2. PATHOGENS
Basic Information
Accession number
GCA_000418345.1
Release date
2013-07-05
Organism
Staphylococcus aureus
Species name
Staphylococcus aureus
Assembly level
Complete Genome
Assembly name
ASM41834v1
Assembly submitter
LNCC
Assembly Type
haploid
Genome size
3.0 Mb
GC percent
33.0
Contig count
2
Collection date
-
Sample location
-
Host
Homo sapiens
Isolation source
-
Isolate type
-
Strain
Bmb9393
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
CP005288.1_44 # 48795 # 49526 400.0 496.508 ErmA 100.0 ARO:3000347 protein homolog model macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic antibiotic target alteration Erm 23S ribosomal RNA methyltransferase ErmA confers the MLSb phenotype. Similar to ErmC, Expression of ErmA is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmA.
CP005288.1_66 # 68945 # 70951 1250.0 1338.94 mecA 99.55 ARO:3000617 protein homolog model penam antibiotic target replacement methicillin resistant PBP2 A foreign PBP2a acquired by lateral gene transfer that is able to perform peptidoglycan synthesis in the presence of beta-lactams.
CP005288.1_67 # 71051 # 72808 1100.0 1202.96 mecR1 100.0 ARO:3000215 protein homolog model penam antibiotic target replacement methicillin resistant PBP2 mecR1 is a transmembrane spanning and signal transducing protein which in response to interaction with beta-lactam antibiotics results in upregulation of the mecA/mecR1/mecI operon.
CP005288.1_112 # 116947 # 118335 525.0 905.59 norC 100.0 ARO:3007010 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump NorC is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 61% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. Like NorA and NorB, NorC is regulated by mgrA, also known as NorR.
CP005288.1_142 # 154326 # 155684 850.0 865.529 tet(38) 99.11 ARO:3000565 protein homolog model tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Tet38 is a tetracycline efflux pump found in the Gram-positive Staphylococcus aureus. It is regulated by mgrA, which also regulates NorB.
CP005288.1_336 # 382392 # 382811 250.0 285.804 mepR 100.0 ARO:3000746 protein homolog model glycylcycline; tetracycline antibiotic antibiotic efflux multidrug and toxic compound extrusion (MATE) transporter MepR is an upstream repressor of MepA in Staphylococcus aureus. It is part of the mepRAB operon.
CP005288.1_337 # 382918 # 384273 850.0 885.174 mepA 100.0 ARO:3000026 protein homolog model glycylcycline; tetracycline antibiotic antibiotic efflux multidrug and toxic compound extrusion (MATE) transporter MepA is an efflux protein regulated by MepR and part of the MepRAB cluster. Its presence in Staphylococcus aureus led to multidrug resistance, while it has also been shown to decrease tigecycline susceptibility.
CP005288.1_364 # 407174 # 407968 500.0 536.184 APH(3')-IIIa 100.0 ARO:3002647 protein homolog model aminoglycoside antibiotic antibiotic inactivation APH(3') APH(3')-IIIa is a plasmid-encoded aminoglycoside phosphotransferase in S. aureus and Enterococcus spp.
CP005288.1_365 # 408061 # 408591 300.0 356.681 SAT-4 97.22 ARO:3002897 protein homolog model nucleoside antibiotic antibiotic inactivation streptothricin acetyltransferase (SAT) SAT-4 is a plasmid-mediated streptothricin acetyltransferase and streptothricin (a nucleoside antibiotic) resistant determinant. Originally described from a Campylobacter coli BE/G4 plasmid gene sequence by Jacob et al, 1994.
CP005288.1_366 # 408588 # 409496 500.0 573.933 aad(6) 100.0 ARO:3002628 protein homolog model aminoglycoside antibiotic antibiotic inactivation ANT(6) ANT(6)-Ia/aad(6) is a plasmid-encoded aminoglycoside nucleotidyltransferase gene in E. faecalis and Streptococcus oralis.
CP005288.1_415 # 455792 # 456832 300.0 692.96 tet(M) 95.66 ARO:3000186 protein homolog model tetracycline antibiotic antibiotic target protection tetracycline-resistant ribosomal protection protein Tet(M) is a ribosomal protection protein that confers tetracycline resistance. It is found on transposable DNA elements and its horizontal transfer between bacterial species has been documented.
CP005288.1_416 # 456844 # 457710 300.0 575.474 tet(M) 97.57 ARO:3000186 protein homolog model tetracycline antibiotic antibiotic target protection tetracycline-resistant ribosomal protection protein Tet(M) is a ribosomal protection protein that confers tetracycline resistance. It is found on transposable DNA elements and its horizontal transfer between bacterial species has been documented.
CP005288.1_709 # 781845 # 782288 270.0 301.212 mgrA 100.0 ARO:3000815 protein homolog model fluoroquinolone antibiotic; cephalosporin; penam; tetracycline antibiotic; peptide antibiotic; disinfecting agents and antiseptics antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump MgrA, also known as NorR, is a regulator for norA, norB, and tet38. It is a positive regulator for norA expression, but is a direct repressor for norB and an indirect repressor of tet38.
CP005288.1_720 # 792603 # 793769 700.0 763.066 Staphylococcus aureus norA 99.74 ARO:3004667 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump NorA gene cloned from Staphylococcus aureus conferred relatively high resistance to hydrophilic quinolones such as norfloxacin, enoxacin, ofloxacin, and ciprofloxacin in S. aureus and Escherichia coli. Had low or no resistance at all to hydrophobic ones such as nalidixic acid, oxolinic acid, and sparfloxacin in S. aureus and Escherichia coli.
CP005288.1_1205 # 1269887 # 1271287 525.0 647.506 norC 70.77 ARO:3007010 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump NorC is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 61% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. Like NorA and NorB, NorC is regulated by mgrA, also known as NorR.
CP005288.1_1226 # 1317415 # 1318074 410.0 442.58 arlR 100.0 ARO:3000838 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump ArlR is a response regulator that binds to the norA promoter to activate expression. ArlR must first be phosphorylated by ArlS.
CP005288.1_1227 # 1318071 # 1319426 880.0 911.753 arlS 100.0 ARO:3000839 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump ArlS is a protein histidine kinase that phosphorylates ArlR, a promoter for norA expression.
CP005288.1_1744 # 1838612 # 1839343 400.0 493.041 ErmA 99.59 ARO:3000347 protein homolog model macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic antibiotic target alteration Erm 23S ribosomal RNA methyltransferase ErmA confers the MLSb phenotype. Similar to ErmC, Expression of ErmA is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmA.
CP005288.1_2142 # 2265687 # 2267126 900.0 966.452 AAC(6')-Ie-APH(2'')-Ia bifunctional protein 99.79 ARO:3002597 protein homolog model aminoglycoside antibiotic antibiotic inactivation aminoglycoside bifunctional resistance protein AAC(6')-Ie-APH(2'')-Ia is an aminoglycoside acetyltransferase encoded by plasmids and transposons in S. aureus, E. faecalis, E. faecium and Staphylococcus warneri.
CP005288.1_2153 # 2275968 # 2277116 175.0 182.185 vanT gene in vanG cluster 33.88 ARO:3002972 protein homolog model glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanT Also known as vanTG, is a vanT variant found in the vanG gene cluster.
CP005288.1_2161 # 2284860 # 2287517 1500.0 1790.01 kdpD 98.76 ARO:3004047 protein homolog model aminoglycoside antibiotic antibiotic efflux kdpDE kdpD is a component of the two-component regulatory system, kdpDE. This system is involved in potassium transport and homeostasis, and has been implicated in virulence factor regulation along with kdpE.
CP005288.1_2245 # 2386396 # 2387838 800.0 955.666 Staphylococcus aureus LmrS 100.0 ARO:3004572 protein homolog model macrolide antibiotic; aminoglycoside antibiotic; oxazolidinone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MFS transporters are secondary active transporters with single-polypeptide chains containing 400-600 amino acids that transport small solutes across the membrane by using electrochemical gradients. LmrS has 14 transmembrane helices and, when expressed in E. coli, is capable of extruding a variety of antibiotics inclinding linezolid, trimethoprim, florfenicol, chlorampheniocol, erythromycin, streptomycin, kanamycin, and fusidic acid.
