliF VF0394 Flagella Motility VFC0204 (fliF) flagellar M-ring protein FliF [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_2240 83.283 0.0 fliG VF0394 Flagella Motility VFC0204 (fliG) flagellar motor switch protein G [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_2242 83.48 0.0 fliI VF0394 Flagella Motility VFC0204 (fliI) flagellum-specific ATP synthase FliI [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_2246 83.784 0.0 fliM VF0394 Flagella Motility VFC0204 (fliM) flagellar motor switch protein FliM [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_2247 74.638 3.17E-69 fliN VF0394 Flagella Motility VFC0204 (fliN) flagellar motor switch protein FliN [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_2249 80.567 4.98E-140 fliP VF0394 Flagella Motility VFC0204 (fliP) flagellar biosynthetic protein FliP [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_2250 77.528 1.94E-37 fliQ VF0394 Flagella Motility VFC0204 (fliQ) flagellar biosynthetic protein FliQ [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_2251 68.605 1.49E-108 fliR VF0394 Flagella Motility VFC0204 (fliR) flagellar biosynthetic protein FliR [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_2252 67.633 3.45E-102 rcsA VF0571 RcsAB Regulation VFC0301 (rcsA) transcriptional activator for ctr capsule biosynthesis [RcsAB (VF0571) - Regulation (VFC0301)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_2342 82.99 0.0 ugd VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (ugd) UDP-glucose 6-dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_2343 95.085 0.0 gndA VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_2344 76.923 0.0 rfbK1 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (rfbK1) O9 family phosphomannomutase RfbK1 [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_2345 61.441 0.0 KP1_RS17280 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17280) mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_2346 61.671 0.0 KP1_RS17295 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17295) glycosyltransferase WbuB [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_2348 77.987 0.0 KP1_RS17305 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17305) GDP-L-fucose synthase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_2349 88.919 0.0 gmd VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gmd) GDP-mannose 4,6-dehydratase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_2358 64.908 0.0 KP1_RS17340 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17340) polysaccharide export protein [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_2423 74.081 0.0 ipaH VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH) invasion plasmid antigen IpaH [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616528.1_2528 96.759 1.41E-152 rcsB VF0571 RcsAB Regulation VFC0301 (rcsB) transcriptional regulator RcsB [RcsAB (VF0571) - Regulation (VFC0301)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_2823 64.735 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_2925 99.668 0.0 ipaH VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH) invasion plasmid antigen IpaH [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616528.1_3001 99.744 0.0 senB VF0258 ShET2 Exotoxin VFC0235 Encoded on inv plasmid (senB) enterotoxin [ShET2 (VF0258) - Exotoxin (VFC0235)] [Shigella boydii Sb227] Shigella flexneri
HE616528.1_3041 65.969 5.37E-91 algU VF0091 Alginate Biofilm VFC0271 Alginate production is frequently referred to as mucoidy because colonies producing alginate have a wet glistening (mucoid) appearance, which is very different from that of colonies not producing alginate; most of the alginate biosynthetic genes are clustered in the algD operon; Alginate production is highly regulated. Regulatory genes are located in two areas far removed from the biosynthetic genes, with one exception algC (algU) alginate biosynthesis protein AlgZ/FimS [Alginate (VF0091) - Biofilm (VFC0271)] [Pseudomonas aeruginosa PAO1] Pseudomonas aeruginosa
HE616528.1_3170 73.099 4.94E-96 luxS VF0406 AI-2 Biofilm VFC0271 AI-2 is produced and detected by a wide variety of bacteria and is presumed to facilitate interspecies communications. (luxS) S-ribosylhomocysteinase [AI-2 (VF0406) - Biofilm (VFC0271)] [Vibrio cholerae O1 biovar El Tor str. N16961] Vibrio cholerae
HE616528.1_3174 76.667 1.4E-30 csrA VF0261 CsrA Regulation VFC0301 Belongs to a highly conserved family of global regulators that typically control stationary phase traits post-transcriptionally (csrA) carbon storage regulator CsrA [CsrA (VF0261) - Regulation (VFC0301)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
HE616528.1_3230 99.394 0.0 rpoS VF0112 RpoS Regulation VFC0301 (rpoS) RNA polymerase sigma factor RpoS [RpoS (VF0112) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
HE616528.1_3484 99.767 0.0 sigA VF0119 SigA Exoenzyme VFC0251 Belongs to the SPATEs (serine protease autotransporters of Enterobacteriaceae) subfamily, cytotoxic SPATE;carried on the she pathogenicity island of Shigella flexneri 2a (sigA) serine protease, autotransporter SigA [SigA (VF0119) - Exoenzyme (VFC0251)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616528.1_3557 70.815 0.0 rfaE VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaE) ADP-heptose synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
HE616528.1_3605 99.448 0.0 cfaD/cfaE VF0213 Adhesive fimbriae Adherence VFC0001 Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT (cfaD/cfaE) minor pilin and initiator [Adhesive fimbriae (VF0213) - Adherence (VFC0001)] [Escherichia coli E24377A] Escherichia coli (ETEC)
HE616528.1_3606 99.776 0.0 cfaC VF0213 Adhesive fimbriae Adherence VFC0001 Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT (cfaC) colonisation factor antigen c, usher [Adhesive fimbriae (VF0213) - Adherence (VFC0001)] [Escherichia coli E24377A] Escherichia coli (ETEC)
HE616528.1_3607 100.0 2.91E-119 cfaB VF0213 Adhesive fimbriae Adherence VFC0001 Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT (cfaB) colonization factor antigen 1 [Adhesive fimbriae (VF0213) - Adherence (VFC0001)] [Escherichia coli E24377A] Escherichia coli (ETEC)
HE616528.1_3608 99.16 3.18E-176 cfaA VF0213 Adhesive fimbriae Adherence VFC0001 Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT (cfaA) colonisation factor antigen a, chaperone [Adhesive fimbriae (VF0213) - Adherence (VFC0001)] [Escherichia coli E24377A] Escherichia coli (ETEC)
HE616528.1_3762 68.267 0.0 acrA VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrA) acriflavine resistance protein A [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_3763 77.778 4.22E-20 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_3764 77.975 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_3825 80.153 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
HE616528.1_3844 66.337 3.92E-99 vfr VF0082 Type IV pili Adherence VFC0001 PilA, B, C, D, E, F, M, N, O, P, Q, T, U, V, W, X, Y1, Y2, Z, and fimT, U, V are involved in the biogenesis and mechanical function of pili, pilG, H, I, K, chpA, B, C, D, E, pilS, R, fimS, rpoN, algR, algU, and vfr are involved in transcriptional regulation and chemosensory pathways that control the expression or activity of the twitching motility of the pili (vfr) cAMP-regulatory protein [Type IV pili (VF0082) - Adherence (VFC0001)] [Pseudomonas aeruginosa PAO1] Pseudomonas aeruginosa
HE616528.1_3875 63.964 5.49E-101 rpe VF0543 Capsule Immune modulation VFC0258 Group 4 capsule; high molecular weight (HMW) O-antigen capsule (rpe) ribulose-phosphate 3-epimerase [Capsule (VF0543) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
HE616528.1_4021 71.022 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
HE616528.1_4099 99.603 0.0 sat VF0231 Sat Effector delivery system VFC0086 Belongs to SPATE (serine protease autotransporters to Enterobacteriaceae) proteins (eight known SPATE proteins: Sat of UPEC, Pet of EAEC, EspC of EPEC, Pic of EAEC and Shigella, SigA of Shigella, SepA of Shigella, Tsh of avian E. coli, and EspP of EHEC); reside within PAI II of E. coli CFT073 (sat) Aecreted auto transpoter toxin [Sat (VF0231) - Effector delivery system (VFC0086)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_4101 99.453 0.0 iutA VF0123 Aerobactin Nutritional/Metabolic factor VFC0272 A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae (iutA) aerobactin receptor IutA [Aerobactin (VF0123) - Nutritional/Metabolic factor (VFC0272)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616528.1_4102 99.775 0.0 iucD VF0123 Aerobactin Nutritional/Metabolic factor VFC0272 A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae (iucD) aerobactin synthesis protein IucC, lysine 6-monooxygenase [Aerobactin (VF0123) - Nutritional/Metabolic factor (VFC0272)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616528.1_4103 99.655 0.0 iucC VF0123 Aerobactin Nutritional/Metabolic factor VFC0272 A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae (iucC) aerobactin synthesis protein IucC [Aerobactin (VF0123) - Nutritional/Metabolic factor (VFC0272)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616528.1_4104 100.0 0.0 iucB VF0123 Aerobactin Nutritional/Metabolic factor VFC0272 A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae (iucB) aerobactin synthesis protein IucB [Aerobactin (VF0123) - Nutritional/Metabolic factor (VFC0272)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616528.1_4105 100.0 0.0 iucA VF0123 Aerobactin Nutritional/Metabolic factor VFC0272 A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae (iucA) aerobactin synthesis protein IucA [Aerobactin (VF0123) - Nutritional/Metabolic factor (VFC0272)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616528.1_4112 100.0 2.17E-137 pic VF0120 Pic Exoenzyme VFC0251 Produced by Shigella flexneri, EAEC and UPEC; belongs to the SPATEs (serine protease autotransporters of Enterobacteriaceae) subfamily, noncytotoxic (class 2) SPATE; the pic gene overlaps two other virulence genes, set1A and set1B (pic) serine protease, autotransporter Pic [Pic (VF0120) - Exoenzyme (VFC0251)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616528.1_4165 64.08 9.7E-159 rfaF VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaF) ADP-heptose-LPS heptosyltransferase II [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
HE616528.1_4166 78.571 0.0 rfaD VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaD) ADP-L-glycero-D-mannoheptose-6-epimerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
HE616528.1_4194 69.762 0.0 rhs/PAAR VF0579 T6SS Effector delivery system VFC0086 (rhs/PAAR) Type VI secretion system protein, PAAR family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_4195 65.741 2.88E-44 rhs/PAAR VF0579 T6SS Effector delivery system VFC0086 (rhs/PAAR) Type VI secretion system protein, PAAR family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_4196 65.333 3.37E-122 rhs/PAAR VF0579 T6SS Effector delivery system VFC0086 (rhs/PAAR) Type VI secretion system protein, PAAR family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_4342 66.667 5.42E-173 rffG VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rffG) dTDP-glucose 46-dehydratase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
HE616528.1_4343 66.667 7.29E-143 wbtL VF0542 LPS Immune modulation VFC0258 The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion (wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
HE616528.1_4352 95.652 9.08E-18 aslA VF0238 AslA Invasion VFC0083 Homology to aslA of E. coli K12; based on its protein sequence, AslA is predicted to be a member of the arylsulfatase family of enzymes that contains highly conserved sulfatase motifs, but E. coli AslA failed to exhibit in vitro arylsulfatase activity (aslA) putative arylsulfatase [AslA (VF0238) - Invasion (VFC0083)] [Escherichia coli O18:K1:H7 str. RS218] Escherichia coli (NMEC)
HE616528.1_4539 65.333 1.28E-121 rhs/PAAR VF0579 T6SS Effector delivery system VFC0086 (rhs/PAAR) Type VI secretion system protein, PAAR family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_4540 64.22 5.76E-44 rhs/PAAR VF0579 T6SS Effector delivery system VFC0086 (rhs/PAAR) Type VI secretion system protein, PAAR family [T6SS (VF0579) - Effector delivery system (VFC0086)] [Shigella sonnei Ss046] Shigella sonnei
HE616528.1_4566 98.96 0.0 ibeC VF0237 Ibes Invasion VFC0083 IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. (ibeC) phosphoethanolamine transferase CptA [Ibes (VF0237) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
HE616528.1_4583 80.153 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
HE616528.1_4616 61.893 5.87E-171 icl VF0253 Isocitrate lyase Others VFC0346 (icl) Isocitrate lyase Icl (isocitrase) (isocitratase) [Isocitrate lyase (VF0253) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
HE616528.1_4618 95.154 3.39E-162 espL4 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espL4) Type III secretion system effector EspL4 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
HE616528.1_4619 84.615 1.69E-54 espL4 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espL4) Type III secretion system effector EspL4 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
HE616528.1_4651 80.328 2.49E-27 espX4 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espX4) Type III secretion system effector EspX4 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
HE616528.1_4652 81.818 1.8E-72 espX4 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espX4) Type III secretion system effector EspX4 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
HE616528.1_4654 86.222 1.62E-136 espX4 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espX4) Type III secretion system effector EspX4 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
HE616528.1_4682 93.367 1.62E-131 espX5 VF1110 TTSS secreted effectors Effector delivery system VFC0086 (espX5) Type III secretion system effector EspX5 [TTSS secreted effectors (VF1110) - Effector delivery system (VFC0086)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
HE616528.1_4683 92.166 1.32E-134 espX5 VF1111 TTSS secreted effectors Effector delivery system VFC0086 (espX5) Type III secretion system effector EspX5 [TTSS secreted effectors (VF1111) - Effector delivery system (VFC0086)] [Escherichia coli O55:H7 str. CB9615] Escherichia coli (EPEC)
HE616528.1_4732 86.197 0.0 pmrB VF1355 PmrAB Regulation VFC0301 (pmrB) sensory kinase PmrB [PmrAB (VF1355) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
HE616528.1_4733 90.541 5.49E-150 pmrA VF1355 PmrAB Regulation VFC0301 (pmrA) response regulator PmrA [PmrAB (VF1355) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
HE616528.1_4778 75.568 0.0 htpB VF0159 Hsp60 Adherence VFC0001 (htpB) Hsp60, 60K heat shock protein HtpB [Hsp60 (VF0159) - Adherence (VFC0001)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
HE616528.1_4928 98.936 7.19E-142 fimB VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimB) Type 1 fimbriae Regulatory protein fimB [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_4930 98.276 9.45E-38 fimD VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_4931 97.241 3.03E-97 fimD VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_4933 99.327 0.0 fimD VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_4935 100.0 0.0 fimD VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimD) Outer membrane usher protein fimD precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_4936 98.295 4.16E-128 fimF VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimF) FimF protein precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_4937 98.802 5.78E-121 fimG VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimG) FimG protein precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_4938 99.0 0.0 fimH VF0221 Type 1 fimbriae Adherence VFC0001 Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases (fimH) FimH protein precursor [Type 1 fimbriae (VF0221) - Adherence (VFC0001)] [Escherichia coli CFT073] Escherichia coli (UPEC)
HE616528.1_4966 63.226 9.51E-130 cheD VF0394 Flagella Motility VFC0204 (cheD) methyl-accepting chemotaxis protein CheD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616528.1_4967 76.86 3.43E-108 cheD VF0394 Flagella Motility VFC0204 (cheD) methyl-accepting chemotaxis protein CheD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
HE616529.1_2 100.0 0.0 ospB VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospB) type III secretion system effector OspB [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_5 93.007 1.09E-91 ospC3 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospC3) type III secretion system effector OspC3, ADP-riboxanase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_8 99.582 0.0 ospD2 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospD2) type III secretion system effector OspD2 [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_9 99.163 1.91E-180 ospF VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospF) type III secretion system effector OspF, phosphothreonine lyase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_18 98.222 1.09E-163 ospD1 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospD1) type III secretion system effector OspD1 [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_21 99.367 2.94E-114 ipgB2 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipgB2) type III secretion system effector IpgB2, guanine nucleotide exchange factor (GEF) [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_40 100.0 9.47E-170 virF VF0979 VirF Regulation VFC0301 A DNA-binding protein belonging to the AraC family of transcriptional regulators; located on the large virulence plasmid, is expressed only within the host, mainly in response to the temperature transition occurring when the bacterium transits from the outer environment to the intestinal milieu (virF) transcriptional activator VirF [VirF (VF0979) - Regulation (VFC0301)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_43 94.318 1.33E-58 ospE2 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospE2) type III secretion system effector OspE2 [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_47 99.362 0.0 ospC1 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospC1) type III secretion system effector OspC1 [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_49 99.646 0.0 ospD3/senA VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospD3/senA) type III secretion system effector OspD3 [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_69 99.823 0.0 ipaH7.8 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH7.8) type III secretion system effector ipaH7.8, E3 ubiquitin ligase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_70 99.652 0.0 ipaH4.5 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH4.5) type III secretion system effector ipaH4.5, E3 ubiquitin ligase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_77 99.38 0.0 ospC2 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospC2) type III secretion system effector OspC2 [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_83 95.868 0.0 ospC3 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospC3) type III secretion system effector OspC3, ADP-riboxanase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_89 100.0 7.11E-172 ipaJ VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaJ) type III secretion system effector IpaJ, cysteine protease [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_90 100.0 0.0 virB VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (virB) transcriptional activator VirB [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_92 99.21 0.0 ipaA VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaA) type III secretion system effector IpaA, vinculin binding protein [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_93 96.988 0.0 ipaD VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (ipaD) type III secretion system hydrophilic translocator, needle tip protein IpaD [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_94 98.623 0.0 ipaC VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (ipaC) type III secretion system hydrophilic translocator, pore protein IpaC [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_95 99.138 0.0 ipaB VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (ipaB) type III secretion system hydrophilic translocator, pore protein IpaB [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_96 100.0 4.56E-114 ipgC VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (ipgC) type III secretion system chaperone for IpaB and IpaC [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_97 97.115 6.35E-150 ipgB1 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipgB1) type III secretion system effector IpgB1, guanine nucleotide exchange factor (GEF) [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_98 100.0 1.74E-92 ipgA VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (ipgA) type III secretion system chaperone for IcsB [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_99 97.571 0.0 icsB VF0978 TTSS secreted effectors Effector delivery system VFC0086 (icsB) type III secretion system effector IcsB, fatty acyltransferase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_100 99.071 0.0 ipgD VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipgD) type III secretion system effector IpgD, phosphoinositide 4-phosphatase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_101 100.0 1.54E-84 ipgE VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (ipgE) type III secretion system chaperone for IpgD [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_102 99.342 9.78E-113 ipgF VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (ipgF) type III secretion system protein IpgF [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_103 100.0 0.0 mxiG VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiG) type III secretion system outer MS ring protein MixG [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_104 100.0 1.04E-57 mxiH VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiH) type III secretion system needle filament protein MxiH [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_105 100.0 1.67E-66 mxiI VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiI) type III secretion system inner rod protein MxiI [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_106 99.585 2.66E-179 mxiJ VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiJ) type III secretion system inner MS ring protein MxiJ [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_107 100.0 9.77E-130 mxiK VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiK) type III secretion system accessory cytosolic protein MxiK [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_108 99.558 5.23E-167 mxiN VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiN) type III secretion system stator MxiN [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_109 99.259 4.16E-95 mxiL VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiL) type III secretion system protein MxiL [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_110 100.0 1.88E-101 mxiM VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiM) type III secretion system pilotin MxiM [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_111 100.0 7.47E-158 mxiE VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiE) type III secretion system regulatory protein MxiE [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_112 99.647 0.0 mxiD VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiD) type III secretion system secretin MxiD [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_113 99.718 0.0 mxiC VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiC) type III secretion system gatekeeper MxiD [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_114 100.0 0.0 mxiA VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (mxiA) type III secretion system major export apparatus protein MxiA [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_115 