| JUSZ01000026.1_46 |
62.876 |
0.0 |
KP1_RS17345 |
VF0560 |
Capsule |
Immune modulation |
VFC0258 |
The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. |
(KP1_RS17345) capsule assembly Wzi family protein [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000028.1_18 |
60.484 |
1.43E-108 |
entA |
VF0228 |
Enterobactin |
Nutritional/Metabolic factor |
VFC0272 |
An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three |
(entA) 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase EntA [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] |
Escherichia coli (UPEC) |
| JUSZ01000046.1_8 |
64.398 |
4.13E-89 |
algU |
VF0091 |
Alginate |
Biofilm |
VFC0271 |
Alginate production is frequently referred to as mucoidy because colonies producing alginate have a wet glistening (mucoid) appearance, which is very different from that of colonies not producing alginate; most of the alginate biosynthetic genes are clustered in the algD operon; Alginate production is highly regulated. Regulatory genes are located in two areas far removed from the biosynthetic genes, with one exception algC |
(algU) alginate biosynthesis protein AlgZ/FimS [Alginate (VF0091) - Biofilm (VFC0271)] [Pseudomonas aeruginosa PAO1] |
Pseudomonas aeruginosa |
| JUSZ01000046.1_13 |
61.3 |
1.04E-121 |
yplA |
VF0622 |
YplA |
Exotoxin |
VFC0235 |
Substrate of the flagellar TTS system, can additionally be secreted by the Ysa and Ysc TTS systems |
(yplA) DUF2974 domain-containing protein [YplA (VF0622) - Exotoxin (VFC0235)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000055.1_11 |
77.812 |
0.0 |
mgtB |
VF0106 |
MgtB |
Nutritional/Metabolic factor |
VFC0272 |
A magnesium transporter |
(mgtB) Mg2+ transport protein [MgtB (VF0106) - Nutritional/Metabolic factor (VFC0272)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| JUSZ01000060.1_1 |
74.347 |
0.0 |
rfbK1 |
VF0560 |
Capsule |
Immune modulation |
VFC0258 |
The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. |
(rfbK1) O9 family phosphomannomutase RfbK1 [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000060.1_17 |
71.618 |
0.0 |
KP1_RS17340 |
VF0560 |
Capsule |
Immune modulation |
VFC0258 |
The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. |
(KP1_RS17340) polysaccharide export protein [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000060.1_18 |
65.763 |
9.6E-142 |
galF |
VF0560 |
Capsule |
Immune modulation |
VFC0258 |
The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. |
(galF) GalU regulator GalF [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000060.1_19 |
72.069 |
8.92E-162 |
galU |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(galU) glucosephosphate uridylyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| JUSZ01000060.1_85 |
69.526 |
0.0 |
yagW/ecpD |
VF0404 |
ECP |
Adherence |
VFC0001 |
|
(yagW/ecpD) polymerized tip adhesin of ECP fibers [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] |
Escherichia coli (EHEC) |
| JUSZ01000060.1_86 |
63.942 |
0.0 |
yagX/ecpC |
VF0404 |
ECP |
Adherence |
VFC0001 |
|
(yagX/ecpC) E. coli common pilus usher EcpC [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] |
Escherichia coli (EHEC) |
| JUSZ01000060.1_87 |
64.904 |
4.69E-95 |
yagY/ecpB |
VF0404 |
ECP |
Adherence |
VFC0001 |
|
(yagY/ecpB) E. coli common pilus chaperone EcpB [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] |
Escherichia coli (EHEC) |
| JUSZ01000060.1_88 |
77.949 |
9.89E-110 |
yagZ/ecpA |
VF0404 |
ECP |
Adherence |
VFC0001 |
|
(yagZ/ecpA) E. coli common pilus structural subunit EcpA [ECP (VF0404) - Adherence (VFC0001)] [Escherichia coli O157:H7 str. EDL933] |
Escherichia coli (EHEC) |
| JUSZ01000061.1_12 |
66.421 |
5.67E-125 |
IlpA |
VF0513 |
IlpA |
Adherence |
VFC0001 |
|
(IlpA) immunogenic lipoprotein A [IlpA (VF0513) - Adherence (VFC0001)] [Vibrio vulnificus YJ016] |
Vibrio vulnificus |
| JUSZ01000062.1_4 |
60.687 |
6.7E-122 |
fepC |
VF0562 |
Ent |
Nutritional/Metabolic factor |
VFC0272 |
Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. |
(fepC) iron-enterobactin transporter ATP-binding protein [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000063.1_20 |
62.5 |
0.0 |
katA |
VF0168 |
KatAB |
Stress survival |
VFC0282 |
|
(katA) catalase/(hydro)peroxidase [KatAB (VF0168) - Stress survival (VFC0282)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] |
Legionella pneumophila |
| JUSZ01000066.1_1 |
75.0 |
5.11E-30 |
csrA |
VF0261 |
CsrA |
Regulation |
VFC0301 |
Belongs to a highly conserved family of global regulators that typically control stationary phase traits post-transcriptionally |
(csrA) carbon storage regulator CsrA [CsrA (VF0261) - Regulation (VFC0301)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] |
Legionella pneumophila |
| JUSZ01000073.1_9 |
89.726 |
1.11E-96 |
fur |
VF0113 |
Fur |
Regulation |
VFC0301 |
|
(fur) ferric iron uptake transcriptional regulator [Fur (VF0113) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| JUSZ01000074.1_1 |
69.799 |
0.0 |
iutA |
VF0565 |
Aerobactin |
Nutritional/Metabolic factor |
VFC0272 |
Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae |
(iutA) ferric aerobactin receptor IutA [Aerobactin (VF0565) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000074.1_15 |
79.688 |
3.55E-114 |
gmhA/lpcA |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(gmhA/lpcA) phosphoheptose isomerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| JUSZ01000076.1_29 |
63.988 |
2.34E-166 |
rffG |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(rffG) dTDP-glucose 46-dehydratase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| JUSZ01000076.1_30 |
66.552 |
6.34E-144 |
wbtL |
VF0542 |
LPS |
Immune modulation |
VFC0258 |
The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion |
(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| JUSZ01000077.1_8 |
74.194 |
4.27E-133 |
nueA |
VF0473 |
Polar flagella |
Motility |
VFC0204 |
Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments |
(nueA) NeuA protein [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119] |
Aeromonas hydrophila |
| JUSZ01000077.1_15 |
64.655 |
0.0 |
msbA |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(msbA) lipid transporter ATP-binding/permease [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| JUSZ01000085.1_9 |
94.444 |
8.92E-149 |
rcsB |
VF0571 |
RcsAB |
Regulation |
VFC0301 |
|
(rcsB) transcriptional regulator RcsB [RcsAB (VF0571) - Regulation (VFC0301)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000085.1_20 |
67.23 |
0.0 |
katA |
VF0454 |
KatA |
Stress survival |
VFC0282 |
|
(katA) catalase [KatA (VF0454) - Stress survival (VFC0282)] [Neisseria meningitidis MC58] |
Neisseria meningitidis |
| JUSZ01000086.1_59 |
62.222 |
2.19E-144 |
pvcA |
VF0094 |
Pyoverdine |
Nutritional/Metabolic factor |
VFC0272 |
A greenish-yellow compound, a hydroxyquinolone chromophore to which an amino acid tail is attached, the tail can vary in length; the synthesis of pyoverdine requires a special sigma factor, PvdS, which is in turn regulated by the Fur repressor; also called pseudobactin |
(pvcA) paerucumarin biosynthesis protein PvcA [Pyoverdine (VF0094) - Nutritional/Metabolic factor (VFC0272)] [Pseudomonas aeruginosa PAO1] |
Pseudomonas aeruginosa |
| JUSZ01000086.1_117 |
75.658 |
4.93E-179 |
lpxC |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lpxC) UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| JUSZ01000086.1_175 |
94.88 |
0.0 |
rpoS |
VF0112 |
RpoS |
Regulation |
VFC0301 |
|
(rpoS) RNA polymerase sigma factor RpoS [RpoS (VF0112) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| JUSZ01000089.1_55 |
64.943 |
5.32E-163 |
rfaF |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(rfaF) ADP-heptose-LPS heptosyltransferase II [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| JUSZ01000089.1_56 |
81.433 |
0.0 |
rfaD |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(rfaD) ADP-L-glycero-D-mannoheptose-6-epimerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| JUSZ01000090.1_137 |
71.674 |
0.0 |
rfaE |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(rfaE) ADP-heptose synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| JUSZ01000091.1_3 |
66.216 |
2.17E-29 |
aprA |
VF0090 |
Alkaline protease |
Exoenzyme |
VFC0251 |
Secreted by type I secretion pathway |
(aprA) alkaline metalloproteinase precursor [Alkaline protease (VF0090) - Exoenzyme (VFC0251)] [Pseudomonas aeruginosa PAO1] |
Pseudomonas aeruginosa |
| JUSZ01000091.1_76 |
61.66 |
1.02E-113 |
shuV |
VF0256 |
Shu |
Nutritional/Metabolic factor |
VFC0272 |
Heme utilization genes have been identified in numerous pathogens, including E. coli O157:H7, Yersinia pestis, Yersinia enterocolitica, Vibrio cholerae, Haemophilus influenzae, Neisseria meningitidis, etc.; Two heme-uptake systems:; (1) direct binding of heme or heme-containing proteins to specific outer membrane receptors; (2) secretion of hemophores to interact with the hemoproteins and present it to specific receptors |
(shuV) ATP-binding component of hemin transport system [Shu (VF0256) - Nutritional/Metabolic factor (VFC0272)] [Shigella dysenteriae Sd197] |
Shigella dysenteriae |
| JUSZ01000091.1_77 |
64.052 |
2.21E-132 |
chuU |
VF0234 |
Chu |
Nutritional/Metabolic factor |
VFC0272 |
ChuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains |
(chuU) heme permease protein ChuU [Chu (VF0234) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli O157:H7 str. EDL933] |
Escherichia coli (EHEC) |
| JUSZ01000091.1_79 |
62.059 |
1.53E-158 |
chuS |
VF0227 |
Chu |
Nutritional/Metabolic factor |
VFC0272 |
ChuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains |
(chuS) heme oxygenase ChuS [Chu (VF0227) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] |
Escherichia coli (UPEC) |
| JUSZ01000091.1_80 |
68.331 |
0.0 |
chuA |
VF0234 |
Chu |
Nutritional/Metabolic factor |
VFC0272 |
ChuA encodes for a 69-kDa outer membrane protein responsible for heme uptake. The chuA nucleotide sequence shows high homology to shuA gene of S. dysenteriae type 1. The gene is part of a larger locus, termed the heme transport locus, which appears to be widely distributed among pathogenic E. coli strains |
(chuA) Outer membrane heme/hemoglobin receptor ChuA [Chu (VF0234) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli O157:H7 str. EDL933] |
Escherichia coli (EHEC) |
| JUSZ01000093.1_75 |
89.126 |
0.0 |
gndA |
VF0560 |
Capsule |
Immune modulation |
VFC0258 |
The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. |
(gndA) NADP-dependent phosphogluconate dehydrogenase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000093.1_82 |
76.044 |
0.0 |
rfbK1 |
VF0560 |
Capsule |
Immune modulation |
VFC0258 |
The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. |
(rfbK1) O9 family phosphomannomutase RfbK1 [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000093.1_83 |
70.701 |
0.0 |
KP1_RS17280 |
VF0560 |
Capsule |
Immune modulation |
VFC0258 |
The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. |
(KP1_RS17280) mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000093.1_84 |
64.985 |
2.09E-165 |
galE |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(galE) UDP-glucose 4-epimerase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| JUSZ01000010.1_26 |
62.338 |
2.99E-28 |
acpXL |
VF0367 |
LPS |
Immune modulation |
VFC0258 |
Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. |
(acpXL) acyl carrier protein [LPS (VF0367) - Immune modulation (VFC0258)] [Brucella melitensis bv. 1 str. 16M] |
Brucella melitensis |
| JUSZ01000010.1_27 |
79.918 |
1.73E-144 |
flmH |
VF0473 |
Polar flagella |
Motility |
VFC0204 |
Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments |
(flmH) short chain dehydrogenase/reductase family oxidoreductase [Polar flagella (VF0473) - Motility (VFC0204)] [Aeromonas hydrophila ML09-119] |
Aeromonas hydrophila |
| JUSZ01000103.1_116 |
62.805 |
1.95E-73 |
sodCI |
VF0109 |
SodCI |
Stress survival |
VFC0282 |
Encoded on the lysogenic phage Gifsy-2 |
(sodCI) Gifsy-2 prophage: superoxide dismutase precursor (Cu-Zn) [SodCI (VF0109) - Stress survival (VFC0282)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| JUSZ01000103.1_129 |
69.11 |
6.58E-101 |
sodB |
VF0169 |
SodB |
Stress survival |
VFC0282 |
|
(sodB) superoxide dismutase [SodB (VF0169) - Stress survival (VFC0282)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] |
Legionella pneumophila |
| JUSZ01000111.1_88 |
60.699 |
5.7E-83 |
mgtC |
VF1365 |
MgtC |
Nutritional/Metabolic factor |
VFC0272 |
An inner membrane protein; anti-virulence protein CigR inhibits the virulence functions of MgtC at early times inside macrophages |
(mgtC) Salmonella virulence protein MgtC [MgtC (VF1365) - Nutritional/Metabolic factor (VFC0272)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| JUSZ01000112.1_17 |
75.568 |
0.0 |
htpB |
VF0159 |
Hsp60 |
Adherence |
VFC0001 |
|
(htpB) Hsp60, 60K heat shock protein HtpB [Hsp60 (VF0159) - Adherence (VFC0001)] [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] |
Legionella pneumophila |
| JUSZ01000114.1_2 |
76.302 |
0.0 |