CP005288.1_2246 # 2388160 # 2388627 100.0 298.13 sepA 96.13 ARO:3007012 protein homolog model disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump sepA is a multidrug efflux pump that confers resistance to disinfecting agents and dyes.
CP005288.1_2247 # 2388732 # 2390075 200.0 870.537 sdrM 100.0 ARO:3007013 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump sdrM encodes an efflux pump that confers resistance to norfloxacin and ethidium bromide, making this a multidrug resistance gene.
CP005288.1_2409 # 2541436 # 2541855 260.0 288.886 Staphylococcus aureus FosB 100.0 ARO:3004661 protein homolog model phosphonic acid antibiotic antibiotic inactivation fosfomycin thiol transferase The Bacillus subtilis fosB gene encodes a fosfomycin resistance protein.
CP005288.1_2520 # 2662263 # 2663663 525.0 533.872 norC 59.4 ARO:3007010 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump NorC is a multidrug efflux pump in Staphylococcus aureus that confers resistance to fluoroquinolones and other structurally unrelated antibiotics like tetracycline. It shares 61% similarity with NorB, and is a structural homolog of Blt of Bacillus subtilis. Like NorA and NorB, NorC is regulated by mgrA, also known as NorR.
CP005288.1_2661 # 2817878 # 2818723 500.0 537.339 PC1 beta-lactamase (blaZ) 96.09 ARO:3000621 protein homolog model penam antibiotic inactivation BlaZ beta-lactamase The blaZ beta-lactamase is found in Bacillus subtilis and Staphylococcus aureus.
CP005289.1_1 # 1 # 588 350.0 356.295 Streptococcus suis chloramphenicol acetyltransferase 94.36 ARO:3004455 protein homolog model phenicol antibiotic antibiotic inactivation chloramphenicol acetyltransferase (CAT) A chloramphenicol resistance determinant described in Streptococcus suis.
CP005288.1_6 # 7004 # 9664 1500.0 1758.81 Staphylococcus aureus gyrA conferring resistance to fluoroquinolones 98.76 ARO:3003296 protein variant model S84L fluoroquinolone antibiotic antibiotic target alteration fluoroquinolone resistant gyrA Point mutation of Staphylococcus aureus gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance.
CP005288.1_563 # 624865 # 628416 2300.0 2420.97 Staphylococcus aureus rpoB mutants conferring resistance to rifampicin 99.83 ARO:3003285 protein variant model H481N rifamycin antibiotic antibiotic target alteration; antibiotic target replacement rifamycin-resistant beta-subunit of RNA polymerase (rpoB) Point mutations that occurs in Staphylococcus aureus rpoB resulting in resistance to rifampicin.
CP005288.1_1286 # 1385186 # 1387588 1400.0 1623.6 Staphylococcus aureus parC conferring resistance to fluoroquinolones 99.88 ARO:3003312 protein variant model S80F fluoroquinolone antibiotic antibiotic target alteration fluoroquinolone resistant parC Point mutation in Staphylococcus aureus parC resulting in fluoroquinolone resistance.
CP005288.1_2181 # 2305682 # 2306947 800.0 840.877 Staphylococcus aureus murA with mutation conferring resistance to fosfomycin 99.29 ARO:3003776 protein variant model G257D phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant murA transferase murA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations confers fosfomycin resistance.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
CP005288.1_23 96.373 0.0 adsA VF0422 AdsA Immune modulation VFC0258 Harbors two 5'-nucleotidase motifs and a C-terminal LPXTG motif sorting signal (adsA) Adenosine synthase A [AdsA (VF0422) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_117 79.472 0.0 spa VF0017 SpA Exotoxin VFC0235 Belongs to MSCRAMMs family (spa) Immunoglobulin G binding protein A precursor [SpA (VF0017) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_153 64.302 0.0 lap VF0444 Lap Adherence VFC0001 Originally named surface protein p104, is a 104 kDa adhesion protein, present in every Listeria spp. except L. grayi (lap) Listeria adhesion protein Lap [Lap (VF0444) - Adherence (VFC0001)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
CP005288.1_155 94.969 2.27E-110 cap8B VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8B) type 8 capsular polysaccharide synthesis protein Cap8B [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_156 95.385 2.17E-39 cap8B VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8B) type 8 capsular polysaccharide synthesis protein Cap8B [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_157 99.213 0.0 cap8C VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8C) type 8 capsular polysaccharide synthesis protein Cap8C [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_158 99.012 0.0 cap8D VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8D) type 8 capsular polysaccharide synthesis protein Cap8D [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_159 99.708 0.0 cap8E VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8E) type 8 capsular polysaccharide synthesis protein Cap8E [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_160 99.187 0.0 cap8F VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8F) type 8 capsular polysaccharide synthesis protein Cap8F [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_161 99.198 0.0 cap8G VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8G) type 8 capsular polysaccharide synthesis protein Cap8G [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_162 97.772 0.0 cap8H VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8H) type 8 capsular polysaccharide synthesis protein Cap8H [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_163 98.922 0.0 cap8I VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8I) type 8 capsular polysaccharide synthesis protein Cap8I [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_164 99.459 1.99E-134 cap8J VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8J) type 8 capsular polysaccharide synthesis protein Cap8J [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_165 99.272 0.0 cap8K VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8K) type 8 capsular polysaccharide synthesis protein Cap8K [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_166 98.753 0.0 cap8L VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8L) type 8 capsular polysaccharide synthesis protein Cap8L [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_167 98.919 6.33E-136 cap8M VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8M) type 8 capsular polysaccharide synthesis protein Cap8M [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_168 97.966 0.0 capN VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (capN) capsular polysaccharide type 5/8 biosynthesis epimerase CapN [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_169 99.286 0.0 cap8O VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8O) type 8 capsular polysaccharide synthesis protein Cap8O [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_170 98.425 0.0 cap8P VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8P) type 8 capsular polysaccharide synthesis protein Cap8P [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_171 97.222 5.94E-77 isdI VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdI) staphylobilin-forming heme oxygenase IsdI [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
CP005288.1_228 73.742 0.0 coa VF0421 Staphylocoagulase Exoenzyme VFC0251 (coa) staphylocoagulase precursor [Staphylocoagulase (VF0421) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_281 100.0 8.66E-67 esxA VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esxA) type VII secretion system secreted protein EsxA [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_282 99.405 0.0 esaA VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaA) type VII secretion system protein EsaA [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_283 99.342 8.35E-110 essA VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (essA) type VII secretion system protein EssA, monotopic membrane protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_284 100.0 6.11E-54 esaB VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaB) type VII secretion system protein EsaB [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_285 99.55 0.0 essB VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (essB) type VII secretion system protein EssB, monotopic membrane protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_286 82.07 0.0 essC VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (essC) type VII secretion system protein EssC, FtsK/SpoIIIE family ATPase [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_295 93.252 4.13E-111 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_296 87.349 1.64E-107 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_297 86.42 1.7E-103 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_302 82.203 2.08E-70 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_303 82.53 6.78E-102 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_304 91.111 1.08E-57 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_305 89.655 8.0E-12 esaG VF0403 Type VII secretion system Effector delivery system VFC0086 At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD) (esaG) TIGR01741 family protein [Type VII secretion system (VF0403) - Effector delivery system (VFC0086)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_323 97.54 0.0 geh VF0012 Lipase Exoenzyme VFC0251 Organized as pre-pro-enzymes: the pre-region represents the signal peptide; secreted in the pro-lipase form. The pro-region protects the proteins from proteolytic degradation and acts as an intramolecular chaperone to facilitate translocation of the lipase (geh) glycerol ester hydrolase [Lipase (VF0012) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_445 68.584 1.94E-107 set16 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set16) superantigen-like protein SSL1 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_446 97.403 1.24E-164 set17 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set17) superantigen-like protein SSL2 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_447 97.753 0.0 set18 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set18) superantigen-like protein SSL3 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_448 84.545 0.0 set19 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set19) superantigen-like protein SSL4 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_449 97.863 2.52E-170 set20 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set20) superantigen-like protein SSL5 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_450 82.328 4.64E-135 set21 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set21) superantigen-like protein SSL6 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_451 92.208 2.53E-154 set22 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set22) superantigen-like protein SSL7 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_452 97.845 1.02E-165 set23 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set23) superantigen-like protein SSL8 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_453 93.103 2.6E-159 set24 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set24) superantigen-like protein SSL9 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_454 98.678 1.92E-164 set25 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set25) superantigen-like protein SSL10 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_457 63.043 1.22E-93 set26 VF0990 SSLs Exotoxin VFC0235 A family of 14 proteins located on two genomic clusters (set26) superantigen-like protein SSL11 [SSLs (VF0990) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_546 70.0 0.0 clpC VF0072 ClpC Stress survival VFC0282 27-kDa stress protein belongs to the Hsp100/Clp family; Regulation of Clp protease expression is mediated by CtsR, the product of the first gene in the ClpC operon (clpC) endopeptidase Clp ATP-binding chain C [ClpC (VF0072) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
CP005288.1_569 74.619 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
CP005288.1_582 94.346 0.0 sdrC VF0019 SDr Adherence VFC0001 (sdrC) Ser-Asp rich fibrinogen-binding bone sialoprotein-binding protein [SDr (VF0019) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_583 96.162 0.0 sdrD VF0019 SDr Adherence VFC0001 (sdrD) Ser-Asp rich fibrinogen-binding bone sialoprotein-binding protein [SDr (VF0019) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_584 97.502 0.0 sdrE VF0019 SDr Adherence VFC0001 (sdrE) Ser-Asp rich fibrinogen-binding bone sialoprotein-binding protein [SDr (VF0019) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_794 77.835 4.73E-114 clpP VF0074 ClpP Stress survival VFC0282 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
