MPA

Mycobacterium tuberculosis PanR0604

Protein-related phenotypes

Virulence Factors
Hypothetical protein
Glutamate racemase
PcaA
Cyclopropane synthase that incorporates a single proximal cycloproprane ring on the <alpha>-mycolic acids and the production of cord factor in the cell wall; Required for virulence and persistance
Inhibition of cyclopropanation of cell wall mycolic acid can result in a change in lipid fluidity and cell wall permeability, and therefore a change in resistance to reactive oxygen intermediates (ROIs) and reactive nitrogen intermediates (RNIs)
MmaA4
Methyltransferase forms methoxy and keto derivatives of the meromycolic acid chain
PDIM (phthiocerol dimycocerosate)
Play a mainly structural role in providing a stable base for the insertion of other lipid and also play a role as a fluidity modifier, whose function could be to modulate cell wall viscosity
Possible conserved protein cpsA
Antigen 85
Mycolyltransferase activity that transfer long-chain mycolic acids to trehalose derivatives (i.e., cord factor, a toxic glycolipid consisting of two mycolic acid molecules linked to trehalose by the hydroxyl groups of carbons 6 and 6' --> trehalose 6,6'-dimycolate (TDM), is an important immunomodulatory component of the cell wall), pivotal for the biosynthesis of the mycobacterial cell wall and for the survival of mycobacteria; Binds the cell matrix protein fibronectin thereby enhancing the uptake of mycobacteria macrophages via complement-mediated phagocytosis
Mycobactin
Cell-association mycobactin participates in iron internalization and/or to serve as a temporary iron-holding molecule to prevent sudden influx of excess iron if the metal suddenly becomes available after a period of iron limitation
Endonuclease IV
end
Probable transcriptional regulatory protein
Probable DNA repair protein RecN (recombination protein n)
PhoP
Senses Mg2+ starvation, controls expression of genes involved in surface remodeling and adaptation to intracellular growth
Probable transcriptional regulatory protein (probably crp/fnr-family)
crp
SodC
Copper/zinc-dependent enzyme, responsible for a small part of total SOD activity in M. tuberculosis
KatG
Catalase:peroxidase degrades H2O2 and organic peroxides, the major role is to catabolize the peroxides generated by phagocyte NADPH oxidase
SodA
Iron-dependent enzyme, important fro survival of intracellular pathogens during infection
Mce1
Probable conserved mce associated transmembrane protein
GPL locus
Mce2
F0F1 ATP synthase subunit A
Lysyl-tRNA synthetase
Fused nitrate reductase
Copper exporter
PE family protein
Trehalose-recycling ABC transporter
Mce3
Heme uptake
Protein kinase G
Possible transmembrane phospholipid biosynthesis bifunctionnal enzyme plsc: putative l-3-phosphoserine phosphatase (o-phosphoserine phosphohydrolase) (psp) (pspase) + 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-agp acyltransferase) (1-agpat) (lysoph
Hypothetical protein
Probable polyketide synthase pks5
Fibronectin-binding protein
Exochelin (smegmatis)
Prolyl-tRNA synthetase
Probable transposase
Carboxylesterase
Pyruvate dehydrogenase subunit E1
MymA operon
Molybdopterin biosynthesis-like protein MoeZ
Lipid phosphatase
Possible cyclase
ESX-4
Mce4
Cyp125
Sulfolipid-1 biosynthesis and transport
ESX-2 (T7SS)

Mutation
Submission Date Amino acid mutations Description Related gene Count
2013-02-01 G72A Retains diadenylate cyclase activity glnA1, narJ, devS 100