Mycobacterium tuberculosis PanR0603
Protein-related phenotypes
Virulence Factors
No data
PcaA
Cyclopropane synthase that incorporates a single proximal cycloproprane ring on the <alpha>-mycolic acids and the production of cord factor in the cell wall; Required for virulence and persistance
Inhibition of cyclopropanation of cell wall mycolic acid can result in a change in lipid fluidity and cell wall permeability, and therefore a change in resistance to reactive oxygen intermediates (ROIs) and reactive nitrogen intermediates (RNIs)
MmaA4
Methyltransferase forms methoxy and keto derivatives of the meromycolic acid chain
Hypothetical protein
Glutamate racemase
PDIM (phthiocerol dimycocerosate)
Play a mainly structural role in providing a stable base for the insertion of other lipid and also play a role as a fluidity modifier, whose function could be to modulate cell wall viscosity
Antigen 85
Mycolyltransferase activity that transfer long-chain mycolic acids to trehalose derivatives (i.e., cord factor, a toxic glycolipid consisting of two mycolic acid molecules linked to trehalose by the hydroxyl groups of carbons 6 and 6' --> trehalose 6,6'-dimycolate (TDM), is an important immunomodulatory component of the cell wall), pivotal for the biosynthesis of the mycobacterial cell wall and for the survival of mycobacteria; Binds the cell matrix protein fibronectin thereby enhancing the uptake of mycobacteria macrophages via complement-mediated phagocytosis
Possible conserved protein cpsA
No data
Myo-inositol-1-phosphate synthase ino1 (inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (glucose 6-phosphate cyclase) (glucocycloaldolase)
Acyl-CoA synthetase
Probable conserved lipoprotein lpqt
Probable polyketide synthase pks12
No data
Hypothetical protein
Nitrate reductase
Nitrate respiration helps the bacteria to survive in O2-depleted areas of inflammatory or necrotic tissue
Probable hydrolase
Probable precorrin-6y methyltransferase CobL
Coproporphyrinogen III oxidase
TRK system potassium uptake protein CeoC
Probable ferric uptake regulation protein furB
Probable acetyl-/propionyl-COA carboxylase (beta subunit) accD1
Possible COA-transferase (alpha subunit)
Acetyl-CoA acetyltransferase
Probable acyl-COA dehydrogenase fadE32
Carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)
Possible linoleoyl-COA desaturase (delta(6)-desaturase)
Endonuclease IV
PhoP
Senses Mg2+ starvation, controls expression of genes involved in surface remodeling and adaptation to intracellular growth
Probable transcriptional regulatory protein
Probable DNA repair protein RecN (recombination protein n)
Probable transcriptional regulatory protein (probably crp/fnr-family)
No data
SodC
Copper/zinc-dependent enzyme, responsible for a small part of total SOD activity in M. tuberculosis
KatG
Catalase:peroxidase degrades H2O2 and organic peroxides, the major role is to catabolize the peroxides generated by phagocyte NADPH oxidase
SodA
Iron-dependent enzyme, important fro survival of intracellular pathogens during infection
No data
GPL locus
Mce1
Probable conserved mce associated transmembrane protein
Heme uptake
Protein kinase G
Mce2
Copper exporter
F0F1 ATP synthase subunit A
Probable polyketide synthase pks5
Hypothetical protein
Lysyl-tRNA synthetase
Fused nitrate reductase
Fibronectin-binding protein
Exochelin (smegmatis)
Pyruvate dehydrogenase subunit E1
Trehalose-recycling ABC transporter
Possible transmembrane phospholipid biosynthesis bifunctionnal enzyme plsc: putative l-3-phosphoserine phosphatase (o-phosphoserine phosphohydrolase) (psp) (pspase) + 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-agp acyltransferase) (1-agpat) (lysoph
Mce3
Carboxylesterase
Prolyl-tRNA synthetase
Sulfolipid-1 biosynthesis and transport
ESX-2 (T7SS)
MymA operon
Molybdopterin biosynthesis-like protein MoeZ
Possible cyclase
Probable transposase
ESX-4
Mce4
Cyp125
Lipid phosphatase
Mutation
Orthologous Groups
| Proteins | Pfam Domains | Tigrfam Domains | Count |
|---|---|---|---|
| Starch synthase 1, chloroplastic/amyloplastic (Q9FNF2) | Bac_DnaA_C | phosphocarrier, HPr family TIGRFAMs entry | 11 |
| Starch synthase 1, chloroplastic/amyloplastic (Q9FNF2) | Bac_DnaA_C | phosphocarrier, HPr family TIGRFAMs entry | 11 |