2. PATHOGENS
Basic Information
Accession number
GCA_001027885.1
Release date
2015-06-14
Organism
Acinetobacter baumannii MRSN 7341
Species name
Acinetobacter baumannii
Assembly level
Contig
Assembly name
gdodcwi07 v01
Assembly submitter
J. Craig Venter Institute
Assembly Type
haploid
Genome size
3.9 Mb
GC percent
39.0
Contig count
52
Collection date
2004-09
Sample location
USA
Host
Homo sapiens
Isolation source
respiratory tract
Isolate type
-
Strain
MRSN 7341
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
JPIB01000032.1_70 # 74323 # 75168 500.0 540.036 APH(3'')-Ib 99.25 ARO:3002639 protein homolog model aminoglycoside antibiotic antibiotic inactivation APH(3'') APH(3'')-Ib is an aminoglycoside phosphotransferase encoded by plasmids, transposons, integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp.
JPIB01000032.1_71 # 75168 # 76004 500.0 568.155 APH(6)-Id 99.64 ARO:3002660 protein homolog model aminoglycoside antibiotic antibiotic inactivation APH(6) APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids, integrative conjugative elements and chromosomal genomic islands in K. pneumoniae, Salmonella spp., E. coli, Shigella flexneri, Providencia alcalifaciens, Pseudomonas spp., V. cholerae, Edwardsiella tarda, Pasteurella multocida and Aeromonas bestiarum.
JPIB01000032.1_76 # 79377 # 80594 700.0 785.023 tet(B) 99.25 ARO:3000166 protein homolog model tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Tet(B) is a tetracycline efflux protein expressed in many Gram-negative bacteria. It confers resistance to tetracycline, doxycycline, and minocycline, but not tigecycline.
JPIB01000004.1_41 # 37260 # 38048 200.0 376.326 ANT(3'')-IIc 68.99 ARO:3004091 protein homolog model aminoglycoside antibiotic antibiotic inactivation ANT(3'') ANT(3'')-IIc is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms.
JPIB01000038.1_64 # 58279 # 59103 500.0 566.614 OXA-66 100.0 ARO:3001615 protein homolog model carbapenem; cephalosporin; penam antibiotic inactivation OXA beta-lactamase OXA-66 is a beta-lactamase found in A. baumannii.
JPIB01000038.1_287 # 294956 # 296245 700.0 863.218 Acinetobacter baumannii AbaF 100.0 ARO:3004573 protein homolog model phosphonic acid antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Expression of abaF in E. coli resulted in increased resistance to fosfomycin.
JPIB01000024.1_190 # 198112 # 199212 700.0 741.11 LpsB 97.81 ARO:3005051 protein homolog model peptide antibiotic reduced permeability to antibiotic Intrinsic peptide antibiotic resistant Lps LpsB is involved in lipopolysaccharide synthesis. It confers intrinsic resistance to colistin and other peptide antibiotics.
JPIB01000024.1_227 # 240563 # 241909 850.0 887.1 abeM 99.78 ARO:3000753 protein homolog model fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux multidrug and toxic compound extrusion (MATE) transporter AbeM is an multidrug efflux pump found in Acinetobacter baumannii.
JPIB01000040.1_56 # 67378 # 68529 500.0 786.949 ADC-30 100.0 ARO:3004617 protein homolog model cephalosporin antibiotic inactivation ADC beta-lactamase without carbapenemase activity An ADC beta-lactamase and cephalosporinase from Acinetobacter baumannii.
JPIB01000042.1_165 # 179104 # 180558 950.0 974.926 adeK 100.0 ARO:3000782 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; carbapenem; cephalosporin; tetracycline antibiotic; rifamycin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AdeK is the outer membrane factor protein in the adeIJK multidrug efflux complex.
JPIB01000042.1_166 # 180558 # 183734 2000.0 2149.4 adeJ 99.91 ARO:3000781 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; carbapenem; cephalosporin; tetracycline antibiotic; rifamycin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AdeJ is a RND efflux protein that acts as the inner membrane transporter of the AdeIJK efflux complex. It has 57% identity with E. coli AcrB.
JPIB01000042.1_167 # 183747 # 184997 800.0 832.787 adeI 100.0 ARO:3000780 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; carbapenem; cephalosporin; tetracycline antibiotic; rifamycin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AdeI is the membrane fusion protein of the AdeIJK multidrug efflux complex.
JPIB01000006.1_10 # 11337 # 11591 100.0 102.064 rsmA 89.09 ARO:3005069 protein homolog model fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump rsmA is a gene that regulates virulence of Pseudomonas aeruginosa. However, its negative effect on MexEF-OprN overexpression has been noted to confer resistance to various antibiotics. It's Escherichia coli homolog is csrA.
JPIB01000006.1_30 # 29528 # 30061 300.0 313.153 AAC(3)-Ia 98.7 ARO:3002528 protein homolog model aminoglycoside antibiotic antibiotic inactivation AAC(3) AAC(3)-Ia is an aminoglycoside acetyltransferase encoded by plasmids, transposons, integrons in S. marcescens, E. coli, Acinetobacter baumannii, Klebsiella pneumoniae, Klebsiella oxytoca, P. aeruginosa, Salmonella typhimurium and Proteus mirabilis.
JPIB01000006.1_32 # 31117 # 31896 450.0 519.62 ANT(3'')-IIa 99.61 ARO:3004089 protein homolog model aminoglycoside antibiotic antibiotic inactivation ANT(3'') ANT(3'')-IIa is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms.
JPIB01000006.1_33 # 32060 # 32407 190.0 219.55 qacEdelta1 100.0 ARO:3005010 protein homolog model disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump QacEdelta1 is a resistance gene conferring resistance to antiseptics. It is different from QacE only at the 3'-terminus.
JPIB01000006.1_34 # 32401 # 33240 500.0 553.132 sul1 100.0 ARO:3000410 protein homolog model sulfonamide antibiotic antibiotic target replacement sulfonamide resistant sul Sul1 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria. It is linked to other resistance genes of class 1 integrons.
JPIB01000013.1_3 # 1212 # 2072 500.0 591.267 TEM-1 100.0 ARO:3000873 protein homolog model monobactam; cephalosporin; penam; penem antibiotic inactivation TEM beta-lactamase TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins.
JPIB01000031.1_4 # 1968 # 2297 175.0 209.92 abeS 100.0 ARO:3000768 protein homolog model macrolide antibiotic; aminocoumarin antibiotic antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump AbeS in an efflux pump of the SMR family of transporters found in Acinetobacter baumannii.
JPIB01000001.1_156 # 172292 # 173770 600.0 964.14 Acinetobacter baumannii AmvA 98.98 ARO:3004577 protein homolog model macrolide antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump AmvA has 14 alpha-helical transmembrane segments, qualifying it as a member of the DHA2 transporter family of the major facilitator superfamily (MFS). When AmvA was expressed in E. coli, the cells had at least four-fold decreased susceptibility to erythromycin, acridine orange, acriflavine, deoxycholate and methyl viologen. AmvA from the AC0037 strain of A. baumannii was tested.
JPIB01000001.1_207 # 227810 # 228463 420.0 448.743 adeN 99.08 ARO:3000559 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; lincosamide antibiotic; carbapenem; cephalosporin; tetracycline antibiotic; rifamycin antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AdeN is a repressor of AdeIJK, a RND-type efflux pump in Acinetobacter baumannii. Its inactivation increases expression of AdeJ.
JPIB01000023.1_30 # 27199 # 28272 700.0 705.671 adeS 96.36 ARO:3000549 protein homolog model glycylcycline; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AdeS is a sensor kinase in the AdeRS regulatory system of AdeABC. It is essential for AdeABC expression.
JPIB01000023.1_31 # 28304 # 29047 480.0 505.368 adeR 99.19 ARO:3000553 protein homolog model glycylcycline; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AdeR is a positive regulator of AdeABC efflux system. AdeR inactivation leads to susceptibility to aminoglycoside antibiotics.
JPIB01000023.1_32 # 29193 # 30383 750.0 802.357 adeA 100.0 ARO:3000774 protein homolog model glycylcycline; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AdeA is the membrane fusion protein of the multidrug efflux complex AdeABC.
JPIB01000023.1_33 # 30380 # 33490 2000.0 2091.62 adeB 100.0 ARO:3000775 protein homolog model glycylcycline; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AdeB is the multidrug transporter of the adeABC efflux system.
JPIB01000023.1_34 # 33567 # 34964 850.0 952.97 adeC 100.0 ARO:3003811 protein homolog model glycylcycline; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AdeC is the outer membrane factor of the AdeABC multidrug efflux complex. It can be replaced by other outer membrane channels, and is not essential for antibiotic resistance.
JPIB01000037.1_1 # 468 # 1283 500.0 565.459 APH(3')-Ia 100.0 ARO:3002641 protein homolog model aminoglycoside antibiotic antibiotic inactivation APH(3') APH(3')-Ia is a transposon-encoded aminoglycoside phosphotransferase in E. coli and S. enterica. It is identical at the protein sequence to APH(3')-Ic, an aminoglycoside phosphotransferase encoded by plasmids, transposons and genomic islands in K. pneumoniae, A. baumannii, S. marcescens, Corynebacterium spp., Photobacterium spp. and Citrobacter spp.
JPIB01000043.1_51 # 55610 # 57058 900.0 958.748 adeH 99.59 ARO:3000779 protein homolog model fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AdeH is the outer membrane channel protein of the AdeFGH multidrug efflux complex.
JPIB01000043.1_52 # 57071 # 60250 750.0 2135.53 adeF 99.81 ARO:3000777 protein homolog model fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AdeF is the membrane fusion protein of the multidrug efflux complex AdeFGH.
JPIB01000043.1_53 # 60257 # 61477 800.0 818.15 adeG 100.0 ARO:3000778 protein homolog model fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AdeG is the inner membrane transporter of the AdeFGH multidrug efflux complex.
JPIB01000043.1_54 # 61675 # 62706 650.0 694.501 adeL 100.0 ARO:3000620 protein homolog model fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AdeL is a regulator of AdeFGH in Acinetobacter baumannii. AdeL mutations are associated with AdeFGH overexpression and multidrug resistance.
JPIB01000032.1_98 # 103219 # 105438 1400.0 1509.2 Acinetobacter baumannii parC conferring resistance to fluoroquinolones 100.0 ARO:3003818 protein variant model S84L, V104I, D105E fluoroquinolone antibiotic antibiotic target alteration fluoroquinolone resistant parC Mutations in Acinetobacter baumannii parC that result in resistance to fluoroquinolones.
JPIB01000045.1_69 # 92899 # 95613 1500.0 1835.08 Acinetobacter baumannii gyrA conferring resistance to fluoroquinolones 99.78 ARO:3003817 protein variant model S81L fluoroquinolone antibiotic antibiotic target alteration fluoroquinolone resistant gyrA Mutations in the A subunit of DNA gyrase reduce its affinity for fluoroquinolones, thereby conferring resistance.
JPIB01000032.1_75 # 78672 # 79295 400.0 427.172 tetR 100.0 ARO:3003479 protein overexpression model tetracycline antibiotic antibiotic target alteration; antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites. Mutations arise within tetR results in lower affinity for tetracyclin.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
JPIB01000007.1_28 61.429 2.0E-131 kdsA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
JPIB01000036.1_59 100.0 0.0 ata VF1333 Ata Adherence VFC0001 (ata) trimeric autotransporter adhesin Ata [Ata (VF1333) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000046.1_1 100.0 0.0 ata VF1333 Ata Adherence VFC0001 (ata) trimeric autotransporter adhesin Ata [Ata (VF1333) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000052.1_1 77.749 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
JPIB01000052.1_113 100.0 0.0 bfmS VF0463 BfmRS Regulation VFC0301 Two-component system: BfmS sensor kinase acts as a BfmR phosphatase to negatively regulate BfmR activity in certain conditions (bfmS) signal transduction histidine kinase [BfmRS (VF0463) - Regulation (VFC0301)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000052.1_114 100.0 3.98E-173 bfmR VF0463 BfmRS Regulation VFC0301 Two-component system: BfmS sensor kinase acts as a BfmR phosphatase to negatively regulate BfmR activity in certain conditions (bfmR) biofilm-controlling response regulator [BfmRS (VF0463) - Regulation (VFC0301)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000052.1_171 66.359 1.69E-98 rpe VF0543 Capsule Immune modulation VFC0258 Group 4 capsule; high molecular weight (HMW) O-antigen capsule (rpe) ribulose-phosphate 3-epimerase [Capsule (VF0543) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
JPIB01000032.1_12 77.749 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
JPIB01000032.1_17 100.0 0.0 gspD VF1335 T2SS Effector delivery system VFC0086 Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB (gspD) general secretion pathway protein D [T2SS (VF1335) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000032.1_18 100.0 0.0 gspC VF1335 T2SS Effector delivery system VFC0086 Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB (gspC) general secretion pathway protein C [T2SS (VF1335) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000032.1_19 100.0 0.0 gspN VF1335 T2SS Effector delivery system VFC0086 Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB (gspN) type II secretion system protein N [T2SS (VF1335) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000032.1_49 100.0 0.0 pbpG VF0468 PbpG Immune modulation VFC0258 (pbpG) D-alanyl-D-alanine endopeptidase PBP7/8 [PbpG (VF0468) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000032.1_51 99.234 0.0 pilS VF1334 TFP Adherence VFC0001 (pilS) PAS domain-containing sensor histidine kinase [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000032.1_52 98.943 0.0 pilR VF1334 TFP Adherence VFC0001 (pilR) sigma-54 dependent transcriptional regulator [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000004.1_7 99.219 0.0 tsaP VF1334 TFP Adherence VFC0001 (tsaP) LysM peptidoglycan-binding domain-containing protein [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000004.1_59 99.16 4.07E-180 abaR VF0471 Quorom sensing Biofilm VFC0271 (abaR) DNA-binding HTH domain-containing protein [Quorom sensing (VF0471) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000004.1_61 98.361 3.96E-136 abaI VF0471 Quorom sensing Biofilm VFC0271 (abaI) N-acyl-L-homoserine lactone synthetase [Quorom sensing (VF0471) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000004.1_87 99.194 0.0 tse1 VF1338 T6SS secreted effectors Effector delivery system VFC0086 (tse1) T6SS effector Tse1, predicted lipase [T6SS secreted effectors (VF1338) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ATCC 17978] Acinetobacter baumannii
JPIB01000004.1_88 94.26 0.0 vgrG/tssI VF1337 T6SS Effector delivery system VFC0086 (vgrG/tssI) type VI secretion system tip protein VgrG [T6SS (VF1337) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000004.1_105 98.684 0.0 ACICU_RS00500 VF0465 Capsule Immune modulation VFC0258 A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. (ACICU_RS00500) phosphomannomutase/phosphoglucomutase [Capsule (VF0465) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000004.1_106 99.704 0.0 galE VF0465 Capsule Immune modulation VFC0258 A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. (galE) UDP-glucose 4-epimerase GalE [Capsule (VF0465) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000004.1_107 98.921 0.0 pgi VF0465 Capsule Immune modulation VFC0258 A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. (pgi) glucose-6-phosphate isomerase [Capsule (VF0465) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000004.1_108 98.571 0.0 ACICU_RS00485 VF0465 Capsule Immune modulation VFC0258 A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. (ACICU_RS00485) nucleotide sugar dehydrogenase [Capsule (VF0465) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000004.1_109 96.22 0.0 galU VF0465 Capsule Immune modulation VFC0258 A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. (galU) UTP--glucose-1-phosphate uridylyltransferase GalU [Capsule (VF0465) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000004.1_117 70.783 4.05E-173 cap8E VF0003 Capsule Immune modulation VFC0258 Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans (cap8E) type 8 capsular polysaccharide synthesis protein Cap8E [Capsule (VF0003) - Immune modulation (VFC0258)] [Staphylococcus aureus subsp. aureus MW2] Staphylococcus aureus
JPIB01000004.1_132 97.877 0.0 tviB VF0465 Capsule Immune modulation VFC0258 A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. (tviB) Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB [Capsule (VF0465) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000004.1_133 91.257 0.0 ACICU_RS00405 VF0465 Capsule Immune modulation VFC0258 A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. (ACICU_RS00405) polysaccharide biosynthesis/export family protein [Capsule (VF0465) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000004.1_134 92.254 2.87E-99 ACICU_RS00400 VF0465 Capsule Immune modulation VFC0258 A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. (ACICU_RS00400) low molecular weight phosphotyrosine protein phosphatase [Capsule (VF0465) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000004.1_135 94.231 0.0 ACICU_RS00395 VF0465 Capsule Immune modulation VFC0258 A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. (ACICU_RS00395) polysaccharide biosynthesis tyrosine autokinase [Capsule (VF0465) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000004.1_142 98.476 0.0 plc1 VF0470 Phospholipase C Exotoxin VFC0235 (plc1) phospholipase C [Phospholipase C (VF0470) - Exotoxin (VFC0235)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000045.1_1 94.382 3.32E-48 bap VF0462 Bap Biofilm VFC0271 A large cell surface protein comprised of multiple copies of repeat elements; Bap homologues have also been identified and characterized in other bacteria, including members of other genera typically associated with hospital-acquired infection, such as Staphylococcus, Enterococcus, and Pseudomonas (bap) biofilm-associated protein [Bap (VF0462) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000045.1_2 99.74 0.0 bap VF0462 Bap Biofilm VFC0271 A large cell surface protein comprised of multiple copies of repeat elements; Bap homologues have also been identified and characterized in other bacteria, including members of other genera typically associated with hospital-acquired infection, such as Staphylococcus, Enterococcus, and Pseudomonas (bap) biofilm-associated protein [Bap (VF0462) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000045.1_32 73.004 0.0 htpB VF0159 Hsp60 Adherence VFC0001 (htpB) Hsp60, 60K heat shock protein HtpB [Hsp60 (VF0159) - Adherence (VFC0001)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
JPIB01000045.1_86 100.0 0.0 lpxM VF0466 LPS Immune modulation VFC0258 (lpxM) lysophospholipid acyltransferase family protein [LPS (VF0466) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000038.1_13 99.687 0.0 gspK VF1335 T2SS Effector delivery system VFC0086 Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB (gspK) general secretion pathway protein K [T2SS (VF1335) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000038.1_15 100.0 2.76E-91 gspI VF1335 T2SS Effector delivery system VFC0086 Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB (gspI) general secretion pathway protein I [T2SS (VF1335) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000038.1_16 100.0 3.61E-137 gspH VF1335 T2SS Effector delivery system VFC0086 Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB (gspH) general secretion pathway protein H [T2SS (VF1335) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000038.1_89 60.816 4.42E-101 CBU_1566 VF0696 T4SS secreted effectors Effector delivery system VFC0086 (CBU_1566) Coxiella Dot/Icm type IVB secretion system translocated effector [T4SS secreted effectors (VF0696) - Effector delivery system (VFC0086)] [Coxiella burnetii RSA 493] Coxiella burnetii
JPIB01000024.1_8 100.0 0.0 gspE1 VF1335 T2SS Effector delivery system VFC0086 Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB (gspE1) general secretion pathway protein E [T2SS (VF1335) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000024.1_121 100.0 0.0 pilF VF1334 TFP Adherence VFC0001 (pilF) type IV pilus biogenesis/stability protein PilW [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000024.1_143 67.021 6.67E-97 clpP VF0074 ClpP Stress survival VFC0282 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
JPIB01000024.1_189 100.0 0.0 lpxL VF0466 LPS Immune modulation VFC0258 (lpxL) lauroyl acyltransferase [LPS (VF0466) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000024.1_190 100.0 0.0 lpsB VF0466 LPS Immune modulation VFC0258 (lpsB) glycosyltransferase family 4 protein [LPS (VF0466) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000024.1_194 100.0 0.0 fimV VF1334 TFP Adherence VFC0001 (fimV) hypothetical protein [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000024.1_249 100.0 7.06E-147 gspG VF1335 T2SS Effector delivery system VFC0086 Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB (gspG) general secretion pathway protein G [T2SS (VF1335) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000024.1_250 100.0 0.0 gspF VF1335 T2SS Effector delivery system VFC0086 Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB (gspF) general secretion pathway protein F [T2SS (VF1335) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000024.1_286 100.0 0.0 pilB VF1334 TFP Adherence VFC0001 (pilB) type IV-A pilus assembly ATPase PilB [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000024.1_287 100.0 0.0 pilC VF1334 TFP Adherence VFC0001 (pilC) type II secretion system F family protein [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000024.1_288 100.0 0.0 gspO/pilD VF1334 TFP Adherence VFC0001 (gspO/pilD) A24 family peptidase [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_30 100.0 0.0 bauF VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (bauF) siderophore-interacting protein [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_31 100.0 0.0 basA VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (basA) acinetobactin biosynthesis protein [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_32 100.0 0.0 basB VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (basB) non-ribosomal peptide synthetase with condensation and peptidyl carrier protein domains [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_35 100.0 0.0 bauD VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (bauD) ferric siderophore ABC transporter, permease protein BauD [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_36 100.0 0.0 bauC VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (bauC) ferric siderophore ABC transporter, permease protein BauC [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_37 100.0 0.0 bauE VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (bauE) ferric siderophore ABC transporter, ATP-binding protein BauE [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_38 100.0 0.0 bauB VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (bauB) ferric siderophore ABC transporter, periplasmic siderophore-binding protein [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_39 100.0 0.0 bauA VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (bauA) TonB-dependent siderophore receptor BauA [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_40 100.0 0.0 basC VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (basC) acinetobactin biosynthesis protein BasC [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_41 100.0 0.0 basD VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (basD) acinetobactin biosynthesis protein BasD [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_42 100.0 0.0 entE VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (entE) non-ribosomal peptide synthetase adenylate-forming enzyme of acinetobactin synthesis [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_43 100.0 0.0 basF VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (basF) aryl carrier protein BasF [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_44 100.0 0.0 basG VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (basG) acinetobactin biosynthesis protein BasF [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_46 100.0 0.0 barA VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (barA) siderophore efflux system of the ABC superfamily [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_47 100.0 0.0 barB VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (barB) siderophore efflux system of the ABC superfamily [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_48 100.0 0.0 basH VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (basH) non-ribosomal peptide biosynthesis thioesterase BasH [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_49 100.0 0.0 basI VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (basI) phosphopantetheinyl transferase component of acinetobactin biosynthesis protein BasI [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000040.1_50 100.0 0.0 basJ VF0467 Acinetobactin Nutritional/Metabolic factor VFC0272 (basJ) acinetobactin biosynthesis protein BasJ [Acinetobactin (VF0467) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000029.1_8 98.909 0.0 vgrG/tssI VF1337 T6SS Effector delivery system VFC0086 (vgrG/tssI) type VI secretion system tip protein VgrG [T6SS (VF1337) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000029.1_52 100.0 0.0 lpxC VF0466 LPS Immune modulation VFC0258 (lpxC) UDP-3-O-acyl-N-acetylglucosamine deacetylase [LPS (VF0466) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000042.1_63 100.0 1.11E-127 fimT VF1334 TFP Adherence VFC0001 (fimT) GspH/FimT family pseudopilin [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000042.1_64 100.0 0.0 ompA VF0464 OmpA Immune modulation VFC0258 (ompA) outer membrane protein OmpA [OmpA (VF0464) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000042.1_90 100.0 9.66E-94 pilG VF1334 TFP Adherence VFC0001 (pilG) twitching motility response regulator PilG [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000042.1_91 100.0 1.26E-86 pilH VF1334 TFP Adherence VFC0001 (pilH) response regulator [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000042.1_92 100.0 4.53E-135 pilI VF1334 TFP Adherence VFC0001 (pilI) chemotaxis protein CheW [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000042.1_93 100.0 0.0 pilJ VF1334 TFP Adherence VFC0001 (pilJ) methyl-accepting chemotaxis protein [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000011.1_10 100.0 0.0 tagX VF1337 T6SS Effector delivery system VFC0086 (tagX) type VI-associated gene X, peptidoglycan hydrolase [T6SS (VF1337) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000011.1_12 100.0 0.0 tssL VF1337 T6SS Effector delivery system VFC0086 (tssL) type IVB secretion system protein TssL [T6SS (VF1337) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000011.1_13 100.0 0.0 tssK VF1337 T6SS Effector delivery system VFC0086 (tssK) type VI secretion system baseplate subunit TssK [T6SS (VF1337) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000011.1_14 100.0 0.0 tssA VF1337 T6SS Effector delivery system VFC0086 (tssA) type VI secretion system protein TssA [T6SS (VF1337) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000011.1_15 100.0 0.0 clpV/tssH VF1337 T6SS Effector delivery system VFC0086 (clpV/tssH) type VI secretion system ATPase TssH [T6SS (VF1337) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000011.1_19 99.922 0.0 tssM VF1337 T6SS Effector delivery system VFC0086 (tssM) type VI secretion system membrane subunit TssM [T6SS (VF1337) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000011.1_21 100.0 0.0 tssG VF1337 T6SS Effector delivery system VFC0086 (tssG) type VI secretion system baseplate subunit TssG [T6SS (VF1337) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000011.1_22 100.0 0.0 tssF VF1337 T6SS Effector delivery system VFC0086 (tssF) type VI secretion system baseplate subunit TssF [T6SS (VF1337) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000011.1_23 100.0 2.59E-116 tssE VF1337 T6SS Effector delivery system VFC0086 (tssE) type VI secretion system baseplate subunit TssE [T6SS (VF1337) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000011.1_24 100.0 5.53E-126 hcp/tssD VF1337 T6SS Effector delivery system VFC0086 (hcp/tssD) type VI secretion system tube protein Hcp [T6SS (VF1337) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000011.1_25 100.0 0.0 tssC VF1337 T6SS Effector delivery system VFC0086 (tssC) type VI secretion system contractile sheath large subunit [T6SS (VF1337) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000011.1_26 100.0 4.65E-120 tssB VF1337 T6SS Effector delivery system VFC0086 (tssB) type VI secretion system contractile sheath small subunit [T6SS (VF1337) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000011.1_58 100.0 0.0 vgrG/tssI VF1337 T6SS Effector delivery system VFC0086 (vgrG/tssI) type VI secretion system tip protein VgrG [T6SS (VF1337) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000011.1_69 66.23 1.07E-156 lpxL VF0466 LPS Immune modulation VFC0258 (lpxL) lauroyl acyltransferase [LPS (VF0466) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000009.1_18 78.256 0.0 vgrG/tssI VF1337 T6SS Effector delivery system VFC0086 (vgrG/tssI) type VI secretion system tip protein VgrG [T6SS (VF1337) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000020.1_14 61.421 8.95E-94 ureG VF0050 Urease Stress survival VFC0282 (ureG) urease accessory protein (ureG) [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] Helicobacter pylori
JPIB01000020.1_19 61.0 2.5E-34 ureA VF0050 Urease Stress survival VFC0282 (ureA) urease alpha subunit UreA [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] Helicobacter pylori
JPIB01000031.1_12 100.0 0.0 gspE2 VF1335 T2SS Effector delivery system VFC0086 Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB (gspE2) putative secretion pathway ATPase [T2SS (VF1335) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000031.1_45 100.0 0.0 gspL VF1335 T2SS Effector delivery system VFC0086 Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB (gspL) general secretion pathway protein L [T2SS (VF1335) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000031.1_46 100.0 1.73E-114 gspM VF1335 T2SS Effector delivery system VFC0086 Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB (gspM) general secretion pathway protein M [T2SS (VF1335) - Effector delivery system (VFC0086)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000022.1_10 100.0 9.77E-129 csuA/B VF0461 Csu fimbriae Biofilm VFC0271 Chaperone-usher pathway assembled fimbriae (csuA/B) Csu pilus major pilin subunit CsuA/B [Csu fimbriae (VF0461) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000022.1_12 100.0 3.75E-127 csuB VF0461 Csu fimbriae Biofilm VFC0271 Chaperone-usher pathway assembled fimbriae (csuB) Csu pilus subunit CsuB [Csu fimbriae (VF0461) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000022.1_13 100.0 0.0 csuC VF0461 Csu fimbriae Biofilm VFC0271 Chaperone-usher pathway assembled fimbriae (csuC) Csu pilus chaperone protein CsuC [Csu fimbriae (VF0461) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000022.1_14 100.0 0.0 csuD VF0461 Csu fimbriae Biofilm VFC0271 Chaperone-usher pathway assembled fimbriae (csuD) Csu pilus usher protein CsuD [Csu fimbriae (VF0461) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000022.1_15 99.41 0.0 csuE VF0461 Csu fimbriae Biofilm VFC0271 Chaperone-usher pathway assembled fimbriae (csuE) Csu pilus tip adhesin CsuE [Csu fimbriae (VF0461) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000002.1_71 93.407 1.52E-62 ACICU_RS04610 VF0636 HemO cluster Nutritional/Metabolic factor VFC0272 (ACICU_RS04610) hypothetical protein [HemO cluster (VF0636) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000002.1_72 97.635 0.0 ACICU_RS04565 VF0636 HemO cluster Nutritional/Metabolic factor VFC0272 (ACICU_RS04565) LysR family transcriptional regulator [HemO cluster (VF0636) - Nutritional/Metabolic factor (VFC0272)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000002.1_110 100.0 0.0 pilT VF1334 TFP Adherence VFC0001 (pilT) type IV pilus twitching motility protein PilT [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000002.1_111 100.0 0.0 pilU VF1334 TFP Adherence VFC0001 (pilU) PilT/PilU family type 4a pilus ATPase [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000001.1_47 100.0 0.0 pgaB VF0472 PNAG Biofilm VFC0271 PNAG is produced by the Pga machinery consisting of PgaABCD proteins. Pga complex probably spans the inner and outer bacterial membrane. PgaC and PgaD form an inner membrane-intergrated complex. PgaC is the cataytic glycosyltransferase containing 4-5 predicted transmembrane helices (TMHs). PgaD probably contains two TMHs with a short periplasmic loop and small cytosolic C terminus. PgaA is an outer membrane porin and might associate with PgaB, a periplasmic lipoprotein that is probably anchored to the outer membrane. PgaB deacetylates a small fraction of the polymer's NAG units. (pgaB) poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB [PNAG (VF0472) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000001.1_48 100.0 0.0 pgaC VF0472 PNAG Biofilm VFC0271 PNAG is produced by the Pga machinery consisting of PgaABCD proteins. Pga complex probably spans the inner and outer bacterial membrane. PgaC and PgaD form an inner membrane-intergrated complex. PgaC is the cataytic glycosyltransferase containing 4-5 predicted transmembrane helices (TMHs). PgaD probably contains two TMHs with a short periplasmic loop and small cytosolic C terminus. PgaA is an outer membrane porin and might associate with PgaB, a periplasmic lipoprotein that is probably anchored to the outer membrane. PgaB deacetylates a small fraction of the polymer's NAG units. (pgaC) poly-beta-1,6 N-acetyl-D-glucosamine synthase [PNAG (VF0472) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000001.1_49 100.0 7.33E-113 pgaD VF0472 PNAG Biofilm VFC0271 PNAG is produced by the Pga machinery consisting of PgaABCD proteins. Pga complex probably spans the inner and outer bacterial membrane. PgaC and PgaD form an inner membrane-intergrated complex. PgaC is the cataytic glycosyltransferase containing 4-5 predicted transmembrane helices (TMHs). PgaD probably contains two TMHs with a short periplasmic loop and small cytosolic C terminus. PgaA is an outer membrane porin and might associate with PgaB, a periplasmic lipoprotein that is probably anchored to the outer membrane. PgaB deacetylates a small fraction of the polymer's NAG units. (pgaD) poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD [PNAG (VF0472) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000001.1_159 100.0 0.0 plc2 VF0470 Phospholipase C Exotoxin VFC0235 (plc2) phospholipase C [Phospholipase C (VF0470) - Exotoxin (VFC0235)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000001.1_219 100.0 0.0 lpxD VF0466 LPS Immune modulation VFC0258 (lpxD) UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase [LPS (VF0466) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000001.1_221 100.0 0.0 lpxA VF0466 LPS Immune modulation VFC0258 (lpxA) acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase [LPS (VF0466) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000049.1_78 100.0 0.0 lpxB VF0466 LPS Immune modulation VFC0258 (lpxB) lipid-A-disaccharide synthase [LPS (VF0466) - Immune modulation (VFC0258)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000034.1_24 100.0 0.0 plcD VF0469 Phospholipase D Exotoxin VFC0235 (plcD) phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase [Phospholipase D (VF0469) - Exotoxin (VFC0235)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000016.1_11 89.286 1.85E-11 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
JPIB01000039.1_77 99.716 0.0 pilM VF1334 TFP Adherence VFC0001 (pilM) pilus assembly protein PilM [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000039.1_78 100.0 1.36E-161 pilN VF1334 TFP Adherence VFC0001 (pilN) PilN domain-containing protein [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000039.1_79 99.187 0.0 pilO VF1334 TFP Adherence VFC0001 (pilO) type 4a pilus biogenesis protein PilO [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000039.1_80 100.0 2.48E-129 pilP VF1334 TFP Adherence VFC0001 (pilP) pilus assembly protein PilP [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000039.1_81 100.0 0.0 pilQ VF1334 TFP Adherence VFC0001 (pilQ) type IV pilus secretin PilQ [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000043.1_13 62.944 1.11E-87 sodB VF0169 SodB Stress survival VFC0282 (sodB) superoxide dismutase [SodB (VF0169) - Stress survival (VFC0282)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
JPIB01000043.1_51 100.0 0.0 adeH VF0504 AdeFGH efflux pump Biofilm VFC0271 Belongs to resistance-nodulation-cell division (RND)-type efflux system; RND efflux systems, composed of an inner membrane protein (RND pump) linked by a periplasmic adaptor protein (PAP) to an outer membrane factor (OMF), can extrude a wide range of substrates often unrelated in structure; To date, three Acinetobacter drug efflux (Ade) RND systems, AdeABC, AdeFGH, and AdeIJK, have been characterized in A. baumannii (adeH) outer membrane protein [AdeFGH efflux pump (VF0504) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000043.1_52 100.0 0.0 adeG VF0504 AdeFGH efflux pump Biofilm VFC0271 Belongs to resistance-nodulation-cell division (RND)-type efflux system; RND efflux systems, composed of an inner membrane protein (RND pump) linked by a periplasmic adaptor protein (PAP) to an outer membrane factor (OMF), can extrude a wide range of substrates often unrelated in structure; To date, three Acinetobacter drug efflux (Ade) RND systems, AdeABC, AdeFGH, and AdeIJK, have been characterized in A. baumannii (adeG) cation/multidrug efflux pump [AdeFGH efflux pump (VF0504) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000043.1_53 100.0 0.0 adeF VF0504 AdeFGH efflux pump Biofilm VFC0271 Belongs to resistance-nodulation-cell division (RND)-type efflux system; RND efflux systems, composed of an inner membrane protein (RND pump) linked by a periplasmic adaptor protein (PAP) to an outer membrane factor (OMF), can extrude a wide range of substrates often unrelated in structure; To date, three Acinetobacter drug efflux (Ade) RND systems, AdeABC, AdeFGH, and AdeIJK, have been characterized in A. baumannii (adeF) membrane-fusion protein [AdeFGH efflux pump (VF0504) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000043.1_66 94.483 3.47E-95 pilA VF1334 TFP Adherence VFC0001 (pilA) pilin [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000043.1_76 98.089 3.03E-109 fimU VF1334 TFP Adherence VFC0001 (fimU) GspH/FimT family pseudopilin [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000043.1_77 99.457 1.29E-137 pilV VF1334 TFP Adherence VFC0001 (pilV) type IV pilus modification protein PilV [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000043.1_78 98.498 0.0 pilW VF1334 TFP Adherence VFC0001 (pilW) PilW family protein [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000043.1_79 99.632 0.0 pilX VF1334 TFP Adherence VFC0001 (pilX) hypothetical protein [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000043.1_80 99.299 0.0 pilY1 VF1334 TFP Adherence VFC0001 (pilY1) VWA domain-containing protein [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000043.1_81 100.0 1.95E-118 ACICU_RS16840 VF1334 TFP Adherence VFC0001 (ACICU_RS16840) prepilin-type N-terminal cleavage/methylation domain-containing protein [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
JPIB01000043.1_82 100.0 8.32E-104 pilE VF1334 TFP Adherence VFC0001 (pilE) type IV pilin protein [TFP (VF1334) - Adherence (VFC0001)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii