Mycobacterium avium MAV_120709_2344
Protein-related phenotypes
Virulence Factors
HbhA
A multifunctional protein involved in adherence of Mycobacterium tuberculosis to non-phagocytic cells and in the formation of intracytosolic lipid inclusions.
PcaA
Cyclopropane synthase that incorporates a single proximal cycloproprane ring on the α-mycolic acids and the production of cord factor in the cell wall; Required for virulence and persistence
Inhibition of cyclopropanation of cell wall mycolic acid can result in a change in lipid fluidity and cell wall permeability, and therefore a change in resistance to reactive oxygen intermediates (ROIs) and reactive nitrogen intermediates (RNIs)
MmaA4
Methyltransferase forms methoxy and keto derivatives of the meromycolic acid chain
Antigen 85
Mycolyltransferase activity that transfer long-chain mycolic acids to trehalose derivatives (i.e., cord factor, a toxic glycolipid consisting of two mycolic acid molecules linked to trehalose by the hydroxyl groups of carbons 6 and 6' --> trehalose 6,6'-dimycolate (TDM), is an important immunomodulatory component of the cell wall), pivotal for the biosynthesis of the mycobacterial cell wall and for the survival of mycobacteria; Binds the cell matrix protein fibronectin thereby enhancing the uptake of mycobacteria macrophages via complement-mediated phagocytosis
PDIM (phthiocerol dimycocerosate)
Play a mainly structural role in providing a stable base for the insertion of other lipid and also play a role as a fluidity modifier, whose function could be to modulate cell wall viscosity
No data
No data
Mycobactin
Cell-association mycobactin participates in iron internalization and/or to serve as a temporary iron-holding molecule to prevent sudden influx of excess iron if the metal suddenly becomes available after a period of iron limitation
MgtC
Magnesium acquisition
Isocitrate lyase
Required for persistant infection
Isocitrate lyase is the initial enzyme in the glyoxylate shunt, a secondary metabolic pathway that allows bacteria to utilize fatty acids as carbon and energy sources when the availability of primary carbon sources is limiting; Isocitrate lyase, in combination with malate synthase, catalyzes the conversion of isocitrate to malate, a reation that allows maintenance of the TCA cycle and synthesize carbohydrates from fatty acids
Nitrate reductase
Nitrate respiration helps the bacteria to survive in O2-depleted areas of inflammatory or necrotic tissue
SigA
Sigma A interacts with a transcriptional activator WhiB3 to allow the expression of genes necessary for virulence
SigF
Controls the bacterial response to environmental stress, SigF-dependent genes includes numerous regulatory genes and those involved in cell envelop synthesis
SigE
Controls the bacterial response to external stimuli such as high temperature and detergent stress
SigH
Involved in response to heat shock and oxidative stress
No data
SodC
Copper/zinc-dependent enzyme, responsible for a small part of total SOD activity in M. tuberculosis
SodA
Iron-dependent enzyme, important for survival of intracellular pathogens during infection
KatG
Catalase:peroxidase degrades H2O2 and organic peroxides, the major role is to catabolize the peroxides generated by phagocyte NADPH oxidase
AhpC
Alkyl hydroperoxide reductase involved in protecting mycobacteria from the oxidative and nitrosative responses of macrophages
No data
ESX-3 (T7SS)
Heme uptake
P(1)-type Mn2+ transporting ATPase
Copper exporter
GPL locus
Mycolic acid trans-cyclopropane synthetase
RegX3
SenX3
Mce1
Mce2
Leucine synthesis
Proline synthesis
Protein kinase G
ABC transporter
MymA operon
Lipoprotein
ESX-4 (T7SS)
Lipid phosphatase
Potassium/proton antiporter
Sigma L
Trehalose-recycling ABC transporter
Sigma M
Lysine synthesis
PrrA/B
Mce7
Mce4
FadE29
Cyp125
ESX-2 (T7SS)
Mce9
NuoG
Enhanced intracellular survival protein
Nucleoside diphosphate kinase
FadE28
Sulfolipid-1 biosynthesis and transport
Mce3
19-kD protein
Tyrosine phosphatase
Carboxylesterase
Glutamine synthesis
Mce5
Proteasome-associated proteins
Fibronectin-binding protein
Mutation
Orthologous Groups
| Proteins | Pfam Domains | Tigrfam Domains | Count |
|---|---|---|---|
| Starch synthase 1, chloroplastic/amyloplastic (Q9FNF2) | Bac_DnaA_C | phosphocarrier, HPr family TIGRFAMs entry | 11 |
| Starch synthase 1, chloroplastic/amyloplastic (Q9FNF2) | Bac_DnaA_C | phosphocarrier, HPr family TIGRFAMs entry | 11 |