CP005288.1_813 95.163 0.0 clfA VF0004 Clumping factor Adherence VFC0001 Belongs to MSCRAMMs family; Ser-Asp rich fibrinogen-binding proteins (the proteins having the SD dipeptide repeats have so far been found only in S. aureus and S. epidermidis); The clfA and clfB genes are not allelic variants but are distinct genes. They are not closely linked, in contrast to the fnbA and fnbB genes (clfA) Clumping factor A, fibrinogen-binding protein [Clumping factor (VF0004) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_814 100.0 0.0 vWbp VF0420 VWbp Exoenzyme VFC0251 (vWbp) secreted von Willebrand factor-binding protein precursor [VWbp (VF0420) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
CP005288.1_1000 100.0 1.84E-78 sspC VF0006 Staphopain Exoenzyme VFC0251 Staphopains A (encoded by scpA) and B (encoded by sspB) are the major secreted cysteine proteases of S. aureus; A novel type of cysteine proteinase inhibitor, referred as staphostatins (ScpC, SspC), has been recently identified. They specifically inhibit cysteine proteinases (staphopains) (sspC) Staphostatin B [Staphopain (VF0006) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_1001 98.982 0.0 sspB VF0006 Staphopain Exoenzyme VFC0251 Staphopains A (encoded by scpA) and B (encoded by sspB) are the major secreted cysteine proteases of S. aureus; A novel type of cysteine proteinase inhibitor, referred as staphostatins (ScpC, SspC), has been recently identified. They specifically inhibit cysteine proteinases (staphopains) (sspB) staphopain cysteine proteinase SspB [Staphopain (VF0006) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_1002 97.024 0.0 sspA VF0023 V8 protease Exoenzyme VFC0251 A member of the glutamyl endopeptidase family of enzymes; narrow substrate specificity: cleaving peptide bonds exclusively on the carbonyl side of aspartate and glutamate residues; synthesized as a preproenzyme, the zymogen undergoes proteolytic activation via cleavage by the staphylococcal extracellular metalloprotease; The ssp gene encoding V8 protease is designated as sspA, and is followed by sspB, which encodes a cysteine protease, and sspC, which encodes a protein of unknown function (sspA) serine protease; V8 protease; glutamyl endopeptidase [V8 protease (VF0023) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_1162 95.885 0.0 ebp VF0008 EbpS Adherence VFC0001 Belongs to MSCRAMMs family (ebp) cell surface elastin binding protein [EbpS (VF0008) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_1306 68.116 0.0 katA VF0454 KatA Stress survival VFC0282 (katA) catalase [KatA (VF0454) - Stress survival (VFC0282)] [Neisseria meningitidis MC58] Neisseria meningitidis
CP005288.1_1418 72.464 9.19E-29 acpXL VF0367 LPS Immune modulation VFC0258 Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. (acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] Brucella melitensis
CP005288.1_1490 99.373 0.0 hly/hla VF0001 Alpha-hemolysin Exotoxin VFC0235 (hly/hla) Alpha-Hemolysin precursor [Alpha-hemolysin (VF0001) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_1515 100.0 4.18E-78 isdG VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdG) iron-regulated surface determinant protein G [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
CP005288.1_1516 100.0 0.0 srtB VF0015 Isd Nutritional/Metabolic factor VFC0272 (srtB) NPQTN specific sortase B [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
CP005288.1_1517 100.0 0.0 isdF VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdF) iron-regulated surface determinant protein F, ATP-binding-cassette-type transmembrane transporter [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
CP005288.1_1518 100.0 0.0 isdE VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdE) iron-regulated surface determinant protein E [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
CP005288.1_1519 100.0 0.0 isdD VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdD) iron-regulated surface determinant protein D [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
CP005288.1_1520 100.0 1.4E-166 isdC VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdC) iron-regulated surface determinant protein C [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
CP005288.1_1521 100.0 0.0 isdA VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdA) iron-regulated surface determinant protein A [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
CP005288.1_1522 100.0 0.0 isdB VF0015 Isd Nutritional/Metabolic factor VFC0272 (isdB) iron-regulated surface determinant protein B, haemoglobin receptor [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
CP005288.1_1604 67.097 0.0 gndA VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
CP005288.1_1653 62.376 9.78E-131 sigA/rpoV VF0257 SigA Regulation VFC0301 In M. tuberculosis, 13 sigma factor genes have been annotated in the genome, 9 of which belong to a special subfamily thought to direct extracytoplasmic functions and various other stress responses (temperature, oxidative stress, pH, and infection of macrophages); sigma A also known as RpoV, is the essential principal mycobacterial sigma factors, necessary for most mycobacterial housekeeping gene transcription; It was the first mycobacterial sigma factor to be associated with virulence (sigA/rpoV) RNA polymerase sigma factor SigA [SigA (VF0257) - Regulation (VFC0301)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
CP005288.1_1820 100.0 0.0 harA VF0015 Isd Nutritional/Metabolic factor VFC0272 (harA) haptoglobin-binding heme uptake protein HarA [Isd (VF0015) - Nutritional/Metabolic factor (VFC0272)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
CP005288.1_1917 82.769 0.0 lukF-PV VF0018 PVL Exotoxin VFC0235 PVL, together with gamma-hemolysin and other leukocidins such as LukE-LukD, belongs to the family of bicomponent synergohymenotropic toxins; pore-forming toxin rich in beta-sheet structures (lukF-PV) Panton-Valentine leukocidin chain F precursor [PVL (VF0018) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_1918 70.874 1.49E-163 hlgA VF0011 Gamma-hemolysin Exotoxin VFC0235 Three protein (HlgA, HlgB, HlgC) are virtually identical in sequence to leukocidin component S and F, thus gamma-hemolysin may act similarly to leukocidin; S component: HlgA, HlgC. F component: HlgB (hlgA) gamma-hemolysin chain II precursor [Gamma-hemolysin (VF0011) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2029 88.832 0.0 eap/map VF0016 Eap/Map Adherence VFC0001 Belongs to MSCRAMMs family; unusual property: Eap can bind back to the S. aureus cell wall (eap/map) extracellular adherence protein Eap/Map [Eap/Map (VF0016) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2030 100.0 1.02E-35 hlb VF0002 Beta-hemolysin Exotoxin VFC0235 (hlb) beta-hemolysin [Beta-hemolysin (VF0002) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus COL] Staphylococcus aureus
CP005288.1_2031 99.138 9.99E-79 scn VF0425 SCIN Immune modulation VFC0258 Located on the beta-hemolysin (hlb)-converting bacteriophages (scn) complement inhibitor SCIN [SCIN (VF0425) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2032 99.329 1.45E-105 chp VF0424 CHIPS Immune modulation VFC0258 Located on the beta-hemolysin (hlb)-converting bacteriophages (chp) chemotaxis-inhibiting protein CHIPS [CHIPS (VF0424) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus str. Newman] Staphylococcus aureus
CP005288.1_2034 98.16 6.55E-115 sak VF0021 Staphylokinase Exoenzyme VFC0251 Bacteria plasminogen activator: staphylokinase, strepokinase, act as cofactor molecules that contribute to exosite formation and enhance the substrate presentation to the enzyme; The gene for Staphylokinase is carried by certain prophages (sak) Staphylokinase precursor [Staphylokinase (VF0021) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2098 99.635 0.0 hlb VF0002 Beta-hemolysin Exotoxin VFC0235 (hlb) beta-hemolysin [Beta-hemolysin (VF0002) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus COL] Staphylococcus aureus
CP005288.1_2108 66.856 0.0 groEL VF0594 GroEL Adherence VFC0001 GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. (groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] Clostridium difficile
CP005288.1_2114 97.727 4.4E-25 hld VF0007 Delta-hemolysin Exotoxin VFC0235 (hld) delta-hemolysin [Delta-hemolysin (VF0007) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2192 60.8 1.13E-174 cap8P VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8P) type 8 capsular polysaccharide synthesis protein Cap8P [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2282 87.469 0.0 hysA VF0013 Hyaluronate lyase Exoenzyme VFC0251 (hysA) hyaluronate lyase precursor [Hyaluronate lyase (VF0013) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2367 61.421 4.46E-92 ureG VF0050 Urease Stress survival VFC0282 (ureG) urease accessory protein (ureG) [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] Helicobacter pylori
CP005288.1_2494 97.254 0.0 sbi VF0423 Sbi Immune modulation VFC0258 A secreted protein that is also associated with the bacterial envelope, lacks a C-terminal LPXTG sorting signal (sbi) IgG-binding protein SBI [Sbi (VF0423) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2495 100.0 0.0 hlgA VF0011 Gamma-hemolysin Exotoxin VFC0235 Three protein (HlgA, HlgB, HlgC) are virtually identical in sequence to leukocidin component S and F, thus gamma-hemolysin may act similarly to leukocidin; S component: HlgA, HlgC. F component: HlgB (hlgA) gamma-hemolysin chain II precursor [Gamma-hemolysin (VF0011) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2497 99.683 0.0 hlgC VF0011 Gamma-hemolysin Exotoxin VFC0235 Three protein (HlgA, HlgB, HlgC) are virtually identical in sequence to leukocidin component S and F, thus gamma-hemolysin may act similarly to leukocidin; S component: HlgA, HlgC. F component: HlgB (hlgC) gamma-hemolysin component C [Gamma-hemolysin (VF0011) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2498 100.0 0.0 hlgB VF0011 Gamma-hemolysin Exotoxin VFC0235 Three protein (HlgA, HlgB, HlgC) are virtually identical in sequence to leukocidin component S and F, thus gamma-hemolysin may act similarly to leukocidin; S component: HlgA, HlgC. F component: HlgB (hlgB) gamma-hemolysin component B [Gamma-hemolysin (VF0011) - Exotoxin (VFC0235)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2571 83.017 0.0 fnbB VF0010 FnBPs Adherence VFC0001 Belongs to MSCRAMMs family; most strains of S. aureus express two related Fn-binding proteins FnBPA and FnBPB, which are encoded by closely linked genes (fnbB) fibronectin-binding protein B [FnBPs (VF0010) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2572 85.98 0.0 fnbA VF0010 FnBPs Adherence VFC0001 Belongs to MSCRAMMs family; most strains of S. aureus express two related Fn-binding proteins FnBPA and FnBPB, which are encoded by closely linked genes (fnbA) fibronectin-binding protein A [FnBPs (VF0010) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2727 93.124 0.0 aur VF0024 Aureolysin Exoenzyme VFC0251 The aur gene encoding aureolysin is present in two allelic forms: type I and type II; low substrate specificity: cleaving peptide bonds on the N-terminal side of bulky, aliphatic, hydrophobic residues (aur) zinc metalloproteinase aureolysin [Aureolysin (VF0024) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2756 100.0 2.31E-134 icaR VF0014 Intercellular adhesion proteins Biofilm VFC0271 IcaA, icaB, icaC, icaD synthesize a polysaccharide, poly-n-succinyl-beta-1,6 glucosamine (PNSG) during infection (icaR) ica operon transcriptional regulator IcaR [Intercellular adhesion proteins (VF0014) - Biofilm (VFC0271)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2757 99.757 0.0 icaA VF0014 Intercellular adhesion proteins Biofilm VFC0271 IcaA, icaB, icaC, icaD synthesize a polysaccharide, poly-n-succinyl-beta-1,6 glucosamine (PNSG) during infection (icaA) N-acetylglucosaminyltransferase, involved in polysaccharide intercellular adhesin(PIA) synthesis [Intercellular adhesion proteins (VF0014) - Biofilm (VFC0271)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2758 98.02 1.19E-69 icaD VF0014 Intercellular adhesion proteins Biofilm VFC0271 IcaA, icaB, icaC, icaD synthesize a polysaccharide, poly-n-succinyl-beta-1,6 glucosamine (PNSG) during infection (icaD) intercellular adhesion protein D, involved in polysaccharide intercellular adhesin(PIA) synthesis [Intercellular adhesion proteins (VF0014) - Biofilm (VFC0271)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2759 98.621 0.0 icaB VF0014 Intercellular adhesion proteins Biofilm VFC0271 IcaA, icaB, icaC, icaD synthesize a polysaccharide, poly-n-succinyl-beta-1,6 glucosamine (PNSG) during infection (icaB) N-deacetylase, involved in polysaccharide intercellular adhesin(PIA) synthesis [Intercellular adhesion proteins (VF0014) - Biofilm (VFC0271)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2760 98.951 0.0 icaC VF0014 Intercellular adhesion proteins Biofilm VFC0271 IcaA, icaB, icaC, icaD synthesize a polysaccharide, poly-n-succinyl-beta-1,6 glucosamine (PNSG) during infection (icaC) intercellular adhesion protein C, involved in polysaccharide intercellular adhesin(PIA) synthesis [Intercellular adhesion proteins (VF0014) - Biofilm (VFC0271)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2761 100.0 2.39E-24 icaC VF0014 Intercellular adhesion proteins Biofilm VFC0271 IcaA, icaB, icaC, icaD synthesize a polysaccharide, poly-n-succinyl-beta-1,6 glucosamine (PNSG) during infection (icaC) intercellular adhesion protein C, involved in polysaccharide intercellular adhesin(PIA) synthesis [Intercellular adhesion proteins (VF0014) - Biofilm (VFC0271)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2762 97.941 0.0 lip VF0012 Lipase Exoenzyme VFC0251 Organized as pre-pro-enzymes: the pre-region represents the signal peptide; secreted in the pro-lipase form. The pro-region protects the proteins from proteolytic degradation and acts as an intramolecular chaperone to facilitate translocation of the lipase (lip) triacylglycerol lipase precursor [Lipase (VF0012) - Exoenzyme (VFC0251)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
CP005288.1_2783 97.778 0.0 cna VF0005 CNA Adherence VFC0001 Belongs to MSCRAMMs family (cna) collagen adhesin precursor [CNA (VF0005) - Adherence (VFC0001)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus