2. PATHOGENS
Basic Information
Accession number
GCA_001030835.1
Release date
2015-06-22
Organism
Klebsiella pneumoniae
Species name
Klebsiella pneumoniae
Assembly level
Scaffold
Assembly name
Kleb_pneu_CHS83_V1
Assembly submitter
Broad Institute
Assembly Type
haploid
Genome size
5.9 Mb
GC percent
57.0
Contig count
44
Collection date
2014
Sample location
USA
Host
Homo sapiens
Isolation source
-
Isolate type
-
Strain
CHS83
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
KQ088057.1_866 # 965765 # 968887 1800.0 1834.31 mdtB 90.0 ARO:3000793 protein homolog model aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex.
KQ088057.1_867 # 968888 # 971965 1800.0 1865.12 mdtC 91.61 ARO:3000794 protein homolog model aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB, MdtC can form a homomultimer complex that results in a functioning efflux complex with a narrower drug specificity. mdtC corresponds to 3 loci in Pseudomonas aeruginosa PAO1 (gene name: muxC/muxB) and 3 loci in Pseudomonas aeruginosa LESB58.
KQ088057.1_870 # 974854 # 975576 450.0 452.981 baeR 91.67 ARO:3000828 protein homolog model aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes.
KQ088057.1_1134 # 1273858 # 1276971 1900.0 1951.79 acrD 91.03 ARO:3000491 protein homolog model aminoglycoside antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrD is an aminoglycoside efflux pump expressed in E. coli. Its expression can be induced by indole, and is regulated by baeRS and cpxAR.
KQ088057.1_1371 # 1511479 # 1512654 670.0 798.119 oqxA 100.0 ARO:3003922 protein homolog model fluoroquinolone antibiotic; glycylcycline; tetracycline antibiotic; diaminopyrimidine antibiotic; nitrofuran antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump RND efflux pump conferring resistance to fluoroquinolone.
KQ088057.1_1372 # 1512678 # 1515830 2000.0 2118.2 oqxB 100.0 ARO:3003923 protein homolog model fluoroquinolone antibiotic; glycylcycline; tetracycline antibiotic; diaminopyrimidine antibiotic; nitrofuran antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump RND efflux pump conferring resistance to fluoroquinolone.
KQ088057.1_1417 # 1560100 # 1560630 280.0 338.961 emrR 92.57 ARO:3000516 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression.
KQ088057.1_1418 # 1560756 # 1561928 700.0 788.875 Klebsiella pneumoniae KpnG 99.74 ARO:3004588 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penam; peptide antibiotic; penem antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump KpnG consists of ~390 residues and resembles EmrA of E. coli. Disruption of the pump components KpnG-KpnH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin.
KQ088057.1_1419 # 1561944 # 1563482 700.0 937.947 Klebsiella pneumoniae KpnH 94.02 ARO:3004597 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; penam; peptide antibiotic; penem antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump KpnH consists of ~511 residues, resembles EmrB of E. coli, and is probably a translocase in the KpnGH-TolC efflux protein in K. pneumoniae. Disruption of the pump components KpnG-KpnH signficantly decrease resistance to azithromycin, ceftazidime, ciprofloxacin, ertapenem, erythromycin, gentamicin, imipenem, ticarcillin, norfloxacin, polymyxin-B, piperacillin, spectinomycin, tobramycin, and streptomycin.
KQ088057.1_1427 # 1571342 # 1571527 100.0 109.383 rsmA 85.25 ARO:3005069 protein homolog model fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump rsmA is a gene that regulates virulence of Pseudomonas aeruginosa. However, its negative effect on MexEF-OprN overexpression has been noted to confer resistance to various antibiotics. It's Escherichia coli homolog is csrA.
KQ088057.1_2194 # 2334271 # 2334903 400.0 432.95 CRP 99.05 ARO:3000518 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump CRP is a global regulator that represses MdtEF multidrug efflux pump expression.
KQ088057.1_2294 # 2444649 # 2446304 400.0 1097.03 ArnT 99.64 ARO:3005053 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase ArnT is involved in Cell Wall Biosynthesis, specifically 4-amino-4-deoxy-L-arabinose (Ara4N). It confers resistance to peptide antibiotics.
KQ088057.1_2297 # 2449185 # 2450168 550.0 577.785 PmrF 83.69 ARO:3003578 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58.
KQ088057.1_2355 # 2526287 # 2527960 1000.0 1160.98 eptB 99.46 ARO:3005047 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase eptB is a phosphoethanolamine transferase. It confers resistance to peptide antibiotics.
KQ088057.1_3167 # 3434295 # 3434714 280.0 283.108 FosA6 97.84 ARO:3004111 protein homolog model phosphonic acid antibiotic antibiotic inactivation fosfomycin thiol transferase FosA6 is a plasmid-encoded enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule.
KQ088058.1_50 # 54950 # 57298 1500.0 1619.75 LptD 100.0 ARO:3005059 protein homolog model peptide antibiotic; aminocoumarin antibiotic; rifamycin antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump LptD is involved in LPS transport in a ABC Transporter efflux system. It confers resistance to rifamycin, aminocoumarin, and peptide antibiotics.
KQ088058.1_80 # 95829 # 96779 500.0 541.576 leuO 83.44 ARO:3003843 protein homolog model nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump leuO, a LysR family transcription factor, exists in a wide variety of bacteria of the family Enterobacteriaceae and is involved in the regulation of as yet unidentified genes affecting the stress response and pathogenesis expression. LeuO is also an activator of the MdtNOP efflux pump.
KQ088058.1_322 # 367359 # 368456 250.0 260.766 vanG 38.66 ARO:3002909 protein homolog model glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; Van ligase VanG is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis.
KQ088058.1_443 # 488979 # 492125 1900.0 1941.39 acrB 91.52 ARO:3000216 protein homolog model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump Protein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter.
KQ088058.1_881 # 979933 # 981165 700.0 706.057 Escherichia coli mdfA 85.61 ARO:3001328 protein homolog model tetracycline antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter.
KQ088058.1_997 # 1099088 # 1100836 1000.0 1126.69 msbA 92.78 ARO:3003950 protein homolog model nitroimidazole antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A, a major component of the bacterial outer cell membrane, and is the only bacterial ABC transporter that is essential for cell viability.
KQ088058.1_1038 # 1150229 # 1151299 700.0 726.857 OmpA 99.44 ARO:3005044 protein homolog model peptide antibiotic reduced permeability to antibiotic General Bacterial Porin with reduced permeability to peptide antibiotics OmpA is a porin that confers resistance to beta-lactam antibiotics.
KQ088058.1_1394 # 1507598 # 1508377 450.0 522.316 aadA2 100.0 ARO:3002602 protein homolog model aminoglycoside antibiotic antibiotic inactivation ANT(3'') aadA2 is an aminoglycoside nucleotidyltransferase gene encoded by plasmids and integrons in K. pneumoniae, Salmonella spp., Corynebacterium glutamicum, C. freundii and Aeromonas spp.
KQ088058.1_1395 # 1508541 # 1508888 190.0 219.55 qacEdelta1 100.0 ARO:3005010 protein homolog model disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump QacEdelta1 is a resistance gene conferring resistance to antiseptics. It is different from QacE only at the 3'-terminus.
KQ088058.1_1396 # 1508882 # 1509721 500.0 553.132 sul1 100.0 ARO:3000410 protein homolog model sulfonamide antibiotic antibiotic target replacement sulfonamide resistant sul Sul1 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria. It is linked to other resistance genes of class 1 integrons.
KQ088058.1_1547 # 1649783 # 1650937 700.0 720.309 Klebsiella pneumoniae OmpK37 94.27 ARO:3004122 protein homolog model monobactam; carbapenem; cephalosporin; cephamycin; penam; penem reduced permeability to antibiotic General Bacterial Porin with reduced permeability to beta-lactams Klebsiella pneumoniae outer membrane porin protein. Is preferentially detected in porin-deficient strains. Functional characterization of this new porin revealed a narrower pore than those of porins OmpK35 and OmpK36, which did not allow penetration by certain beta-lactams. Also, when a resistant strain expresses porin OmpK37 is less susceptible to cefotaxime and cefoxitin than when it is expressing either OmpK36 or OmpK35.
KQ088058.1_1659 # 1777706 # 1778068 150.0 223.402 Klebsiella pneumoniae KpnE 99.17 ARO:3004580 protein homolog model macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic; disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump KpnE subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan.
KQ088058.1_1660 # 1778055 # 1778384 150.0 206.453 Klebsiella pneumoniae KpnF 100.0 ARO:3004583 protein homolog model macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic; disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump KpnF subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan.
KQ088058.1_1724 # 1851398 # 1851772 230.0 243.432 marA 92.74 ARO:3000263 protein homolog model fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux; reduced permeability to antibiotic resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF.
KQ088060.1_12 # 10295 # 11110 500.0 528.865 sul2 100.0 ARO:3000412 protein homolog model sulfonamide antibiotic antibiotic target replacement sulfonamide resistant sul Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria, usually found on small plasmids.
KQ088060.1_14 # 11973 # 12809 500.0 568.155 APH(6)-Id 99.64 ARO:3002660 protein homolog model aminoglycoside antibiotic antibiotic inactivation APH(6) APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids, integrative conjugative elements and chromosomal genomic islands in K. pneumoniae, Salmonella spp., E. coli, Shigella flexneri, Providencia alcalifaciens, Pseudomonas spp., V. cholerae, Edwardsiella tarda, Pasteurella multocida and Aeromonas bestiarum.
KQ088060.1_65 # 58257 # 59138 550.0 593.964 KPC-3 100.0 ARO:3002313 protein homolog model monobactam; carbapenem; cephalosporin; penam antibiotic inactivation KPC beta-lactamase KPC-3 is a beta-lactamase found in Klebsiella pneumoniae.
KQ088062.1_15 # 13541 # 14401 550.0 582.022 SHV-12 100.0 ARO:3001071 protein homolog model carbapenem; cephalosporin; penam antibiotic inactivation SHV beta-lactamase SHV-12 is an extended-spectrum beta-lactamase found in Acinetobacter baumannii.
KQ088065.1_13 # 11596 # 12411 500.0 528.865 sul2 100.0 ARO:3000412 protein homolog model sulfonamide antibiotic antibiotic target replacement sulfonamide resistant sul Sul2 is a sulfonamide resistant dihydropteroate synthase of Gram-negative bacteria, usually found on small plasmids.
KQ088065.1_14 # 12472 # 13275 500.0 541.191 APH(3'')-Ib 99.63 ARO:3002639 protein homolog model aminoglycoside antibiotic antibiotic inactivation APH(3'') APH(3'')-Ib is an aminoglycoside phosphotransferase encoded by plasmids, transposons, integrative conjugative elements and chromosomes in Enterobacteriaceae and Pseudomonas spp.
KQ088065.1_15 # 13275 # 14111 500.0 568.155 APH(6)-Id 99.64 ARO:3002660 protein homolog model aminoglycoside antibiotic antibiotic inactivation APH(6) APH(6)-Id is an aminoglycoside phosphotransferase encoded by plasmids, integrative conjugative elements and chromosomal genomic islands in K. pneumoniae, Salmonella spp., E. coli, Shigella flexneri, Providencia alcalifaciens, Pseudomonas spp., V. cholerae, Edwardsiella tarda, Pasteurella multocida and Aeromonas bestiarum.
KQ088065.1_17 # 14832 # 15692 500.0 591.267 TEM-1 100.0 ARO:3000873 protein homolog model monobactam; cephalosporin; penam; penem antibiotic inactivation TEM beta-lactamase TEM-1 is a broad-spectrum beta-lactamase found in many Gram-negative bacteria. Confers resistance to penicillins and first generation cephalosphorins.
KQ088065.1_19 # 16392 # 17216 500.0 569.311 OXA-9 100.0 ARO:3001404 protein homolog model carbapenem; cephalosporin; penam antibiotic inactivation OXA beta-lactamase OXA-9 is a beta-lactamase found in Klebsiella pneumoniae.
KQ088065.1_20 # 17276 # 18052 450.0 513.072 ANT(3'')-IIa 99.23 ARO:3004089 protein homolog model aminoglycoside antibiotic antibiotic inactivation ANT(3'') ANT(3'')-IIa is a aminoglycoside nucleotidyltransferase identified in Acinetobacter spp. via horizontal gene transfer mechanisms.
KQ088065.1_21 # 18134 # 18739 275.0 399.438 AAC(6')-Ib10 98.97 ARO:3002581 protein homolog model aminoglycoside antibiotic antibiotic inactivation AAC(6') AAC(6')-Ib10 is an integron-encoded aminoglycoside acetyltransferase in P. aeruginosa.
KQ088057.1_978 # 1104636 # 1107269 1500.0 1642.48 Escherichia coli gyrA conferring resistance to fluoroquinolones 92.23 ARO:3003294 protein variant model S83I fluoroquinolone antibiotic antibiotic target alteration fluoroquinolone resistant gyrA Point mutation of Escherichia coli gyrA resulted in the lowered affinity between fluoroquinolones and gyrA. Thus, conferring resistance.
KQ088057.1_1875 # 2032536 # 2034794 1400.0 1470.29 Escherichia coli parC conferring resistance to fluoroquinolones 94.41 ARO:3003308 protein variant model S80I fluoroquinolone antibiotic antibiotic target alteration fluoroquinolone resistant parC Point mutation in Escherichia coli parC resulting in fluoroquinolone resistance.
KQ088057.1_2175 # 2318040 # 2319224 700.0 785.023 Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin 97.97 ARO:3003369 protein variant model R234F elfamycin antibiotic antibiotic target alteration elfamycin resistant EF-Tu Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin.
KQ088057.1_2521 # 2703010 # 2704401 850.0 864.374 Escherichia coli UhpT with mutation conferring resistance to fosfomycin 95.03 ARO:3003890 protein variant model E350Q phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant UhpT Mutations to the active importer UhpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria.
KQ088057.1_2555 # 2737140 # 2739554 1200.0 1568.52 Salmonella serovars gyrB conferring resistance to fluoroquinolones 94.78 ARO:3003307 protein variant model E466D fluoroquinolone antibiotic antibiotic target alteration fluoroquinolone resistant gyrB Point mutation in Salmonella serovars resulting in fluoroquinolone resistance.
KQ088057.1_2781 # 3000319 # 3001503 700.0 785.023 Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin 97.97 ARO:3003369 protein variant model R234F elfamycin antibiotic antibiotic target alteration elfamycin resistant EF-Tu Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin.
KQ088058.1_87 # 102998 # 104764 500.0 595.89 Haemophilus influenzae PBP3 conferring resistance to beta-lactam antibiotics 52.37 ARO:3004446 protein variant model D350N, S357N cephalosporin; cephamycin; penam antibiotic target alteration Penicillin-binding protein mutations conferring resistance to beta-lactam antibiotics PBP3 is a penicillin-binding protein and beta-lactam resistance enzyme encoded by the ftsI gene in Haemophilus influenzae. Mutations in ftsI confer resistance to beta-lactam antibiotics.
KQ088058.1_1725 # 1851793 # 1852227 210.0 251.906 Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline 83.33 ARO:3003378 protein overexpression model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
KQ088057.1_57 70.852 1.21E-105 mgtC VF1365 MgtC Nutritional/Metabolic factor VFC0272 An inner membrane protein; anti-virulence protein CigR inhibits the virulence functions of MgtC at early times inside macrophages (mgtC) Salmonella virulence protein MgtC [MgtC (VF1365) - Nutritional/Metabolic factor (VFC0272)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
KQ088057.1_229 66.492 3.86E-99 sodB VF0169 SodB Stress survival VFC0282 (sodB) superoxide dismutase [SodB (VF0169) - Stress survival (VFC0282)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
KQ088057.1_433 74.394 2.7E-160 galU VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (galU) glucosephosphate uridylyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
KQ088057.1_459 83.039 3.67E-180 kdsA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
KQ088057.1_611 60.082 2.36E-103 CBU_1566 VF0696 T4SS secreted effectors Effector delivery system VFC0086 (CBU_1566) Coxiella Dot/Icm type IVB secretion system translocated effector [T4SS secreted effectors (VF0696) - Effector delivery system (VFC0086)] [Coxiella burnetii RSA 493] Coxiella burnetii
KQ088057.1_651 100.0 2.05E-156 rcsA VF0571 RcsAB Regulation VFC0301 (rcsA) transcriptional activator for ctr capsule biosynthesis [RcsAB (VF0571) - Regulation (VFC0301)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_701 98.387 0.0 ybtS VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (ybtS) salicylate synthase Irp9 [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
KQ088057.1_702 98.357 0.0 ybtX VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (ybtX) putative signal transducer [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
KQ088057.1_703 99.5 0.0 ybtQ VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (ybtQ) yersiniabactin ABC transporter ATP-binding/permease protein YbtQ [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
KQ088057.1_704 99.825 0.0 ybtP VF0564 Ybt Nutritional/Metabolic factor VFC0272 Ybt is the most common virulence factor associated with human K. pneumoniae infections (ybtP) yersiniabactin ABC transporter ATP-binding/permease protein YbtP [Ybt (VF0564) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_705 100.0 0.0 ybtA VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (ybtA) transcriptional regulator YbtA [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
KQ088057.1_706 99.705 0.0 irp2 VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (irp2) yersiniabactin biosynthetic protein Irp2 [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
KQ088057.1_707 99.368 0.0 irp1 VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (irp1) yersiniabactin biosynthetic protein Irp1 [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
KQ088057.1_708 99.727 0.0 ybtU VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (ybtU) yersiniabactin biosynthetic protein YbtU [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
KQ088057.1_709 99.251 0.0 ybtT VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (ybtT) type II thioesterase YbtT [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
KQ088057.1_710 99.619 0.0 ybtE VF0136 Yersiniabactin Nutritional/Metabolic factor VFC0272 One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host (ybtE) yersiniabactin siderophore biosynthetic protein [Yersiniabactin (VF0136) - Nutritional/Metabolic factor (VFC0272)] [Yersinia pestis CO92] Yersinia pestis
KQ088057.1_711 99.851 0.0 fyuA VF0564 Ybt Nutritional/Metabolic factor VFC0272 Ybt is the most common virulence factor associated with human K. pneumoniae infections (fyuA) yersiniabactin receptor FyuA [Ybt (VF0564) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_732 99.412 1.88E-126 clbS VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbS) colibactin self-protection protein ClbS [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_733 100.0 0.0 clbQ VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbQ) colibactin biosynthesis thioesterase ClbQ [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_734 100.0 0.0 clbP VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbP) precolibactin peptidase ClbP [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_735 100.0 0.0 clbO VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbO) colibactin polyketide synthase ClbO [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_736 100.0 0.0 clbN VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbN) colibactin non-ribosomal peptide synthetase ClbN [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_737 99.791 0.0 clbM VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbM) precolibactin export MATE transporter ClbM [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_738 100.0 0.0 clbL VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbL) colibactin biosynthesis amidase ClbL [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_739 98.528 0.0 clbJ VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbJ) colibactin non-ribosomal peptide synthetase ClbJ [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_740 100.0 0.0 clbI VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbI) colibactin polyketide synthase ClbI [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_741 99.937 0.0 clbH VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbH) colibactin non-ribosomal peptide synthetase ClbH [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_742 100.0 0.0 clbG VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbG) colibactin biosynthesis acyltransferase ClbG [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_743 100.0 0.0 clbF VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbF) colibactin biosynthesis dehydrogenase ClbF [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_744 100.0 2.62E-55 clbE VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbE) colibactin biosynthesis aminomalonyl-acyl carrier protein ClbE [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_745 100.0 0.0 clbD VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbD) colibactin biosynthesis dehydrogenase ClbD [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_746 99.885 0.0 clbC VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbC) colibactin polyketide synthase ClbC [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_747 99.929 0.0 clbB VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbB) colibactin hybrid non-ribosomal peptide synthetase/type I polyketide synthase ClbB [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_749 99.706 0.0 clbB VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbB) colibactin hybrid non-ribosomal peptide synthetase/type I polyketide synthase ClbB [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_750 99.59 0.0 clbA VF0573 Colibactin Exotoxin VFC0235 Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Citrobacter koseri harboring the pks genomic island. (clbA) colibactin biosynthesis phosphopantetheinyl transferase ClbA [Colibactin (VF0573) - Exotoxin (VFC0235)] [Klebsiella pneumoniae subsp. pneumoniae 1084] Klebsiella pneumoniae
KQ088057.1_826 99.005 0.0 KP1_RS17220 VF0561 LPS Immune modulation VFC0258 In K. pneumoniae there are nine main O-serotypes. Three of these, O1, O2, and O3, are responsible for almost 80% of all Klebsiella infections.; Compared with other Enterobacteriaceae, such as Escherichia coli 161 defined O serotypes and Shigella flexneri at least 47 O serotypes, Klebsiella has a surprisingly low number of reported O serotypes which promises a more viable alternative for vaccine development compared with K-antigen-based vaccines; The O-antigen biosynthesis enzymes are encoded on the rfb locus. (KP1_RS17220) glycosyltransferase [LPS (VF0561) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_827 99.468 0.0 KP1_RS17225 VF0561 LPS Immune modulation VFC0258 In K. pneumoniae there are nine main O-serotypes. Three of these, O1, O2, and O3, are responsible for almost 80% of all Klebsiella infections.; Compared with other Enterobacteriaceae, such as Escherichia coli 161 defined O serotypes and Shigella flexneri at least 47 O serotypes, Klebsiella has a surprisingly low number of reported O serotypes which promises a more viable alternative for vaccine development compared with K-antigen-based vaccines; The O-antigen biosynthesis enzymes are encoded on the rfb locus. (KP1_RS17225) glycosyltransferase family 4 protein [LPS (VF0561) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_828 98.99 0.0 KP1_RS17230 VF0561 LPS Immune modulation VFC0258 In K. pneumoniae there are nine main O-serotypes. Three of these, O1, O2, and O3, are responsible for almost 80% of all Klebsiella infections.; Compared with other Enterobacteriaceae, such as Escherichia coli 161 defined O serotypes and Shigella flexneri at least 47 O serotypes, Klebsiella has a surprisingly low number of reported O serotypes which promises a more viable alternative for vaccine development compared with K-antigen-based vaccines; The O-antigen biosynthesis enzymes are encoded on the rfb locus. (KP1_RS17230) glycosyltransferase [LPS (VF0561) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_829 98.958 0.0 rfbD VF0561 LPS Immune modulation VFC0258 In K. pneumoniae there are nine main O-serotypes. Three of these, O1, O2, and O3, are responsible for almost 80% of all Klebsiella infections.; Compared with other Enterobacteriaceae, such as Escherichia coli 161 defined O serotypes and Shigella flexneri at least 47 O serotypes, Klebsiella has a surprisingly low number of reported O serotypes which promises a more viable alternative for vaccine development compared with K-antigen-based vaccines; The O-antigen biosynthesis enzymes are encoded on the rfb locus. (rfbD) UDP-galactopyranose mutase [LPS (VF0561) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_830 98.257 0.0 KP1_RS17240 VF0561 LPS Immune modulation VFC0258 In K. pneumoniae there are nine main O-serotypes. Three of these, O1, O2, and O3, are responsible for almost 80% of all Klebsiella infections.; Compared with other Enterobacteriaceae, such as Escherichia coli 161 defined O serotypes and Shigella flexneri at least 47 O serotypes, Klebsiella has a surprisingly low number of reported O serotypes which promises a more viable alternative for vaccine development compared with K-antigen-based vaccines; The O-antigen biosynthesis enzymes are encoded on the rfb locus. (KP1_RS17240) DUF4422 domain-containing protein [LPS (VF0561) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_831 99.593 0.0 rfbB VF0561 LPS Immune modulation VFC0258 In K. pneumoniae there are nine main O-serotypes. Three of these, O1, O2, and O3, are responsible for almost 80% of all Klebsiella infections.; Compared with other Enterobacteriaceae, such as Escherichia coli 161 defined O serotypes and Shigella flexneri at least 47 O serotypes, Klebsiella has a surprisingly low number of reported O serotypes which promises a more viable alternative for vaccine development compared with K-antigen-based vaccines; The O-antigen biosynthesis enzymes are encoded on the rfb locus. (rfbB) O-antigen export ABC transporter ATP-binding protein RfbB [LPS (VF0561) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_832 100.0 0.0 rfbA VF0561 LPS Immune modulation VFC0258 In K. pneumoniae there are nine main O-serotypes. Three of these, O1, O2, and O3, are responsible for almost 80% of all Klebsiella infections.; Compared with other Enterobacteriaceae, such as Escherichia coli 161 defined O serotypes and Shigella flexneri at least 47 O serotypes, Klebsiella has a surprisingly low number of reported O serotypes which promises a more viable alternative for vaccine development compared with K-antigen-based vaccines; The O-antigen biosynthesis enzymes are encoded on the rfb locus. (rfbA) O-antigen export ABC transporter permease RfbA [LPS (VF0561) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_839 99.742 0.0 ugd VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (ugd) UDP-glucose 6-dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_842 66.096 1.26E-145 wbtL VF0542 LPS Immune modulation VFC0258 The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion (wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
KQ088057.1_843 60.0 1.83E-156 rffG VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rffG) dTDP-glucose 46-dehydratase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
KQ088057.1_844 98.932 0.0 gndA VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_850 92.553 0.0 KP1_RS17340 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17340) polysaccharide export protein [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_851 95.388 0.0 KP1_RS17345 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17345) capsule assembly Wzi family protein [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_852 96.172 5.61E-144 KP1_RS17355 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17355) phosphatase PAP2 family protein [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_853 99.324 0.0 galF VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (galF) GalU regulator GalF [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_975 100.0 7.49E-49 rcsB VF0571 RcsAB Regulation VFC0301 (rcsB) transcriptional regulator RcsB [RcsAB (VF0571) - Regulation (VFC0301)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_976 100.0 2.14E-88 rcsB VF0571 RcsAB Regulation VFC0301 (rcsB) transcriptional regulator RcsB [RcsAB (VF0571) - Regulation (VFC0301)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1134 65.226 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1281 64.921 6.04E-90 algU VF0091 Alginate Biofilm VFC0271 Alginate production is frequently referred to as mucoidy because colonies producing alginate have a wet glistening (mucoid) appearance, which is very different from that of colonies not producing alginate; most of the alginate biosynthetic genes are clustered in the algD operon; Alginate production is highly regulated. Regulatory genes are located in two areas far removed from the biosynthetic genes, with one exception algC (algU) alginate biosynthesis protein AlgZ/FimS [Alginate (VF0091) - Biofilm (VFC0271)] [Pseudomonas aeruginosa PAO1] Pseudomonas aeruginosa
KQ088057.1_1372 61.148 0.0 adeG VF0504 AdeFGH efflux pump Biofilm VFC0271 Belongs to resistance-nodulation-cell division (RND)-type efflux system; RND efflux systems, composed of an inner membrane protein (RND pump) linked by a periplasmic adaptor protein (PAP) to an outer membrane factor (OMF), can extrude a wide range of substrates often unrelated in structure; To date, three Acinetobacter drug efflux (Ade) RND systems, AdeABC, AdeFGH, and AdeIJK, have been characterized in A. baumannii (adeG) cation/multidrug efflux pump [AdeFGH efflux pump (VF0504) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
KQ088057.1_1422 73.099 4.43E-95 luxS VF0406 AI-2 Biofilm VFC0271 AI-2 is produced and detected by a wide variety of bacteria and is presumed to facilitate interspecies communications. (luxS) S-ribosylhomocysteinase [AI-2 (VF0406) - Biofilm (VFC0271)] [Vibrio cholerae O1 biovar El Tor str. N16961] Vibrio cholerae
KQ088057.1_1427 76.667 1.4E-30 csrA VF0261 CsrA Regulation VFC0301 Belongs to a highly conserved family of global regulators that typically control stationary phase traits post-transcriptionally (csrA) carbon storage regulator CsrA [CsrA (VF0261) - Regulation (VFC0301)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
KQ088057.1_1488 65.192 1.39E-165 chuS VF0227 Chu Nutritional/Metabolic factor VFC0272 ChuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains (chuS) heme oxygenase ChuS [Chu (VF0227) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
KQ088057.1_1492 63.804 1.54E-72 hcp/tssD VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (hcp/tssD) type VI secretion system protein, Hcp family [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1503 98.182 0.0 rpoS VF0112 RpoS Regulation VFC0301 (rpoS) RNA polymerase sigma factor RpoS [RpoS (VF0112) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
KQ088057.1_1661 100.0 6.55E-59 mrkH VF0567 Type 3 fimbriae Biofilm VFC0271 Approximately 2~4 nm wide and 0.5~2 <mu>m in length in length; mrkA gene expression is affected by c-di-GMP (mrkH) transcriptional activator [Type 3 fimbriae (VF0567) - Biofilm (VFC0271)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1662 100.0 2.53E-139 mrkI VF0567 Type 3 fimbriae Biofilm VFC0271 Approximately 2~4 nm wide and 0.5~2 <mu>m in length in length; mrkA gene expression is affected by c-di-GMP (mrkI) LuxR family regulatory protein [Type 3 fimbriae (VF0567) - Biofilm (VFC0271)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1663 99.58 1.01E-180 mrkJ VF0567 Type 3 fimbriae Biofilm VFC0271 Approximately 2~4 nm wide and 0.5~2 <mu>m in length in length; mrkA gene expression is affected by c-di-GMP (mrkJ) phosphodiesterase [Type 3 fimbriae (VF0567) - Biofilm (VFC0271)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1664 100.0 6.47E-159 mrkF VF0567 Type 3 fimbriae Biofilm VFC0271 Approximately 2~4 nm wide and 0.5~2 <mu>m in length in length; mrkA gene expression is affected by c-di-GMP (mrkF) type 3 fimbrial minor pilin subunit MrkF [Type 3 fimbriae (VF0567) - Biofilm (VFC0271)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1665 99.698 0.0 mrkD VF0567 Type 3 fimbriae Biofilm VFC0271 Approximately 2~4 nm wide and 0.5~2 <mu>m in length in length; mrkA gene expression is affected by c-di-GMP (mrkD) fimbrial adhesin protein precursor MrkD [Type 3 fimbriae (VF0567) - Biofilm (VFC0271)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1666 100.0 0.0 mrkC VF0567 Type 3 fimbriae Biofilm VFC0271 Approximately 2~4 nm wide and 0.5~2 <mu>m in length in length; mrkA gene expression is affected by c-di-GMP (mrkC) fimbrial biogenesis outer membrane usher protein mrkC precursor [Type 3 fimbriae (VF0567) - Biofilm (VFC0271)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1667 100.0 4.53E-173 mrkB VF0567 Type 3 fimbriae Biofilm VFC0271 Approximately 2~4 nm wide and 0.5~2 <mu>m in length in length; mrkA gene expression is affected by c-di-GMP (mrkB) fimbrial chaperone protein mrkB precursor [Type 3 fimbriae (VF0567) - Biofilm (VFC0271)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1668 99.505 4.97E-146 mrkA VF0567 Type 3 fimbriae Biofilm VFC0271 Approximately 2~4 nm wide and 0.5~2 <mu>m in length in length; mrkA gene expression is affected by c-di-GMP (mrkA) type 3 fimbrial major pilin subunit MrkA [Type 3 fimbriae (VF0567) - Biofilm (VFC0271)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1673 99.502 3.54E-152 fimB VF0566 Type I fimbriae Adherence VFC0001 Type I fimbriae are expressed in 90% of both clinical and environmental K. pneumoniae isolates as well as almost all members of the Enterobacteriaceae.; Type I fimbriae are filamentous, membrane-bound, adhesive structures composed primarily of FimA subunits, with the FimH subunit on the tip. (fimB) tyrosine recombinase [Type I fimbriae (VF0566) - Adherence (VFC0001)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1674 100.0 2.78E-152 fimE VF0566 Type I fimbriae Adherence VFC0001 Type I fimbriae are expressed in 90% of both clinical and environmental K. pneumoniae isolates as well as almost all members of the Enterobacteriaceae.; Type I fimbriae are filamentous, membrane-bound, adhesive structures composed primarily of FimA subunits, with the FimH subunit on the tip. (fimE) tyrosine recombinase [Type I fimbriae (VF0566) - Adherence (VFC0001)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1675 100.0 3.8E-128 fimA VF0566 Type I fimbriae Adherence VFC0001 Type I fimbriae are expressed in 90% of both clinical and environmental K. pneumoniae isolates as well as almost all members of the Enterobacteriaceae.; Type I fimbriae are filamentous, membrane-bound, adhesive structures composed primarily of FimA subunits, with the FimH subunit on the tip. (fimA) type 1 major fimbrial subunit precursor [Type I fimbriae (VF0566) - Adherence (VFC0001)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1676 98.315 1.02E-129 fimI VF0566 Type I fimbriae Adherence VFC0001 Type I fimbriae are expressed in 90% of both clinical and environmental K. pneumoniae isolates as well as almost all members of the Enterobacteriaceae.; Type I fimbriae are filamentous, membrane-bound, adhesive structures composed primarily of FimA subunits, with the FimH subunit on the tip. (fimI) type 1 pilus biosynthesis fimbrial protein [Type I fimbriae (VF0566) - Adherence (VFC0001)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1677 99.145 1.39E-174 fimC VF0566 Type I fimbriae Adherence VFC0001 Type I fimbriae are expressed in 90% of both clinical and environmental K. pneumoniae isolates as well as almost all members of the Enterobacteriaceae.; Type I fimbriae are filamentous, membrane-bound, adhesive structures composed primarily of FimA subunits, with the FimH subunit on the tip. (fimC) periplasmic chaperone [Type I fimbriae (VF0566) - Adherence (VFC0001)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1678 99.77 0.0 fimD VF0566 Type I fimbriae Adherence VFC0001 Type I fimbriae are expressed in 90% of both clinical and environmental K. pneumoniae isolates as well as almost all members of the Enterobacteriaceae.; Type I fimbriae are filamentous, membrane-bound, adhesive structures composed primarily of FimA subunits, with the FimH subunit on the tip. (fimD) outer membrane usher protein [Type I fimbriae (VF0566) - Adherence (VFC0001)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1679 98.286 1.27E-125 fimF VF0566 Type I fimbriae Adherence VFC0001 Type I fimbriae are expressed in 90% of both clinical and environmental K. pneumoniae isolates as well as almost all members of the Enterobacteriaceae.; Type I fimbriae are filamentous, membrane-bound, adhesive structures composed primarily of FimA subunits, with the FimH subunit on the tip. (fimF) type 1 fimbrial minor component [Type I fimbriae (VF0566) - Adherence (VFC0001)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1680 98.758 4.22E-114 fimG VF0566 Type I fimbriae Adherence VFC0001 Type I fimbriae are expressed in 90% of both clinical and environmental K. pneumoniae isolates as well as almost all members of the Enterobacteriaceae.; Type I fimbriae are filamentous, membrane-bound, adhesive structures composed primarily of FimA subunits, with the FimH subunit on the tip. (fimG) type 1 fimbrial minor component [Type I fimbriae (VF0566) - Adherence (VFC0001)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1681 99.668 0.0 fimH VF0566 Type I fimbriae Adherence VFC0001 Type I fimbriae are expressed in 90% of both clinical and environmental K. pneumoniae isolates as well as almost all members of the Enterobacteriaceae.; Type I fimbriae are filamentous, membrane-bound, adhesive structures composed primarily of FimA subunits, with the FimH subunit on the tip. (fimH) type 1 fimbrial adhesin precursor [Type I fimbriae (VF0566) - Adherence (VFC0001)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1682 99.091 0.0 fimK VF0566 Type I fimbriae Adherence VFC0001 Type I fimbriae are expressed in 90% of both clinical and environmental K. pneumoniae isolates as well as almost all members of the Enterobacteriaceae.; Type I fimbriae are filamentous, membrane-bound, adhesive structures composed primarily of FimA subunits, with the FimH subunit on the tip. (fimK) transcriptional regulator [Type I fimbriae (VF0566) - Adherence (VFC0001)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_1895 70.172 0.0 rfaE VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaE) ADP-heptose synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
KQ088057.1_1906 61.687 0.0 ureB VF0050 Urease Stress survival VFC0282 (ureB) urease beta subunit UreB, urea amidohydrolase [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] Helicobacter pylori
KQ088057.1_1909 63.265 1.49E-93 ureG VF0050 Urease Stress survival VFC0282 (ureG) urease accessory protein (ureG) [Urease (VF0050) - Stress survival (VFC0282)] [Helicobacter pylori 26695] Helicobacter pylori
KQ088057.1_2127 70.053 0.0 acrA VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrA) acriflavine resistance protein A [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_2128 81.336 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_2175 79.898 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
KQ088057.1_2194 67.327 4.54E-100 vfr VF0082 Type IV pili Adherence VFC0001 PilA, B, C, D, E, F, M, N, O, P, Q, T, U, V, W, X, Y1, Y2, Z, and fimT, U, V are involved in the biogenesis and mechanical function of pili, pilG, H, I, K, chpA, B, C, D, E, pilS, R, fimS, rpoN, algR, algU, and vfr are involved in transcriptional regulation and chemosensory pathways that control the expression or activity of the twitching motility of the pili (vfr) cAMP-regulatory protein [Type IV pili (VF0082) - Adherence (VFC0001)] [Pseudomonas aeruginosa PAO1] Pseudomonas aeruginosa
KQ088057.1_2209 65.315 3.1E-103 rpe VF0543 Capsule Immune modulation VFC0258 Group 4 capsule; high molecular weight (HMW) O-antigen capsule (rpe) ribulose-phosphate 3-epimerase [Capsule (VF0543) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
KQ088057.1_2414 78.247 0.0 rfaD VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaD) ADP-L-glycero-D-mannoheptose-6-epimerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
KQ088057.1_2415 62.018 4.73E-145 rfaF VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaF) ADP-heptose-LPS heptosyltransferase II [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
KQ088057.1_2724 64.881 1.43E-168 rffG VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rffG) dTDP-glucose 46-dehydratase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
KQ088057.1_2725 64.948 5.4E-142 wbtL VF0542 LPS Immune modulation VFC0258 The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion (wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
KQ088057.1_2781 79.898 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
KQ088057.1_2817 62.295 0.0 icl VF0253 Isocitrate lyase Others VFC0346 (icl) Isocitrate lyase Icl (isocitrase) (isocitratase) [Isocitrate lyase (VF0253) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
KQ088057.1_2870 74.74 0.0 fepA VF0562 Ent Nutritional/Metabolic factor VFC0272 Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. (fepA) outer membrane receptor FepA [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088057.1_2956 75.665 0.0 htpB VF0159 Hsp60 Adherence VFC0001 (htpB) Hsp60, 60K heat shock protein HtpB [Hsp60 (VF0159) - Adherence (VFC0001)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
KQ088057.1_3148 74.837 0.0 ibeB VF0237 Ibes Invasion VFC0083 IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC [Ibes (VF0237) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
KQ088058.1_99 77.632 0.0 lpxC VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxC) UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
KQ088058.1_157 77.206 4.65E-75 exeG VF0478 Exe T2SS Effector delivery system VFC0086 (exeG) general secretion pathway protein G [Exe T2SS (VF0478) - Effector delivery system (VFC0086)] [Aeromonas hydrophila ML09-119] Aeromonas hydrophila
KQ088058.1_159 63.711 0.0 exeE VF0478 Exe T2SS Effector delivery system VFC0086 (exeE) general secretory pathway protein E [Exe T2SS (VF0478) - Effector delivery system (VFC0086)] [Aeromonas hydrophila ML09-119] Aeromonas hydrophila
KQ088058.1_160 60.731 0.0 exeD VF0478 Exe T2SS Effector delivery system VFC0086 (exeD) general secretion pathway protein D [Exe T2SS (VF0478) - Effector delivery system (VFC0086)] [Aeromonas hydrophila ML09-119] Aeromonas hydrophila
KQ088058.1_192 65.089 1.19E-161 lpxD VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxD) UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
KQ088058.1_194 67.557 1.57E-133 lpxA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxA) UDP-N-acetylglucosamine acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
KQ088058.1_195 63.926 1.27E-175 lpxB VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxB) lipid-A-disaccharide synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
KQ088058.1_211 69.004 6.03E-129 IlpA VF0513 IlpA Adherence VFC0001 (IlpA) immunogenic lipoprotein A [IlpA (VF0513) - Adherence (VFC0001)] [Vibrio vulnificus YJ016] Vibrio vulnificus
KQ088058.1_229 79.167 6.02E-114 gmhA/lpcA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (gmhA/lpcA) phosphoheptose isomerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
KQ088058.1_289 90.556 1.89E-117 ykgK/ecpR VF0404 ECP Adherence VFC0001 (ykgK/ecpR) regulator protein EcpR [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
KQ088058.1_290 95.897 4.03E-133 yagZ/ecpA VF0404 ECP Adherence VFC0001 (yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
KQ088058.1_291 90.09 4.95E-138 yagY/ecpB VF0404 ECP Adherence VFC0001 (yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
KQ088058.1_292 93.579 0.0 yagX/ecpC VF0404 ECP Adherence VFC0001 (yagX/ecpC) E. coli common pilus usher EcpC [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
KQ088058.1_293 94.333 0.0 yagW/ecpD VF0404 ECP Adherence VFC0001 (yagW/ecpD) polymerized tip adhesin of ECP fibers [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
KQ088058.1_294 86.864 4.22E-158 yagV/ecpE VF0404 ECP Adherence VFC0001 (yagV/ecpE) E. coli common pilus chaperone EcpE [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] Escherichia coli (EHEC)
KQ088058.1_399 66.495 2.25E-98 clpP VF0074 ClpP Stress survival VFC0282 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
KQ088058.1_443 100.0 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_444 99.748 0.0 acrA VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrA) acriflavine resistance protein A [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_622 83.981 5.29E-125 entD VF0562 Ent Nutritional/Metabolic factor VFC0272 Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. (entD) enterochelin synthetase component D [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_623 99.326 0.0 fepA VF0562 Ent Nutritional/Metabolic factor VFC0272 Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. (fepA) outer membrane receptor FepA [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_624 99.005 0.0 fes VF0562 Ent Nutritional/Metabolic factor VFC0272 Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. (fes) enterobactin/ferric enterobactin esterase [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_626 99.613 0.0 entF VF0562 Ent Nutritional/Metabolic factor VFC0272 Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. (entF) enterobactin synthase subunit F [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_627 100.0 0.0 fepC VF0562 Ent Nutritional/Metabolic factor VFC0272 Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. (fepC) iron-enterobactin transporter ATP-binding protein [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_628 100.0 0.0 fepG VF0562 Ent Nutritional/Metabolic factor VFC0272 Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. (fepG) iron-enterobactin transporter permease [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_629 99.701 0.0 fepD VF0562 Ent Nutritional/Metabolic factor VFC0272 Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. (fepD) iron-enterobactin transporter membrane protein [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_630 100.0 0.0 entS VF0562 Ent Nutritional/Metabolic factor VFC0272 Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. (entS) enterobactin exporter EntS [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_631 99.373 0.0 fepB VF0562 Ent Nutritional/Metabolic factor VFC0272 Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. (fepB) iron-enterobactin transporter periplasmic binding protein [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_632 98.721 0.0 entC VF0562 Ent Nutritional/Metabolic factor VFC0272 Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. (entC) isochorismate synthase [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_633 99.626 0.0 entE VF0562 Ent Nutritional/Metabolic factor VFC0272 Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. (entE) enterobactin synthase subunit E [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_634 99.293 0.0 entB VF0562 Ent Nutritional/Metabolic factor VFC0272 Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. (entB) 2,3-dihydro-2,3-dihydroxybenzoate synthetase, isochroismatase [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_635 98.79 0.0 entA VF0562 Ent Nutritional/Metabolic factor VFC0272 Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. (entA) 2,3-dihydroxybenzoate-2,3-dehydrogenase [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_722 96.0 1.17E-106 fur VF0113 Fur Regulation VFC0301 (fur) ferric iron uptake transcriptional regulator [Fur (VF0113) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
KQ088058.1_810 63.739 3.85E-161 pmrB VF1355 PmrAB Regulation VFC0301 (pmrB) sensory kinase PmrB [PmrAB (VF1355) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
KQ088058.1_811 79.63 7.78E-128 pmrA VF1355 PmrAB Regulation VFC0301 (pmrA) response regulator PmrA [PmrAB (VF1355) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
KQ088058.1_997 66.436 0.0 msbA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (msbA) lipid transporter ATP-binding/permease [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
KQ088058.1_1001 72.112 2.48E-132 nueA VF0473 Polar flagella Motility VFC0204 Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments (nueA) NeuA protein [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119] Aeromonas hydrophila
KQ088058.1_1038 85.393 0.0 ompA VF0236 OmpA Invasion VFC0083 Major outer membrane protein in E. coli, homologous to Neisseria Opa proteins which have been shown to be involved in invasion of eukaryotic cells (ompA) outer membrane protein A [OmpA (VF0236) - Invasion (VFC0083)] [Escherichia coli O18:K1:H7 str. RS218] Escherichia coli (NMEC)
KQ088058.1_1133 77.869 3.08E-141 flmH VF0473 Polar flagella Motility VFC0204 Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments (flmH) short chain dehydrogenase/reductase family oxidoreductase [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119] Aeromonas hydrophila
KQ088058.1_1134 61.538 1.93E-27 acpXL VF0367 LPS Immune modulation VFC0258 Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. (acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] Brucella melitensis
KQ088058.1_1150 99.863 0.0 iutA VF0565 Aerobactin Nutritional/Metabolic factor VFC0272 Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae (iutA) ferric aerobactin receptor IutA [Aerobactin (VF0565) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_1169 80.698 0.0 phoQ VF0111 PhoPQ Regulation VFC0301 (phoQ) sensor protein PhoQ [PhoPQ (VF0111) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
KQ088058.1_1170 93.274 4.86E-154 phoP VF0111 PhoPQ Regulation VFC0301 (phoP) response regulator in two-component regulatory system with PhoQ [PhoPQ (VF0111) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
KQ088058.1_1285 66.347 0.0 iroN VF0563 Sal Nutritional/Metabolic factor VFC0272 Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport (iroN) salmochelin receptor IroN [Sal (VF0563) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_1498 99.387 1.33E-115 vipA/tssB VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (vipA/tssB) type VI secretion system contractile sheath small subunit VipA [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_1499 99.611 0.0 vipB/tssC VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (vipB/tssC) type VI secretion system contractile sheath large subunit VipB [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_1500 99.329 0.0 vasE/tssK VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (vasE/tssK) type VI secretion system baseplate subunit TssK [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_1501 99.563 8.3E-170 dotU/tssL VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (dotU/tssL) type VI secretion system protein, DotU/TssL family [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_1502 97.887 0.0 ompA VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (ompA) OmpA family protein [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_1503 100.0 1.77E-122 hcp/tssD VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (hcp/tssD) type VI secretion system protein, Hcp family [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_1504 99.095 0.0 clpV/tssH VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (clpV/tssH) type VI secretion system ATPase TssH [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_1505 80.934 0.0 vgrG/tssI VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (vgrG/tssI) type VI secretion system tip protein VgrG [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_1511 95.873 0.0 icmF/tssM VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (icmF/tssM) type VI secretion protein TssM [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_1512 75.556 2.5E-69 impA/tssA VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (impA/tssA) type VI secretion system protein TssA [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_1514 99.658 0.0 tssF VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (tssF) type VI secretion system baseplate subunit TssF [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_1515 99.723 0.0 tssG VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (tssG) type VI secretion system baseplate subunit TssG [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_1516 100.0 5.06E-134 sciN/tssJ VF0569 T6SS Effector delivery system VFC0086 Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1Tle5. The Tle1Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif (sciN/tssJ) type VI secretion system lipoprotein TssJ [T6SS (VF0569) - Effector delivery system (VFC0086)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088058.1_1790 98.706 0.0 iroE VF0563 Sal Nutritional/Metabolic factor VFC0272 Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport (iroE) siderophore esterase IroE [Sal (VF0563) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
KQ088059.1_99 71.895 0.0 ibeB VF0237 Ibes Invasion VFC0083 IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC [Ibes (VF0237) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)