2. PATHOGENS
Basic Information
Accession number
GCA_001038105.1
Release date
2015-06-23
Organism
Salmonella enterica subsp. enterica serovar Typhimurium
Species name
Salmonella enterica
Assembly level
Contig
Assembly name
ASM103810v1
Assembly submitter
IZSAM
Assembly Type
haploid
Genome size
4.7 Mb
GC percent
52.0
Contig count
13
Collection date
2014-04-29
Sample location
Italy: PonteRosarolo
Host
-
Isolation source
Superficial water
Isolate type
-
Strain
smonpas009854
Isolate
-
ARG List
ORF_ID Pass_Bitscore Best_Hit_Bitscore Best_Hit_ARO Best_Identities ARO Model_type SNPs_in_Best_Hit_ARO Other_SNPs Drug class Resistance mechanism AMR gene family Description
LFGR01000002.1_42 # 42941 # 43762 500.0 532.717 bacA 97.07 ARO:3002986 protein homolog model peptide antibiotic antibiotic target alteration undecaprenyl pyrophosphate related proteins The bacA gene product (BacA) recycles undecaprenyl pyrophosphate during cell wall biosynthesis which confers resistance to bacitracin.
LFGR01000007.1_117 # 105699 # 105884 100.0 109.383 rsmA 85.25 ARO:3005069 protein homolog model fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump rsmA is a gene that regulates virulence of Pseudomonas aeruginosa. However, its negative effect on MexEF-OprN overexpression has been noted to confer resistance to various antibiotics. It's Escherichia coli homolog is csrA.
LFGR01000007.1_123 # 112330 # 113868 900.0 995.342 emrB 95.7 ARO:3000074 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP), nalidixic acid, and thioloactomycin.
LFGR01000007.1_124 # 113885 # 115057 675.0 706.057 emrA 89.74 ARO:3000027 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump EmrA is a membrane fusion protein, providing an efflux pathway with EmrB and TolC between the inner and outer membranes of E. coli, a Gram-negative bacterium.
LFGR01000007.1_125 # 115184 # 115714 280.0 337.806 emrR 93.14 ARO:3000516 protein homolog model fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression.
LFGR01000007.1_356 # 382051 # 385164 1900.0 2019.97 acrD 94.21 ARO:3000491 protein homolog model aminoglycoside antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrD is an aminoglycoside efflux pump expressed in E. coli. Its expression can be induced by indole, and is regulated by baeRS and cpxAR.
LFGR01000007.1_554 # 567486 # 569132 400.0 711.064 ArnT 62.79 ARO:3005053 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase ArnT is involved in Cell Wall Biosynthesis, specifically 4-amino-4-deoxy-L-arabinose (Ara4N). It confers resistance to peptide antibiotics.
LFGR01000007.1_557 # 572004 # 572987 550.0 590.112 PmrF 87.74 ARO:3003578 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase PmrF is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. pmrF corresponds to 1 locus in Pseudomonas aeruginosa PAO1 and 1 locus in Pseudomonas aeruginosa LESB58.
LFGR01000007.1_741 # 753425 # 754147 450.0 469.544 baeR 96.67 ARO:3000828 protein homolog model aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump BaeR is a response regulator that promotes the expression of MdtABC and AcrD efflux complexes.
LFGR01000007.1_745 # 756955 # 760035 1800.0 1862.04 mdtC 91.71 ARO:3000794 protein homolog model aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtC is a transporter that forms a heteromultimer complex with MdtB to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex. In the absence of MdtB, MdtC can form a homomultimer complex that results in a functioning efflux complex with a narrower drug specificity. mdtC corresponds to 3 loci in Pseudomonas aeruginosa PAO1 (gene name: muxC/muxB) and 3 loci in Pseudomonas aeruginosa LESB58.
LFGR01000007.1_746 # 760036 # 763158 1800.0 1871.29 mdtB 91.73 ARO:3000793 protein homolog model aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdtB is a transporter that forms a heteromultimer complex with MdtC to form a multidrug transporter. MdtBC is part of the MdtABC-TolC efflux complex.
LFGR01000007.1_803 # 819567 # 820733 700.0 715.301 ugd 88.92 ARO:3003577 protein homolog model peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase PmrE is required for the synthesis and transfer of 4-amino-4-deoxy-L-arabinose (Ara4N) to Lipid A, which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin.
LFGR01000007.1_876 # 882783 # 884309 900.0 930.628 MdtK 99.58 ARO:3001327 protein homolog model fluoroquinolone antibiotic antibiotic efflux multidrug and toxic compound extrusion (MATE) transporter A multidrug and toxic compound extrusions (MATE) transporter conferring resistance to norfloxacin, doxorubicin and acriflavine.
LFGR01000008.1_71 # 56198 # 56920 470.0 505.368 sdiA 100.0 ARO:3000826 protein homolog model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump SdiA is a cell division regulator that is also a positive regulator of AcrAB only when it's expressed from a plasmid. When the sdiA gene is on the chromosome, it has no effect on expression of acrAB.
LFGR01000009.1_274 # 256034 # 256471 275.0 305.449 AAC(6')-Iaa 100.0 ARO:3002571 protein homolog model aminoglycoside antibiotic antibiotic inactivation AAC(6') AAC(6')-Iaa is a chromosomal-encoded aminoglycoside acetyltransferase in S. typhimurium.
LFGR01000009.1_389 # 366341 # 366724 230.0 251.136 marA 95.24 ARO:3000263 protein homolog model fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux; reduced permeability to antibiotic resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams In the presence of antibiotic stress, E. coli overexpresses the global activator protein MarA, which besides inducing MDR efflux pump AcrAB, also down- regulates synthesis of the porin OmpF.
LFGR01000009.1_430 # 403200 # 403562 150.0 177.178 Klebsiella pneumoniae KpnE 76.67 ARO:3004580 protein homolog model macrolide antibiotic; aminoglycoside antibiotic; cephalosporin; tetracycline antibiotic; peptide antibiotic; rifamycin antibiotic; disinfecting agents and antiseptics antibiotic efflux small multidrug resistance (SMR) antibiotic efflux pump KpnE subunit of KpnEF resembles EbrAB from E. coli. Mutation in KpnEF resulted in increased susceptibility to cefepime, ceftriaxon, colistin, erythromycin, rifampin, tetracycline, and streptomycin as well as enhanced sensitivity toward sodium dodecyl sulfate, deoxycholate, dyes, benzalkonium chloride, chlorhexidine, and triclosan.
LFGR01000010.1_54 # 44476 # 46224 1000.0 1160.59 msbA 96.39 ARO:3003950 protein homolog model nitroimidazole antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MsbA is a multidrug resistance transporter homolog from E. coli and belongs to a superfamily of transporters that contain an adenosine triphosphate (ATP) binding cassette (ABC) which is also called a nucleotide-binding domain (NBD). MsbA is a member of the MDR-ABC transporter group by sequence homology. MsbA transports lipid A, a major component of the bacterial outer cell membrane, and is the only bacterial ABC transporter that is essential for cell viability.
LFGR01000010.1_140 # 134034 # 135266 700.0 726.087 Escherichia coli mdfA 87.93 ARO:3001328 protein homolog model tetracycline antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump Multidrug efflux pump in E. coli. This multidrug efflux system was originally identified as the Cmr/CmlA chloramphenicol exporter.
LFGR01000010.1_319 # 307081 # 307758 400.0 424.861 kdpE 91.96 ARO:3003841 protein homolog model aminoglycoside antibiotic antibiotic efflux kdpDE kdpE is a transcriptional activator that is part of the two-component system KdpD/KdpE that is studied for its regulatory role in potassium transport and has been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. kdpE regulates a range of virulence loci through direct promoter binding.
LFGR01000010.1_562 # 540472 # 541665 670.0 696.041 Escherichia coli acrA 91.69 ARO:3004043 protein homolog model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrA is a subunit of the AcrAB-TolC multidrug efflux system found in E. coli.
LFGR01000010.1_667 # 639418 # 640530 250.0 268.47 vanG 38.98 ARO:3002909 protein homolog model glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; Van ligase VanG is a D-Ala-D-Ala ligase homolog that can synthesize D-Ala-D-Ser, an alternative substrate for peptidoglycan synthesis that reduces vancomycin binding affinity in Enterococcus faecalis.
LFGR01000010.1_693 # 672747 # 673211 290.0 319.316 golS 100.0 ARO:3000504 protein homolog model monobactam; carbapenem; cephalosporin; cephamycin; penam; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump GolS is a regulator activated by the presence of golD, and promotes the expression of the MdsABC efflux pump.
LFGR01000010.1_697 # 677010 # 680177 2090.0 2121.28 mdsB 100.0 ARO:3000790 protein homolog model monobactam; carbapenem; cephalosporin; cephamycin; penam; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MdsB is the inner membrane transporter of the multidrug and metal efflux complex MdsABC. mdsB corresponds to 1 locus in Pseudomonas aeruginosa PAO1 (gene name: mexQ) and 2 loci in Pseudomonas aeruginosa LESB58.
LFGR01000011.1_228 # 234104 # 235048 500.0 583.178 leuO 86.94 ARO:3003843 protein homolog model nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump leuO, a LysR family transcription factor, exists in a wide variety of bacteria of the family Enterobacteriaceae and is involved in the regulation of as yet unidentified genes affecting the stress response and pathogenesis expression. LeuO is also an activator of the MdtNOP efflux pump.
LFGR01000011.1_915 # 957109 # 958482 890.0 908.286 cpxA 96.94 ARO:3000830 protein homolog model aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump CpxA is a membrane-localized sensor kinase that is activated by envelope stress. It starts a kinase cascade that activates CpxR, which promotes efflux complex expression.
LFGR01000013.1_14 # 13242 # 13874 400.0 432.95 CRP 99.05 ARO:3000518 protein homolog model macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump CRP is a global regulator that represses MdtEF multidrug efflux pump expression.
LFGR01000007.1_574 # 588136 # 589494 850.0 895.575 Escherichia coli GlpT with mutation conferring resistance to fosfomycin 96.9 ARO:3003889 protein variant model E448K phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant GlpT Point mutations to the active importer GlpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria.
LFGR01000007.1_589 # 601751 # 604387 1500.0 1773.44 Salmonella enterica gyrA conferring resistance to fluoroquinolones 99.89 ARO:3003926 protein variant model D87N D87N:1545 fluoroquinolone antibiotic antibiotic target alteration fluoroquinolone resistant gyrA Point mutations in Salmonella gyrA that confer resistance to Nalidixic acid, a fluoroquinolone antibiotic. These mutations have also been shown to reduce susceptibility to ciprofloxacin.
LFGR01000011.1_832 # 865081 # 866265 700.0 796.579 Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin 99.49 ARO:3003369 protein variant model R234F elfamycin antibiotic antibiotic target alteration elfamycin resistant EF-Tu Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin.
LFGR01000011.1_1188 # 1239070 # 1240461 850.0 905.975 Escherichia coli UhpT with mutation conferring resistance to fosfomycin 95.68 ARO:3003890 protein variant model E350Q phosphonic acid antibiotic antibiotic target alteration antibiotic-resistant UhpT Mutations to the active importer UhpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria.
LFGR01000013.1_36 # 30034 # 31389 700.0 788.489 Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin 98.98 ARO:3003369 protein variant model R234F elfamycin antibiotic antibiotic target alteration elfamycin resistant EF-Tu Sequence variants of Escherichia coli elongation factor Tu that confer resistance to Pulvomycin.
LFGR01000009.1_388 # 365887 # 366321 210.0 273.478 Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline 92.36 ARO:3003378 protein overexpression model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MarR is a repressor of the mar operon marRAB, thus regulating the expression of marA, the activator of multidrug efflux pump AcrAB.
LFGR01000010.1_561 # 539677 # 540330 375.0 394.815 Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime 87.38 ARO:3003807 protein overexpression model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump AcrR is a repressor of the AcrAB-TolC multidrug efflux complex. AcrR mutations result in high level antibiotic resistance. The mutations associated with this model are specific to E. coli.
LFGR01000011.1_704 # 722270 # 722728 300.0 300.056 Escherichia coli soxR with mutation conferring antibiotic resistance 96.05 ARO:3003381 protein overexpression model fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump SoxR is a sensory protein that upregulates soxS expression in the presence of redox-cycling drugs. This stress response leads to the expression many multidrug efflux pumps.
LFGR01000011.1_705 # 722815 # 723138 200.0 212.231 Escherichia coli soxS with mutation conferring antibiotic resistance 95.33 ARO:3003511 protein overexpression model fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux; reduced permeability to antibiotic ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams SoxS is a global regulator that up-regulates the expression of AcrAB efflux genes. It also reduces OmpF expression to decrease cell membrane permeability.
VF List
Query_id %Identity E-value Related genes VF ID Virulence factor VFcategory VFcategoryID Characteristics Description Strain
LFGR01000001.1_2 80.747 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000001.1_3 68.533 0.0 acrA VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrA) acriflavine resistance protein A [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000002.1_48 69.892 0.0 rfaE VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaE) ADP-heptose synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
LFGR01000002.1_125 60.606 3.64E-72 hcp/tssD VF0944 HSI-3 Effector delivery system VFC0086 The expression of T6SSs in P. aeruginosa is regulated by the QS system. There are several QS systems in P. aeruginosa, two N-acyl-homoserine lactone based QS systems (las and rhl systems) and one quinolone PQS system (pqs). The expression of H1-T6SS is negatively regulated by both las and pqs QS systems, while the expression of H2- and H3-T6SS is positively regulated by las, rhl, and pqs (hcp/tssD) Hcp family type VI secretion system effector [HSI-3 (VF0944) - Effector delivery system (VFC0086)] [Pseudomonas aeruginosa PAO1] Pseudomonas aeruginosa
LFGR01000004.1_7 100.0 0.0 sopD VF0949 TTSS-1 secreted effectors Effector delivery system VFC0086 (sopD) type III secretion system effector SopD [TTSS-1 secreted effectors (VF0949) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_13 100.0 0.0 rpoS VF0112 RpoS Regulation VFC0301 (rpoS) RNA polymerase sigma factor RpoS [RpoS (VF0112) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_38 100.0 2.29E-107 invH VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (invH) type III secretion system pilotin invG [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_39 100.0 1.76E-163 invF VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (invF) type III secretion system regulatory protein InvF [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_40 100.0 0.0 invG VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (invG) type III secretion system secretin invG [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_41 100.0 0.0 invE VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (invE) type III secretion system gatekeeper invE [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_42 100.0 0.0 invA VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (invA) type III secretion system major export apparatus protein InvA [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_43 99.083 3.67E-77 invB VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (invB) type III secretion system protein InvB [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_44 100.0 0.0 invC/sctN VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (invC/sctN) type III secretion system ATPase InvC [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_45 100.0 2.13E-100 invI VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (invI) type III secretion system stalk protein InvI [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_47 100.0 0.0 spaO/sctQ VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (spaO/sctQ) type III secretion system C ring protein SpaO [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_48 100.0 1.06E-165 spaP VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (spaP) type III secretion system minor export apparatus protein SpaP [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_49 100.0 1.03E-56 spaQ VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (spaQ) type III secretion system minor export apparatus protein SpaQ [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_50 100.0 0.0 spaR VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (spaR) type III secretion system minor export apparatus protein SpaR [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_51 100.0 0.0 spaS VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (spaS) type III secretion system export apparatus switch protein SpaS [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_52 100.0 1.17E-124 sicA VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (sicA) chaparone for SipC and SipB [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_53 100.0 0.0 sipB/sspB VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (sipB/sspB) type III secretion system hydrophilic translocator, pore protein SipB (Salmonella invasion protein B) [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_54 100.0 0.0 sipC/sspC VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (sipC/sspC) type III secretion system hydrophilic translocator, pore protein SipC [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_55 100.0 0.0 sipD VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (sipD) type III secretion system hydrophilic translocator, needle tip protein SipD [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_56 100.0 0.0 sipA/sspA VF0949 TTSS-1 secreted effectors Effector delivery system VFC0086 (sipA/sspA) type III secretion system effector SipA (Salmonella invasion protein A) [TTSS-1 secreted effectors (VF0949) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_57 98.462 8.5E-43 iacP VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (iacP) putative acyl carrier protein [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_59 100.0 2.12E-93 sicP VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (sicP) chaparone for SptP [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_60 99.813 0.0 sptP VF0949 TTSS-1 secreted effectors Effector delivery system VFC0086 (sptP) type III secretion system effector SptP, tyrosine phosphatase and GTPase-activating protein [TTSS-1 secreted effectors (VF0949) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_61 100.0 1.37E-119 iagB VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (iagB) invasion protein IagB [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_62 100.0 0.0 hilA VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (hilA) transcriptional regulator [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_63 99.569 2.27E-176 hilD VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (hilD) AraC family transcriptional regulator [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_64 100.0 3.46E-51 hilD VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (hilD) AraC family transcriptional regulator [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_65 100.0 0.0 prgH VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (prgH) type III secretion system outer MS ring protein PrgH [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_66 100.0 1.28E-55 prgI VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (prgI) type III secretion system needle filament protein PrgI [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_67 100.0 4.28E-70 prgJ VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (prgJ) type III secretion system inner rod protein PrgJ [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_68 100.0 0.0 prgK VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (prgK) type III secretion system inner MS ring protein PrgK [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_69 100.0 8.49E-141 orgA/sctK VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (orgA/sctK) type III secretion system accessory cytosolic protein OrgA [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_70 100.0 1.2E-172 orgB/SctL VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (orgB/SctL) type III secretion system stator OrgB [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_71 100.0 1.69E-110 orgC VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (orgC) type III secretion system effector OrgC [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_72 100.0 0.0 hilC VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (hilC) AraC family transcriptional regulator [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_73 100.0 0.0 sprB VF0116 TTSS (SPI-1 encode) Effector delivery system VFC0086 (sprB) transcriptional regulator [TTSS (SPI-1 encode) (VF0116) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_74 100.0 0.0 avrA VF0949 TTSS-1 secreted effectors Effector delivery system VFC0086 (avrA) type III secretion system effector AvrA, acetyltransferease [TTSS-1 secreted effectors (VF0949) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_117 76.667 1.4E-30 csrA VF0261 CsrA Regulation VFC0301 Belongs to a highly conserved family of global regulators that typically control stationary phase traits post-transcriptionally (csrA) carbon storage regulator CsrA [CsrA (VF0261) - Regulation (VFC0301)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
LFGR01000007.1_121 71.93 2.39E-93 luxS VF0406 AI-2 Biofilm VFC0271 AI-2 is produced and detected by a wide variety of bacteria and is presumed to facilitate interspecies communications. (luxS) S-ribosylhomocysteinase [AI-2 (VF0406) - Biofilm (VFC0271)] [Vibrio cholerae O1 biovar El Tor str. N16961] Vibrio cholerae
LFGR01000007.1_162 100.0 0.0 mig-14 VF0395 Mig-14 Antimicrobial activity/Competitive advantage VFC0325 Mig-14 expression is induced within macrophages and is under the control of the global regulator PhoP (mig-14) antimicrobial peptide resistance protein Mig-14 [Mig-14 (VF0395) - Antimicrobial activity/Competitive advantage (VFC0325)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_164 100.0 0.0 pipB2 VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (pipB2) type III secretion system effector PipB3 [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_165 83.564 0.0 iroN VF0563 Sal Nutritional/Metabolic factor VFC0272 Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport (iroN) salmochelin receptor IroN [Sal (VF0563) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000007.1_166 85.106 2.5E-83 iroN VF0563 Sal Nutritional/Metabolic factor VFC0272 Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport (iroN) salmochelin receptor IroN [Sal (VF0563) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000007.1_167 61.587 1.39E-131 iroE VF0230 Salmochelin siderophore Nutritional/Metabolic factor VFC0272 Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi (iroE) esterase [Salmochelin siderophore (VF0230) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
LFGR01000007.1_168 68.608 0.0 iroD VF0230 Salmochelin siderophore Nutritional/Metabolic factor VFC0272 Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi (iroD) esterase [Salmochelin siderophore (VF0230) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
LFGR01000007.1_169 70.588 2.16E-148 iroC VF0563 Sal Nutritional/Metabolic factor VFC0272 Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport (iroC) ABC transporter [Sal (VF0563) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000007.1_170 85.397 0.0 iroC VF0563 Sal Nutritional/Metabolic factor VFC0272 Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport (iroC) ABC transporter [Sal (VF0563) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000007.1_171 86.792 0.0 iroB VF0230 Salmochelin siderophore Nutritional/Metabolic factor VFC0272 Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi (iroB) glucosyltransferase IroB [Salmochelin siderophore (VF0230) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
LFGR01000007.1_197 99.421 0.0 bapA VF0971 BapA Adherence VFC0001 "
LFGR01000007.1_198 99.371 4.59E-103 bapA VF0971 BapA Adherence VFC0001 "
LFGR01000007.1_244 65.445 1.05E-90 algU VF0091 Alginate Biofilm VFC0271 Alginate production is frequently referred to as mucoidy because colonies producing alginate have a wet glistening (mucoid) appearance, which is very different from that of colonies not producing alginate; most of the alginate biosynthetic genes are clustered in the algD operon; Alginate production is highly regulated. Regulatory genes are located in two areas far removed from the biosynthetic genes, with one exception algC (algU) alginate biosynthesis protein AlgZ/FimS [Alginate (VF0091) - Biofilm (VFC0271)] [Pseudomonas aeruginosa PAO1] Pseudomonas aeruginosa
LFGR01000007.1_320 99.658 0.0 sinH VF0400 SinH Adherence VFC0001 N-terminal 350 residues exhibits homology with invasin of Yersinia pseudotuberculosis (49.5% identity) and intimin of E. coli O111 (enteropathogenic E. coli) (48% identity). The amino termini of invasin and intimin serve as membrane-spanning anchors in the bacterial outer membrane. (sinH) intimin-like protein [SinH (VF0400) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_321 99.123 4.01E-77 sinH VF0400 SinH Adherence VFC0001 N-terminal 350 residues exhibits homology with invasin of Yersinia pseudotuberculosis (49.5% identity) and intimin of E. coli O111 (enteropathogenic E. coli) (48% identity). The amino termini of invasin and intimin serve as membrane-spanning anchors in the bacterial outer membrane. (sinH) intimin-like protein [SinH (VF0400) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_324 99.959 0.0 ratB VF0399 RatB Adherence VFC0001 Three putative intestinal colonization factors SinH, RatB and ShdA, are located in the same 25-kb pathogenicity island, called CS54. This island is present only in subspecies 1 of S. enterica. (ratB) putative outer membrane protein [RatB (VF0399) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_325 99.647 0.0 shdA VF0398 ShdA Adherence VFC0001 The shdA gene is carried on a 25-kb genetic island at centisome 54 (CS54 island) of the Salmonella enterica serotype Typhimurium chromosome. (shdA) AIDA autotransporter-like protein [ShdA (VF0398) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_326 94.9 0.0 shdA VF0398 ShdA Adherence VFC0001 The shdA gene is carried on a 25-kb genetic island at centisome 54 (CS54 island) of the Salmonella enterica serotype Typhimurium chromosome. (shdA) AIDA autotransporter-like protein [ShdA (VF0398) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_356 65.029 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000007.1_453 72.436 4.5E-174 pla VF0139 Pla Exoenzyme VFC0251 Belongs to the family of OM proteases/adhesins known as omptins that share high sequence identity but differ in biological function; Omptins appear to constitute a unique class of proteases. Other omptin family outer membrane proteases include PgtE from S. enterica, OmpT and OmpR from E. coli, and SopA/IcsP from S. flexneri. Their catalytic residues are conserved. They require the presence of rough LPS for enzymatic activity and are inhibited by the O-antigen chains present in smooth LPS; unique to Y. pestis encoded by the pPCP1 plasmid not present in the enteropathogenic yersiniae Y. pseudotuberculosis and Y. enterocolitica (pla) plasminogen activator protease precursor [Pla (VF0139) - Exoenzyme (VFC0251)] [Yersinia pestis CO92] Yersinia pestis
LFGR01000007.1_570 98.058 5.19E-151 sseL VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (sseL) type III secretion system effector SseL, deubiquitinase [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_592 97.685 5.01E-154 rcsB VF0571 RcsAB Regulation VFC0301 (rcsB) transcriptional regulator RcsB [RcsAB (VF0571) - Regulation (VFC0301)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000007.1_622 92.208 0.0 sspH2 VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (sspH2) type III secretion system effector SspH2 (Salmonella secreted protein H2), novel E3 ubiquitin ligase [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_623 98.571 4.62E-41 sspH2 VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (sspH2) type III secretion system effector SspH2 (Salmonella secreted protein H2), novel E3 ubiquitin ligase [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_624 100.0 0.0 sspH2 VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (sspH2) type III secretion system effector SspH2 (Salmonella secreted protein H2), novel E3 ubiquitin ligase [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_732 100.0 6.84E-59 steD VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (steD) type III secretion system effector SteD [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_734 98.802 2.3E-124 sseK2 VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (sseK2) type III secretion system effector SseK2 [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_735 100.0 6.63E-118 sseK2 VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (sseK2) type III secretion system effector SseK2 [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_757 64.644 0.0 KP1_RS17340 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17340) polysaccharide export protein [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000007.1_767 88.649 0.0 gmd VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gmd) GDP-mannose 4,6-dehydratase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000007.1_768 76.803 0.0 KP1_RS17305 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17305) GDP-L-fucose synthase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000007.1_770 60.688 0.0 KP1_RS17295 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17295) glycosyltransferase WbuB [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000007.1_771 64.63 7.58E-143 KP1_RS17280 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (KP1_RS17280) mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000007.1_772 64.78 6.73E-71 manC VF0436 Capsule I Immune modulation VFC0258 (manC) GDP-mannose pyrophosphorylase [Capsule I (VF0436) - Immune modulation (VFC0258)] [Burkholderia pseudomallei K96243] Burkholderia pseudomallei
LFGR01000007.1_773 76.044 0.0 rfbK1 VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (rfbK1) O9 family phosphomannomutase RfbK1 [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000007.1_775 76.327 3.12E-132 wcaJ VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (wcaJ) undecaprenyl-phosphate glucose phosphotransferase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000007.1_780 92.542 0.0 galF VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (galF) GalU regulator GalF [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000007.1_781 62.573 2.11E-159 rffG VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rffG) dTDP-glucose 46-dehydratase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
LFGR01000007.1_783 63.103 6.09E-141 wbtL VF0542 LPS Immune modulation VFC0258 The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion (wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
LFGR01000007.1_787 79.377 9.4E-162 rfbF VF0392 O-antigen Immune modulation VFC0258 Clinical Y. enterocolitica isolates from humans predominantly belong to serotypes O:3, O:9, O:8 and O:5,27; Y. enterocolitica O antigen expression is temperature regulated. (rfbF) glucose-1-phosphate cytidylyltransferase [O-antigen (VF0392) - Immune modulation (VFC0258)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000007.1_788 69.663 0.0 rfbG VF0392 O-antigen Immune modulation VFC0258 Clinical Y. enterocolitica isolates from humans predominantly belong to serotypes O:3, O:9, O:8 and O:5,27; Y. enterocolitica O antigen expression is temperature regulated. (rfbG) CDP-glucose 4,6-dehydratase [O-antigen (VF0392) - Immune modulation (VFC0258)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000007.1_800 64.286 2.93E-141 wbaP/rfbP VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (wbaP/rfbP) undecaprenyl-phosphate galactosephosphotransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
LFGR01000007.1_801 95.479 0.0 gndA VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000007.1_802 93.902 5.07E-53 gndA VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000007.1_803 81.701 0.0 ugd VF0560 Capsule Immune modulation VFC0258 The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. (ugd) UDP-glucose 6-dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000007.1_819 99.479 5.71E-137 sopA VF0949 TTSS-1 secreted effectors Effector delivery system VFC0086 (sopA) type III secretion system effector SopA, HECT-like E3 ubiquitin ligase [TTSS-1 secreted effectors (VF0949) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000007.1_820 100.0 0.0 sopA VF0949 TTSS-1 secreted effectors Effector delivery system VFC0086 (sopA) type III secretion system effector SopA, HECT-like E3 ubiquitin ligase [TTSS-1 secreted effectors (VF0949) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000008.1_38 60.92 1.01E-75 rcsA VF0571 RcsAB Regulation VFC0301 (rcsA) transcriptional activator for ctr capsule biosynthesis [RcsAB (VF0571) - Regulation (VFC0301)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000008.1_39 65.891 2.28E-103 fliR VF0394 Flagella Motility VFC0204 (fliR) flagellar biosynthetic protein FliR [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_40 74.157 2.47E-36 fliQ VF0394 Flagella Motility VFC0204 (fliQ) flagellar biosynthetic protein FliQ [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_41 85.652 1.78E-141 fliP VF0394 Flagella Motility VFC0204 (fliP) flagellar biosynthetic protein FliP [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_43 76.812 9.48E-71 fliN VF0394 Flagella Motility VFC0204 (fliN) flagellar motor switch protein FliN [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_44 84.985 0.0 fliM VF0394 Flagella Motility VFC0204 (fliM) flagellar motor switch protein FliM [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_48 83.921 0.0 fliI VF0394 Flagella Motility VFC0204 (fliI) flagellum-specific ATP synthase FliI [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_50 83.283 0.0 fliG VF0394 Flagella Motility VFC0204 (fliG) flagellar motor switch protein G [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_51 63.489 0.0 fliF VF0394 Flagella Motility VFC0204 (fliF) flagellar M-ring protein FliF [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_60 71.875 9.53E-63 fliS VF0394 Flagella Motility VFC0204 (fliS) flagellar protein FliS [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_65 83.193 9.01E-144 fliA VF0394 Flagella Motility VFC0204 (fliA) flagellar biosynthesis sigma factor [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_92 75.862 5.28E-53 flhD VF0394 Flagella Motility VFC0204 (flhD) flagellar transcriptional activator FlhD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_93 81.865 1.31E-116 flhC VF0394 Flagella Motility VFC0204 (flhC) flagellar biosynthesis transcription activator FlhC [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_94 83.051 0.0 motA VF0394 Flagella Motility VFC0204 (motA) flagellar motor protein MotA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_95 68.571 3.59E-154 motB VF0394 Flagella Motility VFC0204 (motB) flagellar motor protein MotB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_96 75.664 0.0 cheA VF0394 Flagella Motility VFC0204 (cheA) chemotaxis protein CheA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_97 85.0 2.26E-97 cheW VF0394 Flagella Motility VFC0204 (cheW) purine-binding chemotaxis protein CheW [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_99 73.944 3.54E-152 cheR VF0394 Flagella Motility VFC0204 (cheR) chemotaxis methyltransferase CheR [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_100 85.387 0.0 cheB VF0394 Flagella Motility VFC0204 (cheB) chemotaxis-specific methylesterase CheB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_101 90.698 5.38E-84 cheY VF0394 Flagella Motility VFC0204 (cheY) chemotaxis regulatory protein CheY [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_103 78.333 6.57E-67 cheZ VF0394 Flagella Motility VFC0204 (cheZ) chemotaxis regulator CheZ [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_104 66.053 0.0 flhB VF0394 Flagella Motility VFC0204 (flhB) flagellar biosynthetic protein FlhB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_105 85.507 0.0 flhA VF0394 Flagella Motility VFC0204 (flhA) flagellar biosynthesis protein FlhA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000008.1_120 60.494 6.26E-107 CBU_1566 VF0696 T4SS secreted effectors Effector delivery system VFC0086 (CBU_1566) Coxiella Dot/Icm type IVB secretion system translocated effector [T4SS secreted effectors (VF0696) - Effector delivery system (VFC0086)] [Coxiella burnetii RSA 493] Coxiella burnetii
LFGR01000009.1_13 100.0 0.0 sopE2 VF0949 TTSS-1 secreted effectors Effector delivery system VFC0086 (sopE2) type III secretion system effector SopE2, guanine nucleotide exchange factor [TTSS-1 secreted effectors (VF0949) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_104 81.915 1.9E-178 kdsA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
LFGR01000009.1_124 74.672 1.96E-122 galU VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (galU) glucosephosphate uridylyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
LFGR01000009.1_125 70.909 1.14E-25 galU VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (galU) glucosephosphate uridylyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
LFGR01000009.1_184 100.0 0.0 steC VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (steC) type III secretion system effector SteC (Salmonella translocated effector C), kinase [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_185 100.0 3.08E-78 steC VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (steC) type III secretion system effector SteC (Salmonella translocated effector C), kinase [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_261 100.0 0.0 sseJ VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (sseJ) type III secretion system effector SseJ, glycerophospholipid:cholesterol acyltransferase [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_267 70.161 5.34E-100 cheD VF0394 Flagella Motility VFC0204 (cheD) methyl-accepting chemotaxis protein CheD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000009.1_292 100.0 8.14E-153 sifB VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (sifB) type III secretion system effector SifB (Salmonella induced filament protein B) [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_313 100.0 4.64E-160 steA VF0948 TTSS effectors secreted via both systems Effector delivery system VFC0086 (steA) type III secretion system effector SteA (Salmonella translocated effector A) [TTSS effectors secreted via both systems (VF0948) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_483 68.063 3.66E-100 sodB VF0169 SodB Stress survival VFC0282 (sodB) superoxide dismutase [SodB (VF0169) - Stress survival (VFC0282)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
LFGR01000009.1_491 100.0 0.0 ssaU VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaU) type III secretion system export apparatus switch protein SsaU [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_492 100.0 0.0 ssaT VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaT) type III secretion system minor export apparatus protein SsaT [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_493 100.0 7.18E-59 ssaS VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaS) type III secretion system minor export apparatus protein SsaS [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_494 100.0 1.64E-153 ssaR VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaR) type III secretion system minor export apparatus protein SsaR [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_495 100.0 7.86E-177 ssaQ VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaQ) type III secretion system C ring protein SsaQ [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_496 100.0 2.45E-92 ssaP VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaP) type III secretion system needle length regulator SsaP [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_497 100.0 7.25E-88 ssaO VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaO) type III secretion system stalk protein SsaO [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_498 100.0 0.0 ssaN VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaN) type III secretion system ATPase SsaN [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_499 100.0 0.0 ssaV VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaV) type III secretion system major export apparatus protein ssaV [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_500 100.0 4.68E-90 ssaM VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaM) type III secretion system protein SsaM [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_501 100.0 0.0 ssaL VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaL) type III secretion system gatekeeper SsaL [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_502 100.0 3.76E-170 ssaK VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaK) type III secretion system stator SsaK [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_503 99.451 4.25E-133 ssaX VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaX) type III secretion system base-pod connector [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_504 100.0 0.0 ssaJ VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaJ) type III secretion system inner MS ring protein SsaJ [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_505 100.0 2.94E-56 ssaI VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaI) type III secretion system inner rod protein SsaI [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_507 100.0 1.02E-47 ssaG VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaG) type III secretion system needle filament protein SsaG [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_508 100.0 1.2E-172 sseG VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (sseG) type III secretion system effector SseG [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_509 100.0 0.0 sseF VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (sseF) type III secretion system effector SseF [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_510 100.0 1.8E-106 sscB VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (sscB) chaperone for sseF [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_511 100.0 5.4E-100 sseE VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (sseE) type III secretion system effector SseE [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_512 100.0 7.29E-141 sseD VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (sseD) type III secretion system hydrophilic translocator, pore protein SseD [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_513 99.685 0.0 sseC VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (sseC) type III secretion system hydrophilic translocator, pore protein SseC [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_514 98.101 1.2E-111 sseC VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (sseC) type III secretion system hydrophilic translocator, pore protein SseC [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_515 100.0 4.13E-118 sscA VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (sscA) chaperone for sseC [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_516 100.0 6.21E-145 sseB VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (sseB) type III secretion system effector SseB [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_517 100.0 1.55E-76 sseA VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (sseA) chaperone for sseB and sseD [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_518 100.0 1.75E-53 ssaE VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaE) chaperone for sseB [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_519 100.0 0.0 ssaD VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaD) type III secretion system outer MS ring protein SsaD [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_520 99.793 0.0 ssaC VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssaC) type III secretion system secretin SsaC [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_521 100.0 5.28E-80 spiC/ssaB VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (spiC/ssaB) Salmonella pathogenicity island 2 protein C (SpiC); Type III secretion system apparatus protein B (SsaB) [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_522 100.0 0.0 ssrA VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssrA) hybrid sensor histidine kinase/response regulator [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_523 100.0 0.0 ssrA VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssrA) hybrid sensor histidine kinase/response regulator [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_524 100.0 1.39E-132 ssrB VF0321 TTSS (SPI-2 encode) Effector delivery system VFC0086 SPI-2 T3SS effector repertoire varies greatly among different Salmonella serovars.; All serovars seem to have a set of 'core' effectors (SseF, SseG, PipB, SteA, SifA, SteD and PipB2), suggesting that they are critical for virulence in different hosts.; Another group of effectors (SseL, SifB, SopD2, SseJ, SteB, SteC, SlrP, and SseK2) always seem to be present in intestinal serovars but are frequently non-functional in extraintestinal or highly host-adapted serovars, suggesting these effectors contribute to virulence in the intestine, but not always in deeper tissues.;A further group of 'accessory' effectors (SspH2, SseK1, SrfJ, GtgA, GtgE, SseI, GogB, SteE, SseK3, SspH1, SpvB, SpvC, and SpvD) encoded on mobile genetic elements (MGEs) or DNA close to the remnants of MGEs are found sporadically across different serovars.;The only known effector genes in SPI-2, sseF and sseG, are likely to have conferred an early selective advantage to intracellular bacteria.;several sets of effectors that share high levels of sequence similarity. Examples of paralog effectors include Pathogenicity island-encoded protein B (PipB) and PipB2, which share 33% identity and 67% similarity, SifA and SifB that share 26% identity and 46% similarity, SopE and SopE2, which share 69% similarity, SopD and SopD2 that share 43% identity and 63% similarity. These effector protein paralogs often share structural similarity and/or biochemical activities but demonstrate functional divergence in intracellular localization and/or host protein targets or interaction partners. (ssrB) DNA-binding response regulator [TTSS (SPI-2 encode) (VF0321) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_696 100.0 1.34E-166 phoP VF0111 PhoPQ Regulation VFC0301 (phoP) response regulator in two-component regulatory system with PhoQ [PhoPQ (VF0111) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_697 99.787 0.0 phoQ VF0111 PhoPQ Regulation VFC0301 (phoQ) sensor protein PhoQ [PhoPQ (VF0111) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_703 100.0 0.0 sifA VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (sifA) type III secretion system effector SifA (Salmonella induced filament protein A) [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_732 61.538 1.93E-27 acpXL VF0367 LPS Immune modulation VFC0258 Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. (acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] Brucella melitensis
LFGR01000009.1_733 77.459 1.72E-139 flmH VF0473 Polar flagella Motility VFC0204 Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments (flmH) short chain dehydrogenase/reductase family oxidoreductase [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119] Aeromonas hydrophila
LFGR01000009.1_746 61.465 7.65E-138 flgJ VF0394 Flagella Motility VFC0204 (flgJ) <beta>-N-acetylglucosaminidase [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000009.1_747 79.05 0.0 flgI VF0394 Flagella Motility VFC0204 (flgI) flagellar P-ring protein precursor FlgI [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000009.1_748 93.902 5.89E-52 flgH VF0394 Flagella Motility VFC0204 (flgH) flagellar L-ring protein precursor FlgH [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000009.1_750 87.308 5.49E-170 flgG VF0394 Flagella Motility VFC0204 (flgG) flagellar basal-body rod protein FlgG [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000009.1_751 69.721 8.16E-126 flgF VF0394 Flagella Motility VFC0204 (flgF) flagellar basal-body rod protein FlgF [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000009.1_752 63.183 2.55E-180 flgE VF0394 Flagella Motility VFC0204 (flgE) flagellar hook protein FlgE [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000009.1_753 71.287 9.94E-99 flgD VF0394 Flagella Motility VFC0204 (flgD) flagellar basal-body rod modification protein FlgD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000009.1_754 81.343 1.06E-80 flgC VF0394 Flagella Motility VFC0204 (flgC) flagellar basal-body rod protein FlgC [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000009.1_755 76.642 3.3E-76 flgB VF0394 Flagella Motility VFC0204 (flgB) flagellar basal-body rod protein FlgB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000009.1_786 100.0 5.6E-75 csgC VF0103 Agf Adherence VFC0001 Homology to csg of E.coli; nucleator-dependent assembly pathway (csgC) curli assembly protein CsgC [Agf (VF0103) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_787 100.0 3.01E-106 csgA VF0103 Agf Adherence VFC0001 Homology to csg of E.coli; nucleator-dependent assembly pathway (csgA) curlin major subunit CsgA [Agf (VF0103) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_788 100.0 1.03E-108 csgB VF0103 Agf Adherence VFC0001 Homology to csg of E.coli; nucleator-dependent assembly pathway (csgB) minor curlin subunit precursor, curli nucleator protein CsgB [Agf (VF0103) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_789 100.0 8.63E-164 csgD VF0103 Agf Adherence VFC0001 Homology to csg of E.coli; nucleator-dependent assembly pathway (csgD) DNA-binding transcriptional regulator CsgD [Agf (VF0103) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_790 100.0 1.59E-96 csgE VF0103 Agf Adherence VFC0001 Homology to csg of E.coli; nucleator-dependent assembly pathway (csgE) curli production assembly/transport protein CsgE [Agf (VF0103) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_791 100.0 2.24E-100 csgF VF0103 Agf Adherence VFC0001 Homology to csg of E.coli; nucleator-dependent assembly pathway (csgF) curli production assembly/transport protein CsgF [Agf (VF0103) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_792 100.0 0.0 csgG VF0103 Agf Adherence VFC0001 Homology to csg of E.coli; nucleator-dependent assembly pathway (csgG) curli production assembly/transport protein CsgG [Agf (VF0103) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_848 100.0 0.0 sopB/sigD VF0949 TTSS-1 secreted effectors Effector delivery system VFC0086 (sopB/sigD) type III secretion system effector SopB, phosphoinositide phosphatase [TTSS-1 secreted effectors (VF0949) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_850 100.0 0.0 pipB VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (pipB) type III secretion system effector PipB [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_867 92.571 0.0 ompA VF0236 OmpA Invasion VFC0083 Major outer membrane protein in E. coli, homologous to Neisseria Opa proteins which have been shown to be involved in invasion of eukaryotic cells (ompA) outer membrane protein A [OmpA (VF0236) - Invasion (VFC0083)] [Escherichia coli O18:K1:H7 str. RS218] Escherichia coli (NMEC)
LFGR01000009.1_881 100.0 7.15E-174 gtgE VF0948 TTSS effectors secreted via both systems Effector delivery system VFC0086 (gtgE) type III secretion system effector GtgE (Gifsy-2 gene E), cysteine protease [TTSS effectors secreted via both systems (VF0948) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_884 99.689 0.0 sseI/srfH VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (sseI/srfH) type III secretion system effector SseI/SrfH (SsrB regulated factor H), deamidase [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000009.1_898 100.0 2.93E-128 sodCI VF0109 SodCI Stress survival VFC0282 Encoded on the lysogenic phage Gifsy-2 (sodCI) Gifsy-2 prophage: superoxide dismutase precursor (Cu-Zn) [SodCI (VF0109) - Stress survival (VFC0282)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000010.1_48 70.93 2.33E-86 nueA VF0473 Polar flagella Motility VFC0204 Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments (nueA) NeuA protein [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119] Aeromonas hydrophila
LFGR01000010.1_49 65.278 4.98E-30 kdsB VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (kdsB) 3-deoxy-manno-octulosonate cytidylyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
LFGR01000010.1_54 66.263 0.0 msbA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (msbA) lipid transporter ATP-binding/permease [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
LFGR01000010.1_68 100.0 0.0 sopD2 VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (sopD2) type III secretion system effector SopD2 [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000010.1_219 100.0 0.0 slrP VF0948 TTSS effectors secreted via both systems Effector delivery system VFC0086 (slrP) type III secretion system effector SlrP (Salmonella leucine-rich repeat protein),novel E3 ubiquitin ligase [TTSS effectors secreted via both systems (VF0948) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000010.1_299 67.203 1.29E-161 KP1_RS17225 VF0561 LPS Immune modulation VFC0258 In K. pneumoniae there are nine main O-serotypes. Three of these, O1, O2, and O3, are responsible for almost 80% of all Klebsiella infections.; Compared with other Enterobacteriaceae, such as Escherichia coli 161 defined O serotypes and Shigella flexneri at least 47 O serotypes, Klebsiella has a surprisingly low number of reported O serotypes which promises a more viable alternative for vaccine development compared with K-antigen-based vaccines; The O-antigen biosynthesis enzymes are encoded on the rfb locus. (KP1_RS17225) glycosyltransferase family 4 protein [LPS (VF0561) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000010.1_300 71.154 2.41E-23 KP1_RS17225 VF0561 LPS Immune modulation VFC0258 In K. pneumoniae there are nine main O-serotypes. Three of these, O1, O2, and O3, are responsible for almost 80% of all Klebsiella infections.; Compared with other Enterobacteriaceae, such as Escherichia coli 161 defined O serotypes and Shigella flexneri at least 47 O serotypes, Klebsiella has a surprisingly low number of reported O serotypes which promises a more viable alternative for vaccine development compared with K-antigen-based vaccines; The O-antigen biosynthesis enzymes are encoded on the rfb locus. (KP1_RS17225) glycosyltransferase family 4 protein [LPS (VF0561) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000010.1_302 79.297 2.77E-157 rfbD VF0561 LPS Immune modulation VFC0258 In K. pneumoniae there are nine main O-serotypes. Three of these, O1, O2, and O3, are responsible for almost 80% of all Klebsiella infections.; Compared with other Enterobacteriaceae, such as Escherichia coli 161 defined O serotypes and Shigella flexneri at least 47 O serotypes, Klebsiella has a surprisingly low number of reported O serotypes which promises a more viable alternative for vaccine development compared with K-antigen-based vaccines; The O-antigen biosynthesis enzymes are encoded on the rfb locus. (rfbD) UDP-galactopyranose mutase [LPS (VF0561) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000010.1_330 100.0 4.99E-111 fur VF0113 Fur Regulation VFC0301 (fur) ferric iron uptake transcriptional regulator [Fur (VF0113) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000010.1_426 89.516 1.88E-164 entA VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entA) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase EntA [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
LFGR01000010.1_427 88.07 0.0 entB VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entB) isochorismatase [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
LFGR01000010.1_428 86.142 0.0 entE VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entE) 2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
LFGR01000010.1_429 84.399 0.0 entC VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entC) isochorismate synthase 1 [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
LFGR01000010.1_430 79.56 0.0 fepB VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepB) ferrienterobactin ABC transporter periplasmic binding protein [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
LFGR01000010.1_431 90.709 0.0 entS VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entS) enterobactin exporter, iron-regulated [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
LFGR01000010.1_432 84.179 0.0 fepD VF0562 Ent Nutritional/Metabolic factor VFC0272 Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. (fepD) iron-enterobactin transporter membrane protein [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000010.1_433 86.626 0.0 fepG VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepG) iron-enterobactin ABC transporter permease [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
LFGR01000010.1_434 92.395 0.0 fepC VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepC) ferrienterobactin ABC transporter ATPase [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
LFGR01000010.1_435 77.477 6.07E-128 fepE VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepE) LPS O-antigen length regulator [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
LFGR01000010.1_436 66.887 2.77E-69 fepE VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepE) LPS O-antigen length regulator [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
LFGR01000010.1_437 81.437 0.0 entF VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entF) enterobactin synthase multienzyme complex component, ATP-dependent [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
LFGR01000010.1_438 76.19 0.0 entF VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (entF) enterobactin synthase multienzyme complex component, ATP-dependent [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
LFGR01000010.1_440 74.372 0.0 fes VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fes) enterobactin/ferric enterobactin esterase [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
LFGR01000010.1_441 87.402 5.4E-158 fepA VF0562 Ent Nutritional/Metabolic factor VFC0272 Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. (fepA) outer membrane receptor FepA [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000010.1_442 79.352 0.0 fepA VF0228 Enterobactin Nutritional/Metabolic factor VFC0272 An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three (fepA) ferrienterobactin outer membrane transporter [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] Escherichia coli (UPEC)
LFGR01000010.1_469 79.167 2.31E-70 gtrA VF0124 LPS Immune modulation VFC0258 Composed of the O-antigen, core polysaccharides and lipid A; the genes involved in the biosynthesis of the basic O-antigen are located in the rfb/rfc loci; O-antigen modification is associated with temperate bacteriophages. Four different serotype-converting phages have been found: SfII, Sf6, SfV and SfX, which are involved in conversion of a serotype Y stain to serotypes 2a, 3b, 5a and X, respectively (gtrA) bactoprenol-linked glucose translocase/flippase [LPS (VF0124) - Immune modulation (VFC0258)] [Shigella flexneri 2a str. 301] Shigella flexneri
LFGR01000010.1_470 90.476 0.0 gtrB VF0124 LPS Immune modulation VFC0258 Composed of the O-antigen, core polysaccharides and lipid A; the genes involved in the biosynthesis of the basic O-antigen are located in the rfb/rfc loci; O-antigen modification is associated with temperate bacteriophages. Four different serotype-converting phages have been found: SfII, Sf6, SfV and SfX, which are involved in conversion of a serotype Y stain to serotypes 2a, 3b, 5a and X, respectively (gtrB) bactoprenol glucosyl transferase [LPS (VF0124) - Immune modulation (VFC0258)] [Shigella flexneri 2a str. 301] Shigella flexneri
LFGR01000010.1_476 100.0 8.27E-150 fimW VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimW) helix-turn-helix transcriptional regulator [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000010.1_478 100.0 3.78E-179 fimY VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimY) fimbriae Y protein [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000010.1_479 100.0 1.07E-155 fimZ VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimZ) DNA-binding response regulator [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000010.1_480 100.0 1.7E-126 fimF VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimF) type I fimbriae adaptor protein FimF [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000010.1_481 100.0 0.0 fimH VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimH) type I fimbriae minor fimbrial subunit FimH, adhesin [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000010.1_482 100.0 0.0 fimD VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimD) usher protein FimD [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000010.1_483 100.0 1.69E-170 fimC VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimC) chaperone protein FimC [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000010.1_484 100.0 1.56E-131 fimI VF0102 Type 1 fimbriae Adherence VFC0001 Chaperone-usher assembly pathway (fimI) fimbrial protein internal segment [Type 1 fimbriae (VF0102) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000010.1_500 82.235 0.0 allD VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allD) ureidoglycolate dehydrogenase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000010.1_502 81.098 0.0 allC VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allC) allantoate amidohydrolase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000010.1_506 93.377 0.0 allB VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allB) allantoinase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000010.1_514 85.874 9.99E-177 allR VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allR) DNA-binding transcriptional repressor AllR [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000010.1_515 78.125 3.99E-94 allA VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allA) ureidoglycolate hydrolase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000010.1_516 73.77 4.84E-172 allS VF0572 Allantion utilization Nutritional/Metabolic factor VFC0272 An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. (allS) DNA-binding transcriptional activator AllS [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000010.1_562 85.279 0.0 acrA VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrA) acriflavine resistance protein A [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000010.1_563 89.062 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000010.1_564 93.348 0.0 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000010.1_565 93.841 5.76E-173 acrB VF0568 AcrAB Antimicrobial activity/Competitive advantage VFC0325 (acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] Klebsiella pneumoniae
LFGR01000010.1_594 66.495 2.42E-98 clpP VF0074 ClpP Stress survival VFC0282 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] Listeria monocytogenes
LFGR01000010.1_697 60.478 0.0 adeG VF0504 AdeFGH efflux pump Biofilm VFC0271 Belongs to resistance-nodulation-cell division (RND)-type efflux system; RND efflux systems, composed of an inner membrane protein (RND pump) linked by a periplasmic adaptor protein (PAP) to an outer membrane factor (OMF), can extrude a wide range of substrates often unrelated in structure; To date, three Acinetobacter drug efflux (Ade) RND systems, AdeABC, AdeFGH, and AdeIJK, have been characterized in A. baumannii (adeG) cation/multidrug efflux pump [AdeFGH efflux pump (VF0504) - Biofilm (VFC0271)] [Acinetobacter baumannii ACICU] Acinetobacter baumannii
LFGR01000011.1_15 76.042 9.67E-111 gmhA/lpcA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (gmhA/lpcA) phosphoheptose isomerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
LFGR01000011.1_19 99.582 1.44E-177 pagN VF0968 PagN Invasion VFC0083 Unlike rck, pagN is encoded on bacterial chromosome.;PagN is well conserved and widely distributed among the different species and subspecies of Salmonella.;PagN protein displays similarity to the Hek and Tia invasins/adhesins of pathogenic E. coli (pagN) outer membrane adhesin/invasin protein [PagN (VF0968) - Invasion (VFC0083)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_35 72.986 6.2E-98 tre<sup>Tu</sup> VF1195 SCI T6SS secreted effectors Effector delivery system VFC0086 (tre<up>Tu</up>) Rhs polymorphic toxin, ADP-ribosyltransferase, type VI ribosyltransferase effector targeting EF-Tu [SCI T6SS secreted effectors (VF1195) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_37 99.909 0.0 tre<sup>Tu</sup> VF1195 SCI T6SS secreted effectors Effector delivery system VFC0086 (tre<up>Tu</up>) Rhs polymorphic toxin, ADP-ribosyltransferase, type VI ribosyltransferase effector targeting EF-Tu [SCI T6SS secreted effectors (VF1195) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_38 100.0 1.05E-176 tre<sup>Tu</sup> VF1195 SCI T6SS secreted effectors Effector delivery system VFC0086 (tre<up>Tu</up>) Rhs polymorphic toxin, ADP-ribosyltransferase, type VI ribosyltransferase effector targeting EF-Tu [SCI T6SS secreted effectors (VF1195) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_39 100.0 2.92E-111 STM0290 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_40 100.0 0.0 vgrG VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_42 97.297 7.08E-108 tlde1 VF1195 SCI T6SS secreted effectors Effector delivery system VFC0086 (tlde1) type VI secretion system effector tlde1, L,D-transpeptidase [SCI T6SS secreted effectors (VF1195) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_43 100.0 2.5E-104 STM0287 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_44 100.0 0.0 STM0286 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_45 99.407 0.0 STM0285 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_46 97.992 0.0 STM0285 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_47 100.0 3.54E-81 STM0284 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_48 100.0 4.44E-53 STM0283 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_49 100.0 6.28E-136 STM0283 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_50 100.0 0.0 STM0282 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_51 100.0 0.0 tssK VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_52 100.0 3.88E-143 tssK VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_53 100.0 3.03E-132 tssJ VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_54 100.0 1.32E-120 STM0279 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_55 99.187 4.33E-90 STM0278 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_56 100.0 2.56E-120 tae4 VF1195 SCI T6SS secreted effectors Effector delivery system VFC0086 (tae4) type VI secretion system effector tae4, L,D-endopeptidase [SCI T6SS secreted effectors (VF1195) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_57 100.0 2.36E-121 STM0276 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_59 99.783 0.0 STM0274 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_60 100.0 5.26E-131 STM0273 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_61 100.0 0.0 STM0272 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_62 99.574 0.0 STM0272 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_63 100.0 0.0 STM0271 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_64 100.0 0.0 STM0270 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_65 100.0 1.42E-121 STM0269 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_66 99.746 0.0 STM0268 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_67 100.0 9.63E-131 STM0268 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_68 99.678 0.0 STM0267 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_69 100.0 0.0 STM0266 VF0974 SCI (Salmonella centrisome island)/SPI-6 T6SS Effector delivery system VFC0086 "The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1,
LFGR01000011.1_84 67.897 1.25E-127 IlpA VF0513 IlpA Adherence VFC0001 (IlpA) immunogenic lipoprotein A [IlpA (VF0513) - Adherence (VFC0001)] [Vibrio vulnificus YJ016] Vibrio vulnificus
LFGR01000011.1_101 64.721 5.61E-179 lpxB VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxB) lipid-A-disaccharide synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
LFGR01000011.1_102 67.939 4.76E-131 lpxA VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxA) UDP-N-acetylglucosamine acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
LFGR01000011.1_104 64.201 5.76E-159 lpxD VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxD) UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
LFGR01000011.1_207 77.303 0.0 lpxC VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (lpxC) UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
LFGR01000011.1_283 62.317 0.0 carB VF0558 Pyrimidine biosynthesis Nutritional/Metabolic factor VFC0272 CarB, CarA, and PyrB encode the large and small subunits of carbamoylphosphate synthetase and aspartate carbamoyl transferase, respectively. These enzymes catalyze the first two steps in the pyrimidine nucleotide biosynthetic pathway in many bacteria, including Francisella, and are required for the virulence of several pathogens, including Salmonella and E. coli (carB) carbamoyl phosphate synthase large subunit [Pyrimidine biosynthesis (VF0558) - Nutritional/Metabolic factor (VFC0272)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
LFGR01000011.1_419 72.352 0.0 cheD VF0394 Flagella Motility VFC0204 (cheD) methyl-accepting chemotaxis protein CheD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] Yersinia enterocolitica
LFGR01000011.1_538 100.0 0.0 srfJ VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (srfJ) type III secretion system Effector SrfJ, glucosylceramidase activity [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_539 100.0 4.7E-99 srfJ VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (srfJ) type III secretion system Effector SrfJ, glucosylceramidase activity [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_639 75.758 0.0 htpB VF0159 Hsp60 Adherence VFC0001 (htpB) Hsp60, 60K heat shock protein HtpB [Hsp60 (VF0159) - Adherence (VFC0001)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] Legionella pneumophila
LFGR01000011.1_675 100.0 4.18E-165 pmrA VF1355 PmrAB Regulation VFC0301 (pmrA) response regulator PmrA [PmrAB (VF1355) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_676 100.0 0.0 pmrB VF1355 PmrAB Regulation VFC0301 (pmrB) sensory kinase PmrB [PmrAB (VF1355) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_710 99.97 0.0 siiE VF0970 SiiE Adherence VFC0001 SiiE is located within Salmonella Pathogenicity Island SPI-4, a 27-kb region that carries six genes designated siiABCDEF. SiiC, SiiD, and SiiF form a type I secretion apparatus for the secretion of SiiE.;With 595 kDa, SiiE is the largest protein of the Salmonella proteome.;SiiE, like many other non-fimbrial adhesins binds to glycostructures at the cell surface. (siiE) non-fimbrial adhesin SiiE [SiiE (VF0970) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_711 100.0 0.0 siiE VF0970 SiiE Adherence VFC0001 SiiE is located within Salmonella Pathogenicity Island SPI-4, a 27-kb region that carries six genes designated siiABCDEF. SiiC, SiiD, and SiiF form a type I secretion apparatus for the secretion of SiiE.;With 595 kDa, SiiE is the largest protein of the Salmonella proteome.;SiiE, like many other non-fimbrial adhesins binds to glycostructures at the cell surface. (siiE) non-fimbrial adhesin SiiE [SiiE (VF0970) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_773 83.775 0.0 gtrB VF0124 LPS Immune modulation VFC0258 Composed of the O-antigen, core polysaccharides and lipid A; the genes involved in the biosynthesis of the basic O-antigen are located in the rfb/rfc loci; O-antigen modification is associated with temperate bacteriophages. Four different serotype-converting phages have been found: SfII, Sf6, SfV and SfX, which are involved in conversion of a serotype Y stain to serotypes 2a, 3b, 5a and X, respectively (gtrB) bactoprenol glucosyl transferase [LPS (VF0124) - Immune modulation (VFC0258)] [Shigella flexneri 2a str. 301] Shigella flexneri
LFGR01000011.1_798 61.827 0.0 icl VF0253 Isocitrate lyase Others VFC0346 (icl) Isocitrate lyase Icl (isocitrase) (isocitratase) [Isocitrate lyase (VF0253) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] Mycobacterium tuberculosis
LFGR01000011.1_821 100.0 0.0 sseK1 VF0947 TTSS-2 secreted effectors Effector delivery system VFC0086 (sseK1) type III secretion system effector SseK1, Arginine N-Glycosyltransferase [TTSS-2 secreted effectors (VF0947) - Effector delivery system (VFC0086)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_832 80.153 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
LFGR01000011.1_850 89.081 0.0 ibeC VF0237 Ibes Invasion VFC0083 IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. (ibeC) phosphoethanolamine transferase CptA [Ibes (VF0237) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] Escherichia coli (NMEC)
LFGR01000011.1_1053 65.476 1.89E-170 rffG VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rffG) dTDP-glucose 46-dehydratase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
LFGR01000011.1_1211 100.0 1.82E-167 mgtC VF1365 MgtC Nutritional/Metabolic factor VFC0272 An inner membrane protein; anti-virulence protein CigR inhibits the virulence functions of MgtC at early times inside macrophages (mgtC) Salmonella virulence protein MgtC [MgtC (VF1365) - Nutritional/Metabolic factor (VFC0272)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_1212 100.0 0.0 mgtB VF0106 MgtB Nutritional/Metabolic factor VFC0272 A magnesium transporter (mgtB) Mg2+ transport protein [MgtB (VF0106) - Nutritional/Metabolic factor (VFC0272)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_1218 100.0 0.0 misL VF0397 MisL Adherence VFC0001 MisL is located within Salmonella Pathogenicity Island SPI-3 (misL) putative autotransporter [MisL (VF0397) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_1266 63.714 1.96E-157 rfaF VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaF) ADP-heptose-LPS heptosyltransferase II [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
LFGR01000011.1_1267 75.0 2.92E-68 rfaD VF0044 LOS Immune modulation VFC0258 Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. (rfaD) ADP-L-glycero-D-mannoheptose-6-epimerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] Haemophilus influenzae
LFGR01000011.1_1342 100.0 6.02E-124 lpfA VF0105 Lpf Adherence VFC0001 Chaperone-usher assembly pathway (lpfA) long polar fimbria protein LpfA [Lpf (VF0105) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_1343 100.0 5.82E-173 lpfB VF0105 Lpf Adherence VFC0001 Chaperone-usher assembly pathway (lpfB) long polar fimbrial chaperone protein LpfB [Lpf (VF0105) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_1344 100.0 0.0 lpfC VF0105 Lpf Adherence VFC0001 Chaperone-usher assembly pathway (lpfC) long polar fimbrial usher protein LpfC [Lpf (VF0105) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_1345 100.0 0.0 lpfD VF0105 Lpf Adherence VFC0001 Chaperone-usher assembly pathway (lpfD) long polar fimbrial protein LpfD [Lpf (VF0105) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000011.1_1346 100.0 1.43E-130 lpfE VF0105 Lpf Adherence VFC0001 Chaperone-usher assembly pathway (lpfE) long polar fimbrial minor subunit LpfE, adhesin [Lpf (VF0105) - Adherence (VFC0001)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] Salmonella enterica (serovar typhimurium)
LFGR01000012.1_43 63.964 2.07E-101 rpe VF0543 Capsule Immune modulation VFC0258 Group 4 capsule; high molecular weight (HMW) O-antigen capsule (rpe) ribulose-phosphate 3-epimerase [Capsule (VF0543) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis
LFGR01000013.1_14 67.327 4.54E-100 vfr VF0082 Type IV pili Adherence VFC0001 PilA, B, C, D, E, F, M, N, O, P, Q, T, U, V, W, X, Y1, Y2, Z, and fimT, U, V are involved in the biogenesis and mechanical function of pili, pilG, H, I, K, chpA, B, C, D, E, pilS, R, fimS, rpoN, algR, algU, and vfr are involved in transcriptional regulation and chemosensory pathways that control the expression or activity of the twitching motility of the pili (vfr) cAMP-regulatory protein [Type IV pili (VF0082) - Adherence (VFC0001)] [Pseudomonas aeruginosa PAO1] Pseudomonas aeruginosa
LFGR01000013.1_36 79.847 0.0 tufA VF0460 EF-Tu Adherence VFC0001 (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] Francisella tularensis