cheD |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(cheD) methyl-accepting chemotaxis protein CheD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000114.1_3 |
94.512 |
1.11E-109 |
cheW |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(cheW) purine-binding chemotaxis protein CheW [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000114.1_4 |
81.057 |
0.0 |
cheA |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(cheA) chemotaxis protein CheA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000114.1_5 |
75.076 |
0.0 |
motB |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(motB) flagellar motor protein MotB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000114.1_6 |
91.837 |
0.0 |
motA |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(motA) flagellar motor protein MotA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000114.1_7 |
89.119 |
1.9E-131 |
flhC |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flhC) flagellar biosynthesis transcription activator FlhC [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000114.1_8 |
86.207 |
8.26E-62 |
flhD |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flhD) flagellar transcriptional activator FlhD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000114.1_26 |
72.84 |
2.56E-90 |
hsiB1/vipA/tssB |
VF0334 |
HSI-1 |
Effector delivery system |
VFC0086 |
HSI-1 is highly homologous to a group of genes found in many Gram-negative proteobacteria that have been termed the IcmF-associated homologous protein (IAHP) cluster and encodes a secretory system that may play a general role in mediating host interaction |
(hsiB1/vipA/tssB) type VI secretion system tubule-forming protein VipA [HSI-1 (VF0334) - Effector delivery system (VFC0086)] [Pseudomonas aeruginosa PAO1] |
Pseudomonas aeruginosa |
| JUSZ01000114.1_27 |
74.104 |
0.0 |
STM0274 |
VF0974 |
SCI (Salmonella centrisome island)/SPI-6 T6SS |
Effector delivery system |
VFC0086 |
"The T6SS is widely distributed in all Salmonella species and subspecies.; Salmonella T6SSs are located on five different Salmonella pathogenicity island and phylogenetically belong to i1, |
|
|
| JUSZ01000114.1_40 |
62.21 |
0.0 |
clpV1 |
VF0334 |
HSI-1 |
Effector delivery system |
VFC0086 |
HSI-1 is highly homologous to a group of genes found in many Gram-negative proteobacteria that have been termed the IcmF-associated homologous protein (IAHP) cluster and encodes a secretory system that may play a general role in mediating host interaction |
(clpV1) type VI secretion system AAA+ family ATPase [HSI-1 (VF0334) - Effector delivery system (VFC0086)] [Pseudomonas aeruginosa PAO1] |
Pseudomonas aeruginosa |
| JUSZ01000115.1_20 |
74.854 |
5.34E-96 |
luxS |
VF0406 |
AI-2 |
Biofilm |
VFC0271 |
AI-2 is produced and detected by a wide variety of bacteria and is presumed to facilitate interspecies communications. |
(luxS) S-ribosylhomocysteinase [AI-2 (VF0406) - Biofilm (VFC0271)] [Vibrio cholerae O1 biovar El Tor str. N16961] |
Vibrio cholerae |
| JUSZ01000117.1_31 |
65.395 |
0.0 |
KP1_RS17340 |
VF0560 |
Capsule |
Immune modulation |
VFC0258 |
The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. |
(KP1_RS17340) polysaccharide export protein [Capsule (VF0560) - Immune modulation (VFC0258)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000117.1_64 |
84.615 |
7.9E-109 |
fliZ |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliZ) alternative sigma factor regulatory protein [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_65 |
90.0 |
6.67E-159 |
fliA |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliA) flagellar biosynthesis sigma factor [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_68 |
80.153 |
1.32E-74 |
fliS |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliS) flagellar protein FliS [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_75 |
70.192 |
5.73E-47 |
fliE |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliE) flagellar hook-basal body complex protein FliE [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_76 |
72.487 |
0.0 |
fliF |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliF) flagellar M-ring protein FliF [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_77 |
88.485 |
0.0 |
fliG |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliG) flagellar motor switch protein G [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_78 |
67.083 |
5.87E-114 |
fliH |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliH) flagellar assembly protein H [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_79 |
90.044 |
0.0 |
fliI |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliI) flagellum-specific ATP synthase FliI [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_80 |
72.297 |
2.07E-72 |
fliJ |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliJ) flagellar protein FliJ [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_82 |
73.292 |
6.15E-72 |
fliL |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliL) flagellar basal body protein FliL [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_83 |
93.114 |
0.0 |
fliM |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliM) flagellar motor switch protein FliM [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_84 |
89.855 |
5.77E-87 |
fliN |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliN) flagellar motor switch protein FliN [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_85 |
72.5 |
2.51E-49 |
fliO |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliO) flagellar protein FliO [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_86 |
91.775 |
9.84E-153 |
fliP |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliP) flagellar biosynthetic protein FliP [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_87 |
86.517 |
7.05E-42 |
fliQ |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliQ) flagellar biosynthetic protein FliQ [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_88 |
79.457 |
3.18E-130 |
fliR |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(fliR) flagellar biosynthetic protein FliR [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_92 |
64.11 |
1.55E-150 |
flgL |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgL) flagellar hook-associated protein 3 FlgL [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_93 |
71.429 |
0.0 |
flgK |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgK) flagellar hook-associated protein 1 FlgK [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_94 |
78.75 |
0.0 |
flgJ |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgJ) <beta>-N-acetylglucosaminidase [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_95 |
87.5 |
0.0 |
flgI |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgI) flagellar P-ring protein precursor FlgI [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_96 |
88.938 |
4.11E-142 |
flgH |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgH) flagellar L-ring protein precursor FlgH [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_97 |
91.538 |
1.67E-176 |
flgG |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgG) flagellar basal-body rod protein FlgG [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_98 |
78.884 |
3.39E-149 |
flgF |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgF) flagellar basal-body rod protein FlgF [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_99 |
68.019 |
0.0 |
flgE |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgE) flagellar hook protein FlgE [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_100 |
75.5 |
2.64E-107 |
flgD |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgD) flagellar basal-body rod modification protein FlgD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_101 |
91.045 |
9.93E-90 |
flgC |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgC) flagellar basal-body rod protein FlgC [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_102 |
85.401 |
1.85E-86 |
flgB |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgB) flagellar basal-body rod protein FlgB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_104 |
64.286 |
1.52E-35 |
flgM |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flgM) negative regulator of flagellin synthesis [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_110 |
88.439 |
0.0 |
flhA |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flhA) flagellar biosynthesis protein FlhA [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_111 |
79.112 |
0.0 |
flhB |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(flhB) flagellar biosynthetic protein FlhB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_112 |
84.579 |
1.13E-123 |
cheZ |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(cheZ) chemotaxis regulator CheZ [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_113 |
93.798 |
1.42E-86 |
cheY |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(cheY) chemotaxis regulatory protein CheY [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_114 |
90.258 |
0.0 |
cheB |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(cheB) chemotaxis-specific methylesterase CheB [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_115 |
87.273 |
4.45E-178 |
cheR |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(cheR) chemotaxis methyltransferase CheR [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000117.1_116 |
80.184 |
1.07E-99 |
cheD |
VF0394 |
Flagella |
Motility |
VFC0204 |
|
(cheD) methyl-accepting chemotaxis protein CheD [Flagella (VF0394) - Motility (VFC0204)] [Yersinia enterocolitica subsp. enterocolitica 8081] |
Yersinia enterocolitica |
| JUSZ01000122.1_7 |
65.815 |
0.0 |
acrB |
VF0568 |
AcrAB |
Antimicrobial activity/Competitive advantage |
VFC0325 |
|
(acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000124.1_40 |
72.759 |
9.27E-164 |
galU |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(galU) glucosephosphate uridylyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| JUSZ01000128.1_22 |
60.148 |
4.34E-118 |
IlpA |
VF0513 |
IlpA |
Adherence |
VFC0001 |
|
(IlpA) immunogenic lipoprotein A [IlpA (VF0513) - Adherence (VFC0001)] [Vibrio vulnificus YJ016] |
Vibrio vulnificus |
| JUSZ01000128.1_58 |
80.919 |
2.15E-177 |
kdsA |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| JUSZ01000128.1_78 |
62.474 |
0.0 |
phoQ |
VF0111 |
PhoPQ |
Regulation |
VFC0301 |
|
(phoQ) sensor protein PhoQ [PhoPQ (VF0111) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| JUSZ01000128.1_79 |
82.96 |
6.81E-140 |
phoP |
VF0111 |
PhoPQ |
Regulation |
VFC0301 |
|
(phoP) response regulator in two-component regulatory system with PhoQ [PhoPQ (VF0111) - Regulation (VFC0301)] [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] |
Salmonella enterica (serovar typhimurium) |
| JUSZ01000129.1_130 |
70.103 |
8.76E-104 |
clpP |
VF0074 |
ClpP |
Stress survival |
VFC0282 |
21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes |
(clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] |
Listeria monocytogenes |
| JUSZ01000129.1_154 |
64.898 |
0.0 |
exeE |
VF0478 |
Exe T2SS |
Effector delivery system |
VFC0086 |
|
(exeE) general secretory pathway protein E [Exe T2SS (VF0478) - Effector delivery system (VFC0086)] [Aeromonas hydrophila ML09-119] |
Aeromonas hydrophila |
| JUSZ01000129.1_156 |
70.803 |
7.98E-72 |
exeG |
VF0478 |
Exe T2SS |
Effector delivery system |
VFC0086 |
|
(exeG) general secretion pathway protein G [Exe T2SS (VF0478) - Effector delivery system (VFC0086)] [Aeromonas hydrophila ML09-119] |
Aeromonas hydrophila |
| JUSZ01000129.1_175 |
84.637 |
0.0 |
acrB |
VF0568 |
AcrAB |
Antimicrobial activity/Competitive advantage |
VFC0325 |
|
(acrB) acriflavine resistance protein B [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000129.1_176 |
78.553 |
0.0 |
acrA |
VF0568 |
AcrAB |
Antimicrobial activity/Competitive advantage |
VFC0325 |
|
(acrA) acriflavine resistance protein A [AcrAB (VF0568) - Antimicrobial activity/Competitive advantage (VFC0325)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000129.1_212 |
65.038 |
3.54E-128 |
allR |
VF0572 |
Allantion utilization |
Nutritional/Metabolic factor |
VFC0272 |
An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. |
(allR) DNA-binding transcriptional repressor AllR [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000129.1_220 |
68.059 |
0.0 |
allC |
VF0572 |
Allantion utilization |
Nutritional/Metabolic factor |
VFC0272 |
An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. |
(allC) allantoate amidohydrolase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000129.1_221 |
71.264 |
0.0 |
allD |
VF0572 |
Allantion utilization |
Nutritional/Metabolic factor |
VFC0272 |
An allantoin utilization operon has been associated with hypervirulent K. pneumoniae strains that cause pyogenic liver abscesses. |
(allD) ureidoglycolate dehydrogenase [Allantion utilization (VF0572) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000154.1_1 |
79.74 |
0.0 |
tufA |
VF0460 |
EF-Tu |
Adherence |
VFC0001 |
|
(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| JUSZ01000158.1_4 |
74.648 |
2.02E-160 |
entB |
VF0562 |
Ent |
Nutritional/Metabolic factor |
VFC0272 |
Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. |
(entB) 2,3-dihydro-2,3-dihydroxybenzoate synthetase, isochroismatase [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000158.1_5 |
72.881 |
0.0 |
entE |
VF0228 |
Enterobactin |
Nutritional/Metabolic factor |
VFC0272 |
An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three |
(entE) 2,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] |
Escherichia coli (UPEC) |
| JUSZ01000158.1_7 |
66.259 |
1.78E-162 |
entS |
VF0228 |
Enterobactin |
Nutritional/Metabolic factor |
VFC0272 |
An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three |
(entS) enterobactin exporter, iron-regulated [Enterobactin (VF0228) - Nutritional/Metabolic factor (VFC0272)] [Escherichia coli CFT073] |
Escherichia coli (UPEC) |
| JUSZ01000158.1_8 |
60.538 |
0.0 |
entF |
VF0562 |
Ent |
Nutritional/Metabolic factor |
VFC0272 |
Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. |
(entF) enterobactin synthase subunit F [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000158.1_11 |
69.525 |
0.0 |
fepA |
VF0562 |
Ent |
Nutritional/Metabolic factor |
VFC0272 |
Various iron acquisition systems in Klebsiella are needed to overcome host defenses in different anatomical compartments. |
(fepA) outer membrane receptor FepA [Ent (VF0562) - Nutritional/Metabolic factor (VFC0272)] [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044] |
Klebsiella pneumoniae |
| JUSZ01000159.1_126 |
63.964 |
3.3E-100 |
rpe |
VF0543 |
Capsule |
Immune modulation |
VFC0258 |
Group 4 capsule; high molecular weight (HMW) O-antigen capsule |
(rpe) ribulose-phosphate 3-epimerase [Capsule (VF0543) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| JUSZ01000159.1_150 |
66.832 |
4.84E-100 |
vfr |
VF0082 |
Type IV pili |
Adherence |
VFC0001 |
PilA, B, C, D, E, F, M, N, O, P, Q, T, U, V, W, X, Y1, Y2, Z, and fimT, U, V are involved in the biogenesis and mechanical function of pili, pilG, H, I, K, chpA, B, C, D, E, pilS, R, fimS, rpoN, algR, algU, and vfr are involved in transcriptional regulation and chemosensory pathways that control the expression or activity of the twitching motility of the pili |
(vfr) cAMP-regulatory protein [Type IV pili (VF0082) - Adherence (VFC0001)] [Pseudomonas aeruginosa PAO1] |
Pseudomonas aeruginosa |
| JUSZ01000159.1_178 |
79.245 |
1.31E-24 |
tufA |
VF0460 |
EF-Tu |
Adherence |
VFC0001 |
|
(tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| JUSZ01000166.1_33 |
64.985 |
1.17E-158 |
lpxD |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lpxD) UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| JUSZ01000166.1_35 |
67.176 |
3.33E-129 |
lpxA |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lpxA) UDP-N-acetylglucosamine acyltransferase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| JUSZ01000166.1_36 |
61.88 |
6.53E-175 |
lpxB |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(lpxB) lipid-A-disaccharide synthase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |
| JUSZ01000167.1_18 |
71.678 |
0.0 |
ibeB |
VF0237 |
Ibes |
Invasion |
VFC0083 |
IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. |
(ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC [Ibes (VF0237) - Invasion (VFC0083)] [Escherichia coli O45:K1:H7 str. S88] |
Escherichia coli (NMEC) |
| JUSZ01000176.1_3 |
60.422 |
0.0 |
icl |
VF0253 |
Isocitrate lyase |
Others |
VFC0346 |
|
(icl) Isocitrate lyase Icl (isocitrase) (isocitratase) [Isocitrate lyase (VF0253) - Others (VFC0346)] [Mycobacterium tuberculosis H37Rv] |
Mycobacterium tuberculosis |
| JUSZ01000183.1_27 |
74.444 |
0.0 |
ompA |
VF0236 |
OmpA |
Invasion |
VFC0083 |
Major outer membrane protein in E. coli, homologous to Neisseria Opa proteins which have been shown to be involved in invasion of eukaryotic cells |
(ompA) outer membrane protein A [OmpA (VF0236) - Invasion (VFC0083)] [Escherichia coli O18:K1:H7 str. RS218] |
Escherichia coli (NMEC) |
| JUSZ01000016.1_7 |
66.781 |
8.12E-146 |
wbtL |
VF0542 |
LPS |
Immune modulation |
VFC0258 |
The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion |
(wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] |
Francisella tularensis |
| JUSZ01000016.1_8 |
63.582 |
1.31E-167 |
rffG |
VF0044 |
LOS |
Immune modulation |
VFC0258 |
Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. |
(rffG) dTDP-glucose 46-dehydratase [LOS (VF0044) - Immune modulation (VFC0258)] [Haemophilus influenzae Rd KW20] |
Haemophilus influenzae |