| ORF_ID | Pass_Bitscore | Best_Hit_Bitscore | Best_Hit_ARO | Best_Identities | ARO | Model_type | SNPs_in_Best_Hit_ARO | Other_SNPs | Drug class | Resistance mechanism | AMR gene family | Description |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| JFOH01000001.1_232 # 245377 # 246024 | 50.0 | 100.908 | vanY gene in vanF cluster | 40.58 | ARO:3002958 | protein homolog model | glycopeptide antibiotic | antibiotic target alteration | vanY; glycopeptide resistance gene cluster | Also known as vanYF, is a vanY variant found in the vanF gene cluster. | ||
| JFOH01000022.1_91 # 95540 # 97459 | 300.0 | 1305.81 | tet(M) | 98.9 | ARO:3000186 | protein homolog model | tetracycline antibiotic | antibiotic target protection | tetracycline-resistant ribosomal protection protein | Tet(M) is a ribosomal protection protein that confers tetracycline resistance. It is found on transposable DNA elements and its horizontal transfer between bacterial species has been documented. | ||
| JFOH01000022.1_175 # 192938 # 194197 | 50.0 | 97.0561 | vanW gene in vanI cluster | 27.39 | ARO:3003724 | protein homolog model | glycopeptide antibiotic | antibiotic target alteration | vanW; glycopeptide resistance gene cluster | Also known as vanWI, is a vanW variant found in the vanI gene cluster. | ||
| JFOH01000024.1_48 # 46501 # 47658 | 175.0 | 207.223 | vanT gene in vanG cluster | 34.78 | ARO:3002972 | protein homolog model | glycopeptide antibiotic | antibiotic target alteration | glycopeptide resistance gene cluster; vanT | Also known as vanTG, is a vanT variant found in the vanG gene cluster. | ||
| JFOH01000046.1_72 # 88477 # 89214 | 400.0 | 489.189 | ErmB | 97.96 | ARO:3000375 | protein homolog model | macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic | antibiotic target alteration | Erm 23S ribosomal RNA methyltransferase | ErmB confers the MLSb phenotype. Similar to ErmC, expression of ErmB is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmB. | ||
| JFOH01000046.1_77 # 92098 # 93537 | 900.0 | 969.148 | AAC(6')-Ie-APH(2'')-Ia bifunctional protein | 100.0 | ARO:3002597 | protein homolog model | aminoglycoside antibiotic | antibiotic inactivation | aminoglycoside bifunctional resistance protein | AAC(6')-Ie-APH(2'')-Ia is an aminoglycoside acetyltransferase encoded by plasmids and transposons in S. aureus, E. faecalis, E. faecium and Staphylococcus warneri. | ||
| JFOH01000047.1_45 # 47096 # 48034 | 550.0 | 602.438 | CDD-2 | 96.15 | ARO:3006905 | protein homolog model | carbapenem | antibiotic inactivation | CDD beta-lactamase | CDD-2 is a CDD beta-lactamase. | ||
| JFOH01000055.1_45 # 51580 # 53049 | 50.0 | 134.806 | vanW gene in vanI cluster | 33.76 | ARO:3003724 | protein homolog model | glycopeptide antibiotic | antibiotic target alteration | vanW; glycopeptide resistance gene cluster | Also known as vanWI, is a vanW variant found in the vanI gene cluster. | ||
| JFOH01000055.1_114 # 126722 # 128047 | 810.0 | 851.277 | cdeA | 98.41 | ARO:3003835 | protein homolog model | fluoroquinolone antibiotic; disinfecting agents and antiseptics | antibiotic efflux | multidrug and toxic compound extrusion (MATE) transporter | Clostridioides difficile and Escherichia coli multidrug efflux transporter with antiporter function. Confers resistance to fluoroquinolones in E. coli and acriflavin in Clostridioides difficile. | ||
| JFOH01000008.1_55 # 60529 # 61245 | 50.0 | 116.701 | vanY gene in vanG cluster | 36.45 | ARO:3002959 | protein homolog model | glycopeptide antibiotic | antibiotic target alteration | vanY; glycopeptide resistance gene cluster | Also known as vanYG, is a vanY variant found in the vanG gene cluster. |
| Query_id | %Identity | E-value | Related genes | VF ID | Virulence factor | VFcategory | VFcategoryID | Characteristics | Description | Strain |
|---|---|---|---|---|---|---|---|---|---|---|
| JFOH01000010.1_89 | 89.821 | 0.0 | CD3246 | VF0599 | CD3246 | Adherence | VFC0001 | Cell surface protein cleaved and covalently anchored to m-DAP in the peptidoglycan by SrtB | (CD3246) Cys-Gln thioester bond-forming surface protein [CD3246 (VF0599) - Adherence (VFC0001)] [Clostridium difficile 630] | Clostridium difficile |
| JFOH01000010.1_152 | 69.43 | 7.02E-101 | clpP | VF0074 | ClpP | Stress survival | VFC0282 | 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes | (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] | Listeria monocytogenes |
| JFOH01000011.1_42 | 65.263 | 1.37E-92 | clpP | VF0074 | ClpP | Stress survival | VFC0282 | 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes | (clpP) ATP-dependent Clp protease proteolytic subunit [ClpP (VF0074) - Stress survival (VFC0282)] [Listeria monocytogenes EGD-e] | Listeria monocytogenes |
| JFOH01000003.1_40 | 85.032 | 0.0 | cbpA | VF0592 | CbpA | Adherence | VFC0001 | MSCRAMMs have a common surface localization that in Gram-positive bacteria is usually mediated by a cell wall sorting signal through which they are covalently anchored to the cell wall peptidoglycan by sortase. | (cbpA) collagen-binding adhesin CbpA [CbpA (VF0592) - Adherence (VFC0001)] [Clostridium difficile 630] | Clostridium difficile |
| JFOH01000036.1_179 | 98.235 | 0.0 | CD0873 | VF0593 | CD0873 | Adherence | VFC0001 | Numerous bacterial adhesins also characterized as lipoproteins, similar to CD0873, including the adhesin PsaA, a solute-binding lipoprotein of the Mn2+ ABC transporter of S. pneumoniae; CD0873 is annotated as a substrate-binding protein component SBP of an ABC transporter and is an immunoreactive protein in human infection | (CD0873) ABC transporter substrate-binding protein [CD0873 (VF0593) - Adherence (VFC0001)] [Clostridium difficile 630] | Clostridium difficile |
| JFOH01000037.1_80 | 60.833 | 5.77E-169 | cps4I | VF0144 | Capsule | Immune modulation | VFC0258 | Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages | (cps4I) capsular polysaccharide biosynthesis protein Cps4I [Capsule (VF0144) - Immune modulation (VFC0258)] [Streptococcus pneumoniae TIGR4] | Streptococcus pneumoniae |
| JFOH01000039.1_1 | 79.57 | 7.75E-50 | tufA | VF0460 | EF-Tu | Adherence | VFC0001 | (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] | Francisella tularensis | |
| JFOH01000040.1_69 | 99.377 | 0.0 | cwp84 | VF0590 | Cwp84 | Exoenzyme | VFC0251 | (cwp84) cell wall-binding cysteine protease Cwp84 [Cwp84 (VF0590) - Exoenzyme (VFC0251)] [Clostridium difficile 630] | Clostridium difficile | |
| JFOH01000040.1_71 | 78.852 | 0.0 | cwp66 | VF0591 | Cwp66 | Adherence | VFC0001 | (cwp66) cell wall-binding protein Cwp66 [Cwp66 (VF0591) - Adherence (VFC0001)] [Clostridium difficile 630] | Clostridium difficile | |
| JFOH01000040.1_114 | 99.091 | 2.98E-164 | zmp1 | VF0600 | Zmp1 | Exoenzyme | VFC0251 | (zmp1) zinc metalloprotease Zmp1 [Zmp1 (VF0600) - Exoenzyme (VFC0251)] [Clostridium difficile 630] | Clostridium difficile | |
| JFOH01000040.1_115 | 94.468 | 0.0 | CD2831 | VF0598 | CD2831 | Adherence | VFC0001 | Cell surface protein cleaved and covalently anchored to m-DAP in the peptidoglycan by SrtB | (CD2831) SrtB-anchored collagen-binding adhesin [CD2831 (VF0598) - Adherence (VFC0001)] [Clostridium difficile 630] | Clostridium difficile |
| JFOH01000042.1_1 | 79.57 | 7.75E-50 | tufA | VF0460 | EF-Tu | Adherence | VFC0001 | (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] | Francisella tularensis | |
| JFOH01000042.1_15 | 75.532 | 1.88E-46 | tufA | VF0460 | EF-Tu | Adherence | VFC0001 | (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] | Francisella tularensis | |
| JFOH01000050.1_37 | 98.816 | 0.0 | fbpA/fbp68 | VF0595 | FbpA/Fbp68 | Adherence | VFC0001 | Fibronectin is a dimeric glycoprotein (~440 kDa) which is present in a soluble form in plasma and in an immobilized form on cell surfaces and in extracellular matrix. It is an important target for bacterial attachment in many pathogens, such as S. pyogenes, S. pneumoniae and L. monocytogenes, where fibronectin-binding proteins are important virulence factors. | (fbpA/fbp68) fibronectin-binding protein FbpA [FbpA/Fbp68 (VF0595) - Adherence (VFC0001)] [Clostridium difficile 630] | Clostridium difficile |
| JFOH01000051.1_84 | 99.631 | 0.0 | groEL | VF0594 | GroEL | Adherence | VFC0001 | GroEL of numerous bacteria, such as L. pneumophila, H. pylori, H. ducreyi, M. avium, S. typhimurium, A. actinomycetemcomitans and B. burgdorferi, has been shown to be involved in adhesion or invasion of various target cells or tissues. | (groEL) chaperonin GroEL [GroEL (VF0594) - Adherence (VFC0001)] [Clostridium difficile 630] | Clostridium difficile |
| JFOH01000051.1_145 | 61.565 | 2.24E-132 | wbtL | VF0542 | LPS | Immune modulation | VFC0258 | The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion | (wbtL) glucose-1-phosphate thymidylyltransferase [LPS (VF0542) - Immune modulation (VFC0258)] [Francisella tularensis subsp. tularensis SCHU S4] | Francisella tularensis |
| JFOH01000052.1_41 | 75.532 | 1.88E-46 | tufA | VF0460 | EF-Tu | Adherence | VFC0001 | (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] | Francisella tularensis | |
| JFOH01000053.1_21 | 62.93 | 0.0 | cwp84 | VF0590 | Cwp84 | Exoenzyme | VFC0251 | (cwp84) cell wall-binding cysteine protease Cwp84 [Cwp84 (VF0590) - Exoenzyme (VFC0251)] [Clostridium difficile 630] | Clostridium difficile | |
| JFOH01000061.1_1 | 74.559 | 0.0 | tufA | VF0460 | EF-Tu | Adherence | VFC0001 | (tufA) elongation factor Tu [EF-Tu (VF0460) - Adherence (VFC0001)] [Francisella tularensis subsp. tularensis SCHU S4] | Francisella tularensis | |
| JFOH01000062.1_2 | 69.322 | 2.0E-175 | CD0873 | VF0593 | CD0873 | Adherence | VFC0001 | Numerous bacterial adhesins also characterized as lipoproteins, similar to CD0873, including the adhesin PsaA, a solute-binding lipoprotein of the Mn2+ ABC transporter of S. pneumoniae; CD0873 is annotated as a substrate-binding protein component SBP of an ABC transporter and is an immunoreactive protein in human infection | (CD0873) ABC transporter substrate-binding protein [CD0873 (VF0593) - Adherence (VFC0001)] [Clostridium difficile 630] | Clostridium difficile |