99.248 1.41E-94 spa15 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa15) type III secretion system chaparone [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_116 99.767 0.0 spa47 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa47) type III secretion system ATPase spa47 [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_117 100.0 7.87E-78 spa13 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa13) type III secretion system stalk protein Spa13 [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_118 100.0 0.0 spa32 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa32) type III secretion system needle length regulator Spa32 [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_119 99.194 0.0 spa33 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa33) type III secretion system C ring protein Spa33 [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_120 99.537 3.62E-158 spa24 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa24) type III secretion system minor export apparatus protein Spa24 [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_121 100.0 1.84E-56 spa9 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa9) type III secretion system minor export apparatus protein Spa9 [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_122 100.0 0.0 spa29 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa29) type III secretion system minor export apparatus protein Spa29 [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_123 99.415 0.0 spa40 VF0118 TTSS Effector delivery system VFC0086 Encoded on the large virulence plasimid; The activity of type III secretion systems is tightly regulated. It is activated upon contact with the cellular surface; Abbreviations: Ipg for invasion plasmid gene; Spa for surface presentation of invasion plasmid antigens; Mxi for membrane excretion of Ipa (spa40) type III secretion system export apparatus switch protein Spa40 [TTSS (VF0118) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_148 98.75 0.0 virA VF0978 TTSS secreted effectors Effector delivery system VFC0086 (virA) type III secretion system effector VirA, GTPase-activating protein (GAP) [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_149 99.456 0.0 icsA/virG VF0121 IcsA (VirG) Motility VFC0204 (icsA/virG) autotransporter, actin tail assembly protein IcsA/VirG [IcsA (VirG) (VF0121) - Motility (VFC0204)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_160 100.0 1.06E-162 ospI VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospI) type III secretion system effector OspI, glutamine deamidase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_171 99.083 0.0 ipaH9.8 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH9.8) type III secretion system effector ipaH9.8, E3 ubiquitin ligase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_175 100.0 2.81E-146 ospG VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospG) type III secretion system effector OspG, protein kinase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_211 99.304 0.0 ipaH1.4 VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ipaH1.4) type III secretion system effector ipaH1.4, E3 ubiquitin ligase [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella flexneri 2a str. 301] Shigella flexneri
HE616529.1_219 72.249 0.0 tviB VF0465 Capsule Immune modulation VFC0258 A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. (tviB) Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB [Capsule (VF0465) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
HE616529.1_220 65.68 1.04E-167 tviC VF0101 Vi antigen Immune modulation VFC0258 Vi is abbreviation for virulence; the viaB locus is within Salmonella pathogenicity island SPI-7, which also encodes SopE and a type IVB pilus; The viaB locus encodes genes involved in regulation (tviA), Vi biosynthesis (tviBCDE), export, and retention of the Vi on the bacterial cell surface (vexABCDE); A viaB locus is absent from S. Paratyphi A, and most gastroenteritis-causing serovars including S. Typhimurium (tviC) Vi polysaccharide biosynthesis protein, UDP-GlcNAcA 4-epimerase TviC [Vi antigen (VF0101) - Immune modulation (VFC0258)] [Salmonella enterica subsp. enterica serovar Typhi str. CT18] Salmonella enterica (serovar typhi)
HE616529.1_234 99.13 9.05E-171 ospZ VF0978 TTSS secreted effectors Effector delivery system VFC0086 (ospZ) type III secretion system effector cysteine methyltransferase OspZ [TTSS secreted effectors (VF0978) - Effector delivery system (VFC0086)] [Shigella boydii CDC 3083-94] Shigella flexneri
HE616529.1_236 98.73 0.0 icsP/sopA VF0122 IcsP (SopA) Exoenzyme VFC0251 (icsP/sopA) outer membrane protease of the OmpP family, involved in cleavage of surface exposed IcsA [IcsP (SopA) (VF0122) - Exoenzyme (VFC0251)] [Shigella flexneri 2a str. 301] Shigella flexneri